CA2401327C - Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use - Google Patents
Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use Download PDFInfo
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- CA2401327C CA2401327C CA2401327A CA2401327A CA2401327C CA 2401327 C CA2401327 C CA 2401327C CA 2401327 A CA2401327 A CA 2401327A CA 2401327 A CA2401327 A CA 2401327A CA 2401327 C CA2401327 C CA 2401327C
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- CA
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- Prior art keywords
- poly
- formulation
- nucleic acid
- anionic polymer
- glutamic acid
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- Expired - Lifetime
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Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Landscapes
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- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| US26175101P | 2001-01-16 | 2001-01-16 | |
| US60/261,751 | 2001-01-16 | ||
| PCT/US2001/006953 WO2001066149A2 (en) | 2000-03-03 | 2001-03-02 | Nucleic acid formulations for gene delivery and methods of use |
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Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551996B1 (en) * | 1999-07-26 | 2003-04-22 | Baylor College Of Medicine | Super-active porcine growth hormone releasing hormone analog |
| US20040192593A1 (en) * | 1999-07-26 | 2004-09-30 | Baylor College Of Medicine | Protease resistant ti-growth hormone releasing hormone |
| ATE428790T1 (de) | 2000-09-25 | 2009-05-15 | Genetronics Inc | Verbessertes system zur regulation der transgenexpression |
| ATE536100T1 (de) | 2001-10-26 | 2011-12-15 | Baylor College Medicine | Zusammensetzung für die änderung der knocheneigenschaften bei einem probanden |
| WO2003059382A2 (en) * | 2001-12-28 | 2003-07-24 | Supratek Pharma Inc. | Pharmaceutical compositions comprising polyanionic polymers and amphiphilic block copolymers and methods of use thereof to improve gene expression |
| EP1513559A4 (en) * | 2002-05-28 | 2006-01-18 | Advisys Inc | INCREASED DELIVERY OF A NUCLEIC ACID CONSTRUCTION IN VIVO WITH THE POLY-L-GLUTAMATE (PLG) SYSTEM |
| US20080269153A1 (en) * | 2002-05-28 | 2008-10-30 | Ruxandra Draghia-Akli | Increased stability of a dna formulation by including poly-l-glutamate |
| US20040014645A1 (en) * | 2002-05-28 | 2004-01-22 | Advisys, Inc. | Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system |
| US7316925B2 (en) | 2002-07-16 | 2008-01-08 | Vgx Pharmaceuticals, Inc. | Codon optimized synthetic plasmids |
| AU2003302337A1 (en) * | 2002-12-31 | 2004-07-29 | The Johns Hopkins University | Wound healing method and kits |
| US20040204358A1 (en) * | 2003-01-28 | 2004-10-14 | Advisys, Inc. | Reducing culling in herd animals growth hormone releasing hormone (GHRH) |
| WO2004081167A2 (en) * | 2003-03-11 | 2004-09-23 | Applied Research Systems Ars Holding N.V. | Expression vectors comprising the mcmv ie2 promoter |
| CA2521979A1 (en) * | 2003-04-09 | 2004-10-28 | University Of Utah Research Foundation | Compositions and methods related to production of erythropoietin |
| TW200424214A (en) * | 2003-04-21 | 2004-11-16 | Advisys Inc | Plasmid mediated GHRH supplementation for renal failures |
| GB0313916D0 (en) * | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| US20090005333A1 (en) * | 2004-01-26 | 2009-01-01 | Vgx Pharmaceuticlas, Inc. | Reducing culling in herd animals growth hormone releasing hormone (ghrh) |
| ES2436741T3 (es) * | 2004-09-22 | 2014-01-07 | St. Jude Children's Research Hospital | Expresión mejorada de Factor IX en vectores de terapia génica |
| US20060094023A1 (en) * | 2004-11-02 | 2006-05-04 | Industrial Technology Research Institute | Method for isolating nucleic acid by using amino surfactants |
| TWI294460B (en) * | 2004-12-23 | 2008-03-11 | Ind Tech Res Inst | Method for stabilizing nucleic acids |
| CN101370927A (zh) * | 2005-12-07 | 2009-02-18 | 基因特伦尼克斯公司 | 可变容积电穿孔室以及其方法 |
| WO2007103070A2 (en) * | 2006-03-03 | 2007-09-13 | Genetronics, Inc. | Method and device for treating microscopic residual tumors remaining in tissues following surgical resection |
| EP2094086B1 (en) | 2006-11-08 | 2013-08-28 | Veritas Bio, LLC | In vivo delivery of double stranded rna to a target cell |
| FR2941152B1 (fr) * | 2009-01-20 | 2013-10-18 | Centre Nat Rech Scient | Vecteurs comprenant une macromolecule anionique et un lipide cationique pour l'administration de petits acides nucleiques. |
| WO2012018594A2 (en) * | 2010-07-26 | 2012-02-09 | Scott & White Healthcare | Plant-derived polysaccharides for delivery of rna-based therapies |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| CN103429606A (zh) | 2010-10-01 | 2013-12-04 | 现代治疗公司 | 设计核酸及其使用方法 |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| KR101955365B1 (ko) | 2011-07-12 | 2019-03-07 | 필라델피아 헬스 앤드 에듀케이션 코포레이션 디/비/에이 드렉셀 유니버시티 컬리지 오브 메디슨 | 신규한 클로스트리듐 디피실(Clostridium Difficile) DNA 백신 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2013040557A2 (en) | 2011-09-16 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Rna engineered t cells for the treatment of cancer |
| WO2013044225A1 (en) | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| ES2816450T3 (es) | 2012-02-22 | 2021-04-05 | Univ Pennsylvania | Uso de CAR basados en ICOS para mejorar la actividad antitumoral y la persistencia del CAR |
| ES2959443T3 (es) | 2012-02-22 | 2024-02-26 | Univ Pennsylvania | Uso del dominio de señalización de CD2 en receptores de antígenos quiméricos de segunda generación |
| AU2013243954A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| CA2876730A1 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Enhancing activity of car t cells by co-introducing a bispecific antibody |
| AR092745A1 (es) | 2012-10-01 | 2015-04-29 | Univ Pennsylvania | Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer |
| US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| JP6395711B2 (ja) * | 2012-10-08 | 2018-09-26 | リポカリクス・ゲーエムベーハー | 形質導入試薬としてのカルボキシル化ポリアミン誘導体 |
| DK2922554T3 (en) | 2012-11-26 | 2022-05-23 | Modernatx Inc | Terminalt modificeret rna |
| DK3889173T5 (da) | 2013-02-15 | 2024-08-05 | Bioverativ Therapeutics Inc | Optimeret faktor viii-gen |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| BR112016007255A2 (pt) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polinucleotídeos que codificam receptor de lipoproteína de baixa densidade |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| US11028143B2 (en) | 2014-01-21 | 2021-06-08 | Novartis Ag | Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| CA2966035A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Compositions and methods of stimulating and expanding t cells |
| HK1243333A1 (zh) | 2014-10-31 | 2018-07-13 | The Trustees Of The University Of Pennsylvania | 用於修饰的t细胞的方法和组合物 |
| KR20170075013A (ko) | 2014-10-31 | 2017-06-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Cart 세포에서 유전자 발현의 변경 및 그의 용도 |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| EP3288580A4 (en) | 2015-05-01 | 2018-12-26 | The Regents of The University of California | Glycan-dependent immunotherapeutic molecules |
| US11649435B2 (en) | 2015-08-28 | 2023-05-16 | The Trustees Of The University Of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| EP3411478B1 (en) | 2016-02-01 | 2022-06-08 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| US10233419B2 (en) | 2016-06-30 | 2019-03-19 | Zymergen Inc. | Apparatuses and methods for electroporation |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| AU2018246143B2 (en) | 2017-03-28 | 2025-06-05 | The Trustees Of The University Of Pennsylvania | Methods to protect transplanted tissue from rejection |
| EP3684399A1 (en) | 2017-12-29 | 2020-07-29 | Cellectis | Method for improving production of car t cells |
| CN118325840A (zh) | 2018-03-27 | 2024-07-12 | 宾夕法尼亚大学董事会 | 具有增强功能的修饰的免疫细胞及其筛选方法 |
| EP3793590A4 (en) | 2018-05-17 | 2022-02-16 | Regents of the University of Minnesota | DRUG RESISTANT IMMUNE CELLS AND METHODS OF USE THEREOF |
| WO2020037142A1 (en) | 2018-08-17 | 2020-02-20 | Yale University | Compositions and methods for high-throughput activation screening to boost t cell effector function |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| US20220170097A1 (en) | 2018-10-29 | 2022-06-02 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
| US20220177863A1 (en) | 2019-03-18 | 2022-06-09 | The Broad Institute, Inc. | Type vii crispr proteins and systems |
| JP7654557B2 (ja) | 2019-03-27 | 2025-04-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法 |
| CN115279896A (zh) | 2019-09-30 | 2022-11-01 | 比奥维拉迪维治疗股份有限公司 | 慢病毒载体配制品 |
| WO2021108050A2 (en) | 2019-10-23 | 2021-06-03 | Yale University | Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy |
| JP2023516080A (ja) | 2020-03-06 | 2023-04-17 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｃｄ４４抗体およびその使用 |
| WO2021191871A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| WO2021191870A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| KR20230074703A (ko) | 2020-06-24 | 2023-05-31 | 바이오버라티브 테라퓨틱스 인크. | 유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법 |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| US20230372484A1 (en) | 2020-09-14 | 2023-11-23 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
| EP4240405A1 (en) | 2020-11-05 | 2023-09-13 | Mendus B.V. | Use of tumor-independent antigens in immunotherapies |
| KR20230135075A (ko) | 2021-01-22 | 2023-09-22 | 멘두스 비.브이. | 종양 백신접종 방법 |
| US20250326855A1 (en) | 2021-03-05 | 2025-10-23 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| US20220305100A1 (en) | 2021-03-12 | 2022-09-29 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
| KR20240107093A (ko) | 2021-08-05 | 2024-07-08 | 고 테라퓨틱스, 인크. | 항-글리코-muc4 항체 및 그의 용도 |
| US20250066498A1 (en) | 2021-09-03 | 2025-02-27 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
| JP2024536722A (ja) | 2021-09-03 | 2024-10-08 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｃｍｅｔ抗体およびその使用 |
| US20240002800A1 (en) | 2022-05-16 | 2024-01-04 | Mendus B.V. | Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy |
| WO2024236547A1 (en) | 2023-05-18 | 2024-11-21 | Inceptor Bio, Llc | Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof |
| WO2025046513A1 (en) | 2023-08-29 | 2025-03-06 | Inceptor Bio, Llc | Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof |
| CN119925619A (zh) * | 2024-12-31 | 2025-05-06 | 首都医科大学 | 一种递送外源质粒dna的赋形剂及其制备和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4543252A (en) * | 1982-01-21 | 1985-09-24 | The Regents Of The University Of California | Cationic oligopeptides having microbicidal activity |
| EP0150184A1 (fr) | 1983-07-01 | 1985-08-07 | Battelle Memorial Institute | Polypeptide biodegradable et son utilisation pour le relargage progressif de medicaments |
| DE3581471D1 (de) | 1984-10-19 | 1991-02-28 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| US5749847A (en) * | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| JP3368603B2 (ja) | 1992-02-28 | 2003-01-20 | オリンパス光学工業株式会社 | 遺伝子治療用処置具 |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| EP0695186A1 (en) | 1993-04-28 | 1996-02-07 | Ribozyme Pharmaceuticals, Inc. | Ocular delivery of nucleic acid |
| US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| FR2715847B1 (fr) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| AU710504B2 (en) | 1994-03-15 | 1999-09-23 | Brown University Research Foundation | Polymeric gene delivery system |
| US6271205B1 (en) * | 1994-09-21 | 2001-08-07 | University Of Massachusetts Medical Center | Cancer treatment by expression of differentiation factor receptor |
| US6040295A (en) * | 1995-01-13 | 2000-03-21 | Genemedicine, Inc. | Formulated nucleic acid compositions and methods of administering the same for gene therapy |
| FR2732218B1 (fr) | 1995-03-28 | 1997-08-01 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation |
| GB9600272D0 (en) * | 1996-01-06 | 1996-03-06 | Univ Nottingham | Polymers |
| US5704908A (en) | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
| GB9623051D0 (en) | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
| US6048551A (en) | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
| FR2766706B1 (fr) | 1997-07-30 | 2001-05-25 | Biovector Therapeutics Sa | Complexes particulaires stables de charge globale neutre ou negative de structure multilamellaire composes par au moins une substance biologiquement active globalement anionique et un constituant cationique, leur preparation et utilisation |
| US6040925A (en) | 1997-12-12 | 2000-03-21 | Hewlett-Packard Company | Radial and pruned radial interpolation |
| US6383811B2 (en) | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| US6697669B2 (en) * | 1998-07-13 | 2004-02-24 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| US7396919B1 (en) * | 1998-07-17 | 2008-07-08 | Mirus Bio Corporation | Charge reversal of polyion complexes |
| US5945290A (en) * | 1998-09-18 | 1999-08-31 | Isis Pharmaceuticals, Inc. | Antisense modulation of RhoA expression |
| FR2786098B1 (fr) * | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
| AU5376500A (en) | 1999-06-17 | 2001-01-09 | Universiteit Gent | Functional poly-alpha-aminoacid derivatives useful for the modification of biologically active materials and their application |
| AU5624500A (en) | 1999-06-18 | 2001-01-09 | Collaborative Group, Ltd., The | Hyaluronic acid microspheres for sustained gene transfer |
| WO2001013723A1 (en) | 1999-08-20 | 2001-03-01 | Mirus Corporation | Charge reversal of polyion complexes |
| BR0108959A (pt) * | 2000-03-03 | 2003-10-14 | Valentis Inc | Composições de poloxmero ou poloxamina melhoradas para distribuição de ácido nucléico |
| ATE428790T1 (de) * | 2000-09-25 | 2009-05-15 | Genetronics Inc | Verbessertes system zur regulation der transgenexpression |
-
2001
- 2001-03-02 WO PCT/US2001/006953 patent/WO2001066149A2/en not_active Ceased
- 2001-03-02 DK DK01918339.1T patent/DK1259265T3/da active
- 2001-03-02 AU AU2001245427A patent/AU2001245427A1/en not_active Abandoned
- 2001-03-02 EP EP01918339A patent/EP1259265B1/en not_active Expired - Lifetime
- 2001-03-02 CA CA2401327A patent/CA2401327C/en not_active Expired - Lifetime
- 2001-03-02 BR BR0108962-5A patent/BR0108962A/pt not_active IP Right Cessation
- 2001-03-02 JP JP2001564801A patent/JP4987205B2/ja not_active Expired - Lifetime
- 2001-03-02 AT AT01918339T patent/ATE511400T1/de not_active IP Right Cessation
-
2002
- 2002-09-03 US US10/234,406 patent/US7173116B2/en not_active Expired - Lifetime
-
2006
- 2006-11-20 US US11/561,847 patent/US7491537B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BR0108962A (pt) | 2002-12-24 |
| US7173116B2 (en) | 2007-02-06 |
| EP1259265B1 (en) | 2011-06-01 |
| JP2003525912A (ja) | 2003-09-02 |
| US20070213287A1 (en) | 2007-09-13 |
| DK1259265T3 (da) | 2011-07-11 |
| CA2401327A1 (en) | 2001-09-13 |
| WO2001066149A2 (en) | 2001-09-13 |
| WO2001066149A3 (en) | 2002-03-14 |
| ATE511400T1 (de) | 2011-06-15 |
| US20030109478A1 (en) | 2003-06-12 |
| US7491537B2 (en) | 2009-02-17 |
| AU2001245427A1 (en) | 2001-09-17 |
| EP1259265A2 (en) | 2002-11-27 |
| JP4987205B2 (ja) | 2012-07-25 |
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