CA2353839A1 - Derives de methotrexate - Google Patents
Derives de methotrexate Download PDFInfo
- Publication number
- CA2353839A1 CA2353839A1 CA002353839A CA2353839A CA2353839A1 CA 2353839 A1 CA2353839 A1 CA 2353839A1 CA 002353839 A CA002353839 A CA 002353839A CA 2353839 A CA2353839 A CA 2353839A CA 2353839 A1 CA2353839 A1 CA 2353839A1
- Authority
- CA
- Canada
- Prior art keywords
- mtx
- group
- compound
- methotrexate
- gtp3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des conjugués de méthotrexate représentés par la formule I, ainsi que leur utilisation pour le traitement d'une maladie présentant une composante auto-immune et de cancers. Un exemple spécifique d'un composé représenté par la formule I consiste en méthotrexate-.gamma.-glycine Tris; dans laquelle M représente méthotrexate ou un de ses analogues; A=H, CX¿2?-O-R¿2? ou halogène; B=H, CX¿2?-O-R¿3? ou halogène; X représente indépendammen t H ou halogène; n est 0 ou égal ou supérieur à 1; Y représente un groupe de liaison, et si n est supérieur à 1, chaque Y est semblable ou différent; R¿1?, R¿2? et R¿3? sont semblables ou différents et représentent hydrogène, méthyle substitué ou non substitué, éthyle, ou un groupe acyle gras saturé ou insaturé, à condition que, quand n est 0 ou 1, et A représente CH¿2?-O-R¿2? et/ou B représente CH¿2?-O-R¿3?, alors R¿1?, R¿2? et R¿3? ne sont pas sélectionnés dans un groupe acyle gras; à condition que, quand n est supérieur ou égal à 2 et A représente CH¿2?-O-R¿2? et/ou B représente CH¿2?-O-R¿3? et au moins un de R¿1?, R¿2? et R¿3? représente un groupe acyle gras, -[Y]¿n?- est différent de -(AA)¿n-1?-, dans laquelle AA représente un acide aminé.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP7513A AUPP751398A0 (en) | 1998-12-04 | 1998-12-04 | Methotrexate derivatives |
AUPP7513 | 1998-12-04 | ||
PCT/AU1999/001073 WO2000034281A1 (fr) | 1998-12-04 | 1999-12-03 | Derives de methotrexate |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2353839A1 true CA2353839A1 (fr) | 2000-06-15 |
Family
ID=3811723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002353839A Abandoned CA2353839A1 (fr) | 1998-12-04 | 1999-12-03 | Derives de methotrexate |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1135390A1 (fr) |
JP (1) | JP2002531566A (fr) |
KR (1) | KR20010081050A (fr) |
CN (1) | CN1334815A (fr) |
AU (1) | AUPP751398A0 (fr) |
CA (1) | CA2353839A1 (fr) |
NO (1) | NO20012720L (fr) |
WO (1) | WO2000034281A1 (fr) |
ZA (1) | ZA200104533B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1958632A1 (fr) * | 2007-02-14 | 2008-08-20 | Dan Stoicescu | Utilisation de dérivés de la pyrimidine condensés pour le traitement de maladies inflammatoires et autoimmunes |
CN101926860A (zh) * | 2010-05-07 | 2010-12-29 | 宁波立华制药有限公司 | 一种芍药提取物甲氨蝶呤组合物及其制备方法与应用 |
CN110174363A (zh) * | 2019-01-09 | 2019-08-27 | 北京九强生物技术股份有限公司 | 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69426629T2 (de) * | 1993-08-02 | 2001-08-02 | Commw Scient Ind Res Org | Therapeutische verbindung - fettsäurekonjugate |
US5952499A (en) * | 1995-01-16 | 1999-09-14 | Commonwealth Scientific And Industrial Research Organisation | Therapeutic compound-fatty acid conjugates |
-
1998
- 1998-12-04 AU AUPP7513A patent/AUPP751398A0/en not_active Abandoned
-
1999
- 1999-12-03 EP EP99960710A patent/EP1135390A1/fr not_active Withdrawn
- 1999-12-03 CN CN99815957A patent/CN1334815A/zh active Pending
- 1999-12-03 KR KR1020017006889A patent/KR20010081050A/ko not_active Application Discontinuation
- 1999-12-03 WO PCT/AU1999/001073 patent/WO2000034281A1/fr not_active Application Discontinuation
- 1999-12-03 JP JP2000586727A patent/JP2002531566A/ja not_active Withdrawn
- 1999-12-03 CA CA002353839A patent/CA2353839A1/fr not_active Abandoned
-
2001
- 2001-06-01 ZA ZA200104533A patent/ZA200104533B/en unknown
- 2001-06-01 NO NO20012720A patent/NO20012720L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20012720D0 (no) | 2001-06-01 |
EP1135390A1 (fr) | 2001-09-26 |
AUPP751398A0 (en) | 1999-01-07 |
KR20010081050A (ko) | 2001-08-25 |
NO20012720L (no) | 2001-07-31 |
WO2000034281A1 (fr) | 2000-06-15 |
JP2002531566A (ja) | 2002-09-24 |
ZA200104533B (en) | 2002-06-03 |
CN1334815A (zh) | 2002-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |