CA2274896A1 - Method for production of d-proline derivatives - Google Patents
Method for production of d-proline derivatives Download PDFInfo
- Publication number
- CA2274896A1 CA2274896A1 CA002274896A CA2274896A CA2274896A1 CA 2274896 A1 CA2274896 A1 CA 2274896A1 CA 002274896 A CA002274896 A CA 002274896A CA 2274896 A CA2274896 A CA 2274896A CA 2274896 A1 CA2274896 A1 CA 2274896A1
- Authority
- CA
- Canada
- Prior art keywords
- proline
- general formula
- derivative
- proline derivative
- microorganisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical class OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 title description 15
- 244000005700 microbiome Species 0.000 claims abstract description 40
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 30
- 150000003147 proline derivatives Chemical class 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 23
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 19
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 15
- 125000000180 D-prolyl group Chemical class N1[C@@H](C(=O)*)CCC1 0.000 claims abstract description 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 9
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 8
- 239000001257 hydrogen Substances 0.000 claims abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 125000002252 acyl group Chemical group 0.000 claims abstract description 5
- 125000004104 aryloxy group Chemical group 0.000 claims abstract description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 5
- 230000000694 effects Effects 0.000 claims description 40
- 241000500375 Microbacterium sp. Species 0.000 claims description 34
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
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- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3080/96 | 1996-12-16 | ||
| CH308096 | 1996-12-16 | ||
| PCT/EP1997/007006 WO1998027222A1 (de) | 1996-12-16 | 1997-12-12 | Verfahren zur herstellung von d-prolinderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2274896A1 true CA2274896A1 (en) | 1998-06-25 |
Family
ID=4248188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002274896A Abandoned CA2274896A1 (en) | 1996-12-16 | 1997-12-12 | Method for production of d-proline derivatives |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0944730A1 (cs) |
| JP (1) | JP2001506500A (cs) |
| AU (1) | AU5757498A (cs) |
| CA (1) | CA2274896A1 (cs) |
| CZ (1) | CZ213199A3 (cs) |
| WO (1) | WO1998027222A1 (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220154240A1 (en) * | 2019-02-27 | 2022-05-19 | Guang An Mojia Biotechnology Co., Ltd. | Method for resolving optical isomer by means of electrodialysis technique |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1737818A2 (en) * | 2003-12-04 | 2007-01-03 | Pfizer, Inc. | Methods for the preparation of stereoisomerically enriched amines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5840473B2 (ja) * | 1978-06-29 | 1983-09-06 | 財団法人野田産業科学研究所 | 新規なプロリンアシラ−ゼ及びその製法 |
| JPS5571491A (en) * | 1978-11-24 | 1980-05-29 | Noda Sangyo Kagaku Kenkyusho | Preparation of proline acylase |
| JPH06740B2 (ja) * | 1984-08-16 | 1994-01-05 | 三菱レイヨン株式会社 | 光学活性カルボン酸アミドの製造法 |
| JPH0783712B2 (ja) * | 1987-09-18 | 1995-09-13 | ダイセル化学工業株式会社 | 新規なプロリンアシラーゼ及びその製造法 |
| DE3929570A1 (de) * | 1989-09-06 | 1991-03-07 | Degussa | Mikrobiologisch hergestellte n-acyl-l-prolin-acylase, verfahren zu ihrer gewinnung und ihre verwendung |
| CA2150526C (en) * | 1994-06-09 | 2005-11-15 | Andreas Kiener | Biotechnological process for the preparation of cyclic s-.alpha.-amino carboxylic acids and r-.alpha.-amino carboxamides |
| AU2155797A (en) * | 1996-03-13 | 1997-10-01 | Lonza A.G. | Process for producing n-protected d-proline derivatives |
-
1997
- 1997-12-12 CA CA002274896A patent/CA2274896A1/en not_active Abandoned
- 1997-12-12 AU AU57574/98A patent/AU5757498A/en not_active Abandoned
- 1997-12-12 CZ CZ992131A patent/CZ213199A3/cs unknown
- 1997-12-12 WO PCT/EP1997/007006 patent/WO1998027222A1/de not_active Application Discontinuation
- 1997-12-12 JP JP52729598A patent/JP2001506500A/ja active Pending
- 1997-12-12 EP EP97953805A patent/EP0944730A1/de not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220154240A1 (en) * | 2019-02-27 | 2022-05-19 | Guang An Mojia Biotechnology Co., Ltd. | Method for resolving optical isomer by means of electrodialysis technique |
Also Published As
| Publication number | Publication date |
|---|---|
| CZ213199A3 (cs) | 1999-11-17 |
| JP2001506500A (ja) | 2001-05-22 |
| EP0944730A1 (de) | 1999-09-29 |
| WO1998027222A1 (de) | 1998-06-25 |
| AU5757498A (en) | 1998-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |