CA2317416A1 - 1,2,4-triazolo[3,4-a]pyridazine substituee - Google Patents
1,2,4-triazolo[3,4-a]pyridazine substituee Download PDFInfo
- Publication number
- CA2317416A1 CA2317416A1 CA002317416A CA2317416A CA2317416A1 CA 2317416 A1 CA2317416 A1 CA 2317416A1 CA 002317416 A CA002317416 A CA 002317416A CA 2317416 A CA2317416 A CA 2317416A CA 2317416 A1 CA2317416 A1 CA 2317416A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- triazolo
- triazol
- cognition
- chz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
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- 230000019771 cognition Effects 0.000 claims abstract description 12
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- NZMJFRXKGUCYNP-UHFFFAOYSA-N α5ia Chemical compound O1C(C)=CC(C=2N3N=C(OCC=4N=NN(C)C=4)C4=CC=CC=C4C3=NN=2)=N1 NZMJFRXKGUCYNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000003292 diminished effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 25
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 abstract description 2
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 208000018726 traumatic encephalopathy Diseases 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- RZLMQJSSMROKSS-UHFFFAOYSA-N trimethyl-[2-(triazol-1-ylmethoxy)ethyl]silane Chemical compound C[Si](C)(C)CCOCN1C=CN=N1 RZLMQJSSMROKSS-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Dérivé de triazolopyridazine, utilisation dudit dérivé dans les thérapies d'amélioration cognitive, compositions contenant ledit dérivé et procédés de préparation dudit dérivé.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9803992.8A GB9803992D0 (en) | 1998-02-25 | 1998-02-25 | Therapeutic agents |
| GB9803992.8 | 1998-02-25 | ||
| PCT/GB1998/001307 WO1998050385A1 (fr) | 1997-05-08 | 1998-05-06 | Derives de 1,2,4-triazolo[3,4,-a]phtalazine substitues comme ligands de gaba alpha 5 |
| WOPCT/GB98/01307 | 1998-05-06 | ||
| GBGB9824896.6A GB9824896D0 (en) | 1998-11-12 | 1998-11-12 | Therapeutic compound |
| GB9824896.6 | 1998-11-12 | ||
| PCT/GB1999/000485 WO1999043677A1 (fr) | 1998-02-25 | 1999-02-17 | 1,2,4-TRIAZOLO[3,4-a]PYRIDAZINE SUBSTITUEE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2317416A1 true CA2317416A1 (fr) | 1999-09-02 |
Family
ID=27269184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002317416A Abandoned CA2317416A1 (fr) | 1998-02-25 | 1999-02-17 | 1,2,4-triazolo[3,4-a]pyridazine substituee |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1070066A1 (fr) |
| JP (1) | JP2002504554A (fr) |
| CN (1) | CN1291194A (fr) |
| AU (1) | AU746719B2 (fr) |
| BG (1) | BG104705A (fr) |
| CA (1) | CA2317416A1 (fr) |
| EA (1) | EA002824B1 (fr) |
| HR (1) | HRP20000555A2 (fr) |
| HU (1) | HUP0100647A3 (fr) |
| NZ (1) | NZ505695A (fr) |
| PL (1) | PL341975A1 (fr) |
| SK (1) | SK12772000A3 (fr) |
| TR (1) | TR200002469T2 (fr) |
| WO (1) | WO1999043677A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9821179D0 (en) * | 1998-09-30 | 1998-11-25 | Merck Sharp & Dohme | Therapeutic use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH21834A (en) * | 1982-01-18 | 1988-03-17 | Lepetit Spa | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives |
| US6465462B1 (en) * | 1996-07-25 | 2002-10-15 | Merck Sharp & Dohme Ltd. | Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAα5 receptor subtype |
| AU732455C (en) * | 1997-05-08 | 2002-09-05 | Merck Sharp & Dohme Limited | Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands |
-
1999
- 1999-02-17 PL PL99341975A patent/PL341975A1/xx not_active Application Discontinuation
- 1999-02-17 CA CA002317416A patent/CA2317416A1/fr not_active Abandoned
- 1999-02-17 NZ NZ505695A patent/NZ505695A/en unknown
- 1999-02-17 EP EP99905069A patent/EP1070066A1/fr not_active Withdrawn
- 1999-02-17 CN CN99803190A patent/CN1291194A/zh active Pending
- 1999-02-17 AU AU25368/99A patent/AU746719B2/en not_active Ceased
- 1999-02-17 TR TR2000/02469T patent/TR200002469T2/xx unknown
- 1999-02-17 HU HU0100647A patent/HUP0100647A3/hu unknown
- 1999-02-17 JP JP2000533432A patent/JP2002504554A/ja not_active Withdrawn
- 1999-02-17 SK SK1277-2000A patent/SK12772000A3/sk unknown
- 1999-02-17 WO PCT/GB1999/000485 patent/WO1999043677A1/fr not_active Application Discontinuation
- 1999-02-17 EA EA200000878A patent/EA002824B1/ru not_active IP Right Cessation
-
2000
- 2000-08-22 BG BG104705A patent/BG104705A/bg unknown
- 2000-08-25 HR HR20000555A patent/HRP20000555A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ505695A (en) | 2002-03-01 |
| AU2536899A (en) | 1999-09-15 |
| TR200002469T2 (tr) | 2000-12-21 |
| SK12772000A3 (sk) | 2001-03-12 |
| JP2002504554A (ja) | 2002-02-12 |
| EA002824B1 (ru) | 2002-10-31 |
| WO1999043677A1 (fr) | 1999-09-02 |
| HRP20000555A2 (en) | 2001-08-31 |
| CN1291194A (zh) | 2001-04-11 |
| HUP0100647A2 (hu) | 2001-09-28 |
| EA200000878A1 (ru) | 2001-02-26 |
| EP1070066A1 (fr) | 2001-01-24 |
| HUP0100647A3 (en) | 2003-03-28 |
| PL341975A1 (en) | 2001-05-07 |
| BG104705A (bg) | 2001-04-30 |
| AU746719B2 (en) | 2002-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |