CA2419033A1 - Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors - Google Patents
Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors Download PDFInfo
- Publication number
- CA2419033A1 CA2419033A1 CA002419033A CA2419033A CA2419033A1 CA 2419033 A1 CA2419033 A1 CA 2419033A1 CA 002419033 A CA002419033 A CA 002419033A CA 2419033 A CA2419033 A CA 2419033A CA 2419033 A1 CA2419033 A1 CA 2419033A1
- Authority
- CA
- Canada
- Prior art keywords
- ethyl
- dihydro
- pyrazolo
- pyrimidin
- sildenafil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title claims abstract description 103
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Landscapes
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22492800P | 2000-08-11 | 2000-08-11 | |
| US60/224,928 | 2000-08-11 | ||
| GB0030649A GB0030649D0 (en) | 2000-12-15 | 2000-12-15 | Treatment of the insulin resistance syndrome |
| GB0030649.8 | 2000-12-15 | ||
| US26608301P | 2001-02-02 | 2001-02-02 | |
| US60/266,083 | 2001-02-02 | ||
| GB0106465.8 | 2001-03-15 | ||
| GB0106465A GB0106465D0 (en) | 2001-03-15 | 2001-03-15 | Treatment of the insulin resistance syndrome |
| GB0106468.2 | 2001-03-15 | ||
| GB0106468A GB0106468D0 (en) | 2001-03-15 | 2001-03-15 | Treatment of diabetes mellitus |
| GB0117134.7 | 2001-07-13 | ||
| GB0117134A GB0117134D0 (en) | 2001-07-13 | 2001-07-13 | Treatment of the insulin resistance syndrome |
| PCT/IB2001/001428 WO2002013798A2 (en) | 2000-08-11 | 2001-08-06 | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
Publications (1)
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| CA2419033A1 true CA2419033A1 (en) | 2002-02-21 |
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| EP (1) | EP1307183A2 (enExample) |
| JP (1) | JP2004506009A (enExample) |
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| CN (1) | CN1446084A (enExample) |
| AU (1) | AU2001276607A1 (enExample) |
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| US6683080B2 (en) * | 2001-02-02 | 2004-01-27 | Pfizer Inc. | Treatment of diabetes mellitus |
| US6933127B2 (en) | 2001-07-05 | 2005-08-23 | Eucro European Contract Research Gmbh & Co. Kg | Substrate for PP2C |
| DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| US7019010B2 (en) | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
| JP2005508978A (ja) | 2001-11-02 | 2005-04-07 | ファイザー・プロダクツ・インク | Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療 |
| US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
| MXPA04007713A (es) * | 2002-02-07 | 2004-11-10 | Pfizer | Uso de inhibidores de la fosfodiesterasa tipo 5, tal como sildenafil, en el tratamiento del sindrome de ovario poliquistico. |
| JP2004018524A (ja) * | 2002-06-13 | 2004-01-22 | Eucro European Contract Research Gmbh & Co Kg | 動脈硬化症を処置するための方法 |
| GB0214784D0 (en) * | 2002-06-26 | 2002-08-07 | Pfizer Ltd | Novel combination |
| MXPA05009242A (es) * | 2003-03-17 | 2006-04-18 | Pfizer Prod Inc | Tratamiento de la diabetes tipo 1 con los inhibidores de la pde5. |
| DK1620437T3 (da) | 2003-04-29 | 2009-08-24 | Pfizer Ltd | 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension |
| CN100439371C (zh) * | 2003-04-29 | 2008-12-03 | 辉瑞大药厂 | 可用于治疗高血压的5,7-二氨基吡唑并[4,3-d]嘧啶 |
| JP2007504201A (ja) | 2003-09-05 | 2007-03-01 | アルタナ ファルマ アクチエンゲゼルシャフト | 真性糖尿病の治療のためのｐｄｅ４阻害剤の使用 |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| US7569572B2 (en) | 2004-04-07 | 2009-08-04 | Pfizer Inc | Pyrazolo[4,3-D]pyrimidines |
| US8017633B2 (en) | 2005-03-08 | 2011-09-13 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| EP1909793A2 (de) * | 2005-07-15 | 2008-04-16 | Proxomed Medizintechnik GmbH | Verwendung von phosphodiesterase typ 5-hemmern für die prävention und behandlung von erkrankungen oder gesundheitsstörungen, sowie abgabesysteme für dieselben |
| BRPI0716134A2 (pt) | 2006-09-07 | 2013-09-17 | Nycomed Gmbh | tratamento de combinaÇço para diabetes mellitus |
| EA021544B1 (ru) | 2007-06-04 | 2015-07-30 | Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити | Триарильные соединения и фармацевтические композиции, их содержащие |
| AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
| US20130315891A1 (en) | 2012-05-25 | 2013-11-28 | Matthew Charles | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
| CA2880085C (en) | 2012-06-04 | 2021-09-07 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
| CN108452311A (zh) * | 2012-11-13 | 2018-08-28 | 纽斯尔特科学公司 | 用于增强能量代谢的组合物和方法 |
| AU2014202625B2 (en) | 2013-05-14 | 2018-11-08 | Scimar Ltd. | Hepatic insulin sensitizing substance and test meal for insulin sensitization |
| AU2014347668A1 (en) | 2013-11-05 | 2016-05-19 | Ben-Gurion University Of The Negev Research And Development Authority | Compounds for the treatment of diabetes and disease complications arising from same |
| EP3592377A4 (en) | 2017-03-09 | 2021-02-17 | Diamedica Inc. | TISSUE KALLICREIN DOSAGE FORMS 1 |
| MX2017016930A (es) * | 2017-12-19 | 2019-06-20 | Malesil Research & Tech Llc | Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico. |
| KR102068299B1 (ko) * | 2018-12-21 | 2020-01-20 | 한국기초과학지원연구원 | Cyp4a 저해 화합물을 유효성분으로 포함하는 대사질환의 예방 또는 치료용 조성물 |
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| GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9511220D0 (en) * | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
| EA002357B1 (ru) * | 1995-12-28 | 2002-04-25 | Фудзисава Фармасьютикал Ко., Лтд. | Производные бензимидазола |
| CZ299633B6 (cs) * | 1997-04-25 | 2008-09-24 | Pfizer Inc. | Pyrazolopyrimidinony, meziprodukty pro jejich výrobu a farmaceutické a veterinární kompozice na jejich bázi |
| EP0995742A4 (en) * | 1997-06-27 | 2004-08-25 | Fujisawa Pharmaceutical Co | SULPHONAMIDE COMPOUNDS AND THEIR MEDICAL USE |
| EP1070705A4 (en) * | 1998-04-06 | 2002-04-17 | Fujisawa Pharmaceutical Co | INDOLE DERIVATIVES |
| CZ20011981A3 (cs) * | 1998-12-04 | 2002-01-16 | Fujisawa Pharmaceutical Co., Ltd. | Sulfonamidové sloučeniny |
| JP2002540102A (ja) * | 1999-03-22 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | ｃＧＭＰホスホジエステラーゼの縮合ピリドピリダジン阻害剤 |
| DE19944161A1 (de) * | 1999-09-15 | 2001-03-22 | Bayer Ag | Neue Kombination zur Behandlung von sexueller Dysfunktion |
| DK1088824T3 (da) * | 1999-09-30 | 2004-04-13 | Pfizer Prod Inc | Bicykliske pyrrolylamider som glycogen phosphorylase inhibitorer |
| US6503908B1 (en) * | 1999-10-11 | 2003-01-07 | Pfizer Inc | Pharmaceutically active compounds |
| AU5714601A (en) * | 2000-04-19 | 2001-10-30 | Univ Johns Hopkins | Methods for prevention and treatment of gastrointestinal disorders |
-
2001
- 2001-08-06 CA CA002419033A patent/CA2419033A1/en not_active Abandoned
- 2001-08-06 HU HU0300725A patent/HUP0300725A3/hu unknown
- 2001-08-06 IL IL15415801A patent/IL154158A0/xx unknown
- 2001-08-06 KR KR10-2003-7001961A patent/KR20030023747A/ko not_active Ceased
- 2001-08-06 CN CN01814039A patent/CN1446084A/zh active Pending
- 2001-08-06 EP EP01954266A patent/EP1307183A2/en not_active Withdrawn
- 2001-08-06 JP JP2002518944A patent/JP2004506009A/ja not_active Withdrawn
- 2001-08-06 WO PCT/IB2001/001428 patent/WO2002013798A2/en not_active Ceased
- 2001-08-06 AU AU2001276607A patent/AU2001276607A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002013798A3 (en) | 2003-01-23 |
| HUP0300725A2 (hu) | 2003-11-28 |
| CN1446084A (zh) | 2003-10-01 |
| IL154158A0 (en) | 2003-07-31 |
| EP1307183A2 (en) | 2003-05-07 |
| AU2001276607A1 (en) | 2002-02-25 |
| JP2004506009A (ja) | 2004-02-26 |
| HUP0300725A3 (en) | 2005-11-28 |
| KR20030023747A (ko) | 2003-03-19 |
| WO2002013798A2 (en) | 2002-02-21 |
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| EEER | Examination request | ||
| FZDE | Discontinued |