CA2293682C - Stable particle in liquid formulations - Google Patents
Stable particle in liquid formulations Download PDFInfo
- Publication number
- CA2293682C CA2293682C CA002293682A CA2293682A CA2293682C CA 2293682 C CA2293682 C CA 2293682C CA 002293682 A CA002293682 A CA 002293682A CA 2293682 A CA2293682 A CA 2293682A CA 2293682 C CA2293682 C CA 2293682C
- Authority
- CA
- Canada
- Prior art keywords
- formulation according
- microparticles
- formulation
- continuous phase
- biomolecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000012071 phase Substances 0.000 claims abstract description 36
- 239000000725 suspension Substances 0.000 claims abstract description 26
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 25
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- 239000007788 liquid Substances 0.000 claims abstract description 24
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 6
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- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 3
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
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- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
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- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705588.3A GB9705588D0 (en) | 1997-03-18 | 1997-03-18 | Stable particle in liquid formulations |
| GB9705588.3 | 1997-03-18 | ||
| PCT/GB1998/000817 WO1998041188A2 (en) | 1997-03-18 | 1998-03-18 | Stable particle in liquid formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2293682A1 CA2293682A1 (en) | 1998-09-24 |
| CA2293682C true CA2293682C (en) | 2007-01-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002293682A Expired - Fee Related CA2293682C (en) | 1997-03-18 | 1998-03-18 | Stable particle in liquid formulations |
Country Status (14)
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|---|---|
| US (1) | US6669963B1 (enExample) |
| EP (1) | EP1007000B1 (enExample) |
| JP (1) | JP2002504090A (enExample) |
| CN (1) | CN1256626A (enExample) |
| AT (1) | ATE325605T1 (enExample) |
| AU (1) | AU722627B2 (enExample) |
| BR (1) | BR9808920A (enExample) |
| CA (1) | CA2293682C (enExample) |
| DE (1) | DE69834495T2 (enExample) |
| EA (1) | EA001873B1 (enExample) |
| GB (1) | GB9705588D0 (enExample) |
| NO (1) | NO994508L (enExample) |
| NZ (1) | NZ337666A (enExample) |
| WO (1) | WO1998041188A2 (enExample) |
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| AU3570495A (en) | 1994-09-22 | 1996-04-09 | Quadrant Holdings Cambridge Limited | Compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6946117B1 (en) * | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
| US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| AU2945199A (en) * | 1998-03-18 | 1999-10-11 | Ronai, Peter | Amorphous glasses for stabilising sensitive products |
| US6190701B1 (en) | 1999-03-17 | 2001-02-20 | Peter M. Ronai | Composition and method for stable injectable liquids |
| US6102896A (en) * | 1999-09-08 | 2000-08-15 | Cambridge Biostability Limited | Disposable injector device |
| DE19943491B4 (de) * | 1999-09-10 | 2010-04-01 | Südzucker AG Mannheim/Ochsenfurt | Verbesserte Komprimate |
| AU2046101A (en) * | 1999-11-22 | 2001-06-04 | Universal Preservation Technologies, Inc. | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6653062B1 (en) | 2000-07-26 | 2003-11-25 | Wisconsin Alumni Research Foundation | Preservation and storage medium for biological materials |
| GB0024271D0 (en) * | 2000-09-25 | 2000-11-15 | Colaco Camilo | Improved methods and compositions for pulmonary delivery of actives |
| RU2259817C2 (ru) * | 2000-10-13 | 2005-09-10 | Кембридж Байостэбилити Лтд. | Композиция для доставки стабильных инъецируемых жидкостей и способ доставки |
| DK1452171T3 (da) * | 2000-10-13 | 2010-04-06 | Nova Bio Pharma Technologies Ltd | Farmaceutiske væskesuspensioner |
| AU1198601A (en) * | 2000-10-13 | 2002-04-29 | Cambridge Biostability Ltd | Composition and method for stable injectable liquids |
| WO2002032398A2 (en) * | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for drug delivery |
| US7153472B1 (en) | 2000-11-22 | 2006-12-26 | Quadrant Drug Delivery Limited | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers |
| US6623762B2 (en) | 2001-02-16 | 2003-09-23 | Cambridge Biostability Ltd. | Composition and method for controlled release injections |
| FR2825276B1 (fr) * | 2001-05-31 | 2004-11-26 | Seppic Sa | Adujvant d'immunite sous forme solide et vaccin le contenant |
| ES2322132T3 (es) * | 2001-07-02 | 2009-06-17 | Asahi Kasei Pharma Corporation | Metodo de estabilizacion de fosfatasa alcalina. |
| CN100436466C (zh) * | 2001-08-10 | 2008-11-26 | 株式会社林原生物化学研究所 | 海藻糖或麦芽糖醇和金属离子化合物的缔合物 |
| GB2379390B (en) | 2001-09-11 | 2005-01-26 | Caretek Medical Ltd | A novel drug delivery technology |
| WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| US7943179B2 (en) | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
| PL1675573T4 (pl) * | 2003-10-23 | 2016-04-29 | Otsuka Pharma Co Ltd | Sterylny preparat do wstrzykiwań arypiprazolu o kontrolowanym uwalnianiu i sposób |
| FR2873386B1 (fr) | 2004-07-22 | 2011-01-14 | Agence Francaise De Securite Sanitaire Des Aliments Afssa | Composition vaccinale contre le rhodococcus equi |
| US20060045891A1 (en) * | 2004-08-24 | 2006-03-02 | Lovalenti Phillip M | Density-matched suspension vehicles and pharmaceutical suspensions |
| US20060142630A1 (en) * | 2004-12-29 | 2006-06-29 | Attila Meretei | Systems and methods for treating a thrombus in a blood vessel |
| US7515971B1 (en) * | 2005-09-09 | 2009-04-07 | Pacesetter, Inc. | Left atrial pressure sensor lead |
| GB2430880A (en) * | 2005-10-04 | 2007-04-11 | Cambridge Biostability Ltd | Pharmaceutical compositions stabilized in glassy particles |
| GB0523638D0 (en) | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
| US8946200B2 (en) | 2006-11-02 | 2015-02-03 | Southwest Research Institute | Pharmaceutically active nanosuspensions |
| DE102006056790B3 (de) * | 2006-12-01 | 2008-01-17 | IfP Privates Institut für Produktqualität GmbH | Laboreinmalartikel für Analyse und Diagnosik |
| EP1930396B1 (de) * | 2006-12-04 | 2011-07-06 | Merck Patent GmbH | Furochromanderivate |
| WO2008092084A2 (en) | 2007-01-26 | 2008-07-31 | Centocor, Inc. | Injectable non-aqueous suspension with high concentration of therapeutic agent |
| NO2170279T3 (enExample) * | 2007-07-31 | 2018-05-26 | ||
| CA2716546A1 (en) * | 2008-02-25 | 2009-09-03 | Novavax, Inc. | Sugar glassified virus like particles (vlps) |
| US8404850B2 (en) | 2008-03-13 | 2013-03-26 | Southwest Research Institute | Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors |
| US8722706B2 (en) | 2008-08-15 | 2014-05-13 | Southwest Research Institute | Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts |
| US8309134B2 (en) | 2008-10-03 | 2012-11-13 | Southwest Research Institute | Modified calcium phosphate nanoparticle formation |
| WO2011007327A2 (en) * | 2009-07-16 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Suspension for therapeutic use and device for delivering said suspension |
| US8293299B2 (en) | 2009-09-11 | 2012-10-23 | Kraft Foods Global Brands Llc | Containers and methods for dispensing multiple doses of a concentrated liquid, and shelf stable Concentrated liquids |
| CN102115737B (zh) * | 2009-12-31 | 2015-06-03 | 深圳迈瑞生物医疗电子股份有限公司 | 稳定碱性磷酸酶或其标记物的试剂和方法 |
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| CN102269761A (zh) | 2010-06-04 | 2011-12-07 | 深圳迈瑞生物医疗电子股份有限公司 | 一种碱性磷酸酶结合物的合成工艺 |
| US20120222979A1 (en) | 2011-03-04 | 2012-09-06 | Elwha LLC, a limited liability company of the State of Delaware | Glassy compositions |
| AU2012304887B2 (en) | 2011-09-09 | 2016-07-07 | Kraft Foods Group Brands Llc | Shelf stable, brewed beverage concentrates and methods of making the same |
| HK1198689A1 (en) | 2011-10-25 | 2015-05-29 | Prothena Biosciences Limited | Antibody formulations and methods |
| US11013248B2 (en) | 2012-05-25 | 2021-05-25 | Kraft Foods Group Brands Llc | Shelf stable, concentrated, liquid flavorings and methods of preparing beverages with the concentrated liquid flavorings |
| US10525057B2 (en) | 2013-09-24 | 2020-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function |
| US10863754B2 (en) | 2014-07-03 | 2020-12-15 | Kraft Foods Group Brands Llc | Low water coffee and tea beverage concentrates and methods for making the same |
| CN111558046A (zh) * | 2020-05-27 | 2020-08-21 | 华润昂德生物药业有限公司 | 海藻糖在制备重组人促红素液体制剂中的应用及重组人促红素液体制剂、制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3970765A (en) * | 1975-07-03 | 1976-07-20 | General Foods Corporation | Method for producing sucrose fixed volatile flavors |
| US4031255A (en) * | 1975-07-03 | 1977-06-21 | General Foods Corporation | Fixing acetaldehyde in sucrose |
| GB1490814A (en) * | 1975-07-22 | 1977-11-02 | Cadbury Ltd | Heat-resistant chocolate product and method of manufacturing same |
| JPS562908A (en) * | 1979-06-20 | 1981-01-13 | Nikken Kagaku Kk | Preparation of stable live bacterial pharmaceutical remedy |
| EP0140255B1 (en) * | 1983-10-14 | 1991-05-15 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release injections |
| WO1989003671A1 (fr) * | 1987-10-29 | 1989-05-05 | Dainippon Pharmaceutical Co., Ltd. | Preparation a liberation entretenue |
| US5250429A (en) * | 1991-09-20 | 1993-10-05 | Pharmacia P-L Biochemicals Inc. | Glassified restriction enzymes |
| US5424289A (en) * | 1993-07-30 | 1995-06-13 | Alza Corporation | Solid formulations of therapeutic proteins for gastrointestinal delivery |
| US5955448A (en) | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
| ATE252373T1 (de) | 1994-08-04 | 2003-11-15 | Elan Drug Delivery Ltd | Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US5593824A (en) * | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| GB9508691D0 (en) * | 1995-04-28 | 1995-06-14 | Pafra Ltd | Stable compositions |
| HUP9901716A3 (en) | 1995-06-07 | 2000-04-28 | Quadrant Holdings Cambridge | Methods for stably incorporating substances within dry, foamed glass matrices and compositions obtained thereby |
| US5958455A (en) | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
| US5762961A (en) | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
| US5766520A (en) | 1996-07-15 | 1998-06-16 | Universal Preservation Technologies, Inc. | Preservation by foam formation |
-
1997
- 1997-03-18 GB GBGB9705588.3A patent/GB9705588D0/en active Pending
-
1998
- 1998-03-18 CA CA002293682A patent/CA2293682C/en not_active Expired - Fee Related
- 1998-03-18 DE DE69834495T patent/DE69834495T2/de not_active Expired - Lifetime
- 1998-03-18 EP EP98910875A patent/EP1007000B1/en not_active Revoked
- 1998-03-18 EA EA199900835A patent/EA001873B1/ru not_active IP Right Cessation
- 1998-03-18 JP JP54026298A patent/JP2002504090A/ja not_active Ceased
- 1998-03-18 WO PCT/GB1998/000817 patent/WO1998041188A2/en not_active Ceased
- 1998-03-18 US US09/380,485 patent/US6669963B1/en not_active Expired - Fee Related
- 1998-03-18 AT AT98910875T patent/ATE325605T1/de not_active IP Right Cessation
- 1998-03-18 CN CN98803450A patent/CN1256626A/zh active Pending
- 1998-03-18 AU AU65101/98A patent/AU722627B2/en not_active Ceased
- 1998-03-18 NZ NZ337666A patent/NZ337666A/en unknown
- 1998-03-18 BR BR9808920-0A patent/BR9808920A/pt not_active IP Right Cessation
-
1999
- 1999-09-17 NO NO994508A patent/NO994508L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007000B1 (en) | 2006-05-10 |
| DE69834495T2 (de) | 2006-09-07 |
| NO994508D0 (no) | 1999-09-17 |
| WO1998041188A2 (en) | 1998-09-24 |
| CN1256626A (zh) | 2000-06-14 |
| JP2002504090A (ja) | 2002-02-05 |
| AU722627B2 (en) | 2000-08-10 |
| NO994508L (no) | 1999-11-17 |
| GB9705588D0 (en) | 1997-05-07 |
| EA199900835A1 (ru) | 2000-04-24 |
| BR9808920A (pt) | 2000-08-01 |
| ATE325605T1 (de) | 2006-06-15 |
| DE69834495D1 (de) | 2006-06-14 |
| EP1007000A2 (en) | 2000-06-14 |
| EA001873B1 (ru) | 2001-10-22 |
| CA2293682A1 (en) | 1998-09-24 |
| AU6510198A (en) | 1998-10-12 |
| WO1998041188A3 (en) | 1998-12-10 |
| US6669963B1 (en) | 2003-12-30 |
| NZ337666A (en) | 2001-04-27 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |