CA2315256A1 - Needle-free injection of formulated nucleic acid molecules - Google Patents
Needle-free injection of formulated nucleic acid molecules Download PDFInfo
- Publication number
- CA2315256A1 CA2315256A1 CA002315256A CA2315256A CA2315256A1 CA 2315256 A1 CA2315256 A1 CA 2315256A1 CA 002315256 A CA002315256 A CA 002315256A CA 2315256 A CA2315256 A CA 2315256A CA 2315256 A1 CA2315256 A1 CA 2315256A1
- Authority
- CA
- Canada
- Prior art keywords
- needle
- nucleic acid
- delivering
- acid molecule
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6975497P | 1997-12-16 | 1997-12-16 | |
US60/069,754 | 1997-12-16 | ||
PCT/US1998/026823 WO1999031262A2 (en) | 1997-12-16 | 1998-12-16 | Needle-free injection of formulated nucleic acid molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2315256A1 true CA2315256A1 (en) | 1999-06-24 |
Family
ID=22091009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002315256A Abandoned CA2315256A1 (en) | 1997-12-16 | 1998-12-16 | Needle-free injection of formulated nucleic acid molecules |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1038016A2 (de) |
JP (1) | JP2003528024A (de) |
AU (1) | AU1922999A (de) |
CA (1) | CA2315256A1 (de) |
WO (1) | WO1999031262A2 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393529B2 (en) | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
KR100750695B1 (ko) * | 1999-07-20 | 2007-08-22 | 파멕사 에이/에스 | Gdf-8 활성을 하향-조절하는 방법 |
EP1196617A2 (de) | 1999-07-21 | 2002-04-17 | Immunoporation Ltd. | Methode zum einführen einer substanz in eine zelle |
US7196066B1 (en) * | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US6875748B2 (en) | 2000-04-21 | 2005-04-05 | Vical Incorporated | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
US20050148530A1 (en) | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
FR2835749B1 (fr) | 2002-02-08 | 2006-04-14 | Inst Nat Sante Rech Med | Composition pharmaceutique ameliorant le transfert de gene in vivo |
EP1432724A4 (de) | 2002-02-20 | 2006-02-01 | Sirna Therapeutics Inc | Durch rna-interferenz vermittelte inhibierung von map-kinase-genen |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US7923547B2 (en) | 2002-09-05 | 2011-04-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
CA2535799A1 (en) | 2003-08-15 | 2005-03-03 | University Of Florida | Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases |
EP1671655A4 (de) * | 2003-08-29 | 2009-08-12 | Anges Mg Inc | Gentherapie für hauterkrankungen mit nadelfreier spritze |
EP2395112B1 (de) | 2003-12-31 | 2017-02-15 | The Penn State Research Foundation | Verfahren zur Vorhersage und Überwindung des Widerstands auf eine Chemotherapie bei Eierstockkrebs und zur Vorhersage des Kolonkrebsvorkommens |
JP2005335054A (ja) * | 2004-04-27 | 2005-12-08 | Japan Science & Technology Agency | 金属ナノワイヤー及びその製造方法 |
US20060040882A1 (en) | 2004-05-04 | 2006-02-23 | Lishan Chen | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
EP2298896A1 (de) | 2004-06-22 | 2011-03-23 | The Board of Trustees of the University of Illinois | Verfahren zur Inhibierung von Tumorzellwachstum mit FOXM1 siRNS |
CA2587950C (en) * | 2004-12-01 | 2014-02-11 | Wlt Distributors Inc. | Needle-free injector |
EP1973946B1 (de) | 2006-01-20 | 2015-03-25 | Cell Signaling Technology, Inc. | Translokation und mutations-ros-kinase bei menschlichem nicht-kleinzelligem lungenkrebs |
US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
HUE035732T2 (en) | 2006-04-14 | 2018-05-28 | Cell Signaling Technology Inc | Gene defects and mutant ALK kinase in human solid tumors |
CA2658550C (en) | 2006-07-21 | 2018-06-19 | Silence Therapeutics Ag | Means for inhibiting the expression of protein kinase 3 |
US8188214B2 (en) | 2007-02-28 | 2012-05-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Brachyury polypeptides and methods for use |
EP2157982B1 (de) | 2007-05-04 | 2014-12-17 | Marina Biotech, Inc. | Aminosäurelipide und ihre verwendungen |
EP3741851A1 (de) | 2007-10-18 | 2020-11-25 | Cell Signaling Technology, Inc. | Translokation und mutante ros-kinase in humanem nichtkleinzelligem lungenkarzinom |
AU2009236270B2 (en) | 2008-04-15 | 2014-06-26 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for delivering inhibitory oligonucleotides |
JP2011521649A (ja) | 2008-05-30 | 2011-07-28 | イェール ユニバーシティー | 遺伝子発現を改変するための標的化オリゴヌクレオチド組成物 |
EP2902013A1 (de) | 2008-10-16 | 2015-08-05 | Marina Biotech, Inc. | Verfahren und Zusammensetzungen zur liposomalen und effizienten Abgabe von Gen-Silencing-Therapeutika |
ES2637174T3 (es) | 2009-02-12 | 2017-10-11 | Cell Signaling Technology, Inc. | Expresión de ROS mutante en el cáncer de hígado humano |
JP2012523225A (ja) | 2009-04-10 | 2012-10-04 | アソシアシオン・アンスティテュ・ドゥ・ミオロジー | 疾患の処置のためのトリシクロ−dnaアンチセンスオリゴヌクレオチド、組成物及び方法 |
US8710209B2 (en) | 2009-12-09 | 2014-04-29 | Nitto Denko Corporation | Modulation of HSP47 expression |
WO2011120023A1 (en) | 2010-03-26 | 2011-09-29 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting survivin gene expression uses thereof |
WO2011133584A2 (en) | 2010-04-19 | 2011-10-27 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting hras gene expression and uses thereof |
WO2011139842A2 (en) | 2010-04-28 | 2011-11-10 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof |
WO2011146938A1 (en) | 2010-05-21 | 2011-11-24 | NanoOncology, Inc. | Reagents and methods for treating cancer |
US9045755B2 (en) | 2010-06-24 | 2015-06-02 | Quark Pharmaceuticals, Inc. | Double stranded RNA compounds to RhoA and use thereof |
WO2012019132A2 (en) | 2010-08-06 | 2012-02-09 | Cell Signaling Technology, Inc. | Anaplastic lymphoma kinase in kidney cancer |
EP2609198B8 (de) | 2010-08-24 | 2018-03-28 | Sirna Therapeutics, Inc. | Einsträngige rnai-mittel mit einem internen nukleinsäurefreien spacer |
US20140134231A1 (en) | 2010-10-11 | 2014-05-15 | Sanford-Burnham Medical Research Institute | Mir-211 expression and related pathways in human melanoma |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
AU2011323508B2 (en) | 2010-11-01 | 2017-04-27 | Peptimed, Inc. | Compositions of a peptide targeting system for treating cancer |
JP6000287B2 (ja) | 2011-03-03 | 2016-09-28 | クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. | 肺疾患および損傷を治療するための組成物および方法 |
DE102011018499A1 (de) | 2011-04-23 | 2012-10-25 | Emc Microcollections Gmbh | Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut |
EP2581448B1 (de) | 2011-10-13 | 2015-01-28 | Association Institut de Myologie | Tricyclo-phosphorothioat-DNA |
KR20140111673A (ko) | 2012-01-12 | 2014-09-19 | 쿠아크 파마수티칼스 인코퍼레이티드 | 청력 및 균형 장애를 치료하기 위한 조합요법 |
PL2838998T3 (pl) | 2012-04-18 | 2018-04-30 | Cell Signaling Technology, Inc. | EGFR i ROS1 w nowotworze |
EP3453762B1 (de) | 2012-05-02 | 2021-04-21 | Sirna Therapeutics, Inc. | Sina-zusammensetzungen |
ES2704855T3 (es) | 2012-09-12 | 2019-03-20 | Quark Pharmaceuticals Inc | Moléculas de oligonucleótido de doble cadena para p53 y métodos de uso de las mismas |
US9932578B2 (en) | 2012-09-12 | 2018-04-03 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to P53 and methods of use thereof |
US9884886B2 (en) | 2012-12-06 | 2018-02-06 | Merck Sharp & Dohme | Disulfide masked prodrug compositions and methods |
WO2015020960A1 (en) | 2013-08-09 | 2015-02-12 | Novartis Ag | Novel lncrna polynucleotides |
AU2015307186A1 (en) | 2014-08-27 | 2017-04-13 | Peptimed, Inc. | Anti-tumor compositions and methods |
US20190255143A1 (en) | 2016-04-18 | 2019-08-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (nash) |
WO2022149550A1 (ja) * | 2021-01-05 | 2022-07-14 | 株式会社ダイセル | 注入器 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1026253B2 (de) * | 1989-03-21 | 2012-12-19 | Vical Incorporated | Expression von exogenen Polynukleotidsequenzen in Wirbeltieren |
TW404844B (en) * | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
EP0695186A1 (de) * | 1993-04-28 | 1996-02-07 | Ribozyme Pharmaceuticals, Inc. | Verabreichung von nukleinsäuren an das auge |
EP0800403A2 (de) * | 1994-12-30 | 1997-10-15 | Chiron Corporation | Nichttraumatische erteilung von genbeförderungsmitteln |
US5766901A (en) * | 1995-05-04 | 1998-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for delivering a nucleotide into cell nuclei |
EP0832269A1 (de) * | 1995-06-07 | 1998-04-01 | Baylor College Of Medicine | Nukleinsäure transporter zur abgabe von nukleinsäure in zellen |
-
1998
- 1998-12-16 CA CA002315256A patent/CA2315256A1/en not_active Abandoned
- 1998-12-16 WO PCT/US1998/026823 patent/WO1999031262A2/en not_active Application Discontinuation
- 1998-12-16 AU AU19229/99A patent/AU1922999A/en not_active Abandoned
- 1998-12-16 EP EP98964020A patent/EP1038016A2/de not_active Withdrawn
- 1998-12-16 JP JP2000539160A patent/JP2003528024A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2003528024A (ja) | 2003-09-24 |
AU1922999A (en) | 1999-07-05 |
EP1038016A2 (de) | 2000-09-27 |
WO1999031262A3 (en) | 1999-09-10 |
WO1999031262A2 (en) | 1999-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |