CA2384777A1 - T2r taste receptor family - Google Patents
T2r taste receptor family Download PDFInfo
- Publication number
- CA2384777A1 CA2384777A1 CA002384777A CA2384777A CA2384777A1 CA 2384777 A1 CA2384777 A1 CA 2384777A1 CA 002384777 A CA002384777 A CA 002384777A CA 2384777 A CA2384777 A CA 2384777A CA 2384777 A1 CA2384777 A1 CA 2384777A1
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- Prior art keywords
- seq
- polypeptide
- nucleic acid
- receptor
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
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- Organic Chemistry (AREA)
- Toxicology (AREA)
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- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US09/393,634 US6558910B2 (en) | 1999-09-10 | 1999-09-10 | SF, a novel family of taste receptors |
| US09/393,634 | 1999-09-10 | ||
| US09/510,332 | 2000-02-22 | ||
| US09/510,332 US7244584B2 (en) | 1999-09-10 | 2000-02-22 | T2R, a novel family of taste receptors |
| PCT/US2000/024821 WO2001018050A2 (en) | 1999-09-10 | 2000-09-08 | T2r taste receptor family |
Publications (1)
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| CA2384777A1 true CA2384777A1 (en) | 2001-03-15 |
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| CA002384777A Abandoned CA2384777A1 (en) | 1999-09-10 | 2000-09-08 | T2r taste receptor family |
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| EP (1) | EP1214343A2 (enExample) |
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| WO (1) | WO2001018050A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6558910B2 (en) | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
| WO2001018050A2 (en) | 1999-09-10 | 2001-03-15 | The Regents Of The University Of California | T2r taste receptor family |
| TW201006846A (en) * | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| AU2001251258B2 (en) * | 2000-04-07 | 2008-06-05 | Senomyx, Inc. | T2r taste receptors and genes encoding same |
| TW201022287A (en) | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US20080244761A1 (en) | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US7883856B2 (en) | 2001-04-05 | 2011-02-08 | Senomyx Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| US8030008B2 (en) | 2001-04-05 | 2011-10-04 | Senomyx, Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
| EP2327985B2 (en) | 2001-06-26 | 2019-08-21 | Senomyx, Inc. | T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| EP1502112A4 (en) | 2001-07-10 | 2008-07-23 | Senomyx Inc | USE OF SPECIFIC T2R TASTE RECIPES TO IDENTIFY CONNECTIONS WHICH BLOCK A BITTER TASTE |
| EP1523308A4 (en) | 2001-07-20 | 2007-01-10 | Us Gov Health & Human Serv | PHENYL THIOCARBAMIDE (PTC) TREATMENT RECEPTOR |
| EP1442117A4 (en) * | 2001-10-12 | 2005-04-27 | Univ California | CHEMOLIC RECEPTORS OF THE STOMACH DARM TRAKTS |
| CA2488863A1 (en) | 2002-07-29 | 2004-02-05 | Senomyx, Inc. | Identification of a novel bitter taste receptor, t2r76 |
| EP2163623A3 (en) * | 2002-09-25 | 2010-05-26 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke | Bitter taste receptors |
| WO2004055048A2 (en) | 2002-12-18 | 2004-07-01 | Givaudan Sa | Chimeric alpha q-gustducin g-proteins |
| WO2005007891A2 (en) * | 2003-06-19 | 2005-01-27 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Variants of human taste receptor genes |
| US7829299B2 (en) | 2004-11-18 | 2010-11-09 | Deutsches Institut fur Ernahrungforschung Potsdam-Rehbrucke Stiftung des Offentlichen Rechts | Agonists of bitter taste receptors and uses thereof |
| CA2597085A1 (en) * | 2005-02-08 | 2006-08-17 | Senomyx, Inc. | Phuman t2r receptors for acetaminophen, ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators |
| WO2007074937A1 (ja) | 2005-12-27 | 2007-07-05 | Nihon University | 亜鉛欠乏性味覚異常検査法 |
| US20110097741A1 (en) * | 2006-04-20 | 2011-04-28 | Jay Patrick Slack | Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays |
| JP2009533065A (ja) | 2006-04-20 | 2009-09-17 | ジボダン エス エー | 味覚物質同定のための機能的方法 |
| EP2047254B1 (en) | 2006-04-20 | 2015-10-28 | Givaudan SA | Method relating to sweetness enhancement |
| JP2010514411A (ja) * | 2006-09-05 | 2010-05-06 | セノミクス・インコーポレーテッド | ヒトＴ２Ｒ受容体ｈＴ２Ｒ５０の新規ハプロタイプおよびヒト苦味モジュレータを同定するためのアッセイにおけるその使用 |
| KR101511394B1 (ko) | 2007-01-18 | 2015-04-10 | 지보당 에스아 | 키메라 우마미 미각 수용체, 이를 코딩하는 핵산 및 이의 용도 |
| EP2137322B1 (en) | 2007-03-30 | 2013-02-27 | Givaudan SA | Methods to identify tas2r modulators |
| EP2164976A4 (en) | 2007-06-08 | 2010-06-30 | Senomyx Inc | THEORETICAL BASIS, METHODS AND TESTS FOR IDENTIFYING FLAVOR SPECIES OF HUMAN AND NON-MUSCLE PRIMATES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING TESTS |
| WO2009025793A2 (en) | 2007-08-21 | 2009-02-26 | Senomyx, Inc. | Human t2r bitterness receptors and uses thereof |
| CA2713885A1 (en) * | 2008-02-01 | 2009-08-20 | Chromocell Corporation | Novel cell lines and methods |
| US20130115624A1 (en) | 2010-05-07 | 2013-05-09 | Givaudan S.A. | Methods To Identify Modulators |
| EP2567231A1 (en) | 2010-05-07 | 2013-03-13 | Givaudan SA | Methods to identify modulators of tas2r4s receptors |
| WO2011160093A2 (en) * | 2010-06-17 | 2011-12-22 | California Institute Of Technology | Methods and systems for modulating hormones and related methods, agents and compositions |
| WO2013022948A1 (en) | 2011-08-08 | 2013-02-14 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
| WO2013159227A1 (en) * | 2012-04-25 | 2013-10-31 | University Of Manitoba | Bitter taste receptor constitutively active mutants |
| US9169311B2 (en) | 2013-03-15 | 2015-10-27 | Applied Food Biotechnology, Inc. | Feline bitter taste receptors and methods |
| US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
| ES2797547T3 (es) | 2013-03-15 | 2020-12-02 | Applied Food Biotech Inc | Receptores del sabor amargo felino y métodos. |
| US10107794B2 (en) | 2013-05-10 | 2018-10-23 | Pepsico, Inc. | Methods of using U2-OS cells to identify potential sweet taste modulators |
| MX384586B (es) * | 2013-05-10 | 2025-03-14 | Pepsico Inc | Ensayo de internalización del receptor del gusto. |
| ES2802376T3 (es) | 2014-02-12 | 2021-01-19 | Firmenich Incorporated | Procedimiento mejorado para la síntesis de 1-bencil-3-(1-(isoxazol-4-ilmetil)-1h-pirazol-4-il)imidazolidin-2,4-dionas sustituidas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993016178A2 (en) | 1992-02-12 | 1993-08-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Sequences characteristic of human gene transcription product |
| CN1155714C (zh) | 1996-09-04 | 2004-06-30 | 辛根塔默根有限公司 | 抗真菌蛋白及其编码dna和掺入此dna的宿主 |
| AU2685599A (en) | 1998-02-18 | 1999-09-06 | Genetics Institute Inc. | Secreted proteins and polynucleotides encoding them |
| WO2000038536A2 (en) | 1998-12-23 | 2000-07-06 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
| US6558910B2 (en) | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
| WO2001018050A2 (en) | 1999-09-10 | 2001-03-15 | The Regents Of The University Of California | T2r taste receptor family |
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- 2000-09-08 CA CA002384777A patent/CA2384777A1/en not_active Abandoned
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2013
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2015
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2017
- 2017-10-17 US US15/786,468 patent/US20180128842A1/en not_active Abandoned
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| US20130189712A1 (en) | 2013-07-25 |
| US20080108088A1 (en) | 2008-05-08 |
| AU2004203826A1 (en) | 2004-09-16 |
| US8624012B2 (en) | 2014-01-07 |
| EP1214343A2 (en) | 2002-06-19 |
| MXPA02002538A (es) | 2005-07-01 |
| CN1387536A (zh) | 2002-12-25 |
| WO2001018050A2 (en) | 2001-03-15 |
| US20120009598A1 (en) | 2012-01-12 |
| AU773600B2 (en) | 2004-05-27 |
| US7868150B2 (en) | 2011-01-11 |
| WO2001018050A9 (en) | 2002-02-07 |
| AU7366400A (en) | 2001-04-10 |
| US20050048586A1 (en) | 2005-03-03 |
| US7595166B2 (en) | 2009-09-29 |
| US9063124B2 (en) | 2015-06-23 |
| NO20021164D0 (no) | 2002-03-08 |
| NO20021164L (no) | 2002-05-10 |
| IL148593A0 (en) | 2002-09-12 |
| JP2003510037A (ja) | 2003-03-18 |
| WO2001018050A3 (en) | 2002-01-10 |
| US20100062456A1 (en) | 2010-03-11 |
| US8329885B2 (en) | 2012-12-11 |
| US9817000B2 (en) | 2017-11-14 |
| JP4339542B2 (ja) | 2009-10-07 |
| US20140120553A1 (en) | 2014-05-01 |
| CN1289525C (zh) | 2006-12-13 |
| US20150260733A1 (en) | 2015-09-17 |
| US20180128842A1 (en) | 2018-05-10 |
| US7465550B2 (en) | 2008-12-16 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |