CA2301852C - Angiogenesis promoters and angiogenesis potentiators - Google Patents
Angiogenesis promoters and angiogenesis potentiators Download PDFInfo
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- CA2301852C CA2301852C CA002301852A CA2301852A CA2301852C CA 2301852 C CA2301852 C CA 2301852C CA 002301852 A CA002301852 A CA 002301852A CA 2301852 A CA2301852 A CA 2301852A CA 2301852 C CA2301852 C CA 2301852C
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- halogen atom
- pyridazinone
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 239000000314 lubricant Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
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- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9/232644 | 1997-08-28 | ||
| JP23264497 | 1997-08-28 | ||
| PCT/JP1998/003820 WO1999011268A1 (fr) | 1997-08-28 | 1998-08-26 | Agents promoteurs et agents potentialisateurs de la neovascularisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2301852A1 CA2301852A1 (en) | 1999-03-11 |
| CA2301852C true CA2301852C (en) | 2007-07-10 |
Family
ID=16942531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002301852A Expired - Fee Related CA2301852C (en) | 1997-08-28 | 1998-08-26 | Angiogenesis promoters and angiogenesis potentiators |
Country Status (13)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU768825B2 (en) * | 1998-12-07 | 2004-01-08 | Nissan Chemical Industries Ltd. | Remedial agent for erectile dysfunction |
| KR20060125816A (ko) * | 2003-12-26 | 2006-12-06 | 닛산 가가쿠 고교 가부시키 가이샤 | 호중구증다 억제제 |
| BRPI0507518A8 (pt) * | 2004-02-09 | 2015-12-01 | Nissan Chemical Ind Ltd | Inibidor de hiperplasia vascular da íntima |
| WO2007011707A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
| WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| ES2540059T3 (es) | 2006-04-26 | 2015-07-08 | Micell Technologies, Inc. | Recubrimientos que contienen múltiples fármacos |
| CA2667228C (en) | 2006-10-23 | 2015-07-14 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| EP2111184B1 (en) | 2007-01-08 | 2018-07-25 | Micell Technologies, Inc. | Stents having biodegradable layers |
| WO2008105260A1 (ja) * | 2007-02-28 | 2008-09-04 | Ltt Bio-Pharma Co., Ltd. | 下肢切断手術の予後を改善する治療剤 |
| US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
| AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
| US8685432B2 (en) * | 2008-03-25 | 2014-04-01 | University Of Utah Research Foundation | Controlled release tissue graft combination biomaterials |
| AU2009251504B2 (en) | 2008-04-17 | 2013-09-05 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
| AU2009270849B2 (en) | 2008-07-17 | 2013-11-21 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2011009096A1 (en) | 2009-07-16 | 2011-01-20 | Micell Technologies, Inc. | Drug delivery medical device |
| US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
| CA2756386C (en) | 2009-03-23 | 2019-01-15 | Micell Technologies, Inc. | Drug delivery medical device |
| JP2012522589A (ja) | 2009-04-01 | 2012-09-27 | ミシェル テクノロジーズ，インコーポレイテッド | 被覆ステント |
| US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
| US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
| US9554888B2 (en) | 2010-04-20 | 2017-01-31 | University Of Utah Research Foundation | Phase separation sprayed scaffold |
| US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| EP2593039B1 (en) | 2010-07-16 | 2022-11-30 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
| CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| EP2953581B1 (en) | 2013-02-05 | 2020-09-16 | University of Utah Research Foundation | Implantable devices for bone or joint defects |
| AU2014248508B2 (en) | 2013-03-12 | 2018-11-08 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| AU2014265460B2 (en) | 2013-05-15 | 2018-10-18 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0482208B1 (en) * | 1990-04-25 | 2000-07-19 | Nissan Chemical Industries Ltd. | Pyridazinone derivative |
| CA2063055A1 (en) * | 1991-05-22 | 1992-11-23 | Jacob Eyal | Peptides having thrombospondin-like activity and their therapeutic use |
| JP3666042B2 (ja) | 1994-01-25 | 2005-06-29 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| IL112695A (en) | 1994-02-22 | 1999-04-11 | Green Cross Corp | Pharmaceutical compositions containing pyridazinone derivatives |
-
1998
- 1998-08-26 US US09/486,327 patent/US6284758B1/en not_active Expired - Lifetime
- 1998-08-26 WO PCT/JP1998/003820 patent/WO1999011268A1/ja active IP Right Grant
- 1998-08-26 ES ES98940584T patent/ES2247716T3/es not_active Expired - Lifetime
- 1998-08-26 KR KR1020007001968A patent/KR100559192B1/ko not_active IP Right Cessation
- 1998-08-26 DK DK98940584T patent/DK1025847T3/da active
- 1998-08-26 AT AT98940584T patent/ATE307584T1/de active
- 1998-08-26 DE DE69832089T patent/DE69832089T2/de not_active Expired - Lifetime
- 1998-08-26 CN CNB988105799A patent/CN1142779C/zh not_active Expired - Fee Related
- 1998-08-26 AU AU88862/98A patent/AU8886298A/en not_active Abandoned
- 1998-08-26 JP JP2000508370A patent/JP4352613B2/ja not_active Expired - Fee Related
- 1998-08-26 CA CA002301852A patent/CA2301852C/en not_active Expired - Fee Related
- 1998-08-26 EP EP98940584A patent/EP1025847B1/en not_active Expired - Lifetime
- 1998-08-27 TW TW087114142A patent/TW490303B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2301852A1 (en) | 1999-03-11 |
| DE69832089D1 (de) | 2005-12-01 |
| CN1142779C (zh) | 2004-03-24 |
| CN1277553A (zh) | 2000-12-20 |
| US6284758B1 (en) | 2001-09-04 |
| KR20010023331A (ko) | 2001-03-26 |
| KR100559192B1 (ko) | 2006-03-13 |
| JP4352613B2 (ja) | 2009-10-28 |
| TW490303B (en) | 2002-06-11 |
| DE69832089T2 (de) | 2006-07-20 |
| EP1025847A1 (en) | 2000-08-09 |
| WO1999011268A1 (fr) | 1999-03-11 |
| ES2247716T3 (es) | 2006-03-01 |
| DK1025847T3 (da) | 2006-02-13 |
| ATE307584T1 (de) | 2005-11-15 |
| EP1025847B1 (en) | 2005-10-26 |
| EP1025847A4 (en) | 2003-01-08 |
| AU8886298A (en) | 1999-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160826 |