CA2320136A1 - Traitement de malformations osseuses avec des cellules precurseurs osteoblastiques - Google Patents

Traitement de malformations osseuses avec des cellules precurseurs osteoblastiques Download PDF

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Publication number
CA2320136A1
CA2320136A1 CA002320136A CA2320136A CA2320136A1 CA 2320136 A1 CA2320136 A1 CA 2320136A1 CA 002320136 A CA002320136 A CA 002320136A CA 2320136 A CA2320136 A CA 2320136A CA 2320136 A1 CA2320136 A1 CA 2320136A1
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Prior art keywords
bone
bmp
cell
cells
opcs
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Abandoned
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CA002320136A
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English (en)
Inventor
Jeffrey O. Hollinger
Shelley R. Winn
Edmund Frank
Shou C. Wong
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Oregon Health Science University
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Individual
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Publication of CA2320136A1 publication Critical patent/CA2320136A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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Abstract

L'invention permet d'accélérer la guérison de malformations osseuses au moyen d'une suspension de cellules précurseurs ostéoblastiques (OPC) dans une matrice poreuse implantée dans la malformation osseuse. On peut transformer les OPC pour qu'elles expriment une protéine morphogénique osseuse (BMP) telle que BMP-2. L'invention concerne également des dispositifs pour introduire les OPC dans des malformations osseuses. Un de ces dispositifs se présente comme une canule (100) qui possède des canaux concentriques et permet de faire passer un endoscope (122) à travers l'un des canaux, les OPC étant introduites à travers l'endoscope ou à travers un autre canal, et ce sans devoir augmenter la pression sur les OPC jusqu'à une limite où les cellules pourraient être endommagées. On peut insérer à travers l'endoscope une unité de cartouche (126) afin d'introduire progressivement la suspension cellulaire dans l'os à travers un cathéter.
CA002320136A 1998-02-10 1999-02-10 Traitement de malformations osseuses avec des cellules precurseurs osteoblastiques Abandoned CA2320136A1 (fr)

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US7424098P 1998-02-10 1998-02-10
US7445198P 1998-02-12 1998-02-12
US60/074,451 1998-02-12
US60/074,240 1998-02-12
PCT/US1999/002946 WO1999039724A1 (fr) 1998-02-10 1999-02-10 Traitement de malformations osseuses avec des cellules precurseurs osteoblastiques

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CA2320136A1 true CA2320136A1 (fr) 1999-08-12

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JP (1) JP2002502822A (fr)
AU (1) AU2671599A (fr)
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WO (1) WO1999039724A1 (fr)

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AU2671599A (en) 1999-08-23
WO1999039724A1 (fr) 1999-08-12
EP1053002A1 (fr) 2000-11-22
JP2002502822A (ja) 2002-01-29

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