CA2335711A1 - 4,5,6 and 7-indole and indoline derivatives, their preparation and use - Google Patents
4,5,6 and 7-indole and indoline derivatives, their preparation and use Download PDFInfo
- Publication number
- CA2335711A1 CA2335711A1 CA002335711A CA2335711A CA2335711A1 CA 2335711 A1 CA2335711 A1 CA 2335711A1 CA 002335711 A CA002335711 A CA 002335711A CA 2335711 A CA2335711 A CA 2335711A CA 2335711 A1 CA2335711 A1 CA 2335711A1
- Authority
- CA
- Canada
- Prior art keywords
- indol
- piperazine
- ethyl
- chloro
- benzofuranyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title claims abstract 3
- 238000002360 preparation method Methods 0.000 title claims description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 99
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 97
- 238000000034 method Methods 0.000 claims description 33
- 229910052760 oxygen Inorganic materials 0.000 claims description 19
- 230000005764 inhibitory process Effects 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 15
- 230000000697 serotonin reuptake Effects 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims description 14
- -1 C1-6-alk(en/yn)yl Chemical group 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- 150000002367 halogens Chemical group 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- 208000019901 Anxiety disease Diseases 0.000 claims description 8
- 150000002431 hydrogen Chemical group 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 208000019022 Mood disease Diseases 0.000 claims description 5
- 230000008485 antagonism Effects 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- IEAPSZTWAQJSLE-UHFFFAOYSA-N 4-chloro-3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C1=2C(Cl)=CC=CC=2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 IEAPSZTWAQJSLE-UHFFFAOYSA-N 0.000 claims description 4
- INSUHQMOGXBBBP-UHFFFAOYSA-N 7-bromo-3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C=1NC=2C(Br)=CC=CC=2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 INSUHQMOGXBBBP-UHFFFAOYSA-N 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 4
- 208000028017 Psychotic disease Diseases 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 208000019906 panic disease Diseases 0.000 claims description 4
- 102000034527 Retinoid X Receptors Human genes 0.000 claims description 3
- 108010038912 Retinoid X Receptors Proteins 0.000 claims description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 125000003441 thioacyl group Chemical group 0.000 claims description 3
- KZBQKNHKHLMMIM-UHFFFAOYSA-N 1-benzyl-4-[4-[2-(1h-indol-3-yl)ethyl]piperazin-1-yl]indole Chemical compound C=1NC2=CC=CC=C2C=1CCN(CC1)CCN1C(C=1C=C2)=CC=CC=1N2CC1=CC=CC=C1 KZBQKNHKHLMMIM-UHFFFAOYSA-N 0.000 claims description 2
- HEFXXFLAWUQZNG-UHFFFAOYSA-N 1-benzyl-4-[4-[2-(5-bromo-1h-indol-3-yl)ethyl]piperazin-1-yl]indole Chemical compound C12=CC(Br)=CC=C2NC=C1CCN(CC1)CCN1C(C=1C=C2)=CC=CC=1N2CC1=CC=CC=C1 HEFXXFLAWUQZNG-UHFFFAOYSA-N 0.000 claims description 2
- YQPDLHQWAGGSDB-UHFFFAOYSA-N 1-benzyl-4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]indole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C(C=1C=C2)=CC=CC=1N2CC1=CC=CC=C1 YQPDLHQWAGGSDB-UHFFFAOYSA-N 0.000 claims description 2
- GRUDTMHMQAGHLH-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 GRUDTMHMQAGHLH-UHFFFAOYSA-N 0.000 claims description 2
- HHCBWJJRMRBBCB-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole-7-carbonitrile Chemical compound C=1NC=2C(C#N)=CC=CC=2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 HHCBWJJRMRBBCB-UHFFFAOYSA-N 0.000 claims description 2
- MMOGIDGHFQGENT-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-2h-indazole Chemical compound N=1NC2=CC=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 MMOGIDGHFQGENT-UHFFFAOYSA-N 0.000 claims description 2
- LMWGAMWDWHNJDN-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-5-methyl-1h-indole Chemical compound C12=CC(C)=CC=C2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 LMWGAMWDWHNJDN-UHFFFAOYSA-N 0.000 claims description 2
- KIOPWNRRUQEUTR-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-6-(trifluoromethyl)-1h-indole Chemical compound C=1NC2=CC(C(F)(F)F)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 KIOPWNRRUQEUTR-UHFFFAOYSA-N 0.000 claims description 2
- GRCKVWBWSWHGMB-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-6-methyl-1h-indole Chemical compound C=1NC2=CC(C)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 GRCKVWBWSWHGMB-UHFFFAOYSA-N 0.000 claims description 2
- KHKMOERJTMSLFX-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-7-methyl-1h-indole Chemical compound C=1NC=2C(C)=CC=CC=2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 KHKMOERJTMSLFX-UHFFFAOYSA-N 0.000 claims description 2
- PKBYZVAIOXKLQM-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperidin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC=CC=C2C=1CCN(CC1)CCC1C1=CC=CC2=C1C=CN2 PKBYZVAIOXKLQM-UHFFFAOYSA-N 0.000 claims description 2
- LMBHNEPPNWMRPK-UHFFFAOYSA-N 3-[2-[4-(1h-indol-4-yl)piperidin-1-yl]ethyl]-5-methyl-1h-indole Chemical compound C12=CC(C)=CC=C2NC=C1CCN(CC1)CCC1C1=CC=CC2=C1C=CN2 LMBHNEPPNWMRPK-UHFFFAOYSA-N 0.000 claims description 2
- PJHWEBQBXPDXRE-UHFFFAOYSA-N 3-[3-[4-(1h-indol-4-yl)piperazin-1-yl]propyl]-1h-indole Chemical compound C1=CC=C2C(CCCN3CCN(CC3)C=3C=4C=CNC=4C=CC=3)=CNC2=C1 PJHWEBQBXPDXRE-UHFFFAOYSA-N 0.000 claims description 2
- ULRFMFWYCTWWJP-UHFFFAOYSA-N 3-[4-[4-(1h-indol-4-yl)piperazin-1-yl]butyl]-1h-indole Chemical compound C=1NC2=CC=CC=C2C=1CCCCN(CC1)CCN1C1=CC=CC2=C1C=CN2 ULRFMFWYCTWWJP-UHFFFAOYSA-N 0.000 claims description 2
- AYNLVGHMSHMAHD-UHFFFAOYSA-N 4-[1-[3-(4-methyl-1-benzofuran-3-yl)propyl]piperidin-4-yl]-1h-indole Chemical compound C1=2C(C)=CC=CC=2OC=C1CCCN(CC1)CCC1C1=CC=CC2=C1C=CN2 AYNLVGHMSHMAHD-UHFFFAOYSA-N 0.000 claims description 2
- CDPQAABIPTUSQM-UHFFFAOYSA-N 4-[1-[3-(5-fluoro-1-benzofuran-3-yl)propyl]-3,6-dihydro-2h-pyridin-4-yl]-1h-indole Chemical compound C12=CC(F)=CC=C2OC=C1CCCN(CC=1)CCC=1C1=CC=CC2=C1C=CN2 CDPQAABIPTUSQM-UHFFFAOYSA-N 0.000 claims description 2
- DOUDAIRYOIPBNR-UHFFFAOYSA-N 4-[4-(1-benzofuran-3-ylmethyl)piperazin-1-yl]-1h-indole Chemical compound C1=CC=C2C(CN3CCN(CC3)C=3C=4C=CNC=4C=CC=3)=COC2=C1 DOUDAIRYOIPBNR-UHFFFAOYSA-N 0.000 claims description 2
- VMCIXZDRJYETAU-UHFFFAOYSA-N 4-[4-[(5-fluoro-1-benzofuran-3-yl)methyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(F)=CC=C2OC=C1CN(CC1)CCN1C1=CC=CC2=C1C=CN2 VMCIXZDRJYETAU-UHFFFAOYSA-N 0.000 claims description 2
- HDXTWLXCOPFXCP-UHFFFAOYSA-N 4-[4-[2-(1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C=1OC2=CC=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 HDXTWLXCOPFXCP-UHFFFAOYSA-N 0.000 claims description 2
- KTOWLGUPFBOSIA-UHFFFAOYSA-N 4-[4-[2-(1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole-3-carbonitrile Chemical compound C1=CC=C2C(CCN3CCN(CC3)C=3C=CC=C4NC=C(C=34)C#N)=COC2=C1 KTOWLGUPFBOSIA-UHFFFAOYSA-N 0.000 claims description 2
- DVNUHRSTSJFZBG-UHFFFAOYSA-N 4-[4-[2-(1h-indol-3-yl)ethyl]piperazin-1-yl]-1-prop-2-ynylindole Chemical compound C1=CC=C2C(CCN3CCN(CC3)C3=C4C=CN(C4=CC=C3)CC#C)=CNC2=C1 DVNUHRSTSJFZBG-UHFFFAOYSA-N 0.000 claims description 2
- DOHAKZXOJZQTFL-UHFFFAOYSA-N 4-[4-[2-(1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-3-carbonitrile Chemical compound C1=CC=C2C(CCN3CCN(CC3)C=3C=CC=C4NC=C(C=34)C#N)=CNC2=C1 DOHAKZXOJZQTFL-UHFFFAOYSA-N 0.000 claims description 2
- OLAWEGKMWAGCSU-UHFFFAOYSA-N 4-[4-[2-(4-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-3-carbonitrile Chemical compound C1=2C(Cl)=CC=CC=2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C(C#N)=CN2 OLAWEGKMWAGCSU-UHFFFAOYSA-N 0.000 claims description 2
- KOXLCYACERNFQT-UHFFFAOYSA-N 4-[4-[2-(4-methyl-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C1=2C(C)=CC=CC=2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 KOXLCYACERNFQT-UHFFFAOYSA-N 0.000 claims description 2
- ZSLMASYEALIUIK-UHFFFAOYSA-N 4-[4-[2-(5-bromo-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(Br)=CC=C2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 ZSLMASYEALIUIK-UHFFFAOYSA-N 0.000 claims description 2
- WKGSILDXQBJVCC-UHFFFAOYSA-N 4-[4-[2-(5-bromo-1h-indol-3-yl)ethyl]piperazin-1-yl]-1-prop-2-ynylindole Chemical compound C12=CC(Br)=CC=C2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2CC#C WKGSILDXQBJVCC-UHFFFAOYSA-N 0.000 claims description 2
- UQQVWSLOBRRCHZ-UHFFFAOYSA-N 4-[4-[2-(5-fluoro-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(F)=CC=C2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 UQQVWSLOBRRCHZ-UHFFFAOYSA-N 0.000 claims description 2
- HTXUCZURQGCALZ-UHFFFAOYSA-N 4-[4-[2-(5-fluoro-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole-3-carbonitrile Chemical compound C12=CC(F)=CC=C2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C(C#N)=CN2 HTXUCZURQGCALZ-UHFFFAOYSA-N 0.000 claims description 2
- GOWWAPOSJWQAGR-UHFFFAOYSA-N 4-[4-[2-(5-methyl-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(C)=CC=C2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 GOWWAPOSJWQAGR-UHFFFAOYSA-N 0.000 claims description 2
- JKHASOQAHXASCK-UHFFFAOYSA-N 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1-prop-2-ynylindole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2CC#C JKHASOQAHXASCK-UHFFFAOYSA-N 0.000 claims description 2
- CWCXSYDWHLRBLZ-UHFFFAOYSA-N 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-3-carbonitrile Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C(C#N)=CN2 CWCXSYDWHLRBLZ-UHFFFAOYSA-N 0.000 claims description 2
- SEAQDHYGZRVZFZ-UHFFFAOYSA-N 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-6-carbonitrile Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC(C#N)=CC2=C1C=CN2 SEAQDHYGZRVZFZ-UHFFFAOYSA-N 0.000 claims description 2
- RVLIODWZMRKBCS-UHFFFAOYSA-N 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-7-carbonitrile Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=C(C#N)C2=C1C=CN2 RVLIODWZMRKBCS-UHFFFAOYSA-N 0.000 claims description 2
- YTMJLTSIXRWRDH-UHFFFAOYSA-N 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-6-fluoro-1h-indole Chemical compound ClC1=CC=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)F)=CNC2=C1 YTMJLTSIXRWRDH-UHFFFAOYSA-N 0.000 claims description 2
- OOPAXCAOYWFOLB-UHFFFAOYSA-N 4-[4-[2-(6-methyl-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C=1OC2=CC(C)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 OOPAXCAOYWFOLB-UHFFFAOYSA-N 0.000 claims description 2
- BOXSMMZSRLUSCW-UHFFFAOYSA-N 4-[4-[2-(7-chloro-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C=1OC=2C(Cl)=CC=CC=2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 BOXSMMZSRLUSCW-UHFFFAOYSA-N 0.000 claims description 2
- LXRCFKCRPSWFSI-UHFFFAOYSA-N 4-[4-[3-(4-chloro-1-benzofuran-3-yl)propyl]piperazin-1-yl]-1h-indole Chemical compound C1=2C(Cl)=CC=CC=2OC=C1CCCN(CC1)CCN1C1=CC=CC2=C1C=CN2 LXRCFKCRPSWFSI-UHFFFAOYSA-N 0.000 claims description 2
- LOZKUNKUFQIECJ-UHFFFAOYSA-N 4-[4-[3-(4-methyl-1-benzofuran-3-yl)propyl]piperazin-1-yl]-1h-indole Chemical compound C1=2C(C)=CC=CC=2OC=C1CCCN(CC1)CCN1C1=CC=CC2=C1C=CN2 LOZKUNKUFQIECJ-UHFFFAOYSA-N 0.000 claims description 2
- YVFVKJXNWLSCKB-UHFFFAOYSA-N 4-[4-[3-(5-fluoro-1-benzofuran-3-yl)propyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(F)=CC=C2OC=C1CCCN(CC1)CCN1C1=CC=CC2=C1C=CN2 YVFVKJXNWLSCKB-UHFFFAOYSA-N 0.000 claims description 2
- NDMUORRVNRLHAH-UHFFFAOYSA-N 4-chloro-3-[2-[4-(1h-indol-4-yl)piperidin-1-yl]ethyl]-1h-indole Chemical compound C1=2C(Cl)=CC=CC=2NC=C1CCN(CC1)CCC1C1=CC=CC2=C1C=CN2 NDMUORRVNRLHAH-UHFFFAOYSA-N 0.000 claims description 2
- ULDFQIUEDCUFEE-UHFFFAOYSA-N 5-bromo-3-[2-[4-(1h-indol-5-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C1=C2NC=CC2=CC(N2CCN(CC2)CCC2=CNC3=CC=C(C=C32)Br)=C1 ULDFQIUEDCUFEE-UHFFFAOYSA-N 0.000 claims description 2
- YPAVZUFUVXJNTF-UHFFFAOYSA-N 5-chloro-3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C12=CC(Cl)=CC=C2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 YPAVZUFUVXJNTF-UHFFFAOYSA-N 0.000 claims description 2
- SONZEIXSBAWMLA-UHFFFAOYSA-N 5-chloro-3-[2-[4-(1h-indol-5-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C1=C2NC=CC2=CC(N2CCN(CC2)CCC2=CNC3=CC=C(C=C32)Cl)=C1 SONZEIXSBAWMLA-UHFFFAOYSA-N 0.000 claims description 2
- HHSMYZNWCXZWEH-UHFFFAOYSA-N 5-fluoro-3-[2-[4-(1h-indol-4-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-1h-indole Chemical compound C12=CC(F)=CC=C2NC=C1CCN(CC=1)CCC=1C1=CC=CC2=C1C=CN2 HHSMYZNWCXZWEH-UHFFFAOYSA-N 0.000 claims description 2
- LESVZAQYIYBRAU-UHFFFAOYSA-N 5-fluoro-3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C12=CC(F)=CC=C2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 LESVZAQYIYBRAU-UHFFFAOYSA-N 0.000 claims description 2
- WJEIGMPATUEZQV-UHFFFAOYSA-N 6-chloro-3-[2-[4-(1h-indol-4-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC=1)CCC=1C1=CC=CC2=C1C=CN2 WJEIGMPATUEZQV-UHFFFAOYSA-N 0.000 claims description 2
- CCKRDWKRSKNOEN-UHFFFAOYSA-N 6-chloro-3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 CCKRDWKRSKNOEN-UHFFFAOYSA-N 0.000 claims description 2
- GXWQDXLPDRHDCY-UHFFFAOYSA-N 6-chloro-3-[2-[4-(1h-indol-4-yl)piperazin-1-yl]ethyl]-2h-indazole Chemical compound N=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 GXWQDXLPDRHDCY-UHFFFAOYSA-N 0.000 claims description 2
- FYOIADVSUOQQCR-UHFFFAOYSA-N 6-chloro-3-[2-[4-(1h-indol-6-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C1=C2C=CNC2=CC(N2CCN(CC2)CCC=2C3=CC=C(C=C3NC=2)Cl)=C1 FYOIADVSUOQQCR-UHFFFAOYSA-N 0.000 claims description 2
- ADOICXFBZJAQLI-UHFFFAOYSA-N 6-chloro-3-[2-[4-(1h-indol-7-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1NC=C2 ADOICXFBZJAQLI-UHFFFAOYSA-N 0.000 claims description 2
- GTNTWQDSNUCTOZ-UHFFFAOYSA-N 6-chloro-3-[2-[4-(6-chloro-1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC(Cl)=CC2=C1C=CN2 GTNTWQDSNUCTOZ-UHFFFAOYSA-N 0.000 claims description 2
- KBVVSNDQPDIRET-UHFFFAOYSA-N 6-chloro-3-[2-[4-(7-chloro-1h-indol-4-yl)piperazin-1-yl]ethyl]-1h-indole Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=C(Cl)C2=C1C=CN2 KBVVSNDQPDIRET-UHFFFAOYSA-N 0.000 claims description 2
- HLNWTLBQXXXWBY-UHFFFAOYSA-N 6-fluoro-3-[3-[4-(1h-indol-4-yl)piperazin-1-yl]propyl]-1,2-benzoxazole Chemical compound N=1OC2=CC(F)=CC=C2C=1CCCN(CC1)CCN1C1=CC=CC2=C1C=CN2 HLNWTLBQXXXWBY-UHFFFAOYSA-N 0.000 claims description 2
- DWMYBRIWIIKWBJ-UHFFFAOYSA-N [4-[4-[2-(5-bromo-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indol-6-yl]methanol Chemical compound C1=C(Br)C=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)CO)=CNC2=C1 DWMYBRIWIIKWBJ-UHFFFAOYSA-N 0.000 claims description 2
- FVHATTZHFQNZJP-UHFFFAOYSA-N [4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indol-6-yl]methanol Chemical compound ClC1=CC=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)CO)=CNC2=C1 FVHATTZHFQNZJP-UHFFFAOYSA-N 0.000 claims description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 2
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims description 2
- SYJFLCMSBJPPSG-UHFFFAOYSA-N methyl 4-[4-[2-(5-fluoro-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole-6-carboxylate Chemical compound C1=C(F)C=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)C(=O)OC)=COC2=C1 SYJFLCMSBJPPSG-UHFFFAOYSA-N 0.000 claims description 2
- OHLZRWXXNBGJLI-UHFFFAOYSA-N methyl 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-6-carboxylate Chemical compound ClC1=CC=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)C(=O)OC)=CNC2=C1 OHLZRWXXNBGJLI-UHFFFAOYSA-N 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- WTVXIBRMWGUIMI-UHFFFAOYSA-N trifluoro($l^{1}-oxidanylsulfonyl)methane Chemical group [O]S(=O)(=O)C(F)(F)F WTVXIBRMWGUIMI-UHFFFAOYSA-N 0.000 claims description 2
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 102000017911 HTR1A Human genes 0.000 claims 2
- 101150015707 HTR1A gene Proteins 0.000 claims 2
- 102000003702 retinoic acid receptors Human genes 0.000 claims 2
- 108090000064 retinoic acid receptors Proteins 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- YYTPZWYTPKXSFX-UHFFFAOYSA-N 1-benzyl-4-[4-[2-(5-fluoro-1h-indol-3-yl)ethyl]piperazin-1-yl]indole Chemical compound C12=CC(F)=CC=C2NC=C1CCN(CC1)CCN1C(C=1C=C2)=CC=CC=1N2CC1=CC=CC=C1 YYTPZWYTPKXSFX-UHFFFAOYSA-N 0.000 claims 1
- AGVJFECVGZMPST-UHFFFAOYSA-N 4-[4-[2-(5-chloro-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(Cl)=CC=C2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 AGVJFECVGZMPST-UHFFFAOYSA-N 0.000 claims 1
- VBRDWACMHZFSLL-UHFFFAOYSA-N 4-[4-[2-(5-fluoro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1-prop-2-ynylindole Chemical compound C12=CC(F)=CC=C2NC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2CC#C VBRDWACMHZFSLL-UHFFFAOYSA-N 0.000 claims 1
- DXCVKKBJZUQIBV-UHFFFAOYSA-N 4-[4-[2-(6-chloro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-2-carbonitrile Chemical compound C=1NC2=CC(Cl)=CC=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=C(C#N)N2 DXCVKKBJZUQIBV-UHFFFAOYSA-N 0.000 claims 1
- ZSRIARZGWRFDFJ-UHFFFAOYSA-N 4-[4-[4-(5-fluoro-1-benzofuran-3-yl)butyl]piperazin-1-yl]-1h-indole Chemical compound C12=CC(F)=CC=C2OC=C1CCCCN(CC1)CCN1C1=CC=CC2=C1C=CN2 ZSRIARZGWRFDFJ-UHFFFAOYSA-N 0.000 claims 1
- 208000017194 Affective disease Diseases 0.000 claims 1
- VOJRANLPQBBQCI-UHFFFAOYSA-N [4-[4-[2-(5-fluoro-1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indol-6-yl]methanol Chemical compound C1=C(F)C=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)CO)=CNC2=C1 VOJRANLPQBBQCI-UHFFFAOYSA-N 0.000 claims 1
- KCNKJCHARANTIP-SNAWJCMRSA-N allyl-{4-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-but-2-enyl}-methyl-amine Chemical compound C=1OC2=CC(OC/C=C/CN(CC=C)C)=CC=C2C=1C1=CC=C(Br)C=C1 KCNKJCHARANTIP-SNAWJCMRSA-N 0.000 claims 1
- SYGWYBOJXOGMRU-UHFFFAOYSA-N chembl233051 Chemical compound C1=CC=C2C3=CC(C(N(CCN(C)C)C4=O)=O)=C5C4=CC=CC5=C3SC2=C1 SYGWYBOJXOGMRU-UHFFFAOYSA-N 0.000 claims 1
- VPWYYLAXAUQFGH-UHFFFAOYSA-N methyl 4-[4-[2-(1h-indol-3-yl)ethyl]piperazin-1-yl]-1h-indole-6-carboxylate Chemical compound C1=CC=C2C(CCN3CCN(CC3)C=3C=C(C=C4NC=CC4=3)C(=O)OC)=CNC2=C1 VPWYYLAXAUQFGH-UHFFFAOYSA-N 0.000 claims 1
- WEYVCQFUGFRXOM-UHFFFAOYSA-N perazine Chemical compound C1CN(C)CCN1CCCN1C2=CC=CC=C2SC2=CC=CC=C21 WEYVCQFUGFRXOM-UHFFFAOYSA-N 0.000 claims 1
- 229960002195 perazine Drugs 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 abstract description 12
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract description 4
- 229910052770 Uranium Inorganic materials 0.000 abstract description 3
- 230000003389 potentiating effect Effects 0.000 abstract description 3
- 229910052727 yttrium Inorganic materials 0.000 abstract description 3
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 68
- 238000005481 NMR spectroscopy Methods 0.000 description 46
- 229960005141 piperazine Drugs 0.000 description 46
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 45
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 44
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 33
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 30
- 239000000203 mixture Substances 0.000 description 28
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
- 239000003921 oil Substances 0.000 description 27
- 239000000243 solution Substances 0.000 description 25
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 24
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 22
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 22
- 108020003175 receptors Proteins 0.000 description 20
- 102000005962 receptors Human genes 0.000 description 20
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 125000000217 alkyl group Chemical group 0.000 description 15
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 14
- 238000001914 filtration Methods 0.000 description 13
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 12
- 239000002178 crystalline material Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 239000003480 eluent Substances 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 11
- 238000010626 work up procedure Methods 0.000 description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- 238000003818 flash chromatography Methods 0.000 description 9
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 9
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 229960004132 diethyl ether Drugs 0.000 description 8
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 description 8
- 239000012280 lithium aluminium hydride Substances 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 238000006722 reduction reaction Methods 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 208000020401 Depressive disease Diseases 0.000 description 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 238000005160 1H NMR spectroscopy Methods 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 229910000027 potassium carbonate Inorganic materials 0.000 description 6
- YZKSXUIOKWQABW-UHFFFAOYSA-N 4-piperazin-1-yl-1h-indole Chemical class C1CNCCN1C1=CC=CC2=C1C=CN2 YZKSXUIOKWQABW-UHFFFAOYSA-N 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
- 239000000935 antidepressant agent Substances 0.000 description 4
- 229940005513 antidepressants Drugs 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000003054 catalyst Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 4
- 238000010304 firing Methods 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 150000004885 piperazines Chemical class 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 229940076279 serotonin Drugs 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 210000002348 5-ht neuron Anatomy 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 229910000086 alane Inorganic materials 0.000 description 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 125000001041 indolyl group Chemical group 0.000 description 3
- 239000012442 inert solvent Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229910052763 palladium Inorganic materials 0.000 description 3
- JZQKKSLKJUAGIC-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CN2 JZQKKSLKJUAGIC-UHFFFAOYSA-N 0.000 description 3
- 229960002508 pindolol Drugs 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 2
- POIRAUHZMOVJQN-UHFFFAOYSA-N (5-fluoro-1-benzofuran-3-yl)methanol Chemical compound C1=C(F)C=C2C(CO)=COC2=C1 POIRAUHZMOVJQN-UHFFFAOYSA-N 0.000 description 2
- YJNRVLPKCUSFEM-UHFFFAOYSA-N 1-[2-[(2-chlorophenyl)-phenylmethoxy]ethyl]-4-[(2-methylphenyl)methyl]piperazine;hydrochloride Chemical compound Cl.CC1=CC=CC=C1CN1CCN(CCOC(C=2C=CC=CC=2)C=2C(=CC=CC=2)Cl)CC1 YJNRVLPKCUSFEM-UHFFFAOYSA-N 0.000 description 2
- QWMVFCMIUUHJDH-UHFFFAOYSA-N 2-(1-benzofuran-3-yl)acetic acid Chemical class C1=CC=C2C(CC(=O)O)=COC2=C1 QWMVFCMIUUHJDH-UHFFFAOYSA-N 0.000 description 2
- MMCIQOFFSZZKGF-UHFFFAOYSA-N 2-(5-fluoro-1-benzofuran-3-yl)acetonitrile Chemical compound FC1=CC=C2OC=C(CC#N)C2=C1 MMCIQOFFSZZKGF-UHFFFAOYSA-N 0.000 description 2
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 description 2
- OJXGBTBXZMEQFE-UHFFFAOYSA-N 3-(chloromethyl)-5-fluoro-1-benzofuran Chemical compound FC1=CC=C2OC=C(CCl)C2=C1 OJXGBTBXZMEQFE-UHFFFAOYSA-N 0.000 description 2
- GRJZJFUBQYULKL-UHFFFAOYSA-N 4-bromo-1h-indole Chemical compound BrC1=CC=CC2=C1C=CN2 GRJZJFUBQYULKL-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 2
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 description 2
- 101000865206 Homo sapiens D(4) dopamine receptor Proteins 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 2
- 230000002152 alkylating effect Effects 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 150000004982 aromatic amines Chemical class 0.000 description 2
- 125000002619 bicyclic group Chemical group 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 125000000392 cycloalkenyl group Chemical group 0.000 description 2
- 238000000586 desensitisation Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000008713 feedback mechanism Effects 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 2
- 150000002476 indolines Chemical class 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 125000002346 iodo group Chemical group I* 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229940087646 methanolamine Drugs 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 229940042472 mineral oil Drugs 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
- 235000006408 oxalic acid Nutrition 0.000 description 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 2
- 229960002296 paroxetine Drugs 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- 229940044551 receptor antagonist Drugs 0.000 description 2
- 238000005932 reductive alkylation reaction Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229910000104 sodium hydride Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000003568 synaptosome Anatomy 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- LTHHTJMKYUPWCR-UHFFFAOYSA-N (4-bromoindol-1-yl)-tert-butyl-dimethylsilane Chemical compound C1=CC=C2N([Si](C)(C)C(C)(C)C)C=CC2=C1Br LTHHTJMKYUPWCR-UHFFFAOYSA-N 0.000 description 1
- VPMIAOSOTOODMY-KJAPKAAFSA-N (4r)-6-[(e)-2-[6-tert-butyl-4-(4-fluorophenyl)-2-propan-2-ylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one Chemical compound C([C@H](O)C1)C(=O)OC1/C=C/C=1C(C(C)C)=NC(C(C)(C)C)=CC=1C1=CC=C(F)C=C1 VPMIAOSOTOODMY-KJAPKAAFSA-N 0.000 description 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- BUVZKHNWHDLLET-UHFFFAOYSA-N 1-(6-chloro-1h-indol-3-yl)-2-[4-(1h-indol-4-yl)piperazin-1-yl]ethane-1,2-dione Chemical compound C=1NC2=CC(Cl)=CC=C2C=1C(=O)C(=O)N(CC1)CCN1C1=CC=CC2=C1C=CN2 BUVZKHNWHDLLET-UHFFFAOYSA-N 0.000 description 1
- CALSTBMLFMAZRK-UHFFFAOYSA-N 1-benzyl-4-piperazin-1-ylindole;4-piperazin-1-yl-1-prop-2-ynylindole Chemical compound C1=CC=C2N(CC#C)C=CC2=C1N1CCNCC1.C1=CC2=C(N3CCNCC3)C=CC=C2N1CC1=CC=CC=C1 CALSTBMLFMAZRK-UHFFFAOYSA-N 0.000 description 1
- ZCBIFHNDZBSCEP-UHFFFAOYSA-N 1H-indol-5-amine Chemical compound NC1=CC=C2NC=CC2=C1 ZCBIFHNDZBSCEP-UHFFFAOYSA-N 0.000 description 1
- DYSXLQBUUOPLBB-UHFFFAOYSA-N 2,3-dinitrotoluene Chemical compound CC1=CC=CC([N+]([O-])=O)=C1[N+]([O-])=O DYSXLQBUUOPLBB-UHFFFAOYSA-N 0.000 description 1
- NILLIJQRFBPQCL-UHFFFAOYSA-N 2-(1-benzofuran-3-yl)-1-[4-(1h-indol-4-yl)piperazin-1-yl]ethanone Chemical compound C=1OC2=CC=CC=C2C=1CC(=O)N(CC1)CCN1C1=CC=CC2=C1C=CN2 NILLIJQRFBPQCL-UHFFFAOYSA-N 0.000 description 1
- MKLOJHQDDNNCGX-UHFFFAOYSA-N 2-(2,6-diaminophenyl)ethanol Chemical compound NC1=CC=CC(N)=C1CCO MKLOJHQDDNNCGX-UHFFFAOYSA-N 0.000 description 1
- OCXQLKJLFTYTQK-UHFFFAOYSA-N 2-(2,6-dinitrophenyl)ethanol Chemical compound OCCC1=C([N+]([O-])=O)C=CC=C1[N+]([O-])=O OCXQLKJLFTYTQK-UHFFFAOYSA-N 0.000 description 1
- AEYHIZZYMFAUNU-UHFFFAOYSA-N 2-(3,4-dihydro-2h-pyridin-1-yl)-1h-indole Chemical class C1CCC=CN1C1=CC2=CC=CC=C2N1 AEYHIZZYMFAUNU-UHFFFAOYSA-N 0.000 description 1
- YWDHFBAWBPMIDF-UHFFFAOYSA-N 2-(5-chloro-1-benzofuran-3-yl)acetic acid 2-(7-chloro-1-benzofuran-3-yl)acetic acid 3-(5-fluoro-1-benzofuran-3-yl)propanoic acid Chemical compound FC=1C=CC2=C(C(=CO2)CCC(=O)O)C1.ClC=1C=CC2=C(C(=CO2)CC(=O)O)C1.ClC1=CC=CC=2C(=COC21)CC(=O)O YWDHFBAWBPMIDF-UHFFFAOYSA-N 0.000 description 1
- OBCPUSHYCKCLOK-UHFFFAOYSA-N 2-(5-fluoro-1-benzofuran-2-yl)acetic acid Chemical compound FC1=CC=C2OC(CC(=O)O)=CC2=C1 OBCPUSHYCKCLOK-UHFFFAOYSA-N 0.000 description 1
- IKIKCHVZCYCPAJ-UHFFFAOYSA-N 2-(5-fluoro-1-benzofuran-3-yl)acetic acid Chemical compound C1=C(F)C=C2C(CC(=O)O)=COC2=C1 IKIKCHVZCYCPAJ-UHFFFAOYSA-N 0.000 description 1
- OTOJFEFGCPXZGW-UHFFFAOYSA-N 2-(5-fluoro-1h-indol-3-yl)-2-oxoacetyl chloride Chemical compound FC1=CC=C2NC=C(C(=O)C(Cl)=O)C2=C1 OTOJFEFGCPXZGW-UHFFFAOYSA-N 0.000 description 1
- UJKKIPZDZUKMPF-UHFFFAOYSA-N 2-(6-chloro-1h-indol-3-yl)-2-oxoacetyl chloride Chemical compound ClC1=CC=C2C(C(=O)C(=O)Cl)=CNC2=C1 UJKKIPZDZUKMPF-UHFFFAOYSA-N 0.000 description 1
- PSEDUPQQLIMVBQ-UHFFFAOYSA-N 2-(6-chloro-2h-indazol-3-yl)acetic acid Chemical compound ClC1=CC=C2C(CC(=O)O)=NNC2=C1 PSEDUPQQLIMVBQ-UHFFFAOYSA-N 0.000 description 1
- ZPRQXVPYQGBZON-UHFFFAOYSA-N 2-bromo-1h-indole Chemical class C1=CC=C2NC(Br)=CC2=C1 ZPRQXVPYQGBZON-UHFFFAOYSA-N 0.000 description 1
- YMDZDFSUDFLGMX-UHFFFAOYSA-N 2-chloro-n-(2-chloroethyl)ethanamine;hydron;chloride Chemical compound [Cl-].ClCC[NH2+]CCCl YMDZDFSUDFLGMX-UHFFFAOYSA-N 0.000 description 1
- FBCZWQNVHNIQOD-UHFFFAOYSA-N 2-piperazin-1-yl-1h-indole Chemical class C1CNCCN1C1=CC2=CC=CC=C2N1 FBCZWQNVHNIQOD-UHFFFAOYSA-N 0.000 description 1
- VFMNOSCALKAYNC-UHFFFAOYSA-N 3-(3-bromopropyl)-6-fluoro-1,2-benzoxazole Chemical compound FC1=CC=C2C(CCCBr)=NOC2=C1 VFMNOSCALKAYNC-UHFFFAOYSA-N 0.000 description 1
- PATMVNSSWAZOOJ-UHFFFAOYSA-N 3-(6-fluoro-1,2-benzoxazol-3-yl)propanoic acid Chemical compound FC1=CC=C2C(CCC(=O)O)=NOC2=C1 PATMVNSSWAZOOJ-UHFFFAOYSA-N 0.000 description 1
- CICDIDDGWDNHHW-UHFFFAOYSA-N 4-(1,2,3,6-tetrahydropyridin-4-yl)-1h-indole Chemical compound C1NCCC(C=2C=3C=CNC=3C=CC=2)=C1 CICDIDDGWDNHHW-UHFFFAOYSA-N 0.000 description 1
- LUNUNJFSHKSXGQ-UHFFFAOYSA-N 4-Aminoindole Chemical compound NC1=CC=CC2=C1C=CN2 LUNUNJFSHKSXGQ-UHFFFAOYSA-N 0.000 description 1
- WHVKIZNJOFOVQB-UHFFFAOYSA-N 4-[4-[2-(4,5,6,7-tetrafluoro-2-methyl-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound CC=1OC2=C(F)C(F)=C(F)C(F)=C2C=1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 WHVKIZNJOFOVQB-UHFFFAOYSA-N 0.000 description 1
- OCADYZTYZFYYSU-UHFFFAOYSA-N 4-[4-[2-(4,5-dichloro-1-benzofuran-3-yl)ethyl]piperazin-1-yl]-1h-indole Chemical compound C12=C(Cl)C(Cl)=CC=C2OC=C1CCN(CC1)CCN1C1=CC=CC2=C1C=CN2 OCADYZTYZFYYSU-UHFFFAOYSA-N 0.000 description 1
- ZAPXMYJBUSBVRC-UHFFFAOYSA-N 4-piperazin-1-yl-1h-indole;hydrochloride Chemical compound Cl.C1CNCCN1C1=CC=CC2=C1C=CN2 ZAPXMYJBUSBVRC-UHFFFAOYSA-N 0.000 description 1
- VXWVFZFZYXOBTA-UHFFFAOYSA-N 5-bromo-1h-indole Chemical compound BrC1=CC=C2NC=CC2=C1 VXWVFZFZYXOBTA-UHFFFAOYSA-N 0.000 description 1
- CNGNGGBYKPBLCU-UHFFFAOYSA-N 5-fluoro-1-benzofuran-3-carboxylic acid Chemical compound C1=C(F)C=C2C(C(=O)O)=COC2=C1 CNGNGGBYKPBLCU-UHFFFAOYSA-N 0.000 description 1
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 description 1
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 description 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 description 1
- YTYIMDRWPTUAHP-UHFFFAOYSA-N 6-Chloroindole Chemical compound ClC1=CC=C2C=CNC2=C1 YTYIMDRWPTUAHP-UHFFFAOYSA-N 0.000 description 1
- MAWGHOPSCKCTPA-UHFFFAOYSA-N 6-bromo-1h-indole Chemical compound BrC1=CC=C2C=CNC2=C1 MAWGHOPSCKCTPA-UHFFFAOYSA-N 0.000 description 1
- CSYJRAUZKVJSRI-UHFFFAOYSA-N 6-tert-butyl-5-methoxy-4-piperazin-1-yl-1h-indole Chemical compound COC1=C(C(C)(C)C)C=C2NC=CC2=C1N1CCNCC1 CSYJRAUZKVJSRI-UHFFFAOYSA-N 0.000 description 1
- DVGMYSOOFHJACR-UHFFFAOYSA-N 6-tert-butyl-7-methoxy-4-piperazin-1-yl-1h-indole Chemical compound C1=2C=CNC=2C(OC)=C(C(C)(C)C)C=C1N1CCNCC1 DVGMYSOOFHJACR-UHFFFAOYSA-N 0.000 description 1
- RDSVSEFWZUWZHW-UHFFFAOYSA-N 7-bromo-1h-indole Chemical compound BrC1=CC=CC2=C1NC=C2 RDSVSEFWZUWZHW-UHFFFAOYSA-N 0.000 description 1
- SKTFQHRVFFOHTQ-UHFFFAOYSA-N 8-bromo-1,3-dimethyl-7h-purine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC(Br)=N2 SKTFQHRVFFOHTQ-UHFFFAOYSA-N 0.000 description 1
- 102000007527 Autoreceptors Human genes 0.000 description 1
- 108010071131 Autoreceptors Proteins 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- JIWCGXIDUDECFG-UHFFFAOYSA-N CC1=CC=CC2=C1C(=CO2)CC(=O)O.CC=2C=CC1=C(C(=CO1)CC(=O)O)C2.CC2=CC1=C(C(=CO1)CC(=O)O)C=C2.O2C=C(C1=C2C=CC=C1)CC(=O)O.CC=1OC2=C(C1CC(=O)O)C(=C(C(=C2F)F)F)F Chemical compound CC1=CC=CC2=C1C(=CO2)CC(=O)O.CC=2C=CC1=C(C(=CO1)CC(=O)O)C2.CC2=CC1=C(C(=CO1)CC(=O)O)C=C2.O2C=C(C1=C2C=CC=C1)CC(=O)O.CC=1OC2=C(C1CC(=O)O)C(=C(C(=C2F)F)F)F JIWCGXIDUDECFG-UHFFFAOYSA-N 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 238000003109 Karl Fischer titration Methods 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- 230000006181 N-acylation Effects 0.000 description 1
- 238000007126 N-alkylation reaction Methods 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Natural products O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- DXGTUUQHTDOFFQ-UHFFFAOYSA-N [N].C1=CC=C2NC=CC2=C1 Chemical group [N].C1=CC=C2NC=CC2=C1 DXGTUUQHTDOFFQ-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000674 adrenergic antagonist Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- BHELZAPQIKSEDF-UHFFFAOYSA-N allyl bromide Chemical compound BrCC=C BHELZAPQIKSEDF-UHFFFAOYSA-N 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 125000005129 aryl carbonyl group Chemical group 0.000 description 1
- 238000006254 arylation reaction Methods 0.000 description 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- NDKBVBUGCNGSJJ-UHFFFAOYSA-M benzyltrimethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)CC1=CC=CC=C1 NDKBVBUGCNGSJJ-UHFFFAOYSA-M 0.000 description 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- TXFLGZOGNOOEFZ-UHFFFAOYSA-N bis(2-chloroethyl)amine Chemical compound ClCCNCCCl TXFLGZOGNOOEFZ-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- UORVGPXVDQYIDP-BJUDXGSMSA-N borane Chemical class [10BH3] UORVGPXVDQYIDP-BJUDXGSMSA-N 0.000 description 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
- 125000000480 butynyl group Chemical group [*]C#CC([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001593 cAMP accumulation Effects 0.000 description 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical class C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
- WRJWRGBVPUUDLA-UHFFFAOYSA-N chlorosulfonyl isocyanate Chemical compound ClS(=O)(=O)N=C=O WRJWRGBVPUUDLA-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- WIWBLJMBLGWSIN-UHFFFAOYSA-L dichlorotris(triphenylphosphine)ruthenium(ii) Chemical compound [Cl-].[Cl-].[Ru+2].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 WIWBLJMBLGWSIN-UHFFFAOYSA-L 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- CJPXYKSOUHBYAY-UHFFFAOYSA-N ethyl 4-(1h-indol-4-yl)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound C1N(C(=O)OCC)CCC(C=2C=3C=CNC=3C=CC=2)=C1 CJPXYKSOUHBYAY-UHFFFAOYSA-N 0.000 description 1
- RLPLXSGGQNJIFP-UHFFFAOYSA-N ethyl 4-[1-[tert-butyl(dimethyl)silyl]indol-4-yl]-4-hydroxypiperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1(O)C1=CC=CC2=C1C=CN2[Si](C)(C)C(C)(C)C RLPLXSGGQNJIFP-UHFFFAOYSA-N 0.000 description 1
- LUBGFMZTGFXIIN-UHFFFAOYSA-N ethyl 4-oxopiperidine-1-carboxylate Chemical compound CCOC(=O)N1CCC(=O)CC1 LUBGFMZTGFXIIN-UHFFFAOYSA-N 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- 229960004038 fluvoxamine Drugs 0.000 description 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000000295 fuel oil Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 239000010437 gem Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- WZHJKEUHNJHDLS-QTGUNEKASA-N metergoline Chemical compound C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4N(C)C=C(C=34)C2)C1)C)NC(=O)OCC1=CC=CC=C1 WZHJKEUHNJHDLS-QTGUNEKASA-N 0.000 description 1
- 229960004650 metergoline Drugs 0.000 description 1
- WLXQZCQWRQKPTC-UHFFFAOYSA-N methyl 2-(5-fluoro-1-benzofuran-3-yl)acetate Chemical compound C1=C(F)C=C2C(CC(=O)OC)=COC2=C1 WLXQZCQWRQKPTC-UHFFFAOYSA-N 0.000 description 1
- LXPJDFYUYVHZGX-UHFFFAOYSA-N methyl 4-[4-[2-(5-fluoro-1h-indol-3-yl)-2-oxoacetyl]piperazin-1-yl]-1h-indole-6-carboxylate Chemical compound C1=C(F)C=C2C(C(=O)C(=O)N3CCN(CC3)C=3C=C(C=C4NC=CC4=3)C(=O)OC)=CNC2=C1 LXPJDFYUYVHZGX-UHFFFAOYSA-N 0.000 description 1
- TXQCEQACTNBDCU-UHFFFAOYSA-N methyl 4-piperazin-1-yl-1h-indole-6-carboxylate Chemical compound C=12C=CNC2=CC(C(=O)OC)=CC=1N1CCNCC1 TXQCEQACTNBDCU-UHFFFAOYSA-N 0.000 description 1
- LRKHQYYRUOJNRW-UHFFFAOYSA-N methyl 5-fluoro-1-benzofuran-3-carboxylate Chemical compound C1=C(F)C=C2C(C(=O)OC)=COC2=C1 LRKHQYYRUOJNRW-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 230000010807 negative regulation of binding Effects 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 229940053544 other antidepressants in atc Drugs 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 210000001609 raphe nuclei Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
- 229950001675 spiperone Drugs 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- OEAMZRWFIQSVJQ-UHFFFAOYSA-N tert-butyl 4-(1h-indol-4-yl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=CC2=C1C=CN2 OEAMZRWFIQSVJQ-UHFFFAOYSA-N 0.000 description 1
- YDUXKTCAHJCIGB-UHFFFAOYSA-N tert-butyl 4-(3-cyano-1h-indol-4-yl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=CC2=C1C(C#N)=CN2 YDUXKTCAHJCIGB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK82098 | 1998-06-19 | ||
| DKPA199800820 | 1998-06-19 | ||
| US9282398P | 1998-07-14 | 1998-07-14 | |
| US60/092,823 | 1998-07-14 | ||
| PCT/DK1999/000326 WO1999067237A1 (en) | 1998-06-19 | 1999-06-14 | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2335711A1 true CA2335711A1 (en) | 1999-12-29 |
Family
ID=26064717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002335711A Abandoned CA2335711A1 (en) | 1998-06-19 | 1999-06-14 | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1089997A1 (no) |
| JP (1) | JP2003521443A (no) |
| AU (1) | AU765317C (no) |
| BG (1) | BG105136A (no) |
| CA (1) | CA2335711A1 (no) |
| HR (1) | HRP20000847A2 (no) |
| HU (1) | HUP0101475A3 (no) |
| NO (1) | NO20006460L (no) |
| NZ (1) | NZ508506A (no) |
| WO (1) | WO1999067237A1 (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| SI1212320T1 (en) * | 1999-08-23 | 2005-10-31 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
| AR032712A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| AR032711A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
| ATE316523T1 (de) * | 2002-05-13 | 2006-02-15 | Hoffmann La Roche | Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen |
| AR040967A1 (es) * | 2002-08-12 | 2005-04-27 | Janssen Pharmaceutica Nv | Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos |
| CA2494557C (en) | 2002-08-15 | 2011-10-18 | Janssen Pharmaceutica N.V. | Fused heterocyclic isoxazoline derivatives and their use as anti-depressants |
| AU2003257407A1 (en) * | 2002-08-29 | 2004-03-19 | H. Lundbeck A/S | S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| US7235569B2 (en) | 2003-05-02 | 2007-06-26 | Wyeth | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use |
| US7276603B2 (en) | 2003-05-02 | 2007-10-02 | Wyeth | Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use |
| JP2008523030A (ja) * | 2004-12-08 | 2008-07-03 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体 |
| US7807671B2 (en) * | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| CA2668959A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Indole and benzofuran 2-carboxamide derivatives |
| CA2718138A1 (en) * | 2008-03-14 | 2009-09-17 | Timo Heinrich | Azaindole compounds for treatment of central nervous system disorders |
| CN103420989B (zh) * | 2012-05-15 | 2016-03-23 | 华中科技大学 | 苯并二噁烷类衍生物及其应用 |
| EP3027607B1 (en) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| CN105732591B (zh) * | 2014-12-31 | 2019-10-25 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| WO2017012579A1 (zh) * | 2015-07-23 | 2017-01-26 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
-
1999
- 1999-06-14 AU AU43592/99A patent/AU765317C/en not_active Ceased
- 1999-06-14 EP EP99926281A patent/EP1089997A1/en not_active Withdrawn
- 1999-06-14 WO PCT/DK1999/000326 patent/WO1999067237A1/en not_active Application Discontinuation
- 1999-06-14 CA CA002335711A patent/CA2335711A1/en not_active Abandoned
- 1999-06-14 JP JP2000555890A patent/JP2003521443A/ja not_active Withdrawn
- 1999-06-14 HU HU0101475A patent/HUP0101475A3/hu unknown
- 1999-06-14 NZ NZ508506A patent/NZ508506A/en unknown
-
2000
- 2000-12-11 HR HR20000847A patent/HRP20000847A2/hr not_active Application Discontinuation
- 2000-12-18 NO NO20006460A patent/NO20006460L/no not_active Application Discontinuation
-
2001
- 2001-01-10 BG BG105136A patent/BG105136A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU765317C (en) | 2004-05-20 |
| AU765317B2 (en) | 2003-09-18 |
| WO1999067237A1 (en) | 1999-12-29 |
| NO20006460D0 (no) | 2000-12-18 |
| EP1089997A1 (en) | 2001-04-11 |
| JP2003521443A (ja) | 2003-07-15 |
| HUP0101475A3 (en) | 2003-01-28 |
| BG105136A (en) | 2001-09-28 |
| HUP0101475A2 (hu) | 2001-10-28 |
| HRP20000847A2 (en) | 2001-12-31 |
| NZ508506A (en) | 2004-01-30 |
| AU4359299A (en) | 2000-01-10 |
| NO20006460L (no) | 2001-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU765317C (en) | 4,5,6 and 7-indole and indoline derivatives, their preparation and use | |
| US6476035B1 (en) | Indole and 2,3-dihydroindole derivatives, their preparation and use | |
| SK10302001A3 (sk) | Piperidínové, tetrahydropyridínové a piperazínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie | |
| US5393761A (en) | 3-arylindole compounds | |
| HUT74096A (en) | 3-indolylpiperidine derivatives | |
| US6391882B1 (en) | 4,5,6 and 7-indole and indoline derivatitives, their preparation and use | |
| MXPA00012609A (en) | 4,5,6 and 7-indole and indoline derivatives, their preparation and use | |
| SK952000A3 (en) | Indole and 2,3-dihydroindole derivatives, their preparation and use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |