CA2392284C - Medical device - Google Patents
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- CA2392284C CA2392284C CA002392284A CA2392284A CA2392284C CA 2392284 C CA2392284 C CA 2392284C CA 002392284 A CA002392284 A CA 002392284A CA 2392284 A CA2392284 A CA 2392284A CA 2392284 C CA2392284 C CA 2392284C
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- nucleic acid
- implant
- graft
- endothelialisation
- fgf
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
- External Artificial Organs (AREA)
- Eye Examination Apparatus (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904454-7 | 1999-12-07 | ||
| SE9904454A SE9904454D0 (sv) | 1999-12-07 | 1999-12-07 | Medical implant |
| SE9904747A SE9904747D0 (sv) | 1999-12-07 | 1999-12-23 | Medical Implant |
| SE9904747-4 | 1999-12-23 | ||
| SE0000285-7 | 2000-01-31 | ||
| SE0000285A SE0000285D0 (sv) | 1999-12-07 | 2000-01-31 | Medical implant |
| PCT/SE2000/002460 WO2001041674A1 (en) | 1999-12-07 | 2000-12-07 | Medical device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2392284A1 CA2392284A1 (en) | 2001-06-14 |
| CA2392284C true CA2392284C (en) | 2009-08-18 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002392284A Expired - Fee Related CA2392284C (en) | 1999-12-07 | 2000-12-07 | Medical device |
Country Status (12)
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030008396A1 (en) * | 1999-03-17 | 2003-01-09 | Ku David N. | Poly(vinyl alcohol) hydrogel |
| US6596699B2 (en) | 1998-09-22 | 2003-07-22 | Biosurface Engineering Technologies, Inc. | Nucleic acid coating compositions and methods |
| US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
| US7592017B2 (en) * | 2000-03-10 | 2009-09-22 | Mast Biosurgery Ag | Resorbable thin membranes |
| US8632583B2 (en) * | 2011-05-09 | 2014-01-21 | Palmaz Scientific, Inc. | Implantable medical device having enhanced endothelial migration features and methods of making the same |
| US9089450B2 (en) | 2000-11-14 | 2015-07-28 | Cochlear Limited | Implantatable component having an accessible lumen and a drug release capsule for introduction into same |
| AUPR148400A0 (en) | 2000-11-14 | 2000-12-07 | Cochlear Limited | Apparatus for delivery of pharmaceuticals to the cochlea |
| CA2430112C (en) | 2000-11-27 | 2010-07-27 | Dnavec Research Inc. | Paramyxovirus vector encoding angiogenesis gene and use thereof |
| AUPR879201A0 (en) | 2001-11-09 | 2001-12-06 | Cochlear Limited | Subthreshold stimulation of a cochlea |
| US20030114923A1 (en) * | 2001-11-14 | 2003-06-19 | Swanick Thomas M. | Graft and method of making |
| US8048444B2 (en) * | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
| WO2004010854A2 (en) * | 2002-07-31 | 2004-02-05 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
| US7704520B1 (en) | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
| WO2004050056A1 (en) * | 2002-11-29 | 2004-06-17 | Cochlear Limited | Cochlear implant drug delivery device |
| US7627373B2 (en) * | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
| US7044965B1 (en) * | 2002-12-13 | 2006-05-16 | Spielberg Theodore E | Therapeutic cellular stent |
| US7371256B2 (en) * | 2002-12-16 | 2008-05-13 | Poly-Med, Inc | Composite vascular constructs with selectively controlled properties |
| US20060083767A1 (en) * | 2003-02-27 | 2006-04-20 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
| JP2006519041A (ja) * | 2003-02-28 | 2006-08-24 | シェーラー メイフィールド テクノロジーズ ゲーエムベーハ | 追跡体の標定、操作、および案内のための装置、ならびにマーキング装置の操作のための方法 |
| US20040230298A1 (en) * | 2003-04-25 | 2004-11-18 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
| WO2005018683A2 (en) * | 2003-05-23 | 2005-03-03 | Angiotech International Ag | Anastomotic connector devices |
| DE10328816A1 (de) * | 2003-06-21 | 2005-01-05 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit |
| US20100266663A1 (en) * | 2003-09-10 | 2010-10-21 | Calhoun Christopher J | Tissue-treating implantable compositions |
| US8435285B2 (en) * | 2003-11-25 | 2013-05-07 | Boston Scientific Scimed, Inc. | Composite stent with inner and outer stent elements and method of using the same |
| US7910124B2 (en) * | 2004-02-06 | 2011-03-22 | Georgia Tech Research Corporation | Load bearing biocompatible device |
| US8002830B2 (en) | 2004-02-06 | 2011-08-23 | Georgia Tech Research Corporation | Surface directed cellular attachment |
| US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
| US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
| US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
| US20050278025A1 (en) * | 2004-06-10 | 2005-12-15 | Salumedica Llc | Meniscus prosthesis |
| US7556800B2 (en) * | 2004-07-09 | 2009-07-07 | Viscofan, S.A | Universal fishing bait based on filaments or strips of fibrous collagen |
| US7534422B2 (en) * | 2004-07-09 | 2009-05-19 | Viscofan, S.A. | Universal fishing bait based on fibrous collagen and the procedure for its preparation |
| US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
| ATE448752T1 (de) * | 2004-07-28 | 2009-12-15 | Cordis Corp | Bifurkationsprothese zur reparatur eines bauchaortenaneurysmas |
| KR100895135B1 (ko) * | 2004-08-13 | 2009-05-04 | 마스트 바이오서저리 아게 | 생분해성 및 난분해성 영역을 갖는 수술용 보철물 |
| US20080091277A1 (en) * | 2004-08-13 | 2008-04-17 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
| US7919112B2 (en) * | 2004-08-26 | 2011-04-05 | Pathak Holdings, Llc | Implantable tissue compositions and method |
| US8060219B2 (en) * | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| US20070010741A1 (en) * | 2005-05-19 | 2007-01-11 | Biophan Technologies, Inc. | Electromagnetic resonant circuit sleeve for implantable medical device |
| US20080119878A1 (en) * | 2005-08-12 | 2008-05-22 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
| US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
| US20070134204A1 (en) * | 2005-12-09 | 2007-06-14 | Henrich Cheng | Method for treating nerve injury and vector construct for the same |
| US9629626B2 (en) * | 2006-02-02 | 2017-04-25 | Covidien Lp | Mechanically tuned buttress material to assist with proper formation of surgical element in diseased tissue |
| US20070190028A1 (en) * | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
| DE102006053260A1 (de) * | 2006-07-20 | 2008-01-24 | Clinical House Europe Gmbh | Implantat zur Verankerung von Zahnersatz |
| US20080171972A1 (en) * | 2006-10-06 | 2008-07-17 | Stopek Joshua B | Medical device package |
| US8133215B2 (en) | 2007-08-13 | 2012-03-13 | Cochlear Limited | Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical device |
| CN101474456B (zh) * | 2009-02-09 | 2012-02-22 | 乐普（北京）医疗器械股份有限公司 | 一种携载基因的医疗器械的制备方法 |
| CN101502696B (zh) * | 2009-02-17 | 2012-07-11 | 乐普（北京）医疗器械股份有限公司 | 一种携载基因和/或药物的医疗器械及其制备方法 |
| US8617097B2 (en) | 2010-05-24 | 2013-12-31 | Cochlear Limited | Drug-delivery accessory for an implantable medical device |
| US8597948B2 (en) | 2011-03-10 | 2013-12-03 | First Principles, Inc. | Cloned biological material medical device and method thereof |
| WO2012162552A1 (en) | 2011-05-26 | 2012-11-29 | Cartiva, Inc. | Tapered joint implant and related tools |
| US10350072B2 (en) | 2012-05-24 | 2019-07-16 | Cartiva, Inc. | Tooling for creating tapered opening in tissue and related methods |
| US10550187B2 (en) * | 2014-10-24 | 2020-02-04 | Incept, Llc | Extra luminal scaffold |
| EP3892241A1 (en) | 2015-03-31 | 2021-10-13 | Cartiva, Inc. | Drill bit for carpometacarpal implant |
| EP3277219B1 (en) | 2015-03-31 | 2020-07-29 | Cartiva, Inc. | Hydrogel implants with porous materials |
| CA3066361A1 (en) | 2017-06-07 | 2018-12-13 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| CN111556763B (zh) | 2017-11-13 | 2023-09-01 | 施菲姆德控股有限责任公司 | 血管内流体运动装置、系统 |
| US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
| US12161857B2 (en) | 2018-07-31 | 2024-12-10 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| CN108938143A (zh) * | 2018-08-15 | 2018-12-07 | 湖南工业大学 | 一种三层结构小口径仿生血管及其制备方法 |
| US12220570B2 (en) | 2018-10-05 | 2025-02-11 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
| WO2021016372A1 (en) | 2019-07-22 | 2021-01-28 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
| DE102019121562B4 (de) * | 2019-08-09 | 2024-01-11 | Acandis Gmbh | Medizinische Vorrichtung zur Behandlung von Aneurysmen |
| WO2021062260A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible blood conduits |
| US12102815B2 (en) | 2019-09-25 | 2024-10-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible pump housings |
| WO2021062265A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208179B1 (en) * | 1990-11-27 | 2007-04-24 | The American National Red Cross | Methods for treating disease and forming a supplemented fibrin matrix |
| US5782789A (en) * | 1994-10-19 | 1998-07-21 | Atrium Medical Corporation | Macrochannel phosthetic/delivery patch |
| EP1018977B1 (en) * | 1995-05-26 | 2004-12-08 | SurModics, Inc. | Method and implantable article for promoting endothelialization |
| KR100695590B1 (ko) * | 1996-11-01 | 2007-03-14 | 아크 테라퓨틱스 리미티드 | 산화질소 또는 프로스타시클린 생산을 자극하는 약제의 치료학적 용도 및 전달 기구 |
| US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
| GB9809082D0 (en) * | 1998-04-28 | 1998-06-24 | Eurogene Limited | Delivery device |
| DE69918159T2 (de) * | 1998-11-20 | 2005-03-17 | The University Of Connecticut, Farmington | Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen |
| US6398808B1 (en) * | 1999-06-15 | 2002-06-04 | Scimed Life Systems, Inc. | Localized delivery of genetic information from biostable materials |
-
2000
- 2000-01-31 SE SE0000285A patent/SE0000285D0/xx unknown
- 2000-12-07 AT AT00986137T patent/ATE243479T1/de not_active IP Right Cessation
- 2000-12-07 EP EP00986137A patent/EP1235536B1/en not_active Expired - Lifetime
- 2000-12-07 CN CN00816717.6A patent/CN1239133C/zh not_active Expired - Fee Related
- 2000-12-07 JP JP2001542846A patent/JP2003516180A/ja not_active Withdrawn
- 2000-12-07 DK DK00986137T patent/DK1235536T3/da active
- 2000-12-07 ES ES00986137T patent/ES2206342T3/es not_active Expired - Lifetime
- 2000-12-07 AU AU22429/01A patent/AU782237B2/en not_active Ceased
- 2000-12-07 CA CA002392284A patent/CA2392284C/en not_active Expired - Fee Related
- 2000-12-07 DE DE60003580T patent/DE60003580T2/de not_active Expired - Lifetime
- 2000-12-07 WO PCT/SE2000/002460 patent/WO2001041674A1/en active IP Right Grant
- 2000-12-07 US US10/149,013 patent/US20030059463A1/en not_active Abandoned
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| EP1235536B1 (en) | 2003-06-25 |
| WO2001041674A1 (en) | 2001-06-14 |
| ES2206342T3 (es) | 2004-05-16 |
| AU782237B2 (en) | 2005-07-14 |
| CA2392284A1 (en) | 2001-06-14 |
| EP1235536A1 (en) | 2002-09-04 |
| DK1235536T3 (da) | 2003-10-20 |
| CN1239133C (zh) | 2006-02-01 |
| SE0000285D0 (sv) | 2000-01-31 |
| AU2242901A (en) | 2001-06-18 |
| US20030059463A1 (en) | 2003-03-27 |
| DE60003580D1 (de) | 2003-07-31 |
| ATE243479T1 (de) | 2003-07-15 |
| JP2003516180A (ja) | 2003-05-13 |
| CN1407873A (zh) | 2003-04-02 |
| DE60003580T2 (de) | 2004-05-27 |
| HK1054858A1 (en) | 2003-12-19 |
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