CA2270177C - Transdermal administration of ment - Google Patents
Transdermal administration of ment Download PDFInfo
- Publication number
- CA2270177C CA2270177C CA002270177A CA2270177A CA2270177C CA 2270177 C CA2270177 C CA 2270177C CA 002270177 A CA002270177 A CA 002270177A CA 2270177 A CA2270177 A CA 2270177A CA 2270177 C CA2270177 C CA 2270177C
- Authority
- CA
- Canada
- Prior art keywords
- transdermal
- androgen
- dosage form
- carrier
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
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- 239000010409 thin film Substances 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
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- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- XOALFFJGWSCQEO-UHFFFAOYSA-N tridecyl prop-2-enoate Chemical compound CCCCCCCCCCCCCOC(=O)C=C XOALFFJGWSCQEO-UHFFFAOYSA-N 0.000 description 1
- PRBORDFJHHAISJ-UHFFFAOYSA-N tybamate Chemical compound CCCCNC(=O)OCC(C)(CCC)COC(N)=O PRBORDFJHHAISJ-UHFFFAOYSA-N 0.000 description 1
- 229960002560 tybamate Drugs 0.000 description 1
- DTMPGSXFUXZBDK-UHFFFAOYSA-N uldazepam Chemical compound C12=CC(Cl)=CC=C2N=C(NOCC=C)CN=C1C1=CC=CC=C1Cl DTMPGSXFUXZBDK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5930197P | 1997-09-17 | 1997-09-17 | |
| US60/059,301 | 1997-09-17 | ||
| US09/154,287 US20020012694A1 (en) | 1997-09-17 | 1998-09-16 | Transdermal administration of ment |
| US09/154,287 | 1998-09-16 | ||
| PCT/US1998/019399 WO1999013812A1 (en) | 1997-09-17 | 1998-09-17 | Transdermal administration of ment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2270177A1 CA2270177A1 (en) | 1999-03-25 |
| CA2270177C true CA2270177C (en) | 2006-08-29 |
Family
ID=26738606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002270177A Expired - Fee Related CA2270177C (en) | 1997-09-17 | 1998-09-17 | Transdermal administration of ment |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20020012694A1 (enExample) |
| EP (1) | EP0941039A4 (enExample) |
| JP (1) | JP2001527581A (enExample) |
| BR (1) | BR9806213A (enExample) |
| CA (1) | CA2270177C (enExample) |
| WO (1) | WO1999013812A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100452972B1 (ko) | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
| AU2003206434A1 (en) * | 2002-02-15 | 2003-09-04 | Pantarhei Bioscience B.V. | Pulmonary administration of 6-alpha-alkylated testosterone derivatives for androgen replacement therapy |
| BR0313210A (pt) * | 2002-07-24 | 2005-06-28 | Schering Ag | Processos microbiológicos para a produção de 11alfa-hidróxi esteróides 7alfa-substituìdos |
| DE10233723A1 (de) | 2002-07-24 | 2004-02-12 | Schering Ag | Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene |
| US7879357B2 (en) * | 2003-04-28 | 2011-02-01 | Bayer Schering Pharma Ag | Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients |
| JO2492B1 (en) | 2003-04-28 | 2009-10-05 | شيرينج ايه جي | A pharmaceutical formula in the form of aqueous gel for the skin use of its active ingredients |
| US7056332B2 (en) * | 2003-07-24 | 2006-06-06 | Materials Evolution And Development Usa, Inc. | Nucleic acid biomaterials and methods of formation and use |
| GB0409498D0 (en) * | 2004-04-28 | 2004-06-02 | Hunter Fleming Ltd | Transdermal steroid formulation |
| CA2647801C (en) | 2006-03-24 | 2015-04-14 | Auxilium Pharmaceuticals, Inc. | Process for the preparation of a hot-melt extruded laminate |
| WO2007112286A2 (en) | 2006-03-24 | 2007-10-04 | Auxilium Pharmaceuticals, Inc. | Stabilized compositions containing alkaline labile drugs |
| US20070243714A1 (en) * | 2006-04-18 | 2007-10-18 | Applied Materials, Inc. | Method of controlling silicon-containing polymer build up during etching by using a periodic cleaning step |
| US9574043B2 (en) | 2009-01-12 | 2017-02-21 | University Of Massachusetts Lowell | Polyisobutylene-based polyurethanes |
| EP2467174B1 (en) * | 2009-08-21 | 2018-09-26 | Cardiac Pacemakers, Inc. | Crosslinkable polyisobutylene-based polymers and medical devices containing the same |
| US8374704B2 (en) | 2009-09-02 | 2013-02-12 | Cardiac Pacemakers, Inc. | Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same |
| US8644952B2 (en) | 2009-09-02 | 2014-02-04 | Cardiac Pacemakers, Inc. | Medical devices including polyisobutylene based polymers and derivatives thereof |
| US9484123B2 (en) | 2011-09-16 | 2016-11-01 | Prc-Desoto International, Inc. | Conductive sealant compositions |
| JP2015535538A (ja) | 2012-11-21 | 2015-12-14 | ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | 高強度ポリイソブチレンポリウレタン |
| US10526429B2 (en) | 2017-03-07 | 2020-01-07 | Cardiac Pacemakers, Inc. | Hydroboration/oxidation of allyl-terminated polyisobutylene |
| CN110997746B (zh) | 2017-08-17 | 2021-12-28 | 心脏起搏器股份公司 | 用于增强的耐久性的光交联聚合物 |
| EP3740253B1 (en) | 2018-01-17 | 2023-08-16 | Cardiac Pacemakers, Inc. | End-capped polyisobutylene polyurethane |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4177267A (en) * | 1963-12-09 | 1979-12-04 | Crown Zellerbach | Enhancing tissue penetration of physiologically active steroidal agents with DMSC |
| ATE151286T1 (de) * | 1983-11-14 | 1997-04-15 | Columbia Lab Inc | Bioadhäsive mittel |
| US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| US4666441A (en) * | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
| US5342834A (en) * | 1989-04-07 | 1994-08-30 | The Population Council, Inc. | Method for androgen supplementation |
| EP0500287B1 (en) * | 1991-02-20 | 1995-04-26 | Hitachi, Ltd. | Catalyzer control apparatus |
| US5332576A (en) * | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| CA2075517C (en) * | 1992-04-01 | 1997-03-11 | John Wick | Transdermal patch incorporating a polymer film incorporated with an active agent |
| ATE163262T1 (de) * | 1993-04-20 | 1998-03-15 | Hexal Ag | Wirkstoffplaster |
| US5521166A (en) * | 1994-12-19 | 1996-05-28 | Ortho Pharmaceitical Corporation | Antiprogestin cyclophasic hormonal regimen |
| US5780050A (en) * | 1995-07-20 | 1998-07-14 | Theratech, Inc. | Drug delivery compositions for improved stability of steroids |
| US5733565A (en) * | 1996-02-23 | 1998-03-31 | The Population Council, Center For Biomedical Research | Male contraceptive implant |
-
1998
- 1998-09-16 US US09/154,287 patent/US20020012694A1/en not_active Abandoned
- 1998-09-17 CA CA002270177A patent/CA2270177C/en not_active Expired - Fee Related
- 1998-09-17 EP EP98949365A patent/EP0941039A4/en not_active Withdrawn
- 1998-09-17 JP JP51815599A patent/JP2001527581A/ja active Pending
- 1998-09-17 WO PCT/US1998/019399 patent/WO1999013812A1/en not_active Ceased
- 1998-09-17 BR BR9806213-1A patent/BR9806213A/pt not_active Application Discontinuation
-
2003
- 2003-12-15 US US10/736,428 patent/US20040126418A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0941039A4 (en) | 2006-06-21 |
| CA2270177A1 (en) | 1999-03-25 |
| BR9806213A (pt) | 2000-04-18 |
| US20040126418A1 (en) | 2004-07-01 |
| EP0941039A1 (en) | 1999-09-15 |
| JP2001527581A (ja) | 2001-12-25 |
| US20020012694A1 (en) | 2002-01-31 |
| WO1999013812A1 (en) | 1999-03-25 |
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