ECSP992851A - PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS - Google Patents
PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINSInfo
- Publication number
- ECSP992851A ECSP992851A ECSP992851A ECSP992851A EC SP992851 A ECSP992851 A EC SP992851A EC SP992851 A ECSP992851 A EC SP992851A EC SP992851 A ECSP992851 A EC SP992851A
- Authority
- EC
- Ecuador
- Prior art keywords
- hedgehog
- support
- proteins
- protein
- negatively charged
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composición farmacéutica de una proteína "erizo" que se caracteriza porque la proteina "erizo" se une a un soporte hidrofilico que es biocompatible y biodegradable, en donde el soporte es un polímero, el cual: -se une a la proteína "erizo" como un soporte cargado negativamente a causa de interacciones iónicas, -no desnaturtaliza la proteína "erizo" cuando está se une al soporte, -contiene por lo menos de 0,1 a 2 radicales cargados negativamente por monómero en condiciones neutras, -contiene la carga en forma de grupos de caracter ácido, -tiene un peso molecular medio de por lo menos 50000Da, -y no contiene agarosa, reversible y activamente libera las proteínas "erizo" in vivo a partir de un soporte, en forma retardada.A pharmaceutical composition of a "hedgehog" protein characterized in that the "hedgehog" protein binds to a hydrophilic support that is biocompatible and biodegradable, where the support is a polymer, which: -binds to the "hedgehog" protein as a negatively charged support due to ionic interactions, -does not denaturize the "hedgehog" protein when bound to the support, -contains at least 0.1 to 2 negatively charged radicals per monomer under neutral conditions, -contains charge as acidic groups, -has an average molecular weight of at least 50,000Da, -and does not contain agarose, reversibly and actively releases "hedgehog" proteins in vivo from a support, in a delayed manner.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP992851 ECSP992851A (en) | 1999-02-04 | 1999-02-04 | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP992851 ECSP992851A (en) | 1999-02-04 | 1999-02-04 | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP992851A true ECSP992851A (en) | 2000-09-22 |
Family
ID=42043840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP992851 ECSP992851A (en) | 1999-02-04 | 1999-02-04 | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP992851A (en) |
-
1999
- 1999-02-04 EC ECSP992851 patent/ECSP992851A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004032862A3 (en) | Cyclodextrin-based materials, compositions and uses related thereto | |
CA2621824A1 (en) | Interpenetrating networks, and related methods and compositions | |
DE60208172D1 (en) | MULTICOLORED BLOCK COPOLYMERS AND PHARMACEUTICAL COMPOSITION | |
ATE422880T1 (en) | HETEROFUNCTIONAL COPOLYMERS OF GLYCEROL AND POLYETHYLENE GLYCOL, THEIR CONJUGATES AND COMPOSITIONS | |
AR014940A1 (en) | A CARRIER FOR THE RELEASE OF A BIOACTIVE AGENT, A BIODEGRADABLE POLYESTER POLYMER, COPOLIMEROS AND PHARMACEUTICAL COMPOSITIONS THAT CONNECT THEM. | |
BRPI0414017A (en) | multi-arm polymeric prodrugs | |
CA2406650A1 (en) | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites | |
MX2010001219A (en) | Tunably crosslinked hyaluronic acid compositions. | |
ATE483777T1 (en) | AMPHIPHILIC BLOCK COPOLYMERS AND THEIR USE | |
CA2276661A1 (en) | Personal wash liquid composition comprising low viscosity oils pre-thickened by non-antifoaming hydrophobic polymers | |
BR9812788A (en) | Liquid detergent compositions comprising polymeric foam enhancers | |
DE69835692D1 (en) | LOADED LIPIDS AND THEIR USE | |
WO2004060405A8 (en) | Tissue reactive compounds and compositions and uses thereof | |
ATE252919T1 (en) | COMPOSITIONS AND THEIR USE FOR PREVENTING ADHESIONS BETWEEN BODY TISSUES | |
CA2348495A1 (en) | Intraocular lenses made from polymeric compositions | |
MX341715B (en) | Self-assembling amphiphilic polymers as anticancer agents. | |
BR0003987A (en) | Laxative composition | |
ATE482689T1 (en) | BLOCK COPOLYMER MICELLAR COMPOSITION WITH IMPROVED DRUG LOADING CAPACITY AND SUSTAINED RELEASE | |
GB9924502D0 (en) | Polymer blend materials | |
Rezaei et al. | Smart materials in regenerative medicine | |
PT975334E (en) | BIODEGRADABLE MICROPARTICLES FOR THE SUSTAINED LIBERATION OF THERAPEUTIC PHARMACOS | |
ECSP992851A (en) | PHARMACEUTICAL COMPOSITIONS OF Hedgehog PROTEINS AND THE USE OF THE PROTEINS | |
Logeart-Avramoglou et al. | Interaction of specifically chemically modified dextrans with transforming growth factor β1: potentiation of its biological activity | |
CO4810246A1 (en) | HIGH ACTIVITY AND REDUCED ALLERGENCITY POLYPEPTIDES | |
ATE331533T1 (en) | PHARMACEUTICAL COMPOSITIONS OF HEDGEHOG PROTEINS AND THEIR USE |