CA2283464C - Functional dna clone for hepatitis c virus (hcv) and uses thereof - Google Patents
Functional dna clone for hepatitis c virus (hcv) and uses thereof Download PDFInfo
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- CA2283464C CA2283464C CA002283464A CA2283464A CA2283464C CA 2283464 C CA2283464 C CA 2283464C CA 002283464 A CA002283464 A CA 002283464A CA 2283464 A CA2283464 A CA 2283464A CA 2283464 C CA2283464 C CA 2283464C
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Applications Claiming Priority (3)
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| US08/811,566 US6127116A (en) | 1995-08-29 | 1997-03-04 | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| US08/811,566 | 1997-03-04 | ||
| PCT/US1998/004428 WO1998039031A1 (en) | 1997-03-04 | 1998-02-26 | Functional dna clone for hepatitis c virus (hcv) and uses thereof |
Publications (2)
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| CA2283464A1 CA2283464A1 (en) | 1998-09-11 |
| CA2283464C true CA2283464C (en) | 2006-09-26 |
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| IL (2) | IL131688A0 (enExample) |
| WO (1) | WO1998039031A1 (enExample) |
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Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235394B1 (en) | 1995-08-29 | 2007-06-26 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| US6242187B1 (en) * | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
| US6153421A (en) * | 1997-07-18 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloned genomes of infectious hepatitis C viruses and uses thereof |
| US20020034732A1 (en) * | 1997-07-30 | 2002-03-21 | Daniel J. Capon | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| US20030028011A1 (en) * | 1997-07-30 | 2003-02-06 | Parkin Neil T. | Compositions and methods for determining susceptibility of hepatitis C virus to anti-viral drugs |
| US6893866B1 (en) * | 1997-11-28 | 2005-05-17 | The Crown In The Right Of The Queensland Department Of Health | Flavivirus expression and delivery system |
| DE19915178A1 (de) * | 1999-04-03 | 2000-10-05 | Univ Mainz Johannes Gutenberg | Hepatitis C Virus Zellkultursystem |
| EP1377554A1 (en) | 1999-06-16 | 2004-01-07 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
| ES2306670T3 (es) * | 1999-10-22 | 2008-11-16 | Sanofi Pasteur Limited | Procedimiento de induccion y/o intensificacion de la respuesta inmunitaria frente a antigenos tumorales. |
| DE19953854C2 (de) * | 1999-11-09 | 2002-01-17 | Max Planck Gesellschaft | Verfahren zur Herstellung von Biopolymeren mit veränderten Eigenschaften |
| WO2001036442A1 (en) * | 1999-11-17 | 2001-05-25 | Jiuping Ji | Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay |
| US6921634B2 (en) * | 1999-12-23 | 2005-07-26 | Board Of Regents, The University Of Texas System | Replication competent hepatitus C virus and methods of use |
| US20010055756A1 (en) * | 2000-04-21 | 2001-12-27 | Charles Pellerin | Internal de novo initiation sites of the HCV NS5B polymerase and use thereof |
| ATE346925T1 (de) * | 2000-05-10 | 2006-12-15 | Sanofi Pasteur Ltd | Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen |
| US6447994B1 (en) * | 2000-06-20 | 2002-09-10 | The General Hospital Corporation | Production of replicative hepatitis C virus |
| US20040101827A1 (en) * | 2000-10-03 | 2004-05-27 | Michinori Kohara | Methods of infection with hepatitis c virus |
