EP1089997A1 - Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation - Google Patents

Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation

Info

Publication number
EP1089997A1
EP1089997A1 EP99926281A EP99926281A EP1089997A1 EP 1089997 A1 EP1089997 A1 EP 1089997A1 EP 99926281 A EP99926281 A EP 99926281A EP 99926281 A EP99926281 A EP 99926281A EP 1089997 A1 EP1089997 A1 EP 1089997A1
Authority
EP
European Patent Office
Prior art keywords
indol
ethyl
piperazine
chloro
benzofuranyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99926281A
Other languages
German (de)
English (en)
Inventor
Ejner Knud Moltzen
Ivan Mikkelsen
Christian Krog-Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of EP1089997A1 publication Critical patent/EP1089997A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne un dérivé de 4-, 5-, 6-, et 7-indole ou d'indoline substitué de formule (I), dans laquelle A représente un groupe de formule (IIA), (IIB), (IIC), dans laquelle X, U, Y, R3 à R12, Z, W, n et m sont tels que définis ci-dessus. Les composés de cette invention sont de puissants inhibiteurs du recaptage de la sérotonine, et présentent une action antagoniste du récepteur 5-HT¿1A?.
EP99926281A 1998-06-19 1999-06-14 Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation Withdrawn EP1089997A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK82098 1998-06-19
DK82098 1998-06-19
US9282398P 1998-07-14 1998-07-14
US92823P 1998-07-14
PCT/DK1999/000326 WO1999067237A1 (fr) 1998-06-19 1999-06-14 Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation

Publications (1)

Publication Number Publication Date
EP1089997A1 true EP1089997A1 (fr) 2001-04-11

Family

ID=26064717

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99926281A Withdrawn EP1089997A1 (fr) 1998-06-19 1999-06-14 Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation

Country Status (10)

Country Link
EP (1) EP1089997A1 (fr)
JP (1) JP2003521443A (fr)
AU (1) AU765317C (fr)
BG (1) BG105136A (fr)
CA (1) CA2335711A1 (fr)
HR (1) HRP20000847A2 (fr)
HU (1) HUP0101475A3 (fr)
NO (1) NO20006460L (fr)
NZ (1) NZ508506A (fr)
WO (1) WO1999067237A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
AU772189B2 (en) * 1999-08-23 2004-04-08 Solvay Pharmaceuticals B.V. New phenylpiperazines
AR032711A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
WO2003095434A1 (fr) * 2002-05-13 2003-11-20 F. Hoffmann-La Roche Ag Derives de benzoxazine servant de modulateurs de 5-ht6 et leurs utilisations
AR040967A1 (es) * 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
ES2339444T3 (es) * 2002-08-15 2010-05-20 Janssen Pharmaceutica Nv Derivados de isoxazolina heterociclicos condensados y su uso como antidepresivos.
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
US7235569B2 (en) 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
AU2005313391A1 (en) * 2004-12-08 2006-06-15 Solvay Pharmaceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
JP2010509259A (ja) 2006-11-09 2010-03-25 エフ．ホフマン−ラ ロシュ アーゲー インドール及びベンゾフラン２−カルボキサミド誘導体
MX2010009920A (es) * 2008-03-14 2010-09-30 Merck Patent Gmbh Compuestos de azaindol para tratamiento de trastornos del sistema nervioso central.
CN103420989B (zh) * 2012-05-15 2016-03-23 华中科技大学 苯并二噁烷类衍生物及其应用
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
CN105732591B (zh) * 2014-12-31 2019-10-25 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9967237A1 *

Also Published As

Publication number Publication date
NO20006460D0 (no) 2000-12-18
HUP0101475A2 (hu) 2001-10-28
NZ508506A (en) 2004-01-30
AU765317C (en) 2004-05-20
HRP20000847A2 (en) 2001-12-31
NO20006460L (no) 2001-02-19
BG105136A (en) 2001-09-28
WO1999067237A1 (fr) 1999-12-29
AU4359299A (en) 2000-01-10
JP2003521443A (ja) 2003-07-15
AU765317B2 (en) 2003-09-18
CA2335711A1 (fr) 1999-12-29
HUP0101475A3 (en) 2003-01-28

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US6596722B2 (en) Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use
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Legal Events

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Effective date: 20040831