CA2335711A1 - Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation - Google Patents

Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation Download PDF

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Publication number
CA2335711A1
CA2335711A1 CA002335711A CA2335711A CA2335711A1 CA 2335711 A1 CA2335711 A1 CA 2335711A1 CA 002335711 A CA002335711 A CA 002335711A CA 2335711 A CA2335711 A CA 2335711A CA 2335711 A1 CA2335711 A1 CA 2335711A1
Authority
CA
Canada
Prior art keywords
indol
piperazine
ethyl
chloro
benzofuranyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002335711A
Other languages
English (en)
Inventor
Ivan Mikkelsen
Christian Krog-Jensen
Ejner Knud Moltzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2335711A1 publication Critical patent/CA2335711A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne un dérivé de 4-, 5-, 6-, et 7-indole ou d'indoline substitué de formule (I), dans laquelle A représente un groupe de formule (IIA), (IIB), (IIC), dans laquelle X, U, Y, R?3¿ à R?12¿, Z, W, n et m sont tels que définis ci-dessus. Les composés de cette invention sont de puissants inhibiteurs du recaptage de la sérotonine, et présentent une action antagoniste du récepteur 5-HT¿1A?.
CA002335711A 1998-06-19 1999-06-14 Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation Abandoned CA2335711A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK82098 1998-06-19
DKPA199800820 1998-06-19
US9282398P 1998-07-14 1998-07-14
US60/092,823 1998-07-14
PCT/DK1999/000326 WO1999067237A1 (fr) 1998-06-19 1999-06-14 Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation

Publications (1)

Publication Number Publication Date
CA2335711A1 true CA2335711A1 (fr) 1999-12-29

Family

ID=26064717

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002335711A Abandoned CA2335711A1 (fr) 1998-06-19 1999-06-14 Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation

Country Status (10)

Country Link
EP (1) EP1089997A1 (fr)
JP (1) JP2003521443A (fr)
AU (1) AU765317C (fr)
BG (1) BG105136A (fr)
CA (1) CA2335711A1 (fr)
HR (1) HRP20000847A2 (fr)
HU (1) HUP0101475A3 (fr)
NO (1) NO20006460L (fr)
NZ (1) NZ508506A (fr)
WO (1) WO1999067237A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
SI1212320T1 (en) * 1999-08-23 2005-10-31 Solvay Pharmaceuticals B.V. Phenylpiperazines as serotonin reuptake inhibitors
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR032711A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
ATE316523T1 (de) * 2002-05-13 2006-02-15 Hoffmann La Roche Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen
AR040967A1 (es) * 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
CA2494557C (fr) 2002-08-15 2011-10-18 Janssen Pharmaceutica N.V. Derives d'isoxazoline heterocycliques fusionnes et leur utilisation en tant qu'antidepresseurs
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US7235569B2 (en) 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
JP2008523030A (ja) * 2004-12-08 2008-07-03 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CA2668959A1 (fr) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Derives d'indole et de benzofuran 2-carboxamide
CA2718138A1 (fr) * 2008-03-14 2009-09-17 Timo Heinrich Composes d'azaindole pour le traitement de troubles du systeme nerveux central
CN103420989B (zh) * 2012-05-15 2016-03-23 华中科技大学 苯并二噁烷类衍生物及其应用
EP3027607B1 (fr) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryliques substitués et procédés d'utilisation
CN105732591B (zh) * 2014-12-31 2019-10-25 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
WO2017012579A1 (fr) * 2015-07-23 2017-01-26 广东东阳光药业有限公司 Composés d'indole substitués, méthodes d'utilisation et utilisations de ceux-ci

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives

Also Published As

Publication number Publication date
AU765317C (en) 2004-05-20
AU765317B2 (en) 2003-09-18
WO1999067237A1 (fr) 1999-12-29
NO20006460D0 (no) 2000-12-18
EP1089997A1 (fr) 2001-04-11
JP2003521443A (ja) 2003-07-15
HUP0101475A3 (en) 2003-01-28
BG105136A (en) 2001-09-28
HUP0101475A2 (hu) 2001-10-28
HRP20000847A2 (en) 2001-12-31
NZ508506A (en) 2004-01-30
AU4359299A (en) 2000-01-10
NO20006460L (no) 2001-02-19

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued