CA2274803A1 - Activateur du recepteur de nf-kappab, recepteur membre de la superfamille des recepteurs de tnf - Google Patents

Activateur du recepteur de nf-kappab, recepteur membre de la superfamille des recepteurs de tnf Download PDF

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Publication number
CA2274803A1
CA2274803A1 CA002274803A CA2274803A CA2274803A1 CA 2274803 A1 CA2274803 A1 CA 2274803A1 CA 002274803 A CA002274803 A CA 002274803A CA 2274803 A CA2274803 A CA 2274803A CA 2274803 A1 CA2274803 A1 CA 2274803A1
Authority
CA
Canada
Prior art keywords
rank
amino acid
dna
protein
host cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002274803A
Other languages
English (en)
Other versions
CA2274803C (fr
Inventor
Dirk M. Anderson
Laurent J. Galibert
Eugene Maraskovsky
William C. Dougall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corporation
Dirk M. Anderson
Laurent J. Galibert
Eugene Maraskovsky
William C. Dougall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation, Dirk M. Anderson, Laurent J. Galibert, Eugene Maraskovsky, William C. Dougall filed Critical Immunex Corporation
Priority claimed from PCT/US1997/023866 external-priority patent/WO1998028424A2/fr
Publication of CA2274803A1 publication Critical patent/CA2274803A1/fr
Application granted granted Critical
Publication of CA2274803C publication Critical patent/CA2274803C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Récepteurs isolés, ADNs codant ces récepteurs et compositions pharmaceutiques préparées à partir de ces récepteurs. On peut utiliser ces récepteurs isolés afin de réguler une réaction immune. Ces récepteurs sont également utiles pour rechercher leurs inhibiteurs par criblage.
CA2274803A 1996-12-23 1997-12-22 Activateur du recepteur de nf-kappab, recepteur membre de la superfamille des recepteurs de tnf Expired - Fee Related CA2274803C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5997896P 1996-12-23 1996-12-23
US60/059,978 1996-12-23
US81350997A 1997-03-07 1997-03-07
US08/813,509 1997-03-07
US6467197P 1997-10-14 1997-10-14
US60/064,671 1997-10-14
PCT/US1997/023866 WO1998028424A2 (fr) 1996-12-23 1997-12-22 Activateur du recepteur de nf-kappab, recepteur membre de la superfamille des recepteurs de tnf

Publications (2)

Publication Number Publication Date
CA2274803A1 true CA2274803A1 (fr) 1998-07-02
CA2274803C CA2274803C (fr) 2012-05-22

Family

ID=43981413

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2274803A Expired - Fee Related CA2274803C (fr) 1996-12-23 1997-12-22 Activateur du recepteur de nf-kappab, recepteur membre de la superfamille des recepteurs de tnf

Country Status (4)

Country Link
JP (1) JP2013005802A (fr)
CA (1) CA2274803C (fr)
IL (3) IL130491A (fr)
PT (1) PT946725E (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0951551B9 (fr) * 1996-12-23 2012-12-26 Immunex Corporation Ligand pour l'activateur des recepteurs du nf-kappab, ligand membre de la superfamille de tnf

Also Published As

Publication number Publication date
PT946725E (pt) 2011-04-20
IL215020A0 (fr) 2011-10-31
IL130491A0 (en) 2000-06-01
JP2013005802A (ja) 2013-01-10
CA2274803C (fr) 2012-05-22
IL130491A (en) 2011-10-31
IL215021A0 (en) 2011-10-31

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CA2274803A1 (fr) Activateur du recepteur de nf-kappab, recepteur membre de la superfamille des recepteurs de tnf

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151222