CA2277582A1 - Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors - Google Patents
Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors Download PDFInfo
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- CA2277582A1 CA2277582A1 CA002277582A CA2277582A CA2277582A1 CA 2277582 A1 CA2277582 A1 CA 2277582A1 CA 002277582 A CA002277582 A CA 002277582A CA 2277582 A CA2277582 A CA 2277582A CA 2277582 A1 CA2277582 A1 CA 2277582A1
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- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Rehabilitation Therapy (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/779,767 US6737057B1 (en) | 1997-01-07 | 1997-01-07 | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
| US08/779,767 | 1997-01-07 | ||
| PCT/US1998/000520 WO1998030706A1 (en) | 1997-01-07 | 1998-01-07 | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2277582A1 true CA2277582A1 (en) | 1998-07-16 |
Family
ID=25117492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002277582A Abandoned CA2277582A1 (en) | 1997-01-07 | 1998-01-07 | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6737057B1 (enExample) |
| EP (1) | EP1012308A1 (enExample) |
| JP (1) | JP2001508430A (enExample) |
| AU (1) | AU744885B2 (enExample) |
| CA (1) | CA2277582A1 (enExample) |
| WO (1) | WO1998030706A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020081298A1 (en) * | 1997-01-07 | 2002-06-27 | Habib Zaghouani | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| EP1093464A2 (en) * | 1998-07-06 | 2001-04-25 | The University Of Tennessee Research Corporation | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
| EP1104456A1 (en) * | 1998-08-10 | 2001-06-06 | Chiron Corporation | Engineered antigen-presenting cells expressing an array of antigens and uses thereof |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU778611B2 (en) | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
| EP1598370A3 (en) * | 1999-10-27 | 2006-05-10 | Cel-Sci Corporation | Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions |
| EP1223958A4 (en) * | 1999-10-27 | 2004-07-21 | Cel Sci Corp | PREPARATION METHODS AND COMPOUNDS OF PEPTIDE CONSTRUCTIONS CONCERNING THE TREATMENT OF AUTOIMMUNE AND. TRANSPLANTATION-RELATED "HOST VERSUS GRAFT" PATHOGENESE PROPERTIES |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| JP2004509978A (ja) * | 2000-06-05 | 2004-04-02 | ユニバーシティ オブ テネシー コーポレイション | 免疫抑制因子のエンドサイトーシスによる提示のための組成物及び方法 |
| ATE368475T1 (de) | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| BR0207854A (pt) | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| ATE554787T1 (de) | 2002-04-09 | 2012-05-15 | Univ Missouri | Behandlung von typ-1-diabetes vor und nach der expression von prädispositionsmarkern |
| US8609091B2 (en) | 2002-04-09 | 2013-12-17 | The Curators Of The University Of Missouri | Method for endocytic presentation of an immunosuppressive for the treatment of type 1 diabetes |
| US7744876B2 (en) * | 2002-04-09 | 2010-06-29 | The Curators Of The University Of Missouri | Methods and compositions for treatment, prevention, suppression, and/or delaying the onset of type 1 diabetes |
| US8603471B2 (en) * | 2002-04-09 | 2013-12-10 | The Curators Of The University Of Missouri | Methods and compositions for preventing the onset of type 1 diabetes |
| US8603472B2 (en) * | 2002-04-09 | 2013-12-10 | The Curators Of The University Of Missouri | Methods and compositions reversing pre-diabetes using fusion proteins comprising a GAD peptide |
| WO2003099312A1 (en) * | 2002-05-27 | 2003-12-04 | Östergötlands Läns Landsting | Method for determining immune system affecting compounds |
| DK1572748T3 (da) | 2002-12-17 | 2010-08-23 | Merck Patent Gmbh | Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2 |
| ES2305886T3 (es) | 2003-12-30 | 2008-11-01 | Merck Patent Gmbh | Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo. |
