CA2323687C - Mutant recombinant allergens - Google Patents

Mutant recombinant allergens Download PDF

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Publication number
CA2323687C
CA2323687C CA002323687A CA2323687A CA2323687C CA 2323687 C CA2323687 C CA 2323687C CA 002323687 A CA002323687 A CA 002323687A CA 2323687 A CA2323687 A CA 2323687A CA 2323687 C CA2323687 C CA 2323687C
Authority
CA
Canada
Prior art keywords
allergen
recombinant
derived
amino acid
bet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002323687A
Other languages
English (en)
French (fr)
Other versions
CA2323687A1 (en
Inventor
Hans Henrik Ipsen
Michael Dho Spangfort
Jorgen Nedergaard Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALK Abello AS
Original Assignee
ALK Abello AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8092687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2323687(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ALK Abello AS filed Critical ALK Abello AS
Publication of CA2323687A1 publication Critical patent/CA2323687A1/en
Application granted granted Critical
Publication of CA2323687C publication Critical patent/CA2323687C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002323687A 1998-03-16 1999-03-16 Mutant recombinant allergens Expired - Fee Related CA2323687C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK0364/98 1998-03-16
DK36498 1998-03-16
PCT/DK1999/000136 WO1999047680A1 (en) 1998-03-16 1999-03-16 Mutant recombinant allergens

Publications (2)

Publication Number Publication Date
CA2323687A1 CA2323687A1 (en) 1999-09-23
CA2323687C true CA2323687C (en) 2008-11-25

Family

ID=8092687

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002323687A Expired - Fee Related CA2323687C (en) 1998-03-16 1999-03-16 Mutant recombinant allergens

Country Status (19)

Country Link
US (1) US20040091500A1 (https=)
EP (1) EP1062341B1 (https=)
JP (1) JP2002506648A (https=)
KR (1) KR20010041918A (https=)
CN (1) CN1332029C (https=)
AT (1) ATE408690T1 (https=)
AU (1) AU749749B2 (https=)
CA (1) CA2323687C (https=)
DE (1) DE69939584D1 (https=)
DK (1) DK1062341T3 (https=)
ES (1) ES2313776T3 (https=)
HU (1) HUP0101464A3 (https=)
IL (2) IL138339A0 (https=)
NO (1) NO328354B1 (https=)
NZ (1) NZ506665A (https=)
PL (1) PL194804B1 (https=)
PT (1) PT1062341E (https=)
WO (1) WO1999047680A1 (https=)
ZA (1) ZA200004819B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1280817A2 (en) * 2000-04-28 2003-02-05 Novozymes A/S Production and use of protein variants having modified immunogenecity
IT1318692B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
IT1318690B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti dell'allergene maggiore par j 2 di parietaria judaica.
EP1340085B1 (en) * 2000-10-17 2008-07-30 Besst-Test Aps Assay for directly detecting a biological cell in a body fluid sample
ATE414773T1 (de) * 2000-11-16 2008-12-15 Alk Abello As Mutante allergene
DE60032250T2 (de) * 2000-12-28 2007-03-15 Biomay Produktions- Und Handels-Aktiengesellschaft Behandlung von Allergien
WO2002070665A2 (en) * 2001-03-02 2002-09-12 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
EP1436627A2 (en) * 2001-10-05 2004-07-14 Novozymes A/S Kit for predicting binding of a specific antibody to a potential immunogen and method of screening
EP1478662B2 (de) * 2002-02-27 2017-07-05 Merck Patent GmbH Verfahren zur herstellung von hypoallergenem birkenpollenhauptallergen rbet v 1
CN1668737A (zh) * 2002-05-16 2005-09-14 阿尔克-阿贝洛有限公司 重组Bet.V.1过敏原突变体及其方法和制备
CA2503886A1 (en) * 2002-11-01 2004-05-13 Alk-Abello A/S Recombinant protein variants
WO2004047793A1 (en) 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
US8012505B2 (en) 2003-02-28 2011-09-06 Alk-Abello A/S Dosage form having a saccharide matrix
EP1599185A1 (en) 2003-02-28 2005-11-30 Alk-Abello A/S Dosage form having a saccharide matrix
RU2006126051A (ru) 2003-12-19 2008-01-27 Альк-Абелло А/С (Dk) Способы получения партии активного фармацевтического ингредиента, контейнер, содержащий криогранулы аллергенного продукта, и криогранула аллергенного продукта
AU2006299310A1 (en) 2005-10-04 2007-04-12 Alk-Abello A/S Solid vaccine formulation
ITMI20052517A1 (it) * 2005-12-29 2007-06-30 Lofarma Spa Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
WO2007123488A1 (en) * 2006-04-20 2007-11-01 National University Of Singapore Recombinant lactobacillus and use of the same
CN103736086A (zh) * 2007-02-15 2014-04-23 曼康公司 用于增强t细胞应答的方法
CA2682054A1 (en) 2007-03-28 2008-10-02 Alk-Abello A/S Use of an adjuvanted allergy vaccine formulation for parenteral administration
EP2028188A1 (en) 2007-08-21 2009-02-25 Biomay AG Hypoallergenic molecules
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
WO2010146171A1 (en) 2009-06-19 2010-12-23 Alk-Abelló A/S Novel manner of administering allergen in allergen specific immunotherapy
CN102584966A (zh) * 2011-11-14 2012-07-18 广州医学院第二附属医院 一种重组花生过敏原与突变体及其制备方法和应用
CN102617719A (zh) * 2012-03-30 2012-08-01 广州医学院第二附属医院 一种重组大米过敏原与突变体及其制备方法和应用
CN102690340A (zh) * 2012-03-30 2012-09-26 广州医学院第二附属医院 一种重组巴西坚果过敏原与突变体及其制备方法和应用
CN102603879A (zh) * 2012-03-30 2012-07-25 广州医学院第二附属医院 一种重组大豆过敏原与突变体及其制备方法和应用
CN102617715A (zh) * 2012-03-30 2012-08-01 广州医学院第二附属医院 一种重组真菌主要过敏原与突变体及其制备方法和应用
CN102675439A (zh) * 2012-03-31 2012-09-19 广州医学院第二附属医院 一种重组黑麦草花粉过敏原与突变体的制备方法和应用
EP2952200A1 (en) 2014-06-04 2015-12-09 Alk-Abelló A/S Allergen for prophylactic treatment of allergy
WO2021097174A1 (en) * 2019-11-13 2021-05-20 The Regents Of The University Of Michigan Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation
CN111187606B (zh) * 2020-02-25 2022-06-14 江苏海洋大学 一种用于海水基可循环清洁压裂液的表面活性剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804201A (en) * 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
AU743647B2 (en) * 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions
IT1318692B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.

Also Published As

Publication number Publication date
HK1033591A1 (en) 2001-09-07
ZA200004819B (en) 2001-05-30
KR20010041918A (ko) 2001-05-25
WO1999047680A1 (en) 1999-09-23
NO328354B1 (no) 2010-02-01
DE69939584D1 (de) 2008-10-30
US20040091500A1 (en) 2004-05-13
PL194804B1 (pl) 2007-07-31
NO20004614L (no) 2000-10-26
EP1062341B1 (en) 2008-09-17
ATE408690T1 (de) 2008-10-15
AU749749B2 (en) 2002-07-04
NO20004614D0 (no) 2000-09-15
CA2323687A1 (en) 1999-09-23
CN1293710A (zh) 2001-05-02
IL138339A (en) 2009-06-15
PT1062341E (pt) 2008-12-24
EP1062341A1 (en) 2000-12-27
PL343029A1 (en) 2001-07-30
CN1332029C (zh) 2007-08-15
JP2002506648A (ja) 2002-03-05
HUP0101464A2 (hu) 2001-08-28
HUP0101464A3 (en) 2004-10-28
IL138339A0 (en) 2001-10-31
DK1062341T3 (da) 2008-11-03
NZ506665A (en) 2003-08-29
AU2714799A (en) 1999-10-11
ES2313776T3 (es) 2009-03-01

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Effective date: 20150316