CA2282722A1 - Methode de clonage d'animaux - Google Patents

Methode de clonage d'animaux Download PDF

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Publication number
CA2282722A1
CA2282722A1 CA002282722A CA2282722A CA2282722A1 CA 2282722 A1 CA2282722 A1 CA 2282722A1 CA 002282722 A CA002282722 A CA 002282722A CA 2282722 A CA2282722 A CA 2282722A CA 2282722 A1 CA2282722 A1 CA 2282722A1
Authority
CA
Canada
Prior art keywords
cells
cell
embryo
totipotent
mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002282722A
Other languages
English (en)
Inventor
Nikolai S. Strelchenko
Jeffery M. Betthauser
Gail L. Jurgella
Marvin M. Pace
Michael D. Bishop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infigen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2282722A1 publication Critical patent/CA2282722A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fertilizers (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne des techniques de clonage. L'invention décrit en partie des cellules immortalisées et totipotentes s'utilisant pour le clonage d'animaux, les embryons produits à partir de ces cellules au moyen de techniques de transfert nucléaires, des animaux obtenus à partir de ces cellules et embryons, ainsi que des matières, méthodes et procédés permettant la création de telles cellules, embryons et animaux.
CA002282722A 1997-03-06 1998-03-05 Methode de clonage d'animaux Abandoned CA2282722A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US81203197A 1997-03-06 1997-03-06
US81285197A 1997-03-06 1997-03-06
US08/812,031 1997-03-06
US08/812,851 1997-03-06
US7301998P 1998-01-29 1998-01-29
US60/073,019 1998-01-29
PCT/US1998/004345 WO1998039416A1 (fr) 1997-03-06 1998-03-05 Methode de clonage d'animaux

Publications (1)

Publication Number Publication Date
CA2282722A1 true CA2282722A1 (fr) 1998-09-11

Family

ID=27372211

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002282722A Abandoned CA2282722A1 (fr) 1997-03-06 1998-03-05 Methode de clonage d'animaux

Country Status (7)