| KR20060124656A (ko) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
| US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| SE0402536D0 (sv) | 2004-10-20 | 2004-10-20 | Therim Diagnostica Ab | Immunoregulation in cancer, chronic inflammatory and autoimmune diseases |
| JP4937132B2 (ja) | 2004-12-09 | 2012-05-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫原性の低下したｉｌ−７変種 |
| EP1875246B1 (en) * | 2005-04-15 | 2016-10-05 | CanImGuide Therapeutics AB | Diagnostic method for detecting cancer by measuring amount of a cytokine like il-6 |
| ES2608803T3 (es) | 2007-05-08 | 2017-04-17 | Canimguide Therapeutics Ab | Estructuras inmunorreguladoras procedentes de proteínas naturales |
| MX2011011044A (es) | 2009-04-22 | 2011-11-04 | Merck Patent Gmbh | Proteinas de fusion de anticuerpos con sitios de enlace de receptor fc neonatal (fcrn) modificados. |
| AU2011289579B2 (en) | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| LT3107563T (lt) | 2014-02-21 | 2021-07-12 | Ecole Polytechnique Fédérale De Lausanne (Epfl) Epfl-Tto | Gliko-nukreipiantys terapiniai agenai |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| EP3253419A1 (en) | 2015-02-02 | 2017-12-13 | The University of Birmingham | Targeting moiety peptide epitope complexes having a plurality of t-cell epitopes |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
| AU616338B2 (en) | 1989-02-02 | 1991-10-24 | Mato Maschinen- Und Metallwarenfabrik Curt Matthaei Gmbh & Co Kg | Belt skimming device |
| DE69023900T4 (de) * | 1989-02-24 | 1996-10-02 | The Regents Of The University Of California, Berkeley, Calif. | Gentechnologisch veränderte immunglobuline. |
| US5612035A (en) | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5969109A (en) | 1990-02-28 | 1999-10-19 | Bona; Constantin | Chimeric antibodies comprising antigen binding sites and B and T cell epitopes |
| AU667460B2 (en) | 1990-10-05 | 1996-03-28 | Medarex, Inc. | Targeted immunostimulation with bispecific reagents |
| JPH06511241A (ja) | 1991-09-23 | 1994-12-15 | ジェネンテク，インコーポレイテッド | 自己免疫疾患の診断および治療 |
| US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| AU3220593A (en) | 1991-11-19 | 1993-06-15 | Anergen, Inc. | Soluble mhc molecules and their uses |
| GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
| WO1994014847A1 (en) | 1992-12-24 | 1994-07-07 | The Regents Of The University Of California | Genetically engineered immunoglobulins |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US5820866A (en) | 1994-03-04 | 1998-10-13 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for T cell regulation |
| US6329499B1 (en) | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
| CA2218858A1 (en) | 1995-05-02 | 1996-11-07 | Alexion Pharmaceuticals Inc. | Modified myelin protein molecules |
| US20020081298A1 (en) * | 1997-01-07 | 2002-06-27 | Habib Zaghouani | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
| WO1999009064A1 (en) | 1997-08-19 | 1999-02-25 | Mount Sinai School Of Medicine Of New York University ; | Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules |
-
1997
- 1997-01-07 US US08/779,767 patent/US6737057B1/en not_active Expired - Fee Related
-
1998
- 1998-01-07 AU AU58214/98A patent/AU744885B2/en not_active Ceased
- 1998-01-07 EP EP98901773A patent/EP1012308A1/en not_active Withdrawn
- 1998-01-07 JP JP53040098A patent/JP2001508430A/ja not_active Ceased
- 1998-01-07 CA CA002277582A patent/CA2277582A1/en not_active Abandoned
- 1998-01-07 WO PCT/US1998/000520 patent/WO1998030706A1/en not_active Ceased
-
2004
- 2004-05-17 US US10/847,139 patent/US20060034864A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001508430A (ja) | 2001-06-26 |
| AU744885B2 (en) | 2002-03-07 |
| WO1998030706A1 (en) | 1998-07-16 |
| EP1012308A1 (en) | 2000-06-28 |
| US6737057B1 (en) | 2004-05-18 |
| US20060034864A1 (en) | 2006-02-16 |
| AU5821498A (en) | 1998-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |