CA2301967C - Azetidinone derivatives for the treatment of hcmv infections - Google Patents

Azetidinone derivatives for the treatment of hcmv infections Download PDF

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Publication number
CA2301967C
CA2301967C CA002301967A CA2301967A CA2301967C CA 2301967 C CA2301967 C CA 2301967C CA 002301967 A CA002301967 A CA 002301967A CA 2301967 A CA2301967 A CA 2301967A CA 2301967 C CA2301967 C CA 2301967C
Authority
CA
Canada
Prior art keywords
lower alkyl
group
phenyl
alkyl
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002301967A
Other languages
English (en)
French (fr)
Other versions
CA2301967A1 (en
Inventor
Christiane Yoakim
Catherine Chabot
Robert Deziel
Stephen Kawai
William W. Ogilvie
Jeffrey O'meara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Publication of CA2301967A1 publication Critical patent/CA2301967A1/en
Application granted granted Critical
Publication of CA2301967C publication Critical patent/CA2301967C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA002301967A 1997-10-07 1998-10-06 Azetidinone derivatives for the treatment of hcmv infections Expired - Fee Related CA2301967C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6154897P 1997-10-07 1997-10-07
US60/061,548 1997-10-07
PCT/CA1998/000954 WO1999018073A1 (en) 1997-10-07 1998-10-06 Azetidinone derivatives for the treatment of hcmv infections

Publications (2)

Publication Number Publication Date
CA2301967A1 CA2301967A1 (en) 1999-04-15
CA2301967C true CA2301967C (en) 2005-05-17

Family

ID=22036473

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301967A Expired - Fee Related CA2301967C (en) 1997-10-07 1998-10-06 Azetidinone derivatives for the treatment of hcmv infections

Country Status (10)

Country Link
US (1) US6211170B1 (https=)
EP (1) EP1023265B1 (https=)
JP (1) JP2001519330A (https=)
AT (1) ATE231124T1 (https=)
AU (1) AU9426198A (https=)
CA (1) CA2301967C (https=)
DE (1) DE69810800T2 (https=)
DK (1) DK1023265T3 (https=)
ES (1) ES2187064T3 (https=)
WO (1) WO1999018073A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA91341C2 (ru) 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
GB0608899D0 (en) * 2006-05-05 2006-06-14 Leuven K U Res & Dev Novel viral replication inhibitors
ES2428326T3 (es) * 2007-10-04 2013-11-07 Merck Sharp & Dohme Corp. Derivados de aril sulfona sustituida como bloqueadores de canales de calcio
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8815894B2 (en) * 2009-05-12 2014-08-26 Bristol-Myers Squibb Company Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
EP2429295B1 (en) * 2009-05-12 2013-12-25 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
AU2010247763B2 (en) * 2009-05-12 2015-12-24 Albany Molecular Research, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
US9216180B2 (en) 2012-10-02 2015-12-22 New York University Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
AU2020353055B2 (en) 2019-09-26 2024-03-07 Gilead Sciences, Inc. Antiviral pyrazolopyridinone compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229381A (en) 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL89835A0 (en) * 1988-04-11 1989-12-15 Merck & Co Inc Substituted azetidinones,their preparation and pharmaceutical compositions containing them
EP0377549B1 (en) 1989-01-03 1998-12-09 Marcos Y. Kleinerman Remote measurement of physical variables with fiber optic systems
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
GB2266527A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted azetidinones useful in the treatment of leukemia
GB9314350D0 (en) 1993-07-12 1993-08-25 Zeneca Ltd Armide derivatives
US5900401A (en) * 1994-03-23 1999-05-04 Tokyo Tanabe Company Limited Remedy for respiratory-tract viral disease

Also Published As

Publication number Publication date
JP2001519330A (ja) 2001-10-23
DE69810800D1 (de) 2003-02-20
WO1999018073A1 (en) 1999-04-15
ATE231124T1 (de) 2003-02-15
US6211170B1 (en) 2001-04-03
EP1023265A1 (en) 2000-08-02
ES2187064T3 (es) 2003-05-16
DK1023265T3 (da) 2003-02-24
AU9426198A (en) 1999-04-27
EP1023265B1 (en) 2003-01-15
DE69810800T2 (de) 2003-09-18
CA2301967A1 (en) 1999-04-15

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