| US20040005549A1 (en) * | 2000-11-07 | 2004-01-08 | Anadys Pharmaceuticals, Inc. | Hepatitis C virus constructs characterized by high efficiency replication |
| AU2002225895A1 (en) * | 2000-11-07 | 2002-05-21 | Anadys Pharmaceuticals, Inc. | Hepatitis c virus constructs characterized by high efficiency replication |
| NZ527035A (en) | 2000-12-22 | 2006-02-24 | Boehringer Ingelheim Ca Ltd | Self-replicating RNA molecule from hepatitis C virus |
| CA2441688C (en) * | 2001-03-27 | 2014-01-21 | Vertex Pharmaceuticals Incorporated | Compositions and methods useful for hcv infection |
| FR2824072B1 (fr) * | 2001-04-27 | 2004-03-12 | Centre Nat Rech Scient | Procede de replication et de production du virus de l'hepatite c |
| US20030152942A1 (en) * | 2001-05-09 | 2003-08-14 | Lance Fors | Nucleic acid detection in pooled samples |
| US7871814B2 (en) * | 2001-05-10 | 2011-01-18 | The Regents Of The University Of California | Recombinant bicistronic flaviviruses and methods of use thereof |
| US20050209180A1 (en) * | 2001-05-18 | 2005-09-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US20060211642A1 (en) * | 2001-05-18 | 2006-09-21 | Sirna Therapeutics, Inc. | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
| US20040209831A1 (en) * | 2002-02-20 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| WO2003040356A1 (en) * | 2001-08-06 | 2003-05-15 | Yangling Daiying Biological Engineering Co., Ltd | The intact hepatitis c virus and the method for culturing it in a vitro cell culture |
| CA2461380C (en) * | 2001-10-11 | 2011-03-22 | Merck & Co., Inc. | Hepatitis c virus vaccine |
| US6689559B2 (en) * | 2001-11-29 | 2004-02-10 | The Research Foundation Of The State University Of New York | Efficient hepatitis C virus replicon and its use in identifying antiviral compounds |
| ES2386742T3 (es) * | 2002-03-11 | 2012-08-28 | Lab 21 Limited | Método y composiciones para identificar y caracterizar la Hepatitis C |
| KR100471946B1 (ko) * | 2002-05-08 | 2005-03-08 | (주)팬바이오넷 | C형 간염바이러스(hcv)의 리플리콘, 이를 포함하는세포주, 및 상기 세포주를 이용한 hcv 탐지방법 |
| WO2004005524A1 (en) * | 2002-07-02 | 2004-01-15 | Merck & Co., Inc. | Hepatitis c virus particle formation |
| GB0222824D0 (en) * | 2002-10-02 | 2002-11-06 | Moredun Res Inst | Bacteriophage-mediated immunisation II |
| CA3081071A1 (en) * | 2002-10-16 | 2004-04-29 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| US7927840B2 (en) | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
| WO2004037284A1 (en) * | 2002-10-22 | 2004-05-06 | Sanofi Pasteur Limited | Anti-cancer vaccines and high-dose cytokines as adjuvants |
| AU2003294292A1 (en) * | 2002-11-13 | 2004-06-03 | Washington University | Highly permissive cell lines for hepatitis c virus replication |
| EP1694694B1 (en) * | 2003-12-01 | 2013-01-23 | Board Of Regents, The University Of Texas System | Replication competent hepatitis c virus and methods of use |
| WO2005054450A1 (en) * | 2003-12-01 | 2005-06-16 | Vertex Pharmaceuticals Incorporated | Compositions comprising fetal liver cells and methods useful for hcv infection |
| ATE491810T1 (de) * | 2004-01-23 | 2011-01-15 | Bio Merieux Inc | Neuartiges nukleotidgemisch für eine verbesserte nukleinsäurenamplifikationsleistung |
| AU2005218183B2 (en) | 2004-03-02 | 2012-06-07 | Virco Bvba | Estimation of clinical cut-offs |
| WO2005087926A2 (en) | 2004-03-05 | 2005-09-22 | Benitec, Inc. | Multiple promoter expression cassettes for simultaneous delivery of rnai agents |
| US7833987B2 (en) * | 2004-03-12 | 2010-11-16 | Indian Institute Of Science | Small synthetic RNA, a method of preparing the same and uses thereof |
| JP5031560B2 (ja) * | 2004-06-21 | 2012-09-19 | プロウジェンラ インコーポレーテッド | タンパク質分解活性に関連する診断およびスクリーニング方法ならびにキット |
| US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
| EP1797112B1 (en) * | 2004-09-29 | 2010-07-21 | The Administrators of the Tulane Educational Fund | Inhibitors of hepatitits c virus |
| CN101120086A (zh) * | 2005-02-16 | 2008-02-06 | 昆士兰医学研究所理事会 | 用于肿瘤治疗的黄病毒复制子结构 |
| AU2006220887B2 (en) * | 2005-03-04 | 2010-11-04 | The Rockefeller University | Infectious, chimeric Hepatitis C Virus, methods of producing the same and methods of use thereof |
| US20060234348A1 (en) * | 2005-04-13 | 2006-10-19 | Bujarski Jozef J | Method of production of RNA polymerase protein |
| JP2007312649A (ja) * | 2006-05-24 | 2007-12-06 | Japan Health Science Foundation | 再構築された感染性レトロウイルスゲノムクローンdna及びそれを含む微生物ならびにそれらの製造方法 |
| AU2015234338C1 (en) * | 2006-07-28 | 2017-07-20 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
| US7504255B2 (en) * | 2006-08-17 | 2009-03-17 | Saint Louis University | Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes |
| US20080096274A1 (en) * | 2006-10-24 | 2008-04-24 | Guangpu Li | Recombinant alphavirus vectors and methods of using same |
| AU2008338803B2 (en) * | 2007-11-26 | 2015-02-05 | Glaxosmithkline Biologicals S.A. | Methods of generating alphavirus particles |
| US8921536B2 (en) | 2008-10-29 | 2014-12-30 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
| WO2010050939A1 (en) * | 2008-10-29 | 2010-05-06 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
| US20100129902A1 (en) | 2008-11-24 | 2010-05-27 | Erhard Ralf Schoenbrunner | Replication Stable and RNase Resistant Chimeras of Pestivirus with Insertion in 3' Nontranslated Region (3'NTR) |
| JPWO2011024875A1 (ja) * | 2009-08-28 | 2013-01-31 | 公益財団法人東京都医学総合研究所 | C型肝炎ウイルスの新規株由来のポリヌクレオチド及びその利用 |
| US20110070199A1 (en) * | 2009-09-21 | 2011-03-24 | Scheiber Ii Lane Bernard | Adaptable modified virus vector to deliver ribosomal ribonucleic acid combined with messenger ribonucleic acid as a medical treatment device to manage diabetes mellitus and other protein deficient dieases |
| JP6158171B2 (ja) | 2011-05-02 | 2017-07-05 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 合成c型肝炎ゲノム、並びに、その製造方法及びその使用 |
| US20140242669A1 (en) * | 2011-08-18 | 2014-08-28 | Ycine Llc | Production of infectious rna viruses in yeast |
| CA2962696A1 (en) | 2014-10-01 | 2016-04-07 | National Research Council Of Canada | Animal models, cell lines and methods for screening hepatitis c virus vaccines |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631211A (en) * | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US5218099A (en) * | 1986-04-01 | 1993-06-08 | The United States Of America As Represented By The Department Of Health And Human Services | Post-transfusion, non-A, non-B hepatitis virus polynucleotides |
| JP2661044B2 (ja) * | 1986-06-17 | 1997-10-08 | カイロン コーポレイション | 肝炎δの診断薬およびワクチン |
| US5656731A (en) * | 1987-10-15 | 1997-08-12 | Chiron Corporation | Nucleic acid-amplified immunoassay probes |
| US5698390A (en) * | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
| US5714596A (en) * | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US5683864A (en) * | 1987-11-18 | 1997-11-04 | Chiron Corporation | Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies |
| US5679342A (en) * | 1987-11-18 | 1997-10-21 | Chiron Corporation | Hepatitis C virus infected cell systems |
| US5712088A (en) * | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
| YU48038B (sh) * | 1987-11-18 | 1996-10-18 | Chiron Corp. | Postupak za dijagnostiku ne-a, ne-v hepatitisa |
| HU216017B (hu) * | 1987-11-18 | 1999-04-28 | Chiron Corp. | Eljárás HCV-1 polipeptidek, HCV-1 polinukleotidok, rekombináns vektorok és gazdasejtek, valamint immunesszé kit, hepatitis C vírusfertőzés elleni vakcinák, a fertőzés kimutatására szolgáló diagnosztikumok előállítására, és immunvizsgálati és vírustenyészt |
| US5312737A (en) * | 1988-03-11 | 1994-05-17 | Abbott Laboratories | CKS method of HCV protein synthesis |
| US5010175A (en) * | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5191064A (en) * | 1988-09-30 | 1993-03-02 | The Research Foundation For Microbial Diseases (Osaka University) | Non-a, non-b hepatitis virus antigen peptide |
| JPH02167081A (ja) * | 1988-12-21 | 1990-06-27 | Tetsuo Nakamura | 非A非B型肝炎ウイルスゲノムRNA、cDNAおよびウイルス抗原蛋白質 |
| US5176994A (en) * | 1988-12-21 | 1993-01-05 | Immuno Japan Inc. | Non-A, Non-B hepatitis virus genome RNA, cDNA and virus antigen protein |
| US5354844A (en) * | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
| JP2656995B2 (ja) * | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
| DK0414475T3 (da) * | 1989-08-25 | 1998-02-09 | Chiron Corp | Fremgangsmåder til dyrkning af HCV i B- eller T-lymfocyt-cellelinier |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
| US5106726A (en) * | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
| RU2130969C1 (ru) * | 1990-04-04 | 1999-05-27 | Чирон Корпорейшн | Композиция для диагностики гепатита c человека (варианты), способ и набор для обнаружения антител к вирусу гепатита c человека |
| DK0527788T3 (da) * | 1990-04-04 | 2004-09-06 | Chiron Corp | Hepatitis C virus protease |
| ATE194844T1 (de) * | 1990-04-06 | 2000-08-15 | Genelabs Tech Inc | Hepatitis c-virus-epitope |
| ES2069298T3 (es) * | 1990-06-30 | 1995-05-01 | Akzo Nobel Nv | Secuencias no-a no-b. |
| KR0181517B1 (ko) * | 1990-07-09 | 1999-04-01 | 나까하라 노부유끼 | 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도 |
| CA2095521C (en) * | 1990-11-08 | 2009-06-30 | Robert O. Ralston | Hepatitis c virus asialoglycoproteins |
| US5654179A (en) * | 1990-11-14 | 1997-08-05 | Hri Research, Inc. | Nucleic acid preparation methods |
| EP0510952A1 (en) * | 1991-04-26 | 1992-10-28 | Immuno Japan Inc. | Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus |
| GB2272443B (en) * | 1991-06-10 | 1995-10-25 | Lucky Ltd | Nucleotide and amino acid sequences of Korean hepatitis C virus |
| DE69232871T2 (de) * | 1991-06-24 | 2003-05-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Polypeptide des hepatitis c-virus (hiv) |
| ES2125268T3 (es) * | 1991-07-31 | 1999-03-01 | Hoffmann La Roche | Metodos y reactivos para detectar bacterias en liquido cefalorraquideo. |
| US5428145A (en) * | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
| EP0787807B1 (en) * | 1991-08-27 | 2003-05-28 | F. Hoffmann-La Roche Ag | Primers and probes for hepatitis C detection |
| EP0532258A2 (en) * | 1991-09-09 | 1993-03-17 | Immuno Japan Inc. | Oligonucleotides and determination system of HCV genotypes |
| DE69232859T2 (de) * | 1991-09-13 | 2003-04-10 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden |
| US5576302A (en) * | 1991-10-15 | 1996-11-19 | Isis Pharmaceuticals, Inc. | Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity |
| WO1993015193A1 (en) * | 1992-01-31 | 1993-08-05 | Abbott Laboratories | Mammalian expression systems for hcv proteins |
| JPH06105690A (ja) * | 1992-03-10 | 1994-04-19 | Kunitada Shimotoono | 血液伝播性非a非b型肝炎ウィルスdna |
| US5643578A (en) * | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
| US5610054A (en) * | 1992-05-14 | 1997-03-11 | Ribozyme Pharmaceuticals, Inc. | Enzymatic RNA molecule targeted against Hepatitis C virus |
| US5552310A (en) * | 1992-06-12 | 1996-09-03 | Hiroshi Yoshikura | Replication of hepatitis C virus genome and identification of virus having high infectivity |
| JP2778886B2 (ja) * | 1992-10-16 | 1998-07-23 | エバーニュー バイオテック インコーポレイティド | C型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット |
| JPH06153961A (ja) * | 1992-11-27 | 1994-06-03 | Imuno Japan:Kk | C型肝炎ウイルス部分遺伝子、ならびにc型肝炎ウイルス遺 伝子の高感度検出法 |
| WO1994020114A1 (en) * | 1993-03-12 | 1994-09-15 | Board Of Regents, The University Of Texas System | Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs |
| TW275068B (enExample) * | 1993-09-24 | 1996-05-01 | American Cyanamid Co | |
| ATE475668T1 (de) * | 1994-01-27 | 2010-08-15 | Univ Massachusetts Medical | Immunisierung durch impfung von dns transkriptionseinheit |
| US5861267A (en) * | 1995-05-01 | 1999-01-19 | Vertex Pharmaceuticals Incorporated | Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity |
| US5874565A (en) * | 1995-08-29 | 1999-02-23 | Washington University | Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus |
| US5677124A (en) * | 1996-07-03 | 1997-10-14 | Ambion, Inc. | Ribonuclease resistant viral RNA standards |
| US6153421A (en) * | 1997-07-18 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloned genomes of infectious hepatitis C viruses and uses thereof |
-
1997
- 1997-03-04 US US08/811,566 patent/US6127116A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 EP EP98915130A patent/EP1005366A4/en not_active Ceased
- 1998-02-26 WO PCT/US1998/004428 patent/WO1998039031A1/en not_active Ceased
- 1998-02-26 IL IL13168898A patent/IL131688A0/xx not_active IP Right Cessation
- 1998-02-26 BR BR9808147-0A patent/BR9808147A/pt not_active Application Discontinuation
- 1998-02-26 JP JP53885498A patent/JP4094679B2/ja not_active Expired - Lifetime
- 1998-02-26 CA CA002283464A patent/CA2283464C/en not_active Expired - Lifetime
- 1998-02-26 AU AU69386/98A patent/AU742175B2/en not_active Expired
- 1998-03-04 ZA ZA981838A patent/ZA981838B/xx unknown
- 1998-03-04 US US09/034,756 patent/US6392028B1/en not_active Expired - Lifetime
-
1999
- 1999-01-26 US US09/238,076 patent/US20020102540A1/en not_active Abandoned
- 1999-09-01 IL IL131688A patent/IL131688A/en unknown
-
2001
- 2001-07-27 US US09/917,563 patent/US20030073080A1/en not_active Abandoned
-
2007
- 2007-12-28 JP JP2007339488A patent/JP4223068B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BR9808147A (pt) | 2000-03-28 |
| US20030073080A1 (en) | 2003-04-17 |
| ZA981838B (en) | 1999-02-19 |
| JP2008167755A (ja) | 2008-07-24 |
| AU742175B2 (en) | 2001-12-20 |
| WO1998039031A1 (en) | 1998-09-11 |
| JP4223068B2 (ja) | 2009-02-12 |
| US20020102540A1 (en) | 2002-08-01 |
| CA2283464A1 (en) | 1998-09-11 |
| EP1005366A4 (en) | 2004-05-19 |
| IL131688A (en) | 2007-09-20 |
| IL131688A0 (en) | 2001-03-19 |
| JP4094679B2 (ja) | 2008-06-04 |
| EP1005366A1 (en) | 2000-06-07 |
| AU6938698A (en) | 1998-09-22 |
| US6392028B1 (en) | 2002-05-21 |
| JP2001515353A (ja) | 2001-09-18 |
| US6127116A (en) | 2000-10-03 |
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