CA2399545A1 - Derives de la pyrrolo-isoquinoline et de la tetrahydropyrrolo-isoquinoline et leur utilisation comme mediateurs du recepteur 5-ht7 - Google Patents

Derives de la pyrrolo-isoquinoline et de la tetrahydropyrrolo-isoquinoline et leur utilisation comme mediateurs du recepteur 5-ht7 Download PDF

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Publication number
CA2399545A1
CA2399545A1 CA002399545A CA2399545A CA2399545A1 CA 2399545 A1 CA2399545 A1 CA 2399545A1 CA 002399545 A CA002399545 A CA 002399545A CA 2399545 A CA2399545 A CA 2399545A CA 2399545 A1 CA2399545 A1 CA 2399545A1
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CA
Canada
Prior art keywords
carbon atoms
alkyl
hydrogen
compound
members
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002399545A
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English (en)
Inventor
Michael Gerard Kelly
Young Hee Kang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2399545A1 publication Critical patent/CA2399545A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention porte sur des composés de formule (1) utilisables pour le traitement de l'angoisse, de la dépression et de troubles associés du SNC, et d'autres états tels que la schizophrénie, les troubles du sommeil dont ceux du rythme circadien, le sevrage de l'alcool et de drogues, et certaines dysfonctions sexuelles.
CA002399545A 2000-02-04 2001-02-02 Derives de la pyrrolo-isoquinoline et de la tetrahydropyrrolo-isoquinoline et leur utilisation comme mediateurs du recepteur 5-ht7 Abandoned CA2399545A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49737900A 2000-02-04 2000-02-04
US09/497,379 2000-02-04
PCT/US2001/003430 WO2001057039A1 (fr) 2000-02-04 2001-02-02 Derives de la pyrrolo-isoquinoline et de la tetrahydropyrrolo-isoquinoline et leur utilisation comme mediateurs du recepteur 5-ht7

Publications (1)

Publication Number Publication Date
CA2399545A1 true CA2399545A1 (fr) 2001-08-09

Family

ID=23976619

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002399545A Abandoned CA2399545A1 (fr) 2000-02-04 2001-02-02 Derives de la pyrrolo-isoquinoline et de la tetrahydropyrrolo-isoquinoline et leur utilisation comme mediateurs du recepteur 5-ht7

Country Status (8)

Country Link
EP (1) EP1252161A1 (fr)
JP (1) JP2003522178A (fr)
CN (1) CN1168728C (fr)
AU (1) AU2001231287A1 (fr)
BR (1) BR0108007A (fr)
CA (1) CA2399545A1 (fr)
MX (1) MXPA02007521A (fr)
WO (1) WO2001057039A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1668014T3 (da) 2003-09-17 2009-04-20 Janssen Pharmaceutica Nv Kondenserede heterocykliske forbindelser som serotoninreceptormodulatorer
US7598255B2 (en) 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
WO2007053353A2 (fr) * 2005-10-28 2007-05-10 Wyeth Derives pyrrolo[2,3-f] et [3,2-f]isoquinolinone utilises en tant que ligands de la 5-hydroxytryptamine-6
EP2676954A1 (fr) * 2012-06-19 2013-12-25 Laboratorios del Dr. Esteve S.A. Dérivés de phényle substitués par un hétérocyclyle en tant que vasodilatateurs

Also Published As

Publication number Publication date
EP1252161A1 (fr) 2002-10-30
WO2001057039A1 (fr) 2001-08-09
AU2001231287A1 (en) 2001-08-14
MXPA02007521A (es) 2002-12-13
CN1168728C (zh) 2004-09-29
JP2003522178A (ja) 2003-07-22
CN1396921A (zh) 2003-02-12
BR0108007A (pt) 2002-10-29

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