CA2392685C - Antisense antibacterial method and composition - Google Patents

Antisense antibacterial method and composition Download PDF

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Publication number
CA2392685C
CA2392685C CA2392685A CA2392685A CA2392685C CA 2392685 C CA2392685 C CA 2392685C CA 2392685 A CA2392685 A CA 2392685A CA 2392685 A CA2392685 A CA 2392685A CA 2392685 C CA2392685 C CA 2392685C
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Prior art keywords
seq
sequence
bacterial
antisense
antisense oligomer
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Expired - Lifetime
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CA2392685A
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French (fr)
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CA2392685A1 (en
Inventor
Patrick L. Iversen
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Sarepta Therapeutics Inc
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AVI Biopharma Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3233Morpholino-type ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Feed For Specific Animals (AREA)
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CA2392685A 1999-11-29 2000-11-29 Antisense antibacterial method and composition Expired - Lifetime CA2392685C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16815099P 1999-11-29 1999-11-29
US60/168,150 1999-11-29
PCT/US2000/042391 WO2001042457A2 (en) 1999-11-29 2000-11-29 Uncharged antisense oligonucleotides targeted to bacterial 16s and 23s prnas and their uses

Publications (2)

Publication Number Publication Date
CA2392685A1 CA2392685A1 (en) 2001-06-14
CA2392685C true CA2392685C (en) 2011-02-22

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CA2392685A Expired - Lifetime CA2392685C (en) 1999-11-29 2000-11-29 Antisense antibacterial method and composition

Country Status (9)

Country Link
US (2) US6677153B2 (cg-RX-API-DMAC7.html)
EP (1) EP1238071B1 (cg-RX-API-DMAC7.html)
JP (1) JP2003516151A (cg-RX-API-DMAC7.html)
KR (1) KR20020064915A (cg-RX-API-DMAC7.html)
AT (1) ATE393221T1 (cg-RX-API-DMAC7.html)
AU (1) AU783874B2 (cg-RX-API-DMAC7.html)
CA (1) CA2392685C (cg-RX-API-DMAC7.html)
DE (1) DE60038695T2 (cg-RX-API-DMAC7.html)
WO (1) WO2001042457A2 (cg-RX-API-DMAC7.html)

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JP2003516151A (ja) 2003-05-13
AU783874B2 (en) 2005-12-15
US7238675B2 (en) 2007-07-03
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DE60038695D1 (de) 2008-06-05
US6677153B2 (en) 2004-01-13
CA2392685A1 (en) 2001-06-14
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