CA2271847A1 - Procede de preparation de sels et d'esters d'acide clavulanique - Google Patents
Procede de preparation de sels et d'esters d'acide clavulanique Download PDFInfo
- Publication number
- CA2271847A1 CA2271847A1 CA002271847A CA2271847A CA2271847A1 CA 2271847 A1 CA2271847 A1 CA 2271847A1 CA 002271847 A CA002271847 A CA 002271847A CA 2271847 A CA2271847 A CA 2271847A CA 2271847 A1 CA2271847 A1 CA 2271847A1
- Authority
- CA
- Canada
- Prior art keywords
- clavulanic acid
- amine
- clavulanate
- addition
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention porte sur un procédé amélioré de préparation de sels ou d'esters de métal alcalin pharmaceutiquement acceptables d'acide clavulanique. L'invention porte aussi sur un clavulanate de potassium ayant une teneur en amine extrêmement faible et sur des compositions pharmaceutiques le contenant.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96203117.5 | 1996-11-11 | ||
EP96203117 | 1996-11-11 | ||
PCT/EP1997/006263 WO1998021212A1 (fr) | 1996-11-11 | 1997-11-10 | Procede de preparation de sels et d'esters d'acide clavulanique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2271847A1 true CA2271847A1 (fr) | 1998-05-22 |
Family
ID=8224563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002271847A Abandoned CA2271847A1 (fr) | 1996-11-11 | 1997-11-10 | Procede de preparation de sels et d'esters d'acide clavulanique |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0937084A1 (fr) |
JP (1) | JP2001503763A (fr) |
CN (1) | CN1238776A (fr) |
AU (1) | AU5551698A (fr) |
BR (1) | BR9713339A (fr) |
CA (1) | CA2271847A1 (fr) |
NO (1) | NO992225D0 (fr) |
PL (1) | PL333247A1 (fr) |
TR (1) | TR199901631T2 (fr) |
WO (1) | WO1998021212A1 (fr) |
ZA (1) | ZA9710141B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400033B (de) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SI9500134B (sl) * | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
EP1095046A1 (fr) * | 1998-07-16 | 2001-05-02 | Dsm N.V. | Procede ameliore de preparation de sels et d'esters d'acide clavulanique |
WO2000041478A2 (fr) * | 1999-04-01 | 2000-07-20 | Dsm N.V. | Agglomerats obtenus par cristallisation |
ES2225524T5 (es) * | 2000-05-13 | 2009-03-01 | Smithkline Beecham Plc | Procedimiento para la purificacion de una sal de acido clavulanico. |
WO2008065160A1 (fr) * | 2006-12-01 | 2008-06-05 | Dsm Ip Assets B.V. | Procédé de production d'acide clavulanique |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9300296B (sl) * | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
GB9305565D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB9426261D0 (en) * | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (sl) * | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
KR100200242B1 (ko) * | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
-
1997
- 1997-11-10 CN CN97180163A patent/CN1238776A/zh active Pending
- 1997-11-10 JP JP52216798A patent/JP2001503763A/ja active Pending
- 1997-11-10 PL PL97333247A patent/PL333247A1/xx unknown
- 1997-11-10 CA CA002271847A patent/CA2271847A1/fr not_active Abandoned
- 1997-11-10 EP EP97951881A patent/EP0937084A1/fr not_active Withdrawn
- 1997-11-10 BR BR9713339-6A patent/BR9713339A/pt not_active Application Discontinuation
- 1997-11-10 WO PCT/EP1997/006263 patent/WO1998021212A1/fr not_active Application Discontinuation
- 1997-11-10 AU AU55516/98A patent/AU5551698A/en not_active Abandoned
- 1997-11-10 TR TR1999/01631T patent/TR199901631T2/xx unknown
- 1997-11-11 ZA ZA9710141A patent/ZA9710141B/xx unknown
-
1999
- 1999-05-07 NO NO992225A patent/NO992225D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL333247A1 (en) | 1999-11-22 |
EP0937084A1 (fr) | 1999-08-25 |
CN1238776A (zh) | 1999-12-15 |
BR9713339A (pt) | 2000-05-09 |
WO1998021212A1 (fr) | 1998-05-22 |
ZA9710141B (en) | 1998-06-25 |
JP2001503763A (ja) | 2001-03-21 |
NO992225L (no) | 1999-05-07 |
AU5551698A (en) | 1998-06-03 |
TR199901631T2 (xx) | 1999-09-21 |
NO992225D0 (no) | 1999-05-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20031110 |