CA2339575A1 - Compositions hemostatiques a base de collagene de type i et de type iii, a utiliser en tant que produit de scellement vasculaire et pansement - Google Patents
Compositions hemostatiques a base de collagene de type i et de type iii, a utiliser en tant que produit de scellement vasculaire et pansement Download PDFInfo
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- CA2339575A1 CA2339575A1 CA002339575A CA2339575A CA2339575A1 CA 2339575 A1 CA2339575 A1 CA 2339575A1 CA 002339575 A CA002339575 A CA 002339575A CA 2339575 A CA2339575 A CA 2339575A CA 2339575 A1 CA2339575 A1 CA 2339575A1
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- collagen
- collagen type
- iii
- type iii
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- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 1
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- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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- QQJLHRRUATVHED-UHFFFAOYSA-N tramazoline Chemical compound N1CCN=C1NC1=CC=CC2=C1CCCC2 QQJLHRRUATVHED-UHFFFAOYSA-N 0.000 description 1
- 229960001262 tramazoline Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
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- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des compositions à base de collagène de type I et/ou de type III polymérisé, à usage médical sous forme de produits de scellement vasculaire et de pansements, et la préparation desdites compositions. Avant la polymérisation, des monomères de collagène sont préparés par recombinaison, des modifications chimiques du collagène n'étant pas nécessaires pour la formation desdits monomères. Les compositions à base de collagène de type I et/ou III, comprennent une gélatine constituée de collagènes de type I et III, et sont utiles en tant qu'adhésifs médicaux pour la liaison de tissus mous et comme produit de scellement pour une grande variété d'usages médicaux. Selon un autre aspect de l'invention, les compositions à base de collagène de type I et/ou III polymérisé, comprennent des agents induisant la cicatrisation ou conférant les caractéristiques supplémentaires bénéfiques voulues à un produit de scellement de tissus ou à un pansement. Les compositions de l'invention sont également utiles sous forme non adhésive.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9599798P | 1998-08-10 | 1998-08-10 | |
| US60/095,997 | 1998-08-10 | ||
| PCT/US1999/018095 WO2000009018A1 (fr) | 1998-08-10 | 1999-08-10 | Compositions hemostatiques a base de collagene de type i et de type iii, a utiliser en tant que produit de scellement vasculaire et pansement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2339575A1 true CA2339575A1 (fr) | 2000-02-24 |
Family
ID=22254563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002339575A Abandoned CA2339575A1 (fr) | 1998-08-10 | 1999-08-10 | Compositions hemostatiques a base de collagene de type i et de type iii, a utiliser en tant que produit de scellement vasculaire et pansement |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1105051A4 (fr) |
| JP (1) | JP2002524110A (fr) |
| AU (1) | AU5671899A (fr) |
| CA (1) | CA2339575A1 (fr) |
| MX (1) | MXPA01001510A (fr) |
| WO (1) | WO2000009018A1 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6599526B2 (en) * | 2000-08-18 | 2003-07-29 | The University Of North Texas Health Science Center At Fort Worth | Pericardial anti-adhesion patch |
| JP4199004B2 (ja) | 2000-11-07 | 2008-12-17 | クライオライフ、インコーポレイテッド | 起泡性泡沫様生体材料および方法 |
| AR032800A1 (es) * | 2001-01-25 | 2003-11-26 | Nycomed Pharma As | Una suspension que comprende fibrinogeno, trombina y alcohol, un metodo para preparar dicha suspension, un metodo para recubrir un agente con dicha suspension, y un metodo para secar un recubrimiento de un agente, y una esponja de colageno recubierta |
| US7052713B2 (en) | 2001-02-13 | 2006-05-30 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
