CA2300424C - Hiv nuclear localization inhibitors - Google Patents

Hiv nuclear localization inhibitors Download PDF

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Publication number
CA2300424C
CA2300424C CA002300424A CA2300424A CA2300424C CA 2300424 C CA2300424 C CA 2300424C CA 002300424 A CA002300424 A CA 002300424A CA 2300424 A CA2300424 A CA 2300424A CA 2300424 C CA2300424 C CA 2300424C
Authority
CA
Canada
Prior art keywords
compound
branched
straight
hiv
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002300424A
Other languages
English (en)
French (fr)
Other versions
CA2300424A1 (en
Inventor
Senliang Pan
Michael Bukrinsky
Omar K. Haffar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Cytokine Pharmasciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokine Pharmasciences Inc filed Critical Cytokine Pharmasciences Inc
Publication of CA2300424A1 publication Critical patent/CA2300424A1/en
Application granted granted Critical
Publication of CA2300424C publication Critical patent/CA2300424C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002300424A 1997-08-15 1998-08-13 Hiv nuclear localization inhibitors Expired - Fee Related CA2300424C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/912,076 1997-08-15
US08/912,076 US5808068A (en) 1997-08-15 1997-08-15 HIV nuclear localization inhibitors
PCT/US1998/016814 WO1999009014A1 (en) 1997-08-15 1998-08-13 Hiv nuclear localization inhibitors

Publications (2)

Publication Number Publication Date
CA2300424A1 CA2300424A1 (en) 1999-02-25
CA2300424C true CA2300424C (en) 2009-04-07

Family

ID=25431342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002300424A Expired - Fee Related CA2300424C (en) 1997-08-15 1998-08-13 Hiv nuclear localization inhibitors

Country Status (8)

Country Link
US (1) US5808068A (https=)
EP (1) EP1012146B1 (https=)
JP (1) JP4475487B2 (https=)
AT (1) ATE245983T1 (https=)
AU (1) AU758464B2 (https=)
CA (1) CA2300424C (https=)
DE (1) DE69816835T2 (https=)
WO (1) WO1999009014A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297253B1 (en) * 1996-10-15 2001-10-02 The Picower Institute For Medical Research Compounds and methods of use to treat infectious diseases
CA2686618A1 (en) * 2003-07-17 2005-01-17 At&T Corp. Method and apparatus for windowing in entropy encoding
US20050203150A1 (en) * 2004-03-09 2005-09-15 Haffar Omar K. Compounds, compositions and methods for inhibiting or treating HIV-1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0673022A (ja) * 1992-08-27 1994-03-15 Kumiai Chem Ind Co Ltd ピリミジンまたはトリアジン誘導体及び除草剤

Also Published As

Publication number Publication date
JP4475487B2 (ja) 2010-06-09
WO1999009014A1 (en) 1999-02-25
EP1012146A1 (en) 2000-06-28
EP1012146A4 (en) 2002-12-04
EP1012146B1 (en) 2003-07-30
DE69816835T2 (de) 2004-04-22
DE69816835D1 (de) 2003-09-04
ATE245983T1 (de) 2003-08-15
JP2001515069A (ja) 2001-09-18
US5808068A (en) 1998-09-15
AU758464B2 (en) 2003-03-20
AU8905498A (en) 1999-03-08
CA2300424A1 (en) 1999-02-25

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MKLA Lapsed

Effective date: 20150813