AU765317C - 4,5,6 and 7-indole and indoline derivatives, their preparation and use - Google Patents

4,5,6 and 7-indole and indoline derivatives, their preparation and use

Info

Publication number
AU765317C
AU765317C AU43592/99A AU4359299A AU765317C AU 765317 C AU765317 C AU 765317C AU 43592/99 A AU43592/99 A AU 43592/99A AU 4359299 A AU4359299 A AU 4359299A AU 765317 C AU765317 C AU 765317C
Authority
AU
Australia
Prior art keywords
indol
ethyl
piperazine
chloro
benzofuranyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU43592/99A
Other languages
English (en)
Other versions
AU765317B2 (en
AU4359299A (en
Inventor
Christian Krog-Jensen
Ivan Mikkelsen
Ejner Knud Moltzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of AU4359299A publication Critical patent/AU4359299A/en
Application granted granted Critical
Publication of AU765317B2 publication Critical patent/AU765317B2/en
Publication of AU765317C publication Critical patent/AU765317C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AU43592/99A 1998-06-19 1999-06-14 4,5,6 and 7-indole and indoline derivatives, their preparation and use Ceased AU765317C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK82098 1998-06-19
DK9800820 1998-06-19
US9282398P 1998-07-14 1998-07-14
US60/092823 1998-07-14
PCT/DK1999/000326 WO1999067237A1 (en) 1998-06-19 1999-06-14 4,5,6 and 7-indole and indoline derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
AU4359299A AU4359299A (en) 2000-01-10
AU765317B2 AU765317B2 (en) 2003-09-18
AU765317C true AU765317C (en) 2004-05-20

Family

ID=26064717

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43592/99A Ceased AU765317C (en) 1998-06-19 1999-06-14 4,5,6 and 7-indole and indoline derivatives, their preparation and use

Country Status (10)

Country Link
EP (1) EP1089997A1 (no)
JP (1) JP2003521443A (no)
AU (1) AU765317C (no)
BG (1) BG105136A (no)
CA (1) CA2335711A1 (no)
HR (1) HRP20000847A2 (no)
HU (1) HUP0101475A3 (no)
NO (1) NO20006460L (no)
NZ (1) NZ508506A (no)
WO (1) WO1999067237A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
SI1212320T1 (en) * 1999-08-23 2005-10-31 Solvay Pharmaceuticals B.V. Phenylpiperazines as serotonin reuptake inhibitors
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR032711A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
ATE316523T1 (de) * 2002-05-13 2006-02-15 Hoffmann La Roche Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen
AR040967A1 (es) * 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
CA2494557C (en) 2002-08-15 2011-10-18 Janssen Pharmaceutica N.V. Fused heterocyclic isoxazoline derivatives and their use as anti-depressants
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US7235569B2 (en) 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
JP2008523030A (ja) * 2004-12-08 2008-07-03 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CA2668959A1 (en) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Indole and benzofuran 2-carboxamide derivatives
CA2718138A1 (en) * 2008-03-14 2009-09-17 Timo Heinrich Azaindole compounds for treatment of central nervous system disorders
CN103420989B (zh) * 2012-05-15 2016-03-23 华中科技大学 苯并二噁烷类衍生物及其应用
EP3027607B1 (en) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CN105732591B (zh) * 2014-12-31 2019-10-25 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
WO2017012579A1 (zh) * 2015-07-23 2017-01-26 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021626A1 (en) * 1993-03-18 1994-09-29 Merck Sharp & Dohme Limited Indazole derivatives
AU5310998A (en) * 1996-12-20 1998-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021626A1 (en) * 1993-03-18 1994-09-29 Merck Sharp & Dohme Limited Indazole derivatives
AU5310998A (en) * 1996-12-20 1998-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives

Also Published As

Publication number Publication date
CA2335711A1 (en) 1999-12-29
AU765317B2 (en) 2003-09-18
WO1999067237A1 (en) 1999-12-29
NO20006460D0 (no) 2000-12-18
EP1089997A1 (en) 2001-04-11
JP2003521443A (ja) 2003-07-15
HUP0101475A3 (en) 2003-01-28
BG105136A (en) 2001-09-28
HUP0101475A2 (hu) 2001-10-28
HRP20000847A2 (en) 2001-12-31
NZ508506A (en) 2004-01-30
AU4359299A (en) 2000-01-10
NO20006460L (no) 2001-02-19

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US6596722B2 (en) Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use
US6391882B1 (en) 4,5,6 and 7-indole and indoline derivatitives, their preparation and use
MXPA00012609A (en) 4,5,6 and 7-indole and indoline derivatives, their preparation and use
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Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20030902

FGA Letters patent sealed or granted (standard patent)
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20031009