| US20040037866A1 (en) * | 2002-08-20 | 2004-02-26 | Semertzides John N. | Composition and method for the treatment and prevention of adhesions |
| JPWO2004018615A1 (ja) * | 2002-08-23 | 2005-12-08 | 旭化成メディカル株式会社 | フィブリン含有組成物 |
| WO2004078120A2 (fr) * | 2003-02-28 | 2004-09-16 | Fibrogen, Inc. | Compositions et biomateriaux de collagene |
| JP2007526009A (ja) * | 2003-06-19 | 2007-09-13 | バスキュラー セラピーズ エルエルシー | 血管閉鎖装具に対する組織反応を調節するための医療装具及び方法 |
| CA2567297A1 (fr) * | 2004-05-21 | 2005-12-01 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Preparation de collage de tissu |
| JP5138580B2 (ja) | 2005-04-06 | 2013-02-06 | フジフィルム マニュファクチャリング ユーロプ ビー．ブイ． | 細胞培養用非孔質フィルム |
| WO2006107188A1 (fr) | 2005-04-06 | 2006-10-12 | Fujifilm Manufacturing Europe B.V. | Films non poreux pour cultiver des cellules |
| KR20100052499A (ko) | 2007-08-01 | 2010-05-19 | 에디컨인코포레이티드 | 콜라겐-관련 펩티드 및 이의 용도 |
| CN102014973A (zh) | 2008-02-29 | 2011-04-13 | 弗罗桑医疗设备公司 | 用于促进止血和/或伤口愈合的装置 |
| GB201008404D0 (en) | 2010-05-20 | 2010-07-07 | Fujifilm Mfg Europe Bv | Hemostatic compositions |
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| RU2657955C2 (ru) | 2012-03-06 | 2018-06-18 | Ферросан Медикал Дивайсиз А/С | Контейнер под давлением, содержащий гемостатическую пасту |
| EP2825216B1 (fr) | 2012-06-12 | 2015-08-19 | Ferrosan Medical Devices A/S | Composition hémostatique sèche |
| JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー／エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| US10111980B2 (en) | 2013-12-11 | 2018-10-30 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
| BR112017007466B1 (pt) | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca |
| WO2016102446A1 (fr) | 2014-12-24 | 2016-06-30 | Ferrosan Medical Devices A/S | Seringue pour retenir et mélanger des première et seconde substances |
| WO2017004592A1 (fr) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Croissance cellulaire à l'aide de stimuli mécaniques |
| BR112017027695A2 (pt) | 2015-07-03 | 2018-09-04 | Ferrosan Medical Devices As | seringa para retenção e mistura de primeira e segunda substâncias |
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| WO2023119265A1 (fr) | 2021-12-21 | 2023-06-29 | Omrix Biopharmaceuticals Ltd. | Formulation renfermant du fibrinogène et ses utilisations |
| US11642324B1 (en) | 2022-03-01 | 2023-05-09 | Bio 54, Llc | Topical tranexamic acid compositions and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4852568A (en) * | 1987-02-17 | 1989-08-01 | Kensey Nash Corporation | Method and apparatus for sealing an opening in tissue of a living being |
| US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5667839A (en) * | 1993-01-28 | 1997-09-16 | Collagen Corporation | Human recombinant collagen in the milk of transgenic animals |
| US5759194A (en) * | 1993-09-28 | 1998-06-02 | Hemodynamics, Inc. | Vascular patch applicator |
| EP0805686A1 (fr) * | 1995-01-10 | 1997-11-12 | Fibrogen, Inc. | Methodes et formulations a base de collagene pour le traitement de maladies d'origine immunologique |
| CA2308146A1 (fr) * | 1997-07-28 | 1999-02-04 | Thomas B. Neff | Compositions d'adhesif a base de collagene du type i et du type iii |
-
1999
- 1999-08-10 CA CA002339575A patent/CA2339575A1/fr not_active Abandoned
- 1999-08-10 JP JP2000564526A patent/JP2002524110A/ja not_active Withdrawn
- 1999-08-10 WO PCT/US1999/018095 patent/WO2000009018A1/fr not_active Application Discontinuation
- 1999-08-10 EP EP99943668A patent/EP1105051A4/fr not_active Withdrawn
- 1999-08-10 MX MXPA01001510A patent/MXPA01001510A/es unknown
- 1999-08-10 AU AU56718/99A patent/AU5671899A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU5671899A (en) | 2000-03-06 |
| JP2002524110A (ja) | 2002-08-06 |
| MXPA01001510A (es) | 2003-08-20 |
| EP1105051A4 (fr) | 2003-08-06 |
| WO2000009018A9 (fr) | 2000-08-03 |
| WO2000009018A1 (fr) | 2000-02-24 |
| EP1105051A1 (fr) | 2001-06-13 |
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