CA2396513A1 - Promedicaments de phosphate pseudomycine - Google Patents

Promedicaments de phosphate pseudomycine Download PDF

Info

Publication number
CA2396513A1
CA2396513A1 CA002396513A CA2396513A CA2396513A1 CA 2396513 A1 CA2396513 A1 CA 2396513A1 CA 002396513 A CA002396513 A CA 002396513A CA 2396513 A CA2396513 A CA 2396513A CA 2396513 A1 CA2396513 A1 CA 2396513A1
Authority
CA
Canada
Prior art keywords
alkyl
hydrogen
prodrug
represented
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002396513A
Other languages
English (en)
Inventor
Yanzhi Zhang
Xicheng Sun
Shu Hui Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2396513A1 publication Critical patent/CA2396513A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un promédicament de pseudomycine, représenté par la structure (A), dans laquelle R1 est une liaison benzyloxycarbamate de phosphate ou méthylèneoxycarbamate de phosphate. Ces promédicaments de phosphate présentent une activité antifongique, avec moins d'effets indésirables que le composé de pseudomycine parent.
CA002396513A 1999-12-13 2000-11-29 Promedicaments de phosphate pseudomycine Abandoned CA2396513A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17046699P 1999-12-13 1999-12-13
US60/170,466 1999-12-13
PCT/US2000/030167 WO2001041534A2 (fr) 1999-12-13 2000-11-29 Promedicaments de phosphate pseudomycine

Publications (1)

Publication Number Publication Date
CA2396513A1 true CA2396513A1 (fr) 2001-06-14

Family

ID=22619957

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002396513A Abandoned CA2396513A1 (fr) 1999-12-13 2000-11-29 Promedicaments de phosphate pseudomycine

Country Status (7)

Country Link
JP (1) JP2003515610A (fr)
AU (1) AU3071801A (fr)
BR (1) BR0016328A (fr)
CA (1) CA2396513A1 (fr)
MX (1) MXPA02005791A (fr)
NO (1) NO20022798L (fr)
WO (1) WO2001041534A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002542257A (ja) * 1999-04-15 2002-12-10 イーライ・リリー・アンド・カンパニー シュードマイシン天然産物
BR112020013672A2 (pt) 2018-01-05 2020-12-01 Cybrexa 1, Inc. compostos, composições, e métodos para tratamento de doenças que envolvem tecidos afetados por ácidos ou hipoxia
WO2021007435A1 (fr) 2019-07-10 2021-01-14 Cybrexa 2, Inc. Conjugués peptidiques de cytotoxines servant d'agents thérapeutiques
AU2020311925A1 (en) 2019-07-10 2022-02-03 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576298A (en) * 1992-11-30 1996-11-19 Research And Development Institute, Inc. At Montana State University Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity
AU5725000A (en) * 1999-07-15 2001-02-05 Eli Lilly And Company Pseudomycin amide and ester analogs

Also Published As

Publication number Publication date
BR0016328A (pt) 2002-08-27
AU3071801A (en) 2001-06-18
WO2001041534A2 (fr) 2001-06-14
JP2003515610A (ja) 2003-05-07
NO20022798D0 (no) 2002-06-12
NO20022798L (no) 2002-06-12
WO2001041534A3 (fr) 2001-11-22
MXPA02005791A (es) 2002-09-30

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Legal Events

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FZDE Dead