ECSP992851A - PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS - Google Patents

PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS

Info

Publication number
ECSP992851A
ECSP992851A ECSP992851A ECSP992851A EC SP992851 A ECSP992851 A EC SP992851A EC SP992851 A ECSP992851 A EC SP992851A EC SP992851 A ECSP992851 A EC SP992851A
Authority
EC
Ecuador
Prior art keywords
hedgehog
support
proteins
protein
negatively charged
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Kurt Lang
Apollon Papadimitriou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP992851 priority Critical patent/ECSP992851A/en
Publication of ECSP992851A publication Critical patent/ECSP992851A/en

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una composición farmacéutica de una proteína "erizo" que se caracteriza porque la proteina "erizo" se une a un soporte hidrofilico que es biocompatible y biodegradable, en donde el soporte es un polímero, el cual: -se une a la proteína "erizo" como un soporte cargado negativamente a causa de interacciones iónicas, -no desnaturtaliza la proteína "erizo" cuando está se une al soporte, -contiene por lo menos de 0,1 a 2 radicales cargados negativamente por monómero en condiciones neutras, -contiene la carga en forma de grupos de caracter ácido, -tiene un peso molecular medio de por lo menos 50000Da, -y no contiene agarosa, reversible y activamente libera las proteínas "erizo" in vivo a partir de un soporte, en forma retardada.A pharmaceutical composition of a "hedgehog" protein characterized in that the "hedgehog" protein binds to a hydrophilic support that is biocompatible and biodegradable, where the support is a polymer, which: -binds to the "hedgehog" protein as a negatively charged support due to ionic interactions, -does not denaturize the "hedgehog" protein when bound to the support, -contains at least 0.1 to 2 negatively charged radicals per monomer under neutral conditions, -contains charge as acidic groups, -has an average molecular weight of at least 50,000Da, -and does not contain agarose, reversibly and actively releases "hedgehog" proteins in vivo from a support, in a delayed manner.

ECSP992851 1999-02-04 1999-02-04 PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS ECSP992851A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP992851 ECSP992851A (en) 1999-02-04 1999-02-04 PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP992851 ECSP992851A (en) 1999-02-04 1999-02-04 PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS

Publications (1)

Publication Number Publication Date
ECSP992851A true ECSP992851A (en) 2000-09-22

Family

ID=42043840

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP992851 ECSP992851A (en) 1999-02-04 1999-02-04 PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS

Country Status (1)

Country Link
EC (1) ECSP992851A (en)

Similar Documents

Publication Publication Date Title
WO2004032862A3 (en) Cyclodextrin-based materials, compositions and uses related thereto
CA2621824A1 (en) Interpenetrating networks, and related methods and compositions
DE60208172D1 (en) MULTICOLORED BLOCK COPOLYMERS AND PHARMACEUTICAL COMPOSITION
ATE422880T1 (en) HETEROFUNCTIONAL COPOLYMERS OF GLYCEROL AND POLYETHYLENE GLYCOL, THEIR CONJUGATES AND COMPOSITIONS
AR014940A1 (en) A CARRIER FOR THE RELEASE OF A BIOACTIVE AGENT, A BIODEGRADABLE POLYESTER POLYMER, COPOLIMEROS AND PHARMACEUTICAL COMPOSITIONS THAT CONNECT THEM.
BRPI0414017A (en) multi-arm polymeric prodrugs
CA2406650A1 (en) Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
MX2010001219A (en) Tunably crosslinked hyaluronic acid compositions.
ATE483777T1 (en) AMPHIPHILIC BLOCK COPOLYMERS AND THEIR USE
CA2276661A1 (en) Personal wash liquid composition comprising low viscosity oils pre-thickened by non-antifoaming hydrophobic polymers
BR9812788A (en) Liquid detergent compositions comprising polymeric foam enhancers
DE69835692D1 (en) LOADED LIPIDS AND THEIR USE
WO2004060405A8 (en) Tissue reactive compounds and compositions and uses thereof
ATE252919T1 (en) COMPOSITIONS AND THEIR USE FOR PREVENTING ADHESIONS BETWEEN BODY TISSUES
CA2348495A1 (en) Intraocular lenses made from polymeric compositions
MX341715B (en) Self-assembling amphiphilic polymers as anticancer agents.
BR0003987A (en) Laxative composition
ATE482689T1 (en) BLOCK COPOLYMER MICELLAR COMPOSITION WITH IMPROVED DRUG LOADING CAPACITY AND SUSTAINED RELEASE
GB9924502D0 (en) Polymer blend materials
Rezaei et al. Smart materials in regenerative medicine
PT975334E (en) BIODEGRADABLE MICROPARTICLES FOR THE SUSTAINED LIBERATION OF THERAPEUTIC PHARMACOS
ECSP992851A (en) PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS
Logeart-Avramoglou et al. Interaction of specifically chemically modified dextrans with transforming growth factor β1: potentiation of its biological activity
CO4810246A1 (en) HIGH ACTIVITY AND REDUCED ALLERGENCITY POLYPEPTIDES
ATE331533T1 (en) PHARMACEUTICAL COMPOSITIONS OF HEDGEHOG PROTEINS AND THEIR USE