HU9900251D0 - Pharmaceutical compositions containing hedgehog proteins and use of former compositions - Google Patents
Pharmaceutical compositions containing hedgehog proteins and use of former compositionsInfo
- Publication number
- HU9900251D0 HU9900251D0 HU9900251A HUP9900251A HU9900251D0 HU 9900251 D0 HU9900251 D0 HU 9900251D0 HU 9900251 A HU9900251 A HU 9900251A HU P9900251 A HUP9900251 A HU P9900251A HU 9900251 D0 HU9900251 D0 HU 9900251D0
- Authority
- HU
- Hungary
- Prior art keywords
- carrier
- hedgehog protein
- hedgehog proteins
- former
- hedgehog
- Prior art date
Links
- 102000003693 Hedgehog Proteins Human genes 0.000 title abstract 6
- 108090000031 Hedgehog Proteins Proteins 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 229920000936 Agarose Polymers 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000012052 hydrophilic carrier Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical composition of a hedgehog protein which is characterized in that the hedgehog protein is bound to a hydrophilic carrier that is biocompatible and biodegradable wherein the carrier is a polymer which - binds the hedgehog protein as a negatively-charged carrier as a result of ionic interactions, - does not denature the hedgehog protein when it binds to the carrier, - contains at least 0.1 to 2 negatively-charged residues per monomer under neutral conditions, - contains the charge in the form of acidic groups, - has an average molecular weight of at least 50,000 Da - and contains no agarose reversibly and actively releases hedgehog proteins in vivo from a carrier in a delayed manner.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98101893 | 1998-02-04 | ||
| EP98104416 | 1998-03-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9900251D0 true HU9900251D0 (en) | 1999-03-29 |
| HUP9900251A2 HUP9900251A2 (en) | 1999-09-28 |
| HUP9900251A3 HUP9900251A3 (en) | 2001-01-29 |
Family
ID=26149005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900251A HUP9900251A3 (en) | 1998-02-04 | 1999-02-03 | Pharmaceutical compositions containing hedgehog proteins and use of former compositions |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP3092706B2 (en) |
| KR (2) | KR19990072406A (en) |
| CN (1) | CN1228994A (en) |
| AT (1) | ATE331533T1 (en) |
| AU (1) | AU713568B2 (en) |
| CA (1) | CA2260423C (en) |
| CZ (1) | CZ33799A3 (en) |
| DE (1) | DE69932113T2 (en) |
| HU (1) | HUP9900251A3 (en) |
| IL (1) | IL128329A (en) |
| MA (1) | MA26602A1 (en) |
| NO (1) | NO990471L (en) |
| NZ (1) | NZ334065A (en) |
| SG (1) | SG66504A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
| KR100452752B1 (en) * | 2000-04-18 | 2004-10-12 | 주식회사 펩트론 | Preparation Method of sustained release dosage forms of protein drugs and the drugs prepared by that method |
| KR101705323B1 (en) * | 2010-03-23 | 2017-02-13 | 코웨이 주식회사 | Water purifier of reverse osmosis type |
| CN102174794B (en) * | 2011-03-07 | 2012-08-15 | 江苏科技大学 | Automatic leveling system and method for six-point support bridging platform |
| KR102176832B1 (en) * | 2017-11-29 | 2020-11-10 | 주식회사 파이안바이오테크놀로지 | A microparticle comprising hedgehog protein and biocompatible material and a composition for preventing or treating hair loss comprising the same |
-
1999
- 1999-01-28 CA CA002260423A patent/CA2260423C/en not_active Expired - Fee Related
- 1999-02-01 MA MA25446A patent/MA26602A1/en unknown
- 1999-02-01 NO NO990471A patent/NO990471L/en unknown
- 1999-02-01 CZ CZ99337A patent/CZ33799A3/en unknown
- 1999-02-02 IL IL12832999A patent/IL128329A/en active IP Right Grant
- 1999-02-03 HU HU9900251A patent/HUP9900251A3/en unknown
- 1999-02-03 SG SG1999000333A patent/SG66504A1/en unknown
- 1999-02-04 NZ NZ334065A patent/NZ334065A/en unknown
- 1999-02-04 DE DE69932113T patent/DE69932113T2/en not_active Expired - Fee Related
- 1999-02-04 KR KR1019990003669A patent/KR19990072406A/en active Search and Examination
- 1999-02-04 JP JP11027836A patent/JP3092706B2/en not_active Expired - Fee Related
- 1999-02-04 CN CN99101764A patent/CN1228994A/en active Pending
- 1999-02-04 AT AT99101642T patent/ATE331533T1/en not_active IP Right Cessation
- 1999-02-04 AU AU15426/99A patent/AU713568B2/en not_active Ceased
- 1999-02-04 KR KR1019990003759A patent/KR100311565B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2260423A1 (en) | 1999-08-04 |
| HUP9900251A3 (en) | 2001-01-29 |
| NO990471D0 (en) | 1999-02-01 |
| CZ33799A3 (en) | 1999-08-11 |
| AU713568B2 (en) | 1999-12-02 |
| IL128329A0 (en) | 2000-01-31 |
| CN1228994A (en) | 1999-09-22 |
| ATE331533T1 (en) | 2006-07-15 |
| AU1542699A (en) | 1999-08-26 |
| KR100311565B1 (en) | 2001-11-02 |
| IL128329A (en) | 2005-08-31 |
| CA2260423C (en) | 2006-06-20 |
| HUP9900251A2 (en) | 1999-09-28 |
| NZ334065A (en) | 2000-06-23 |
| SG66504A1 (en) | 2000-07-18 |
| JP3092706B2 (en) | 2000-09-25 |
| JP2000119193A (en) | 2000-04-25 |
| DE69932113T2 (en) | 2007-01-25 |
| MA26602A1 (en) | 2004-12-20 |
| NO990471L (en) | 1999-08-05 |
| KR19990072406A (en) | 1999-09-27 |
| KR19990072423A (en) | 1999-09-27 |
| DE69932113D1 (en) | 2006-08-10 |
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