CA2265571A1 - Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof - Google Patents
Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof Download PDFInfo
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- CA2265571A1 CA2265571A1 CA002265571A CA2265571A CA2265571A1 CA 2265571 A1 CA2265571 A1 CA 2265571A1 CA 002265571 A CA002265571 A CA 002265571A CA 2265571 A CA2265571 A CA 2265571A CA 2265571 A1 CA2265571 A1 CA 2265571A1
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2697896P | 1996-09-20 | 1996-09-20 | |
| US60/026,978 | 1996-09-20 | ||
| US08/928,958 | 1997-09-12 | ||
| US08/928,958 US5877282A (en) | 1996-09-20 | 1997-09-12 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
| PCT/US1997/016217 WO1998011907A1 (en) | 1996-09-20 | 1997-09-15 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2265571A1 true CA2265571A1 (en) | 1998-03-26 |
Family
ID=26701884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002265571A Abandoned CA2265571A1 (en) | 1996-09-20 | 1997-09-15 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5877282A (https=) |
| EP (1) | EP1015012A4 (https=) |
| JP (1) | JP2002514053A (https=) |
| AU (1) | AU731725B2 (https=) |
| CA (1) | CA2265571A1 (https=) |
| TW (1) | TW575580B (https=) |
| WO (1) | WO1998011907A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495518B1 (en) | 1994-06-13 | 2002-12-17 | Vanderbilt University | Method for importing biologically active molecules into cells |
| US7553929B2 (en) * | 1994-06-13 | 2009-06-30 | Vanderbilt University | Cell permeable peptides for inhibition of inflammatory reactions and methods of use |
| FR2739621B1 (fr) * | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| US5962415A (en) * | 1996-09-20 | 1999-10-05 | Bristol-Myers Squibb Co. | Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods of use thereof |
| GB2337329B (en) * | 1997-04-30 | 2001-09-05 | Imp Cancer Res Tech | Inhibitors of nuclear protein/nuclear receptor interaction |
| GB9708676D0 (en) * | 1997-04-30 | 1997-06-18 | Imp Cancer Res Tech | Chemical compounds |
| AU766489B2 (en) * | 1998-11-13 | 2003-10-16 | Cyclacel Limited | Transport vectors |
| AU5011200A (en) * | 1999-05-14 | 2000-12-05 | Arbor Vita Corporation | Molecular interactions in hematopoietic cells |
| ATE385503T1 (de) | 1999-06-28 | 2008-02-15 | Inter K Pty Ltd | Verfahren zur modulierung von integrin- vermittelter zellaktivitaet und hierfuer geeignete reagenzien |
| DE19933492B4 (de) * | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| US6312956B1 (en) * | 1999-10-01 | 2001-11-06 | Vanderbilt University | Nuclear targeted peptide nucleic acid oligomer |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US6844324B1 (en) * | 1999-11-12 | 2005-01-18 | Massachusetts Institute Of Technology | Modular peptide mediated intracellular delivery system and uses therefore |
| EP1235914A2 (en) * | 1999-11-24 | 2002-09-04 | Joseph Rosenecker | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| EP1862471A3 (en) * | 2000-02-07 | 2008-05-28 | Wisconsin Alumni Research Foundation | Pharmacologically active antiviral peptides and methods of their use |
| JP4896333B2 (ja) * | 2000-02-07 | 2012-03-14 | ウイスコンシン アラムニ リサーチ ファンデーション | 薬理活性抗ウイルスペプチドおよびそれらの使用法 |
| GB0103110D0 (en) | 2000-08-25 | 2001-03-28 | Aventis Pharma Inc | A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1 |
| US20040086896A1 (en) * | 2001-04-19 | 2004-05-06 | Julie Carman | Polynucleotides and polypeptides associated with the NF-kB pathway |
| AU2002252705A1 (en) * | 2001-04-19 | 2002-11-05 | Bristol-Myers Squibb Company | Polynucleotides and polypeptides associated with the nf-kb pathway |
| ATE489462T1 (de) * | 2002-04-25 | 2010-12-15 | Toagosei Co Ltd | Antimikrobielles polypeptid und nutzung davon |
| EP2418219B1 (en) * | 2003-10-17 | 2018-06-27 | InterK Peptide Therapeutics Limited | Methods and agents for the treatment of cancer |
| US7674771B2 (en) * | 2003-10-29 | 2010-03-09 | Toagosei Co., Ltd | Antimicrobial peptides and utilization of the same |
| WO2005060541A2 (en) * | 2003-12-01 | 2005-07-07 | Wisconsin Alumni Research Foundation | Peptides and methods for inducing cellular resistance to infection |
| US20050203150A1 (en) * | 2004-03-09 | 2005-09-15 | Haffar Omar K. | Compounds, compositions and methods for inhibiting or treating HIV-1 |
| JP4507080B2 (ja) * | 2004-07-30 | 2010-07-21 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| WO2006056227A1 (en) * | 2004-11-27 | 2006-06-01 | Eberhard-Karls- Universität Tübingen Universitätsklinikum | Conjugates comprising the active agent and flanking or branched-chain peptides |
| JP4730584B2 (ja) | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| US20090030179A1 (en) * | 2005-02-15 | 2009-01-29 | Toagosei Co., Ltd | Antimicrobial peptide and use thereof |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US20110105408A1 (en) * | 2008-02-22 | 2011-05-05 | Inter-K Pty Limited | Therapeutic peptides |
| WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
| WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| JP2012533521A (ja) | 2008-07-17 | 2012-12-27 | ニュートリペップ・ピーティーワイ・リミテッド | 治療剤 |
| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| WO2012048721A1 (en) | 2010-10-14 | 2012-04-19 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| KR20160023669A (ko) | 2013-06-26 | 2016-03-03 | 자이겐 인플라메이션 리미티드 | 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도 |
| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| HUE049292T2 (hu) | 2013-08-07 | 2020-09-28 | Yeda Res & Dev | A P53 mutánsok újraaktíválására képes peptidek |
| KR20150050646A (ko) * | 2013-10-29 | 2015-05-11 | 삼성전자주식회사 | 융합 펩타이드 및 이의 세포막투과를 위한 용도 |
| CN108884137B (zh) * | 2016-02-04 | 2022-04-05 | 耶达研究及发展有限公司 | 肽及其在治疗与突变型p53相关的疾病、病症或病况中的用途 |
| BR112022011744A2 (pt) * | 2020-02-18 | 2022-09-20 | Cellivery Therapeutics Inc | Peptídeo sintético inibidor de importação nuclear permeável à célula melhorado para inibição de tempestade de citocina ou doença inflamatória e uso do mesmo |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| IL106760A (en) * | 1992-08-25 | 1999-12-31 | Miles Inc | Protein-nucleic acid hybrid construct for translocating an exogenous nucleic acid into a target cell and nucleus |
| JPH09510352A (ja) * | 1994-03-15 | 1997-10-21 | プリズム ファーマシューティカルズ，インコーポレイティド | 遺伝子療法及び前部の眼疾患のためのヘパリン結合成長因子 |
| WO1995031999A1 (en) * | 1994-05-23 | 1995-11-30 | Immunogiology Research Institute, Inc. | Compositions of transactivating proteins of human immunodeficiency virus |
| US5807746A (en) * | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
-
1997
- 1997-09-12 US US08/928,958 patent/US5877282A/en not_active Expired - Lifetime
- 1997-09-15 WO PCT/US1997/016217 patent/WO1998011907A1/en not_active Ceased
- 1997-09-15 AU AU43455/97A patent/AU731725B2/en not_active Ceased
- 1997-09-15 CA CA002265571A patent/CA2265571A1/en not_active Abandoned
- 1997-09-15 JP JP51477498A patent/JP2002514053A/ja not_active Withdrawn
- 1997-09-15 EP EP97941572A patent/EP1015012A4/en not_active Withdrawn
- 1997-09-19 TW TW86113642A patent/TW575580B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU731725B2 (en) | 2001-04-05 |
| US5877282A (en) | 1999-03-02 |
| AU4345597A (en) | 1998-04-14 |
| JP2002514053A (ja) | 2002-05-14 |
| WO1998011907A1 (en) | 1998-03-26 |
| TW575580B (en) | 2004-02-11 |
| EP1015012A1 (en) | 2000-07-05 |
| EP1015012A4 (en) | 2004-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |