CA2331197A1 - Mimotopes du virus hiv - Google Patents
Mimotopes du virus hiv Download PDFInfo
- Publication number
- CA2331197A1 CA2331197A1 CA002331197A CA2331197A CA2331197A1 CA 2331197 A1 CA2331197 A1 CA 2331197A1 CA 002331197 A CA002331197 A CA 002331197A CA 2331197 A CA2331197 A CA 2331197A CA 2331197 A1 CA2331197 A1 CA 2331197A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- seq
- phe
- thr
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
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- 238000010348 incorporation Methods 0.000 description 1
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- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 229940031439 squalene Drugs 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Peptide pour le traitement thérapeutique ou prophylactique de l'infection à HIV, capable de réagir avec un anticorps spécifique de l'enveloppe du virus HIV et provenant d'un patient HIV positif appartenant au groupe des "long term non progressor", comprenant une séquence en acides aminés qui mime un épitope conformationnel d'un antigène de l'enveloppe dudit virus sans toutefois correspondre à une séquence continue d'acides aminés de cet antigène et pouvant contenir au choix l'une des 11 séquences en acides aminés telles que spécifiées dans l'invention. Conjugué du peptide selon l'invention résultant de l'association du peptide à une molécule porteuse pour renforcer l'immunogénicité dudit peptide. Vecteur recombinant comprenant une cassette d'expression fonctionnelle permettant l'expression d'un poly nucléotide codant pour un peptide selon l'invention. Composition thérapeutique ou prophylactique de l'infection à HIV, notamment destiné à un usage vaccinal, dont le principe comprend un peptide selon l'invention, le cas échéant un conjugué de ce peptide et/ou un vecteur recombinant codant pour ledit peptide. Utilisation d'un peptide selon l'invention en tant que réactif pour le diagnostic de l'infection à HIV et/ou de la susceptibilité des sujets en contact avec le virus à développer rapidement un SIDA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9807598 | 1998-06-12 | ||
FR98/07598 | 1998-06-12 | ||
PCT/FR1999/001409 WO1999066046A1 (fr) | 1998-06-12 | 1999-06-14 | Mimotopes du virus hiv |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2331197A1 true CA2331197A1 (fr) | 1999-12-23 |
Family
ID=9527466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002331197A Abandoned CA2331197A1 (fr) | 1998-06-12 | 1999-06-14 | Mimotopes du virus hiv |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1084253A1 (fr) |
AU (1) | AU748700B2 (fr) |
CA (1) | CA2331197A1 (fr) |
NZ (1) | NZ508812A (fr) |
WO (1) | WO1999066046A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2603100A (en) * | 1999-01-11 | 2000-08-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Novel hiv related peptides |
US6911527B1 (en) | 1999-01-11 | 2005-06-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | HIV related peptides |
WO2002051865A2 (fr) * | 2000-12-22 | 2002-07-04 | Aventis Pasteur | Antigenes proteiques inducteurs d'anticorps neutralisant le virus vih |
FR2818648B1 (fr) * | 2000-12-22 | 2003-10-10 | Aventis Pasteur | Antigenes proteiques inducteurs d'anticorps neutralisant le virus vih |
JP5861242B2 (ja) * | 2009-04-17 | 2016-02-16 | ナショナル リサーチ カウンシル オブ カナダ | クラステリンのペプチドリガンド及びその使用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1111540C (zh) * | 1993-06-09 | 2003-06-18 | 康诺特实验室有限公司 | 串联的合成hiv-1肽类 |
ATE290592T1 (de) * | 1993-11-04 | 2005-03-15 | Innogenetics Nv | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
DE4405810A1 (de) * | 1994-02-23 | 1995-08-24 | Behringwerke Ag | Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung |
US5877155A (en) * | 1995-03-17 | 1999-03-02 | The Research Foundation Of State University Of New York | Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX |
DE19613253A1 (de) * | 1996-04-02 | 1997-10-09 | Immuno Gmbh | Technik zum Nachweis von Infektionen mit dem TBE-Virus und anderen Flaviviren |
AU9312598A (en) * | 1997-09-10 | 1999-03-29 | Allegheny University Of The Health Sciences | Inhibitors of collagen assembly |
-
1999
- 1999-06-14 EP EP99925080A patent/EP1084253A1/fr not_active Withdrawn
- 1999-06-14 WO PCT/FR1999/001409 patent/WO1999066046A1/fr not_active Application Discontinuation
- 1999-06-14 NZ NZ508812A patent/NZ508812A/xx unknown
- 1999-06-14 AU AU41489/99A patent/AU748700B2/en not_active Ceased
- 1999-06-14 CA CA002331197A patent/CA2331197A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU748700B2 (en) | 2002-06-13 |
EP1084253A1 (fr) | 2001-03-21 |
WO1999066046A1 (fr) | 1999-12-23 |
NZ508812A (en) | 2002-11-26 |
AU4148999A (en) | 2000-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |