CA2390111C - Breathing-controlled inhalation device for dry powder and method for the even distribution of said dry powder in the air - Google Patents
Breathing-controlled inhalation device for dry powder and method for the even distribution of said dry powder in the air Download PDFInfo
- Publication number
- CA2390111C CA2390111C CA002390111A CA2390111A CA2390111C CA 2390111 C CA2390111 C CA 2390111C CA 002390111 A CA002390111 A CA 002390111A CA 2390111 A CA2390111 A CA 2390111A CA 2390111 C CA2390111 C CA 2390111C
- Authority
- CA
- Canada
- Prior art keywords
- air
- dry powder
- inhalation device
- guiding unit
- inhalation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000843 powder Substances 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000009826 distribution Methods 0.000 title claims abstract description 15
- 230000029058 respiratory gaseous exchange Effects 0.000 title claims abstract description 15
- 230000001133 acceleration Effects 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 11
- 238000007373 indentation Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 5
- 230000000630 rising effect Effects 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000001012 protector Effects 0.000 abstract description 3
- 239000002245 particle Substances 0.000 description 10
- 239000000306 component Substances 0.000 description 8
- 230000033001 locomotion Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 238000007664 blowing Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19948289 | 1999-10-06 | ||
| DE19948289.6 | 1999-10-06 | ||
| DE10027631.8 | 2000-06-06 | ||
| DE10027631A DE10027631B4 (de) | 1999-10-06 | 2000-06-06 | Atemzugskontrolliertes Inhalationsgerät für Trockenpulver und Verfahren zum gleichmäßigen Verteilen des Trockenpulvers in Luft |
| PCT/DE2000/003527 WO2001024857A1 (de) | 1999-10-06 | 2000-10-06 | Atemzugskontrolliertes inhalationsgerät für trockenpulver und verfahren zum gleichmässigen verteilen des trockenpulvers in luft |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2390111A1 CA2390111A1 (en) | 2001-04-12 |
| CA2390111C true CA2390111C (en) | 2007-08-07 |
Family
ID=26005955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002390111A Expired - Fee Related CA2390111C (en) | 1999-10-06 | 2000-10-06 | Breathing-controlled inhalation device for dry powder and method for the even distribution of said dry powder in the air |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6729328B2 (https=) |
| EP (1) | EP1220700B1 (https=) |
| JP (1) | JP2003511107A (https=) |
| CN (1) | CN1157236C (https=) |
| AT (1) | ATE236676T1 (https=) |
| AU (1) | AU774573B2 (https=) |
| CA (1) | CA2390111C (https=) |
| DK (1) | DK1220700T3 (https=) |
| ES (1) | ES2195948T3 (https=) |
| HK (1) | HK1049452B (https=) |
| PT (1) | PT1220700E (https=) |
| WO (1) | WO2001024857A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| WO2003047670A1 (de) * | 2001-11-22 | 2003-06-12 | Eckardt, Angela | Atemzugskontrollierte inhalationsvorrichtung für trockenpulver |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| AU2003272935C1 (en) | 2002-10-11 | 2009-06-25 | Otsuka Pharmaceutical Co., Ltd. | Powder inhalation device |
| EP1488819A1 (en) * | 2003-06-16 | 2004-12-22 | Rijksuniversiteit te Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
| GB0320171D0 (en) | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
| EP1720659A1 (de) * | 2004-02-24 | 2006-11-15 | Boehringer Ingelheim International Gmbh | Zerstäuber |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| CN102316936A (zh) * | 2007-11-19 | 2012-01-11 | 护理联合2200公司 | 带有机电驱动器的呼吸疗法系统 |
| JP5570996B2 (ja) | 2007-12-14 | 2014-08-13 | エアロデザインズ インコーポレイテッド | エアロゾル化可能な食料品の送達 |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CN101827626B (zh) | 2008-06-13 | 2015-03-18 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| ES2421385T3 (es) | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
| WO2010133294A2 (de) | 2009-05-18 | 2010-11-25 | Boehringer Ingelheim International Gmbh | Adapter, inhalationseinrichtung und zerstäuber |
| KR102584844B1 (ko) | 2009-06-12 | 2023-10-04 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| JP5658268B2 (ja) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EA026241B1 (ru) | 2009-11-25 | 2017-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Распылитель |
| CN102985125A (zh) | 2010-06-21 | 2013-03-20 | 曼金德公司 | 干粉药物输送系统和方法 |
| WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
| SG194034A1 (en) | 2011-04-01 | 2013-11-29 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| WO2012130757A1 (de) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| MX2014004983A (es) | 2011-10-24 | 2014-09-22 | Mannkid Corp | Metodos y composiciones para tratar dolor. |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| KR102264177B1 (ko) | 2012-07-12 | 2021-06-11 | 맨카인드 코포레이션 | 건조 분말 약물 전달 시스템 및 방법 |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| PL2835146T3 (pl) | 2013-08-09 | 2021-04-06 | Boehringer Ingelheim International Gmbh | Nebulizator |
| EP3030298B1 (en) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Nebulizer |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| HUE055604T2 (hu) | 2014-05-07 | 2021-12-28 | Boehringer Ingelheim Int | Porlasztó |
| AU2015257878B2 (en) | 2014-05-07 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
| EA035261B1 (ru) | 2014-05-07 | 2020-05-21 | Бёрингер Ингельхайм Интернациональ Гмбх | Небулайзер и контейнер |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| CN106237462A (zh) * | 2016-08-08 | 2016-12-21 | 中山市美捷时包装制品有限公司 | 一种用于储库型干粉吸入装置的定量供药机构 |
| CN106267484A (zh) * | 2016-08-08 | 2017-01-04 | 中山市美捷时包装制品有限公司 | 一种干粉吸入装置的定量供料机构 |
| GB2614746B (en) * | 2022-01-18 | 2025-02-26 | Merxin Ltd | Dry power inhalation device |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4004904A1 (de) | 1990-02-16 | 1990-09-13 | Gerhard Brendel | Trommel-applikator |
| GB9015522D0 (en) * | 1990-07-13 | 1990-08-29 | Braithwaite Philip W | Inhaler |
| EP0558879B1 (en) * | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
| DE4340768A1 (de) | 1993-11-30 | 1995-06-01 | Bayer Ag | Vorrichtung zum Inhalieren |
| FI942196L (fi) * | 1994-05-11 | 1995-11-12 | Orion Yhtymae Oy | Jauheinhalaattori |
| US5483954A (en) * | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
| JP2000503565A (ja) * | 1996-01-03 | 2000-03-28 | グラクソ、グループ、リミテッド | 吸入装置 |
| US5699789A (en) * | 1996-03-11 | 1997-12-23 | Hendricks; Mark R. | Dry powder inhaler |
| SE9700421D0 (sv) * | 1997-02-07 | 1997-02-07 | Astra Ab | Single dose inhaler I |
| WO1999033505A1 (en) * | 1997-12-23 | 1999-07-08 | Euro-Celtique S.A. | Particle separator for an inhaler |
| DE19825434C2 (de) | 1998-01-30 | 2002-03-28 | Ig Spruehtechnik Gmbh | Inhalationsgerät für pulverförmige Medikamente |
-
2000
- 2000-10-06 PT PT00982968T patent/PT1220700E/pt unknown
- 2000-10-06 EP EP00982968A patent/EP1220700B1/de not_active Expired - Lifetime
- 2000-10-06 DK DK00982968T patent/DK1220700T3/da active
- 2000-10-06 CA CA002390111A patent/CA2390111C/en not_active Expired - Fee Related
- 2000-10-06 AT AT00982968T patent/ATE236676T1/de not_active IP Right Cessation
- 2000-10-06 AU AU19928/01A patent/AU774573B2/en not_active Ceased
- 2000-10-06 JP JP2001527856A patent/JP2003511107A/ja active Pending
- 2000-10-06 HK HK03100269.1A patent/HK1049452B/zh not_active IP Right Cessation
- 2000-10-06 ES ES00982968T patent/ES2195948T3/es not_active Expired - Lifetime
- 2000-10-06 CN CNB008139032A patent/CN1157236C/zh not_active Expired - Fee Related
- 2000-10-06 WO PCT/DE2000/003527 patent/WO2001024857A1/de not_active Ceased
-
2002
- 2002-04-04 US US10/117,762 patent/US6729328B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2195948T3 (es) | 2003-12-16 |
| US6729328B2 (en) | 2004-05-04 |
| EP1220700B1 (de) | 2003-04-09 |
| HK1049452B (zh) | 2003-10-03 |
| PT1220700E (pt) | 2003-08-29 |
| ATE236676T1 (de) | 2003-04-15 |
| CN1157236C (zh) | 2004-07-14 |
| JP2003511107A (ja) | 2003-03-25 |
| WO2001024857A1 (de) | 2001-04-12 |
| AU1992801A (en) | 2001-05-10 |
| HK1049452A1 (en) | 2003-05-16 |
| AU774573B2 (en) | 2004-07-01 |
| CN1378469A (zh) | 2002-11-06 |
| DK1220700T3 (da) | 2003-08-04 |
| EP1220700A1 (de) | 2002-07-10 |
| US20020129817A1 (en) | 2002-09-19 |
| CA2390111A1 (en) | 2001-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |