CA2332540A1 - Therapeutic dinucleotide and derivatives - Google Patents
Therapeutic dinucleotide and derivatives Download PDFInfo
- Publication number
- CA2332540A1 CA2332540A1 CA002332540A CA2332540A CA2332540A1 CA 2332540 A1 CA2332540 A1 CA 2332540A1 CA 002332540 A CA002332540 A CA 002332540A CA 2332540 A CA2332540 A CA 2332540A CA 2332540 A1 CA2332540 A1 CA 2332540A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8654398P | 1998-05-22 | 1998-05-22 | |
| US60/086,543 | 1998-05-22 | ||
| PCT/US1999/010948 WO1999061012A2 (en) | 1998-05-22 | 1999-05-19 | Therapeutic dinucleotide and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2332540A1 true CA2332540A1 (en) | 1999-12-02 |
Family
ID=22199276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002332540A Abandoned CA2332540A1 (en) | 1998-05-22 | 1999-05-19 | Therapeutic dinucleotide and derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6323187B1 (https=) |
| EP (1) | EP1087777B1 (https=) |
| JP (1) | JP4633927B2 (https=) |
| CN (1) | CN1301168A (https=) |
| AT (1) | ATE232733T1 (https=) |
| AU (1) | AU746750B2 (https=) |
| CA (1) | CA2332540A1 (https=) |
| DE (1) | DE69905464T2 (https=) |
| WO (1) | WO1999061012A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
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| US5292498A (en) | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
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| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| DK0981534T3 (da) * | 1997-02-06 | 2006-09-04 | Inspire Pharmaceuticals Inc | Dinukleotider og deres anvendelser |
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| GB2342176B (en) * | 1998-02-02 | 2001-05-02 | Signature Bioscience Inc | Method and apparatus for detecting molecular binding events |
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- 1999-05-19 CA CA002332540A patent/CA2332540A1/en not_active Abandoned
- 1999-05-19 AT AT99924313T patent/ATE232733T1/de not_active IP Right Cessation
- 1999-05-19 WO PCT/US1999/010948 patent/WO1999061012A2/en not_active Ceased
- 1999-05-19 JP JP2000550472A patent/JP4633927B2/ja not_active Expired - Fee Related
- 1999-05-19 EP EP99924313A patent/EP1087777B1/en not_active Expired - Lifetime
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- 1999-05-19 DE DE69905464T patent/DE69905464T2/de not_active Expired - Fee Related
- 1999-05-19 AU AU40839/99A patent/AU746750B2/en not_active Ceased
- 1999-05-21 US US09/316,571 patent/US6323187B1/en not_active Expired - Fee Related
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| AU746750B2 (en) | 2002-05-02 |
| CN1301168A (zh) | 2001-06-27 |
| DE69905464T2 (de) | 2004-01-15 |
| EP1087777A2 (en) | 2001-04-04 |
| JP2002516273A (ja) | 2002-06-04 |
| AU4083999A (en) | 1999-12-13 |
| JP4633927B2 (ja) | 2011-02-16 |
| WO1999061012A3 (en) | 2000-02-10 |
| DE69905464D1 (de) | 2003-03-27 |
| ATE232733T1 (de) | 2003-03-15 |
| US6323187B1 (en) | 2001-11-27 |
| WO1999061012A2 (en) | 1999-12-02 |
| EP1087777B1 (en) | 2003-02-19 |
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