CA2264610A1 - Sequences de liaison peptidiques ramifiees - Google Patents

Sequences de liaison peptidiques ramifiees Download PDF

Info

Publication number
CA2264610A1
CA2264610A1 CA002264610A CA2264610A CA2264610A1 CA 2264610 A1 CA2264610 A1 CA 2264610A1 CA 002264610 A CA002264610 A CA 002264610A CA 2264610 A CA2264610 A CA 2264610A CA 2264610 A1 CA2264610 A1 CA 2264610A1
Authority
CA
Canada
Prior art keywords
compound
formula
integer
lys
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002264610A
Other languages
English (en)
Inventor
Dalton King
Raymond A. Firestone
Gene M. Dubowchik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2264610A1 publication Critical patent/CA2264610A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/641—Branched, dendritic or hypercomb peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention concerne des conjugués contenant un ligand ciblé tel qu'un anticorps, un médicament thérapeutiquement actif, et une séquence de liaison peptidique ramifiée. Cette séquence de liaison peptidique ramifiée contient au moins deux fractions acide aminé qui constituent un site de clivage d'enzyme. Le nombre de médicaments qu'il est possible de lier aux séquences de liaison ramifiées est multiplié par 2 à chaque génération de ramification.
CA002264610A 1996-11-05 1997-10-31 Sequences de liaison peptidiques ramifiees Abandoned CA2264610A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3036796P 1996-11-05 1996-11-05
US60/030,367 1996-11-05
PCT/US1997/019851 WO1998019705A1 (fr) 1996-11-05 1997-10-31 Sequences de liaison peptidiques ramifiees

Publications (1)

Publication Number Publication Date
CA2264610A1 true CA2264610A1 (fr) 1998-05-14

Family

ID=21853889

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002264610A Abandoned CA2264610A1 (fr) 1996-11-05 1997-10-31 Sequences de liaison peptidiques ramifiees

Country Status (5)

Country Link
EP (1) EP0941120A4 (fr)
JP (1) JP2001505194A (fr)
AU (1) AU5159798A (fr)
CA (1) CA2264610A1 (fr)
WO (1) WO1998019705A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550609B2 (en) 1999-11-24 2009-06-23 Immunogen Inc. Cytotoxic agents comprising taxanes and their therapeutic use

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739028B2 (en) * 1996-09-27 2001-10-04 Bristol-Myers Squibb Company Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
US6261537B1 (en) 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
CA2270120A1 (fr) 1996-10-28 1998-05-07 Pal Rongved Ameliorations apportees a des agents diagnostiques et/ou therapeutiques ou les concernant
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
EP1033372A4 (fr) * 1997-11-18 2000-10-04 Chugai Pharmaceutical Co Ltd Composes possedant une activite antitumorale
US6835807B1 (en) * 1998-05-22 2004-12-28 Daiichi Pharmaceuticals Co., Ltd. Drug complex and drug delivery system
EA003790B1 (ru) * 1998-10-30 2003-10-30 Дайити Фармасьютикал Ко., Лтд. Соединение сдлс и способ его измерения
AU768027B2 (en) * 1999-02-24 2003-11-27 Uab Research Foundation, The Taxane derivatives for targeted therapy of cancer
AU772074B2 (en) * 1999-04-28 2004-04-08 Vectramed, Inc. Enzymatically activated polymeric drug conjugates
DE10048417A1 (de) * 2000-09-29 2002-04-11 Roche Diagnostics Gmbh Verbindungen mit verzweigtem Linker
US6825166B2 (en) 2001-03-23 2004-11-30 Tapestry Pharmaceuticals, Inc. Molecular conjugates for use in treatment of cancer
AU2002366303B2 (en) * 2001-12-17 2007-09-20 University College Cardiff Consultants Limited Enzymatic cleavable reagents for specific delivery to disease sites
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
BR0313197A (pt) 2002-08-02 2005-08-09 Immunogen Inc Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico
WO2004019993A1 (fr) * 2002-08-30 2004-03-11 Ramot At Tel Aviv University Ltd. Dendrimeres auto-immolateurs liberant plusieurs fragments actifs lors d'un seul evenement activateur
EP1560599A1 (fr) * 2002-11-14 2005-08-10 Syntarga B.V. Promedicaments con us en tant qu'espaceurs de liberation multiple a elimination automatique
US6906158B2 (en) 2003-03-13 2005-06-14 Irm, Llc Compositions and methods of vinyl oxazolone polymerization
US20040228831A1 (en) * 2003-05-15 2004-11-18 Belinka Benjamin A. Polymeric conjugates for tissue activated drug delivery
JP2007501014A (ja) * 2003-08-05 2007-01-25 ウイスコンシン アラムニ リサーチ ファンデーション 化学療法剤の送達のための標的化されたキャリア融合物
SG173313A1 (en) 2005-01-05 2011-08-29 Biogen Idec Inc Cripto binding molecules
DK2068886T3 (da) * 2006-10-03 2013-11-18 Tekmira Pharmaceuticals Corp Lipidholdige præparater
US9738707B2 (en) 2011-07-15 2017-08-22 Biogen Ma Inc. Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
KR102104686B1 (ko) 2012-01-10 2020-04-24 바이오젠 엠에이 인코포레이티드 뇌혈관 장벽을 통한 치료학적 분자의 수송 개선법
WO2014194030A2 (fr) * 2013-05-31 2014-12-04 Immunogen, Inc. Conjugués comprenant des agents de liaison cellulaire et des agents cytotoxiques
RU2689388C1 (ru) * 2013-12-16 2019-05-28 Дженентек, Инк. Пептидомиметические соединения и их конъюгаты антител с лекарственными средствами
EP3082875B1 (fr) 2013-12-16 2020-11-25 Genentech, Inc. Composés peptidomimétiques et conjugués anticorps-médicament de ceux-ci
MX2016009862A (es) 2014-02-17 2016-10-31 Seattle Genetics Inc Conjugados de anticuerpo-farmaco hidrofilicos.
WO2015148126A1 (fr) 2014-03-12 2015-10-01 Invictus Oncology Pvt. Ltd. Administration ciblée d'un médicament faisant appel à des coupleurs fondés sur l'affinité
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
JP2018524295A (ja) 2015-06-15 2018-08-30 ジェネンテック， インコーポレイテッド 抗体及び免疫複合体
AU2016359234B2 (en) 2015-11-25 2022-09-08 Legochem Biosciences, Inc. Conjugates comprising peptide groups and methods related thereto
CN113599533A (zh) 2015-11-25 2021-11-05 乐高化学生物科学股份有限公司 包含分支接头的抗体-药物缀合物及其相关方法
KR20180079452A (ko) 2015-11-25 2018-07-10 주식회사 레고켐 바이오사이언스 자기-희생기를 포함하는 접합체 및 이의 제조방법
AU2018246806B2 (en) 2017-03-29 2022-05-12 Legochem Biosciences, Inc. Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof
EP3755707A1 (fr) 2018-02-20 2020-12-30 Seagen Inc. Composés d'auristatine f hydrophobes et conjugués de ceux-ci
JP7459063B2 (ja) 2018-05-09 2024-04-01 レゴケム バイオサイエンシズ， インク． 抗－ｃｄ１９抗体薬物複合体に関連する組成物および方法
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
WO2022029420A1 (fr) 2020-08-03 2022-02-10 Bicycletx Limited Lieurs à base de peptides
CN116348479A (zh) 2020-09-30 2023-06-27 豪夫迈·罗氏有限公司 用于产生丝状噬菌体的细菌菌毛蛋白质复合物FimGt-DsF稳定蛋白质复合物
KR20240016287A (ko) * 2021-06-01 2024-02-06 아지노모토 가부시키가이샤 항체 및 기능성 물질의 콘쥬게이트 또는 이의 염, 및 이의 제조에 사용되는 화합물 또는 이의 염

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084560A (en) * 1986-06-30 1992-01-28 Oncogen Immunoconjugates and methods for their use in tumor therapy
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5563250A (en) * 1987-12-02 1996-10-08 Neorx Corporation Cleavable conjugates for the delivery and release of agents in native form
US5017693A (en) * 1987-12-02 1991-05-21 Neorx Corporation Methods for introducing a sulfhydryl amino or hydroxyl groups to a compound
IL106992A (en) * 1988-02-11 1994-06-24 Bristol Myers Squibb Co Noble hydrazonic history of anthracycline and methods for their preparation
US5252713A (en) * 1988-09-23 1993-10-12 Neorx Corporation Polymeric carriers for non-covalent drug conjugation
US5116944A (en) * 1989-12-29 1992-05-26 Neorx Corporation Conjugates having improved characteristics for in vivo administration
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
CA2107553C (fr) * 1991-04-05 2001-07-31 Nancy Lin Anticorps monoclonaux contre les recepteurs du facteur de croissance des cellules-souches
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550609B2 (en) 1999-11-24 2009-06-23 Immunogen Inc. Cytotoxic agents comprising taxanes and their therapeutic use
US7585857B2 (en) 1999-11-24 2009-09-08 Immunogen Inc. Cytotoxic agents comprising taxanes and their therapeutic use

Also Published As

Publication number Publication date
EP0941120A1 (fr) 1999-09-15
WO1998019705A1 (fr) 1998-05-14
EP0941120A4 (fr) 2004-08-18
JP2001505194A (ja) 2001-04-17
AU5159798A (en) 1998-05-29

Similar Documents

Publication Publication Date Title
CA2264610A1 (fr) Sequences de liaison peptidiques ramifiees
US6759509B1 (en) Branched peptide linkers
US6214345B1 (en) Lysosomal enzyme-cleavable antitumor drug conjugates
US10214560B2 (en) Branched linker for protein drug conjugates
US6512101B1 (en) Branched hydrazone linkers
US6620916B1 (en) Modified physiologically active proteins and medicinal compositions containing the same
US5773522A (en) Polymer-bound camptothecin derivatives
KR20020030270A (ko) Ｆａｐ-활성화된 항종양 화합물
NO180417B (no) Syrelabile linkermolekyler
PT2357006E (pt) Conjugados de fármacos e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infeciosa
DE102005009099A1 (de) Proteinbindende Camptothecin-Peptid-Derivate und diese enthaltende Arzneimittel
CA3070893A1 (fr) Lieurs au tetramaleimide et utilisation de ces derniers
CA3062977A1 (fr) Linkers peptidiques et conjugues de cryptophycine, utiles en therapie, et leur preparation
CN104906592B (zh) 用于蛋白质药物偶联物的支链联接体
WO2024012566A9 (fr) Anticorps, lieurs, charge utile, conjugués et leurs applications
KR20010012558A (ko) 20(ｓ) 캄프토테신 당결합체

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead