CA2344107A1 - Genes et proteines de cassette de liaison avec atp, destines au diagnostic et au traitement de desordres lipidiques et maladies inflammatoires - Google Patents

Genes et proteines de cassette de liaison avec atp, destines au diagnostic et au traitement de desordres lipidiques et maladies inflammatoires Download PDF

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Publication number
CA2344107A1
CA2344107A1 CA002344107A CA2344107A CA2344107A1 CA 2344107 A1 CA2344107 A1 CA 2344107A1 CA 002344107 A CA002344107 A CA 002344107A CA 2344107 A CA2344107 A CA 2344107A CA 2344107 A1 CA2344107 A1 CA 2344107A1
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CA
Canada
Prior art keywords
leu
ser
val
gly
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002344107A
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English (en)
Inventor
Gerd Schmitz
Jochen Klucken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2344107A1 publication Critical patent/CA2344107A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Selon l'invention, la modulation de l'activité de protéines transmembranaires qui appartiennent à la famille de protéines de transport (ABC) de cassette de liaison avec ATP et sont impliquées de manière étiologique dans des processus athérogènes provoqués par le cholestérol et dans des maladies inflammatoires comme le psoriasis, le lupus érythémateux et autres, constitue un moyen thérapeutique de traiter de telles maladies. En outre, la détection des protéines de transport (ABC) ici identifiées et de leurs activités biochimiques respectives, impliquées dans de tels processus athérogènes et inflammatoires, constitue un moyen de diagnostic destiné à l'application clinique de diagnostic et de surveillance des dyslipidémies, de l'athérosclérose ou de maladies inflammatoires telles que le psoriasis ou le lupus érythémateux.
CA002344107A 1998-09-25 1999-09-21 Genes et proteines de cassette de liaison avec atp, destines au diagnostic et au traitement de desordres lipidiques et maladies inflammatoires Abandoned CA2344107A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10170698P 1998-09-25 1998-09-25
US60/101,706 1998-09-25
PCT/EP1999/006991 WO2000018912A2 (fr) 1998-09-25 1999-09-21 Genes et proteines de cassette de liaison avec atp, destines au diagnostic et au traitement de desordres lipidiques et maladies inflammatoires

Publications (1)

Publication Number Publication Date
CA2344107A1 true CA2344107A1 (fr) 2000-04-06

Family

ID=22285989

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002344107A Abandoned CA2344107A1 (fr) 1998-09-25 1999-09-21 Genes et proteines de cassette de liaison avec atp, destines au diagnostic et au traitement de desordres lipidiques et maladies inflammatoires

Country Status (5)

Country Link
EP (1) EP1115865A2 (fr)
JP (1) JP2002525111A (fr)
AU (1) AU5980499A (fr)
CA (1) CA2344107A1 (fr)
WO (1) WO2000018912A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759515B1 (en) 1997-02-25 2004-07-06 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
JP4187412B2 (ja) 1998-02-05 2008-11-26 ユニバーシテイ・オブ・メリーランド・ボルチモア 乳癌耐性蛋白質（ｂｃｒｐ）とそれをコードするｄｎａ
IL140701A0 (en) 1998-07-13 2002-02-10 Univ Texas Cancer treatment methods using antibodies to aminophospholipids
CA2367955C (fr) 1999-03-15 2009-05-19 University Of British Columbia Methodes et reactifs permettant de moduler les taux de cholesterol
EP1854880A1 (fr) * 1999-03-15 2007-11-14 University of British Columbia Procédés et réactifs pour moduler les niveaux de cholestérol
US6821774B1 (en) 1999-06-18 2004-11-23 Cv Therapeutics, Inc. Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter ABC1
US6835563B1 (en) 1999-06-18 2004-12-28 Cv Therapeutics Compositions and methods for increasing cholesterol efflux and raising HDL ATP binding cassette transporter protein ABC1
FR2796808B1 (fr) * 1999-07-30 2004-03-12 Inst Nat Sante Rech Med Nouvelles applications des transporteurs de type abca
AU1452601A (en) 1999-11-01 2001-05-14 Wisconsin Alumni Research Foundation Cholesterol transport gene
US6830913B1 (en) 1999-11-29 2004-12-14 Active Pass Pharmaceuticals, Inc. ABCB9 transporter and uses thereof
JP2003520599A (ja) * 2000-01-24 2003-07-08 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Ａｂｃ１パラログをコードする遺伝子及びそれに由来するポリペプチド
AU2001244196A1 (en) * 2000-03-20 2001-10-03 Bayer Aktiengesellschaft Atp binding cassette transporter 1 (abc1) gene polymorphisms and uses thereof for the diagnosis and treatment of lipid disorders, cardiovascular diseases and inflammatory diseases
EP1136554A1 (fr) * 2000-03-24 2001-09-26 Bayer Aktiengesellschaft Polymorphismes du gène codant le transporteur à cassette de fixation à l'ATP 1 (ABC1), et usages pour le diagnostique et le traitement de désordres lipidiques, de maladies cardiovasculaires et de maladies inflammatoires
EP1136552A1 (fr) * 2000-03-20 2001-09-26 Bayer Aktiengesellschaft Polymorphismes du gène codant le transporteur à cassette de fixation à l'ATP 1 (ABC1), et usages pour le diagnostique et le traitement de désordres lipidiques, de maladies cardiovasculaires et de maladies inflammatoires
WO2001073018A2 (fr) * 2000-03-30 2001-10-04 Merck Patent Gmbh Nouvelle proteine humaine de type tap
WO2001092523A2 (fr) * 2000-05-30 2001-12-06 Curagen Corporation Nouveaux polynucleotides humains et polypeptides codes par ceux-ci
JP2005503764A (ja) 2001-03-19 2005-02-10 ジェンテスト・コーポレーション Ｐ糖タンパク質およびその使用
AU2007251275A1 (en) 2006-05-12 2007-11-22 Solvo Biotechnology Cholesterol loaded insect cell membranes as test systems for ABC transporter proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022846A1 (fr) * 1993-03-30 1994-10-13 Pfizer Inc. Composes stimulant l'activite antitumorale d'autres agents cytotoxiques
EP0914424A1 (fr) * 1996-06-17 1999-05-12 Genzyme Corporation Nouveaux genes du chromosome 16 humain, leurs compositions, et leurs procedes de production et d'utilisation
AU742094B2 (en) * 1997-02-27 2001-12-20 Baylor College Of Medicine Nucleic acid sequences for ATP-binding cassette transporter

Also Published As

Publication number Publication date
JP2002525111A (ja) 2002-08-13
WO2000018912A3 (fr) 2000-08-17
AU5980499A (en) 2000-04-17
WO2000018912A2 (fr) 2000-04-06
EP1115865A2 (fr) 2001-07-18

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