CA2292402C - Intra-vaginal device for pigs - Google Patents
Intra-vaginal device for pigs Download PDFInfo
- Publication number
- CA2292402C CA2292402C CA002292402A CA2292402A CA2292402C CA 2292402 C CA2292402 C CA 2292402C CA 002292402 A CA002292402 A CA 002292402A CA 2292402 A CA2292402 A CA 2292402A CA 2292402 C CA2292402 C CA 2292402C
- Authority
- CA
- Canada
- Prior art keywords
- progesterone
- matrix
- vaginal
- variable geometry
- hymenal ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000282887 Suidae Species 0.000 title claims description 22
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract description 178
- 229960003387 progesterone Drugs 0.000 claims abstract description 88
- 239000000186 progesterone Substances 0.000 claims abstract description 88
- 230000014759 maintenance of location Effects 0.000 claims abstract description 59
- 239000011159 matrix material Substances 0.000 claims abstract description 55
- 241001465754 Metazoa Species 0.000 claims abstract description 50
- 230000012173 estrus Effects 0.000 claims abstract description 27
- 230000001720 vestibular Effects 0.000 claims abstract description 20
- 230000037058 blood plasma level Effects 0.000 claims abstract description 11
- 238000003780 insertion Methods 0.000 claims description 38
- 230000037431 insertion Effects 0.000 claims description 38
- 210000003905 vulva Anatomy 0.000 claims description 12
- 239000004677 Nylon Substances 0.000 claims description 11
- 210000003679 cervix uteri Anatomy 0.000 claims description 11
- 239000012528 membrane Substances 0.000 claims description 11
- 229920001778 nylon Polymers 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 210000001215 vagina Anatomy 0.000 claims description 10
- 229920002379 silicone rubber Polymers 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 8
- 239000004945 silicone rubber Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 230000001419 dependent effect Effects 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000011068 loading method Methods 0.000 claims description 6
- 230000000717 retained effect Effects 0.000 claims description 6
- 238000010276 construction Methods 0.000 claims description 5
- 230000002269 spontaneous effect Effects 0.000 claims description 5
- 208000005392 Spasm Diseases 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 4
- 230000036961 partial effect Effects 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 3
- 229920001971 elastomer Polymers 0.000 claims description 2
- 238000003307 slaughter Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 description 21
- 230000035558 fertility Effects 0.000 description 13
- 229920001296 polysiloxane Polymers 0.000 description 10
- 210000002257 embryonic structure Anatomy 0.000 description 6
- 230000013011 mating Effects 0.000 description 6
- 230000016087 ovulation Effects 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000000465 moulding Methods 0.000 description 5
- 230000036470 plasma concentration Effects 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 210000001672 ovary Anatomy 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- CGFFKDRVHZIQHL-UHFFFAOYSA-N 1-but-3-en-2-yl-3-(methylcarbamothioylamino)thiourea Chemical compound CNC(=S)NNC(=S)NC(C)C=C CGFFKDRVHZIQHL-UHFFFAOYSA-N 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 210000004246 corpus luteum Anatomy 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 206010055690 Foetal death Diseases 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- VWAUPFMBXBWEQY-ANULTFPQSA-N Altrenogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC=C)C=C3)C3=C21 VWAUPFMBXBWEQY-ANULTFPQSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 101150054830 S100A6 gene Proteins 0.000 description 1
- 229960000971 altrenogest Drugs 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000037416 cystogenesis Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000816 effect on animals Effects 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229940025708 injectable product Drugs 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- -1 progesterone Natural products 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 229940050570 regu-mate Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ31493797A NZ314937A (en) | 1997-05-28 | 1997-05-28 | Intravaginal device for controlling fertility in pigs characterised by shape |
| NZ314937 | 1997-11-21 | ||
| NZ32922897 | 1997-11-21 | ||
| NZ329228 | 1997-11-21 | ||
| PCT/NZ1998/000064 WO1998053758A1 (en) | 1997-05-28 | 1998-05-27 | Intra-vaginal device for pigs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2292402A1 CA2292402A1 (en) | 1998-12-03 |
| CA2292402C true CA2292402C (en) | 2007-03-06 |
Family
ID=26651775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002292402A Expired - Fee Related CA2292402C (en) | 1997-05-28 | 1998-05-27 | Intra-vaginal device for pigs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6444224B1 (enExample) |
| EP (1) | EP1021138A4 (enExample) |
| JP (1) | JP4202431B2 (enExample) |
| KR (1) | KR100583275B1 (enExample) |
| CN (1) | CN1193718C (enExample) |
| AU (1) | AU723217B2 (enExample) |
| CA (1) | CA2292402C (enExample) |
| WO (1) | WO1998053758A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5783898A (en) | 1997-02-03 | 1998-08-25 | Dec International Nz Limited | Active delivery device and related procedures |
| WO1999026556A1 (en) * | 1997-11-21 | 1999-06-03 | Interag | Biodegradable intra vaginal devices |
| NZ509894A (en) * | 2001-02-09 | 2002-11-26 | Interag | A "T" or "Y" shaped intravaginal device suitable for delivery of pharmaceuticals such as progesterone |
| AR026386A1 (es) * | 2001-10-24 | 2003-02-12 | Massara Julio Eduardo | Un dispositivo intravaginal que contiene progesterona, util como inductor de celo en bovinos productores de carne y leche, y el procedimiento paraprepararlo |
| US7001317B2 (en) * | 2003-11-24 | 2006-02-21 | Jean-Claude Marcotte | Kegel muscle exercising device and method for exercising Kegel muscle |
| US20100003297A1 (en) | 2005-08-11 | 2010-01-07 | Massachusetts Institute Of Technology | Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues |
| DK1933810T3 (da) * | 2005-08-11 | 2013-01-28 | Childrens Medical Center | Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde |
| US20080306430A1 (en) * | 2007-06-11 | 2008-12-11 | Alon Avisar | Method and device for the insertion of intra-vaginal sponges |
| DK2231254T3 (da) * | 2007-12-11 | 2014-07-21 | Massachusetts Inst Technology | Implanterbar lægemiddelafgivelsesindretning |
| US8343516B2 (en) | 2009-06-26 | 2013-01-01 | Taris Biomedical, Inc. | Solid drug tablets for implantable drug delivery devices |
| US9017312B2 (en) * | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US9017310B2 (en) * | 2009-10-08 | 2015-04-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including microneedles |
| US8882748B2 (en) * | 2009-10-08 | 2014-11-11 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
| US9014799B2 (en) * | 2009-10-08 | 2015-04-21 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including electrically-actuated permeation enhancement |
| US9114111B2 (en) | 2011-01-10 | 2015-08-25 | Allergan, Inc. | Methods for sustained treatment of bladder pain and irritative voiding |
| WO2012106714A1 (en) | 2011-02-04 | 2012-08-09 | Taris Biomedical, Inc. | Implantable device for controlled release of low solubility drug |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| KR101436207B1 (ko) * | 2012-08-14 | 2014-09-01 | 윤성우 | 소 질탈 보정기 |
| US9999720B2 (en) | 2012-09-27 | 2018-06-19 | Palo Alto Research Center Incorporated | Drug reconstitution and delivery device and methods |
| US9005108B2 (en) | 2012-09-27 | 2015-04-14 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9744341B2 (en) | 2013-01-15 | 2017-08-29 | Palo Alto Research Center Incorporated | Devices and methods for intraluminal retention and drug delivery |
| SG11201507294WA (en) | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| WO2015026813A1 (en) | 2013-08-19 | 2015-02-26 | Taris Biomedical Llc | Multi-unit drug delivery devices and methods |
| US9297083B2 (en) | 2013-12-16 | 2016-03-29 | Palo Alto Research Center Incorporated | Electrolytic gas generating devices, actuators, and methods |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10278675B2 (en) | 2014-07-31 | 2019-05-07 | Palo Alto Research Center Incorporated | Implantable estrus detection devices, systems, and methods |
| US9801660B2 (en) | 2014-07-31 | 2017-10-31 | Palo Alto Research Center Incorporated | Implantable fluid delivery devices, systems, and methods |
| WO2016172704A1 (en) | 2015-04-23 | 2016-10-27 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| ES2956708T3 (es) * | 2015-07-09 | 2023-12-26 | Ulti Pharmaceuticals Ltd | Un dispositivo de administración de fármacos |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| PL4013348T3 (pl) * | 2019-08-14 | 2024-07-08 | Elanco Tiergesundheit Ag | Nowy ochraniacz skrzydełek do oskrzydlonej kapsułki i sposób jego stosowania |
| WO2021158129A1 (en) * | 2020-02-07 | 2021-08-12 | Agilis International Limited | Device for insertion into a cavity |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854476A (en) * | 1973-04-05 | 1974-12-17 | R Dickinson | Intra-vaginal device and method |
| NZ207341A (en) * | 1984-03-01 | 1988-02-29 | Harvey Alex Ind Ltd | Device containing chemical impregnants for insertion into a body cavity of an animal |
| FR2562797A1 (fr) * | 1984-04-17 | 1985-10-18 | Synkron Corp | Implant susceptible de liberer un principe actif |
| FR2613942B1 (fr) * | 1987-04-21 | 1990-09-07 | Harvey Alex Ind Ltd | Dispositif pour liberer lentement des substances chimiques, notamment dans des cavites du corps d'un animal |
| US4881664A (en) * | 1988-09-13 | 1989-11-21 | The Meyer Company | Disposable valve with disk-like valve element |
| NZ230023A (en) | 1989-07-21 | 1993-02-25 | Carter Holt Harvey Plastic Pro | Removable intra-vaginal retention device for veterinary use |
| US5217450A (en) | 1989-07-21 | 1993-06-08 | Carter Holt Harvey Plastic Products Group Limited | Retention devices |
| NZ286492A (en) * | 1996-05-01 | 1998-02-26 | Dec International Nz Ltd Subst | Intra vaginal devices for synchronising oestrus of animals is made up of cured silicone rubber material with 5% by weight of progesterone |
-
1998
- 1998-05-27 AU AU79414/98A patent/AU723217B2/en not_active Expired
- 1998-05-27 US US09/424,784 patent/US6444224B1/en not_active Expired - Fee Related
- 1998-05-27 KR KR1019997011160A patent/KR100583275B1/ko not_active Expired - Fee Related
- 1998-05-27 CA CA002292402A patent/CA2292402C/en not_active Expired - Fee Related
- 1998-05-27 WO PCT/NZ1998/000064 patent/WO1998053758A1/en not_active Ceased
- 1998-05-27 CN CNB988076349A patent/CN1193718C/zh not_active Expired - Fee Related
- 1998-05-27 JP JP50054199A patent/JP4202431B2/ja not_active Expired - Lifetime
- 1998-05-27 EP EP98929908A patent/EP1021138A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU723217B2 (en) | 2000-08-24 |
| KR100583275B1 (ko) | 2006-05-24 |
| CN1193718C (zh) | 2005-03-23 |
| EP1021138A4 (en) | 2006-06-14 |
| WO1998053758A1 (en) | 1998-12-03 |
| KR20010013175A (ko) | 2001-02-26 |
| JP4202431B2 (ja) | 2008-12-24 |
| CA2292402A1 (en) | 1998-12-03 |
| CN1265012A (zh) | 2000-08-30 |
| US6444224B1 (en) | 2002-09-03 |
| AU7941498A (en) | 1998-12-30 |
| EP1021138A1 (en) | 2000-07-26 |
| JP2002502283A (ja) | 2002-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170529 |