CA2374595A1 - Synthese de 3,5-bis(trifluoromethyle)bromobenzene - Google Patents

Synthese de 3,5-bis(trifluoromethyle)bromobenzene Download PDF

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Publication number
CA2374595A1
CA2374595A1 CA002374595A CA2374595A CA2374595A1 CA 2374595 A1 CA2374595 A1 CA 2374595A1 CA 002374595 A CA002374595 A CA 002374595A CA 2374595 A CA2374595 A CA 2374595A CA 2374595 A1 CA2374595 A1 CA 2374595A1
Authority
CA
Canada
Prior art keywords
bis
trifluoromethyl
acetic acid
sulfuric acid
bromobenzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002374595A
Other languages
English (en)
Inventor
Raymond Cvetovich
Fuh-Rong Tsay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2374595A1 publication Critical patent/CA2374595A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un procédé permettant l'élaboration de 3,5-bis(trifluorométhyle)bromobenzène (CAS 328-70-1). Ce composé convient particulièrement comme intermédiaire pour la synthèse de composés présentant une activité pharmacologique.
CA002374595A 1999-06-11 2000-06-08 Synthese de 3,5-bis(trifluoromethyle)bromobenzene Abandoned CA2374595A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13888399P 1999-06-11 1999-06-11
US33068499A 1999-06-11 1999-06-11
US60/138,883 1999-06-11
US09/330,684 1999-06-11
PCT/US2000/015735 WO2000076947A1 (fr) 1999-06-11 2000-06-08 Synthese de 3,5-bis(trifluoromethyle)bromobenzene

Publications (1)

Publication Number Publication Date
CA2374595A1 true CA2374595A1 (fr) 2000-12-21

Family

ID=26836648

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002374595A Abandoned CA2374595A1 (fr) 1999-06-11 2000-06-08 Synthese de 3,5-bis(trifluoromethyle)bromobenzene

Country Status (5)

Country Link
EP (1) EP1192116A4 (fr)
JP (1) JP2003505437A (fr)
AU (1) AU5472500A (fr)
CA (1) CA2374595A1 (fr)
WO (1) WO2000076947A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
EP1345878A4 (fr) 2000-12-20 2005-12-14 Merck & Co Inc Synthese du 1-(3,5-bis(trifluoromethyl)-phenyl) than-1-one
JP4569002B2 (ja) * 2000-12-27 2010-10-27 住友化学株式会社 ブロモ芳香族縮環化合物の製造方法
CN1300076C (zh) * 2005-08-05 2007-02-14 上海康鹏化学有限公司 双(2－羟基六氟丙基)苯酚的制备方法
ITMI20060489A1 (it) * 2006-03-17 2007-09-18 Miteni Spa Procedimento per la preparazione di 1-beono-3-trifluorometossibenzene
CN110498729A (zh) * 2019-09-09 2019-11-26 武汉诺安药业有限公司 一种盐酸阿莫罗芬中间体的清洁制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0675095B1 (fr) * 1994-03-23 1999-03-24 Hoechst Aktiengesellschaft Procédé pour la préparation de 1,1'Binaphtyl-2,2'-bis halogénométhyle
JP3806962B2 (ja) * 1995-12-22 2006-08-09 日産化学工業株式会社 ３，５−ビス（トリフルオロメチル）ブロムベンゼンの製造法
GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives

Also Published As

Publication number Publication date
AU5472500A (en) 2001-01-02
WO2000076947A1 (fr) 2000-12-21
EP1192116A4 (fr) 2002-10-24
EP1192116A1 (fr) 2002-04-03
JP2003505437A (ja) 2003-02-12

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Legal Events

Date Code Title Description
FZDE Discontinued