CA2301687A1 - Phenethylamine derivatives - Google Patents

Phenethylamine derivatives Download PDF

Info

Publication number
CA2301687A1
CA2301687A1 CA002301687A CA2301687A CA2301687A1 CA 2301687 A1 CA2301687 A1 CA 2301687A1 CA 002301687 A CA002301687 A CA 002301687A CA 2301687 A CA2301687 A CA 2301687A CA 2301687 A1 CA2301687 A1 CA 2301687A1
Authority
CA
Canada
Prior art keywords
group
tbu
carbon atoms
tyr
chained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002301687A
Other languages
English (en)
French (fr)
Inventor
Ken-Ichiro Kotake
Toshiro Kozono
Tsutomu Sato
Hisanori Takanashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2301687A1 publication Critical patent/CA2301687A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
CA002301687A 1997-08-15 1998-08-14 Phenethylamine derivatives Abandoned CA2301687A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP9/255879 1997-08-15
JP25587997 1997-08-15
JP10/186802 1998-05-28
JP18680298 1998-05-28
PCT/JP1998/003627 WO1999009053A1 (fr) 1997-08-15 1998-08-14 Derives de phenylethylamine

Publications (1)

Publication Number Publication Date
CA2301687A1 true CA2301687A1 (en) 1999-02-25

Family

ID=26503986

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301687A Abandoned CA2301687A1 (en) 1997-08-15 1998-08-14 Phenethylamine derivatives

Country Status (10)

Country Link
US (1) US6255285B1 (US06255285-20010703-C00060.png)
EP (1) EP1006122B1 (US06255285-20010703-C00060.png)
KR (1) KR20010022924A (US06255285-20010703-C00060.png)
CN (1) CN1272114A (US06255285-20010703-C00060.png)
AT (1) ATE416186T1 (US06255285-20010703-C00060.png)
AU (1) AU741216B2 (US06255285-20010703-C00060.png)
CA (1) CA2301687A1 (US06255285-20010703-C00060.png)
DE (1) DE69840296D1 (US06255285-20010703-C00060.png)
TW (1) TW460478B (US06255285-20010703-C00060.png)
WO (1) WO1999009053A1 (US06255285-20010703-C00060.png)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1738753B1 (en) * 1993-06-28 2008-04-23 Wyeth New treatments using phenethylamine derivatives
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
TW509699B (en) * 1998-09-24 2002-11-11 Chugau Pharmaceutical Co Ltd Ethylamine derivatives
JP3715202B2 (ja) * 1999-01-28 2005-11-09 中外製薬株式会社 置換フェネチルアミン誘導体
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6511980B2 (en) 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
GB0030304D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
JP4800558B2 (ja) * 2000-08-24 2011-10-26 中外製薬株式会社 環状ペプチド誘導体
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
AU2002245051A1 (en) * 2000-11-29 2002-07-30 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to grp 38
JPWO2002059141A1 (ja) * 2001-01-25 2004-05-27 中外製薬株式会社 ペプチド誘導体
AU2002258794A1 (en) * 2001-04-10 2003-10-20 Transtech Pharma, Inc. Probes, systems and methods for drug discovery
RS50712B (sr) * 2001-06-28 2010-06-30 Pfizer Products Inc. Triamid-supstituisani indoli, benzofurani i benzotiofeni kao inhibitori mikrozomalnog triglicerid transfer proteina (mtp) i/ili sekrecije apolipoproteina b (apo b)
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
CN1638790A (zh) * 2002-01-29 2005-07-13 Wyeth公司 用于调节连接蛋白半通道的组合物和方法
CN1650024A (zh) * 2002-02-22 2005-08-03 新河药品股份有限公司 应用肽－药物的结合减少受试者间药物血清水平的变异
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
EP2319540A1 (en) * 2002-02-22 2011-05-11 Shire LLC Sustained release pharmaceutical compounds to prevent abuse of controlled substances
ES2380622T5 (es) * 2003-05-29 2018-05-30 Shire Llc Compuestos de anfetamina resistentes al abuso
US7521420B2 (en) 2003-06-18 2009-04-21 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
CA2540678C (en) * 2003-09-30 2011-02-22 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
AU2016338410B2 (en) 2015-10-14 2021-07-15 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
CN112812334B (zh) * 2021-01-11 2022-06-17 浙江博菲电气股份有限公司 一种新能源电机用阻燃槽楔的制备工艺及阻燃槽楔

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003483A1 (en) 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
US5470830A (en) 1993-08-06 1995-11-28 Ohmeda Pharmaceutical Products Division Inc. Motilin-like polypeptides that inhibit gastrointestinal motor activity
JP3449766B2 (ja) 1993-11-19 2003-09-22 中外製薬株式会社 モチリンアンタゴニスト
ES2180781T3 (es) * 1995-06-07 2003-02-16 Torrey Pines Inst Nuevos ligandos del receptor opiaceo mu: agonistas y antagonistas.
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
US6013633A (en) * 1997-08-07 2000-01-11 University Of Cincinnati Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
US5972939A (en) 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor
JP3715202B2 (ja) * 1999-01-28 2005-11-09 中外製薬株式会社 置換フェネチルアミン誘導体

Also Published As

Publication number Publication date
TW460478B (en) 2001-10-21
DE69840296D1 (de) 2009-01-15
EP1006122B1 (en) 2008-12-03
EP1006122A4 (en) 2004-10-13
CN1272114A (zh) 2000-11-01
US6255285B1 (en) 2001-07-03
ATE416186T1 (de) 2008-12-15
AU8649098A (en) 1999-03-08
KR20010022924A (ko) 2001-03-26
AU741216B2 (en) 2001-11-29
WO1999009053A1 (fr) 1999-02-25
EP1006122A1 (en) 2000-06-07

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Legal Events

Date Code Title Description
FZDE Discontinued