CA2373855A1 - Methode de traitement de troubles psychotiques - Google Patents
Methode de traitement de troubles psychotiques Download PDFInfo
- Publication number
- CA2373855A1 CA2373855A1 CA002373855A CA2373855A CA2373855A1 CA 2373855 A1 CA2373855 A1 CA 2373855A1 CA 002373855 A CA002373855 A CA 002373855A CA 2373855 A CA2373855 A CA 2373855A CA 2373855 A1 CA2373855 A1 CA 2373855A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compounds
- base
- alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne l'utilisation de composés présentant à la fois une activité antagoniste à la dopamine D2 et une activité inhibant le recaptage de la sérotonine (IRS) dans le traitement de troubles psychotiques tels que la schizophrénie. L'invention concerne également un groupe de nouveaux dérivés de (1,2,3,6-tétrahydropyridin-4-yl) indole et furane présentant ces activités.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99201524.8 | 1999-05-12 | ||
EP99201524 | 1999-05-12 | ||
PCT/EP2000/003506 WO2000069424A2 (fr) | 1999-05-12 | 2000-04-14 | Methode de traitement de troubles psychotiques |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2373855A1 true CA2373855A1 (fr) | 2000-11-23 |
Family
ID=8240207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002373855A Abandoned CA2373855A1 (fr) | 1999-05-12 | 2000-04-14 | Methode de traitement de troubles psychotiques |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1200072A2 (fr) |
JP (1) | JP2002544223A (fr) |
AU (1) | AU4552200A (fr) |
CA (1) | CA2373855A1 (fr) |
WO (1) | WO2000069424A2 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR028685A1 (es) * | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023508A1 (de) * | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
DE102004023522A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023501A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023507A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
DE102004023632A1 (de) * | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
JP2008521771A (ja) * | 2004-11-26 | 2008-06-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 改良された抗精神病活性および抗不安症活性を有するイソキサゾリン−インドール誘導体 |
US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
MX2007006757A (es) * | 2004-12-07 | 2007-11-09 | Solvay Pharm Bv | Tetrahidropiridin-4-il-indoles con una combinacion de afinidad para receptores de dopamina-d2 y sitios de reabsorcion de serotonina. |
US20060122247A1 (en) | 2004-12-08 | 2006-06-08 | Solvay Pharmaceuticals B.V. | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5124332A (en) * | 1991-01-28 | 1992-06-23 | Warner-Lambert Company | Substituted indoles as central nervous system agents |
CA2091204C (fr) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Piperazinyl- et piperidinylcyclohexanes contre l'ischemie |
DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
DE19500689A1 (de) * | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
AR004229A1 (es) * | 1995-11-06 | 1998-11-04 | Wyeth Corp | Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos |
ZA977967B (en) * | 1996-09-23 | 1999-03-04 | Lilly Co Eli | Combination therapy for treatment of psychoses |
ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
AR020773A1 (es) * | 1998-10-16 | 2002-05-29 | Duphar Int Res | Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto |
-
2000
- 2000-04-14 AU AU45522/00A patent/AU4552200A/en not_active Abandoned
- 2000-04-14 CA CA002373855A patent/CA2373855A1/fr not_active Abandoned
- 2000-04-14 WO PCT/EP2000/003506 patent/WO2000069424A2/fr not_active Application Discontinuation
- 2000-04-14 JP JP2000617883A patent/JP2002544223A/ja active Pending
- 2000-04-14 EP EP00926982A patent/EP1200072A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2000069424A2 (fr) | 2000-11-23 |
WO2000069424A3 (fr) | 2001-06-07 |
AU4552200A (en) | 2000-12-05 |
JP2002544223A (ja) | 2002-12-24 |
EP1200072A2 (fr) | 2002-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |