CA2411818C - Cyclopentabenzofuran compounds and uses thereof - Google Patents
Cyclopentabenzofuran compounds and uses thereof Download PDFInfo
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- CA2411818C CA2411818C CA2411818A CA2411818A CA2411818C CA 2411818 C CA2411818 C CA 2411818C CA 2411818 A CA2411818 A CA 2411818A CA 2411818 A CA2411818 A CA 2411818A CA 2411818 C CA2411818 C CA 2411818C
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- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 125000004784 trichloromethoxy group Chemical group ClC(O*)(Cl)Cl 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 238000012447 xenograft mouse model Methods 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ8665A AUPQ866500A0 (en) | 2000-07-05 | 2000-07-05 | Therapeutic compounds and methods |
| AUPQ8665 | 2000-07-05 | ||
| PCT/AU2001/000810 WO2002002566A1 (en) | 2000-07-05 | 2001-07-05 | Therapeutic compounds and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2411818A1 CA2411818A1 (en) | 2002-01-10 |
| CA2411818C true CA2411818C (en) | 2011-02-22 |
Family
ID=3822729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2411818A Expired - Lifetime CA2411818C (en) | 2000-07-05 | 2001-07-05 | Cyclopentabenzofuran compounds and uses thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6710075B2 (OSRAM) |
| EP (1) | EP1303520B1 (OSRAM) |
| JP (1) | JP2004501983A (OSRAM) |
| AT (1) | ATE374203T1 (OSRAM) |
| AU (1) | AUPQ866500A0 (OSRAM) |
| CA (1) | CA2411818C (OSRAM) |
| DE (1) | DE60130659T2 (OSRAM) |
| ES (1) | ES2295176T3 (OSRAM) |
| PT (1) | PT1303520E (OSRAM) |
| WO (1) | WO2002002566A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1569928A4 (en) * | 2002-11-08 | 2008-12-10 | Government Of The State Of Sar | THERAPEUTIC COMPOUNDS AND METHOD |
| WO2006007634A1 (en) * | 2004-07-16 | 2006-01-26 | Cerylid Biosciences Ltd | Processes and intermediates |
| EP2189158A1 (en) * | 2008-11-20 | 2010-05-26 | DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts | Combination of rocaglamide and apoptosis inducing substances for the treatment of cancer |
| WO2011140334A2 (en) * | 2010-05-06 | 2011-11-10 | Trustees Of Boston University | Compounds, methods of making or identifying compounds, and uses thereof |
| FR3023290B1 (fr) * | 2014-07-04 | 2016-08-19 | Pf Medicament | Derives de flavaglines |
| US10639378B2 (en) | 2016-06-06 | 2020-05-05 | Genentech, Inc. | Silvestrol antibody-drug conjugates and methods of use |
| AU2019221837B2 (en) | 2018-02-19 | 2024-08-01 | Memorial Sloan-Kettering Cancer Center | Agents and methods for treating dysproliferative diseases |
| CN110279687A (zh) * | 2019-07-15 | 2019-09-27 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种抗肿瘤药物 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| MY194199A (en) * | 2020-08-11 | 2022-11-21 | The Government Of The State Of Sarawak Malaysia | A composition for the treatment of autoimmune diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656296A (en) | 1983-06-01 | 1987-04-07 | Sun Chemical Corporation | Novel compounds and their use as insolubilizers for binders for paper coating compositions |
| WO1996004284A1 (en) | 1994-08-04 | 1996-02-15 | Novartis Ag | Insecticidal polycyclic compounds |
| JPH0967360A (ja) | 1995-08-28 | 1997-03-11 | Terumo Corp | 癌遺伝子機能抑制剤 |
| WO1997008161A1 (en) | 1995-08-28 | 1997-03-06 | Terumo Kabushiki Kaisha | Oncogene function depressant |
| JPH1112279A (ja) | 1997-06-27 | 1999-01-19 | Microbial Chem Res Found | Ｒａｓ蛋白の阻害活性を有する新規なアグライアスタチン立体異性体とそれらの製造法 |
| DE19934952A1 (de) * | 1998-07-30 | 2000-02-03 | Novartis Ag | Cyclopentabenzofuran-Derivate |
| DE19835324A1 (de) | 1998-08-05 | 2000-02-10 | Bayer Ag | Cyclopentabenzofuran-Derivate und ihre Verwendung |
| DE19835325A1 (de) * | 1998-08-05 | 2000-02-10 | Bayer Ag | Verwendung von Cyclopentabenzofuran-Derivaten zur Bekämpfung von NF-kB abhängigen Krankheiten |
-
2000
- 2000-07-05 AU AUPQ8665A patent/AUPQ866500A0/en not_active Abandoned
-
2001
- 2001-07-05 CA CA2411818A patent/CA2411818C/en not_active Expired - Lifetime
- 2001-07-05 PT PT01947052T patent/PT1303520E/pt unknown
- 2001-07-05 ES ES01947052T patent/ES2295176T3/es not_active Expired - Lifetime
- 2001-07-05 EP EP01947052A patent/EP1303520B1/en not_active Expired - Lifetime
- 2001-07-05 JP JP2002507818A patent/JP2004501983A/ja active Pending
- 2001-07-05 AT AT01947052T patent/ATE374203T1/de active
- 2001-07-05 WO PCT/AU2001/000810 patent/WO2002002566A1/en not_active Ceased
- 2001-07-05 DE DE60130659T patent/DE60130659T2/de not_active Expired - Lifetime
-
2002
- 2002-11-08 US US10/291,863 patent/US6710075B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1303520A4 (en) | 2005-03-30 |
| US6710075B2 (en) | 2004-03-23 |
| CA2411818A1 (en) | 2002-01-10 |
| WO2002002566A1 (en) | 2002-01-10 |
| DE60130659D1 (de) | 2007-11-08 |
| EP1303520B1 (en) | 2007-09-26 |
| DE60130659T2 (de) | 2008-07-17 |
| ATE374203T1 (de) | 2007-10-15 |
| ES2295176T3 (es) | 2008-04-16 |
| EP1303520A1 (en) | 2003-04-23 |
| JP2004501983A (ja) | 2004-01-22 |
| US20030181514A1 (en) | 2003-09-25 |
| PT1303520E (pt) | 2008-01-07 |
| AUPQ866500A0 (en) | 2000-08-03 |
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| MKEX | Expiry |
Effective date: 20210705 |