Country Link
EP (1) EP0973871A1 (fr)
JP (1) JP2002512510A (fr)
AU (1) AU745334B2 (fr)
BR (1) BR9808192A (fr)
CA (1) CA2282722A1 (fr)
NZ (1) NZ337495A (fr)
WO (1) WO1998039416A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331659B1 (en) * 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
EP1060243A4 (fr) * 1998-03-02 2005-03-09 Univ Massachusetts Lignees cellulaires embryonnaires ou de type souche produites par transplantation nucleaire d'especes croisees
US6700037B2 (en) * 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) * 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
JP2002534118A (ja) * 1999-01-13 2002-10-15 ピーピーエル セラピューティクス （スコットランド） リミテッド 二重核移植法及びその結果物
NZ514620A (en) * 1999-03-04 2004-04-30 Ppl Therapeutics Scotland Ltd Genetic modification of somatic cells and uses thereof
DE69934914T2 (de) * 1999-06-04 2007-10-18 Istituto Zootecnico E Caseario Per La Sardegna Verfahren zur rekonstruktion eines nicht-menschlichen tierischen embryos mittels kerntransfer und die herstellung des tieres daraus.
JP3652308B2 (ja) * 1999-06-30 2005-05-25 ソウル ナショナル ユニバーシティー インダストリー ファウンデーション クローンウシの生産方法
JP2003503045A (ja) * 1999-06-30 2003-01-28 ワン，ウー−サク 異種間核移植技術を用いたクローントラの生産方法
JP2003508079A (ja) * 1999-09-07 2003-03-04 アドバンスド セル テクノロジー、インコーポレイテッド 老年期体細胞からクローン化された動物中の細胞寿命のテロメア回復と延長
DK1356031T3 (da) 2000-03-15 2011-10-31 Univ Georgia Effektiv kerneomprogrammering hos pattedyr
WO2002009510A2 (fr) * 2000-08-01 2002-02-07 Xy Genetics, Llc Procedes de selection et de clonage
CA2430738A1 (fr) * 2000-12-05 2002-06-13 Universite De Montreal Methode de clonage d'animaux
CA2438832A1 (fr) 2001-02-23 2002-09-06 Elan Pharmaceuticals, Inc. Knockouts transgeniques de bace-1
US7265262B2 (en) 2001-03-21 2007-09-04 Roslin Institute (Edinburgh) Telomerizing nuclear donor cells and improving the efficiency on nuclear transfer
NZ555876A (en) * 2002-04-24 2009-04-30 Univ Georgia Res Found Production of cloned offspring in a cattle breeding operation
ES2442615T5 (es) 2002-07-18 2023-03-16 Merus Nv Producción recombinante de mezclas de anticuerpos
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
CA2502490A1 (fr) 2002-11-08 2004-05-27 Hematech, Llc Ongules transgeniques presentant une activite de la proteine prion reduite et leurs utilisations
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1639009B1 (fr) 2003-05-30 2013-02-27 Merus B.V. Bibliothèque de fragments fab pour préparer un mélange d'anticorps
DK1737971T3 (da) 2004-01-20 2017-11-13 Merus Nv Blandinger af bindingsproteiner
CA2563064A1 (fr) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Animaux transgeniques et leurs utilisations
JP2006081542A (ja) * 2004-08-18 2006-03-30 Institute Of Physical & Chemical Research クローン哺乳動物の作成方法
EP2982744A1 (fr) 2007-02-23 2016-02-10 Advanced Cell Technology, Inc. Procédés hautement efficaces pour reprogrammer des cellules différenciées et pour produire des animaux et des cellules souches embryonnaires à partir de cellules reprogrammées
EP3225252A1 (fr) 2008-05-02 2017-10-04 Laboratoire Français du Fractionnement et des Biotechnologies Traitement de saignement par un fibrinogène de faible demi-vie
TR201906650T4 (tr) 2010-02-08 2019-05-21 Regeneron Pharma Ortak hafif zincirli fare.
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
EP2603581B1 (fr) 2010-08-11 2019-07-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Cocultures de cellules de cumulus et d'embryons au cours de procédures de fécondation in vitro
WO2012122512A1 (fr) 2011-03-10 2012-09-13 Hco Antibody, Inc. Production recombinante de mélanges d'anticorps monocaténaires
ES2872081T3 (es) 2011-08-05 2021-11-02 Regeneron Pharma Ratones con cadena ligera universal humanizada
NZ630551A (en) 2012-04-20 2017-11-24 Merus Nv Methods and means for the production of ig-like molecules
KR20210088756A (ko) 2014-03-21 2021-07-14 리제너론 파마슈티칼스 인코포레이티드 단일 도메인 결합 단백질을 생산하는 비-인간 동물
AU2016232715A1 (en) 2015-03-19 2017-09-28 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990001541A1 (fr) * 1988-08-04 1990-02-22 Amrad Corporation Limited Propagation in vitro de cellules a tiges embryonnaires
JP2988753B2 (ja) * 1990-08-29 1999-12-13 科学技術振興事業団 不死化細胞株の樹立方法とその細胞株
AU6136394A (en) * 1992-10-06 1994-04-26 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Long-term proliferation of primordial germ cells
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
AU1439295A (en) * 1993-12-17 1995-07-03 Abs Global, Inc. Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates
GB9417831D0 (en) * 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
FR2726003B1 (fr) * 1994-10-21 2002-10-18 Agronomique Inst Nat Rech Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires
AU1274797A (en) * 1995-11-29 1997-06-19 Utah State University Establishment, maintenance, and transfection of totipotent embryonic stem cells from the embryos of domestic animals
NZ326996A (en) * 1996-01-09 1998-11-25 Univ California Sustained culture of pluripotent ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
CA2255900C (fr) * 1997-03-14 2002-08-06 Cselt - Centro Studi E Laboratori Telecommunicazioni S.P.A. Circuit pour l'estimation des mouvements dans des codeurs de sequences video numerisees

Also Published As

Publication number Publication date
WO1998039416A1 (fr) 1998-09-11
EP0973871A1 (fr) 2000-01-26
AU745334B2 (en) 2002-03-21
BR9808192A (pt) 2000-10-24
AU6688098A (en) 1998-09-22
NZ337495A (en) 2001-06-29
JP2002512510A (ja) 2002-04-23

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued