CA2335900C - Aqueous compositions containing corticosteroids for nasal and pulmonary delivery - Google Patents
Aqueous compositions containing corticosteroids for nasal and pulmonary delivery Download PDFInfo
- Publication number
- CA2335900C CA2335900C CA002335900A CA2335900A CA2335900C CA 2335900 C CA2335900 C CA 2335900C CA 002335900 A CA002335900 A CA 002335900A CA 2335900 A CA2335900 A CA 2335900A CA 2335900 C CA2335900 C CA 2335900C
- Authority
- CA
- Canada
- Prior art keywords
- corticosteroid
- weight
- composition
- surfactant component
- hlb surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 215
- 239000003246 corticosteroid Substances 0.000 title claims abstract description 115
- 230000002685 pulmonary effect Effects 0.000 title abstract description 7
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- 239000004094 surface-active agent Substances 0.000 claims abstract description 63
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/105,838 US6241969B1 (en) | 1998-06-26 | 1998-06-26 | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| US09/105,838 | 1998-06-26 | ||
| PCT/US1999/014351 WO2000000181A1 (en) | 1998-06-26 | 1999-06-24 | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2335900A1 CA2335900A1 (en) | 2000-01-06 |
| CA2335900C true CA2335900C (en) | 2009-04-14 |
Family
ID=22308060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002335900A Expired - Fee Related CA2335900C (en) | 1998-06-26 | 1999-06-24 | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6241969B1 (https=) |
| EP (1) | EP1089715B8 (https=) |
| JP (1) | JP4875239B2 (https=) |
| AT (1) | ATE311174T1 (https=) |
| AU (1) | AU4717199A (https=) |
| CA (1) | CA2335900C (https=) |
| DE (1) | DE69928665T2 (https=) |
| WO (1) | WO2000000181A1 (https=) |
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1998
- 1998-06-26 US US09/105,838 patent/US6241969B1/en not_active Expired - Lifetime
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1999
- 1999-06-24 CA CA002335900A patent/CA2335900C/en not_active Expired - Fee Related
- 1999-06-24 WO PCT/US1999/014351 patent/WO2000000181A1/en not_active Ceased
- 1999-06-24 AU AU47171/99A patent/AU4717199A/en not_active Abandoned
- 1999-06-24 AT AT99930689T patent/ATE311174T1/de not_active IP Right Cessation
- 1999-06-24 JP JP2000556766A patent/JP4875239B2/ja not_active Expired - Fee Related
- 1999-06-24 EP EP99930689A patent/EP1089715B8/en not_active Expired - Lifetime
- 1999-06-24 DE DE69928665T patent/DE69928665T2/de not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| EP1089715A4 (en) | 2004-03-31 |
| EP1089715B1 (en) | 2005-11-30 |
| EP1089715B8 (en) | 2006-02-01 |
| DE69928665T2 (de) | 2006-08-10 |
| EP1089715A1 (en) | 2001-04-11 |
| JP4875239B2 (ja) | 2012-02-15 |
| JP2002519318A (ja) | 2002-07-02 |
| WO2000000181A1 (en) | 2000-01-06 |
| US6241969B1 (en) | 2001-06-05 |
| CA2335900A1 (en) | 2000-01-06 |
| DE69928665D1 (de) | 2006-01-05 |
| AU4717199A (en) | 2000-01-17 |
| ATE311174T1 (de) | 2005-12-15 |
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