CA2260423C - Pharmaceutical composition of hedgehog proteins and use thereof - Google Patents

Pharmaceutical composition of hedgehog proteins and use thereof Download PDF

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Publication number
CA2260423C
CA2260423C CA002260423A CA2260423A CA2260423C CA 2260423 C CA2260423 C CA 2260423C CA 002260423 A CA002260423 A CA 002260423A CA 2260423 A CA2260423 A CA 2260423A CA 2260423 C CA2260423 C CA 2260423C
Authority
CA
Canada
Prior art keywords
carrier matrix
pharmaceutical composition
hedgehog protein
sulfate
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002260423A
Other languages
English (en)
French (fr)
Other versions
CA2260423A1 (en
Inventor
Kurt Lang
Apollon Papadimitriou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of CA2260423A1 publication Critical patent/CA2260423A1/en
Application granted granted Critical
Publication of CA2260423C publication Critical patent/CA2260423C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002260423A 1998-02-04 1999-01-28 Pharmaceutical composition of hedgehog proteins and use thereof Expired - Fee Related CA2260423C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98101893 1998-02-04
EP98104416 1998-03-12
EP98104416.7 1998-03-12
EP98101893.0 1998-03-12

Publications (2)

Publication Number Publication Date
CA2260423A1 CA2260423A1 (en) 1999-08-04
CA2260423C true CA2260423C (en) 2006-06-20

Family

ID=26149005

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002260423A Expired - Fee Related CA2260423C (en) 1998-02-04 1999-01-28 Pharmaceutical composition of hedgehog proteins and use thereof

Country Status (14)

Country Link
JP (1) JP3092706B2 (no)
KR (2) KR19990072406A (no)
CN (1) CN1228994A (no)
AT (1) ATE331533T1 (no)
AU (1) AU713568B2 (no)
CA (1) CA2260423C (no)
CZ (1) CZ33799A3 (no)
DE (1) DE69932113T2 (no)
HU (1) HUP9900251A3 (no)
IL (1) IL128329A (no)
MA (1) MA26602A1 (no)
NO (1) NO990471L (no)
NZ (1) NZ334065A (no)
SG (1) SG66504A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
KR100452752B1 (ko) * 2000-04-18 2004-10-12 주식회사 펩트론 단백질 함유 서방성 제제를 제조하는 방법 및 그 제제
KR101705323B1 (ko) * 2010-03-23 2017-02-13 코웨이 주식회사 역삼투막 방식의 정수기
CN102174794B (zh) * 2011-03-07 2012-08-15 江苏科技大学 一种六点支撑架桥作业平台自动调平系统及方法
KR102176832B1 (ko) * 2017-11-29 2020-11-10 주식회사 파이안바이오테크놀로지 헤지호그 단백질 및 생체 적합성 물질을 포함하는 미세 입자 및 이를 포함하는 탈모 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
KR19990072406A (ko) 1999-09-27
KR100311565B1 (ko) 2001-11-02
DE69932113D1 (de) 2006-08-10
SG66504A1 (en) 2000-07-18
AU1542699A (en) 1999-08-26
AU713568B2 (en) 1999-12-02
IL128329A (en) 2005-08-31
NZ334065A (en) 2000-06-23
NO990471L (no) 1999-08-05
CA2260423A1 (en) 1999-08-04
CN1228994A (zh) 1999-09-22
HU9900251D0 (en) 1999-03-29
JP2000119193A (ja) 2000-04-25
CZ33799A3 (cs) 1999-08-11
NO990471D0 (no) 1999-02-01
KR19990072423A (ko) 1999-09-27
HUP9900251A2 (hu) 1999-09-28
HUP9900251A3 (en) 2001-01-29
MA26602A1 (fr) 2004-12-20
DE69932113T2 (de) 2007-01-25
ATE331533T1 (de) 2006-07-15
IL128329A0 (en) 2000-01-31
JP3092706B2 (ja) 2000-09-25

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