CA2260233A1 - A scalable method of preserving biologically active materials by desiccation - Google Patents
A scalable method of preserving biologically active materials by desiccation Download PDFInfo
- Publication number
- CA2260233A1 CA2260233A1 CA002260233A CA2260233A CA2260233A1 CA 2260233 A1 CA2260233 A1 CA 2260233A1 CA 002260233 A CA002260233 A CA 002260233A CA 2260233 A CA2260233 A CA 2260233A CA 2260233 A1 CA2260233 A1 CA 2260233A1
- Authority
- CA
- Canada
- Prior art keywords
- foam
- solution
- temperature
- biologically active
- dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 46
- 239000011149 active material Substances 0.000 title claims abstract description 16
- 239000006260 foam Substances 0.000 claims abstract description 42
- 238000001035 drying Methods 0.000 claims abstract description 29
- 239000000243 solution Substances 0.000 claims abstract description 28
- 239000000725 suspension Substances 0.000 claims abstract description 22
- 239000006185 dispersion Substances 0.000 claims abstract description 13
- 238000009835 boiling Methods 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 238000003860 storage Methods 0.000 claims description 12
- 238000004321 preservation Methods 0.000 claims description 6
- 230000002706 hydrostatic effect Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000002577 cryoprotective agent Substances 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000001223 reverse osmosis Methods 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 239000012530 fluid Substances 0.000 abstract description 7
- 238000005187 foaming Methods 0.000 abstract description 5
- 239000000758 substrate Substances 0.000 abstract description 4
- 239000000839 emulsion Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 4
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000013341 scale-up Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 239000000654 additive Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000006910 ice nucleation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Colloid Chemistry (AREA)
- Drying Of Solid Materials (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2179696P | 1996-07-15 | 1996-07-15 | |
| US60/021,796 | 1996-07-15 | ||
| US08/785,473 US5766520A (en) | 1996-07-15 | 1997-01-17 | Preservation by foam formation |
| US08/785,473 | 1997-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2260233A1 true CA2260233A1 (en) | 1998-01-22 |
Family
ID=26695104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002260233A Abandoned CA2260233A1 (en) | 1996-07-15 | 1997-07-14 | A scalable method of preserving biologically active materials by desiccation |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5766520A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0914202A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2000515856A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100457748B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1116104C (cg-RX-API-DMAC7.html) |
| AU (1) | AU714328B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9711808A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2260233A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ7999A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE914202T1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA001138B1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUP9903917A3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL127971A (cg-RX-API-DMAC7.html) |
| NO (1) | NO990158L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ333738A (cg-RX-API-DMAC7.html) |
| PL (1) | PL331174A1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR199900127T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998002240A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9307141A (pt) | 1992-09-29 | 1999-03-30 | Inhale Therapeutic Syst | Processo para a liberação sistência pulsátil de um fragmento ativo de hormônio de paratiróide (PTH) para um hospedeiro mamífero e para um paciente e composição farmacêutica |
| CZ295827B6 (cs) | 1994-03-07 | 2005-11-16 | Nektar Therapeutics | Způsob aerosolizace dávky inzulinu, inzulinový přípravek a jeho použití |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| WO1996008979A1 (en) | 1994-09-22 | 1996-03-28 | Quadrant Holdings Cambridge Limited | Compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
| US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| US6509146B1 (en) | 1996-05-29 | 2003-01-21 | Universal Preservation Technologies, Inc. | Scalable long-term shelf preservation of sensitive biological solutions and suspensions |
| US6468782B1 (en) * | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| GB9705588D0 (en) | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| US20020035071A1 (en) * | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
| US20060116330A1 (en) * | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
| US8563522B2 (en) * | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| EP1032647B1 (en) * | 1997-11-26 | 2006-03-29 | Universal Preservation Technologies, Inc. | Preservation of sensitive biological samples by vitrification |
| US6306345B1 (en) * | 1998-05-06 | 2001-10-23 | Universal Preservation Technologies, Inc. | Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures |
| US6214054B1 (en) | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| JP2002534654A (ja) | 1999-01-05 | 2002-10-15 | ユニバーサル プリザーベーション テクノロジーズ インコーポレイテッド | 発泡乾燥装置用の真空制御システム |
| MXPA01011145A (es) * | 1999-05-04 | 2003-07-14 | Anhydro Ltd | Metodo para la conservacion de virus y micoplasma. |
| US6692695B1 (en) | 1999-05-06 | 2004-02-17 | Quadrant Drug Delivery Limited | Industrial scale barrier technology for preservation of sensitive biological materials |
| CA2382061A1 (en) * | 1999-08-19 | 2001-02-22 | Victor Bronshtein | Preservation of bacterial cells at ambient temperatures |
| WO2001037804A2 (en) * | 1999-11-22 | 2001-05-31 | Universal Preservation Technologies, Inc. | Preservation and formulation of bioactive materials |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| TWI290473B (en) | 2000-05-10 | 2007-12-01 | Alliance Pharma | Phospholipid-based powders for drug delivery |
| AU2000264912A1 (en) | 2000-06-07 | 2001-12-17 | Universal Preservation Technologies, Inc. | Industrial scale barrier technology for preservation of sensitive biological materials |
| PT1296656E (pt) | 2000-06-27 | 2006-12-29 | Hoffmann La Roche | Processo para a preparação de uma composição |
| US6537666B1 (en) * | 2000-10-23 | 2003-03-25 | Universal Preservation Technologies, Inc. | Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals |
| US6872357B1 (en) * | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
| US7153472B1 (en) * | 2000-11-22 | 2006-12-26 | Quadrant Drug Delivery Limited | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers |
| US20050074867A1 (en) * | 2001-05-07 | 2005-04-07 | Victor Bronshtein | Preservation of competent cells at ambient temperatures |
| US6884866B2 (en) * | 2001-10-19 | 2005-04-26 | Avant Immunotherapeutics, Inc. | Bulk drying and the effects of inducing bubble nucleation |
| TWI324518B (en) | 2001-12-19 | 2010-05-11 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| AU2003247337B2 (en) * | 2002-04-11 | 2007-09-06 | Medimmune, Llc | Preservation of bioactive materials by freeze dried foam |
| ATE352316T1 (de) * | 2002-11-01 | 2007-02-15 | Glaxosmithkline Biolog Sa | Immunogene zusammensetzung |
| US20050100559A1 (en) * | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
| US20050100636A1 (en) * | 2003-11-10 | 2005-05-12 | Megan Botteri | [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity] |
| US20050152884A1 (en) * | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
| US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
| US8877178B2 (en) * | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| US20050158294A1 (en) * | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US9744227B2 (en) | 2004-06-02 | 2017-08-29 | Universal Stabilization Technologies, Inc. | Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof |
| US9469835B2 (en) * | 2004-06-02 | 2016-10-18 | Victor Bronshtein | Preservation by vaporization |
| JP2007277094A (ja) * | 2004-06-29 | 2007-10-25 | Chemo Sero Therapeut Res Inst | 改変ダニ主要アレルゲン含有医薬組成物 |
| CN1993411B (zh) * | 2004-07-30 | 2010-11-24 | 不列颠哥伦比亚大学 | 水状胶体泡沫的制备方法 |
| PL1885383T3 (pl) * | 2005-05-31 | 2017-06-30 | Iams Europe B.V. | Kocie probiotyczne bifidobakterie |
| WO2006130187A1 (en) * | 2005-05-31 | 2006-12-07 | The Iams Company | Feline probiotic lactobacilli |
| US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| EP1973406B1 (en) | 2005-12-28 | 2014-03-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form |
| US9453675B2 (en) * | 2006-02-10 | 2016-09-27 | Sp Industries, Inc. | Method of inducing nucleation of a material |
| CN101626682B (zh) * | 2006-10-27 | 2014-04-16 | 爱德华兹生命科学公司 | 用于外科植入的生物组织 |
| JP5285617B2 (ja) | 2006-12-18 | 2013-09-11 | アドバンスド バイオニュートリション コーポレーション | 生きたプロバイオティクスを含む乾燥食物製品 |
| EP2124966B1 (en) | 2007-02-01 | 2015-09-09 | IAMS Europe B.V. | Method for decreasing inflammation and stress in a mammal using glucose antimetabolites, avocado or avocado extracts |
| EP2148923B1 (en) * | 2007-05-18 | 2012-08-22 | MedImmune, LLC | Preservation of bioactive materials by freeze dried foam |
| US9101691B2 (en) * | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| CN101801343A (zh) | 2007-07-26 | 2010-08-11 | 圣诺菲·帕斯图尔有限公司 | 抗原佐剂组合物及其方法 |
| WO2009033285A1 (en) * | 2007-09-13 | 2009-03-19 | Enwave Corporation | Apparatus and method for dehydrating biological materials |
| US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| WO2010028488A1 (en) | 2008-09-12 | 2010-03-18 | Enwave Corporation | Apparatus and method for dehydrating biological materials with freezing and microwaving |
| US9623094B2 (en) | 2009-03-27 | 2017-04-18 | Advanced Bionutrition Corporation | Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish |
| CN106987525B (zh) | 2009-05-26 | 2020-10-27 | 先进生物营养公司 | 包含生物活性微生物和/或生物活性材料的稳定干粉组合物及其制造方法 |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| WO2011032108A2 (en) * | 2009-09-13 | 2011-03-17 | Vu Truong-Le | Formulation for room temperature stabilization of a live attenuated bacterial vaccine |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
| RU2535869C2 (ru) | 2010-01-28 | 2014-12-20 | Эдванст Бионутришн Корпорейшн | Сухая стекловидная композиция для стабилизации и защиты биологически активного материала и способ ее получения |
| AU2011232510A1 (en) | 2010-03-23 | 2012-09-20 | Edwards Lifesciences Corporation | Methods of conditioning sheet bioprosthetic tissue |
| WO2011160085A2 (en) | 2010-06-17 | 2011-12-22 | Edwards Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| PL2603100T3 (pl) | 2010-08-13 | 2019-06-28 | Advanced Bionutrition Corp. | Kompozycja stabilizująca przechowywanie na sucho materiałów biologicznych |
| US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
| US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
| CA2913971C (en) | 2013-05-31 | 2022-08-02 | Universal Stabilization Technologies, Inc. | Polymeric compositions containing ambient-temperature stable biopharmaceuticals & methods for formulation thereof |
| US9615922B2 (en) | 2013-09-30 | 2017-04-11 | Edwards Lifesciences Corporation | Method and apparatus for preparing a contoured biological tissue |
| US10959839B2 (en) | 2013-10-08 | 2021-03-30 | Edwards Lifesciences Corporation | Method for directing cellular migration patterns on a biological tissue |
| AU2016282996A1 (en) | 2015-06-25 | 2018-01-18 | Ascus Biosciences, Inc. | Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon |
| US10851399B2 (en) | 2015-06-25 | 2020-12-01 | Native Microbials, Inc. | Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon |
| US9938558B2 (en) | 2015-06-25 | 2018-04-10 | Ascus Biosciences, Inc. | Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon |
| MY194231A (en) | 2015-07-29 | 2022-11-23 | Advanced Bionutrition Corp | Stable dry probiotic compositions for special dietary uses |
| CN116474004A (zh) | 2016-04-15 | 2023-07-25 | 原生微生物股份有限公司 | 通过施用微生物聚生体或其纯化菌株来提高禽类的农业生产的方法 |
| CN106434840B (zh) * | 2016-12-02 | 2019-08-09 | 北京中检葆泰生物技术有限公司 | 一种用于微生物法定量检测维生素b12的微孔板、其试剂盒及其制备方法 |
| CA3048246A1 (en) | 2016-12-28 | 2018-07-05 | Ascus Biosciences, Inc. | Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon |
| AU2017388535A1 (en) | 2016-12-28 | 2019-07-25 | Native Microbials, Inc. | Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles including dosed microbial ensembles and inoculative microbial ensembles |
| CN106676160B (zh) * | 2017-01-03 | 2020-02-21 | 北京中检葆泰生物技术有限公司 | 一种用于微生物法定量检测泛酸的微孔板、其试剂盒及其制备方法 |
| CN106591415B (zh) * | 2017-01-03 | 2019-12-10 | 北京中检葆泰生物技术有限公司 | 一种用于微生物法定量检测生物素的微孔板、其试剂盒及其制备方法 |
| CN106701887B (zh) * | 2017-01-03 | 2020-01-17 | 北京中检葆泰生物技术有限公司 | 一种用于微生物法定量检测叶酸的微孔板、其试剂盒及其制备方法 |
| CN106676161B (zh) * | 2017-01-03 | 2020-01-21 | 北京中检葆泰生物技术有限公司 | 一种用于微生物法定量检测烟酸的微孔板、其试剂盒及其制备方法 |
| US10617756B2 (en) | 2017-01-05 | 2020-04-14 | Shimojani, LLC | Drug regimen for treatment of cerebral ischemia |
| US20200085941A1 (en) * | 2017-04-28 | 2020-03-19 | Universal Stabilization Technologies, Inc. | Antigenic thermostable polio vaccines & related methods |
| CA3062547A1 (en) | 2017-05-31 | 2018-12-06 | Edwards Lifesciences Corporation | Collagen fibers and articles formed therefrom |
| CN111970933A (zh) | 2017-10-18 | 2020-11-20 | 埃斯库斯生物科技股份公司 | 通过施用微生物或其纯化菌株的合成生物集合体来提高禽类产量 |
| SG11202003938PA (en) | 2018-01-23 | 2020-08-28 | Edwards Lifesciences Corp | Method for pre-stretching implantable biocompatible materials, and materials and devices produced thereby |
| JP7138336B2 (ja) * | 2018-06-29 | 2022-09-16 | 国立大学法人九州工業大学 | 生体由来の水溶性高分子乾燥品の製造方法及びその製造装置 |
| EP3852683B1 (en) | 2018-11-01 | 2024-05-29 | Edwards Lifesciences Corporation | Transcatheter pulmonic regenerative valve |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4642903A (en) * | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
| EP0229810B1 (en) * | 1985-07-09 | 1991-10-16 | Quadrant Bioresources Limited | Protection of proteins and the like |
| US5271881A (en) * | 1987-09-28 | 1993-12-21 | Redding Bruce K | Apparatus and method for making microcapsules |
| GB8903593D0 (en) * | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
| US5200399A (en) * | 1990-09-14 | 1993-04-06 | Boyce Thompson Institute For Plant Research, Inc. | Method of protecting biological materials from destructive reactions in the dry state |
| AU659645B2 (en) * | 1991-06-26 | 1995-05-25 | Inhale Therapeutic Systems | Storage of materials |
| US5409703A (en) * | 1993-06-24 | 1995-04-25 | Carrington Laboratories, Inc. | Dried hydrogel from hydrophilic-hygroscopic polymer |
| US5565318A (en) * | 1994-09-02 | 1996-10-15 | Pharmacia Biotech, Inc. | Room temperature stable reagent semi-spheres |
| CN1245957C (zh) * | 1995-06-07 | 2006-03-22 | 廓德伦特控股剑桥有限公司 | 将物质稳定掺入干燥泡沫玻璃基质中的方法以及由此制得的组合物 |
-
1997
- 1997-01-17 US US08/785,473 patent/US5766520A/en not_active Expired - Fee Related
- 1997-07-14 DE DE0914202T patent/DE914202T1/de active Pending
- 1997-07-14 AU AU36606/97A patent/AU714328B2/en not_active Ceased
- 1997-07-14 JP JP10506201A patent/JP2000515856A/ja not_active Ceased
- 1997-07-14 BR BR9711808-7A patent/BR9711808A/pt unknown
- 1997-07-14 KR KR10-1999-7000253A patent/KR100457748B1/ko not_active Expired - Fee Related
- 1997-07-14 CA CA002260233A patent/CA2260233A1/en not_active Abandoned
- 1997-07-14 PL PL97331174A patent/PL331174A1/xx unknown
- 1997-07-14 EP EP97933415A patent/EP0914202A4/en not_active Withdrawn
- 1997-07-14 IL IL12797197A patent/IL127971A/en not_active IP Right Cessation
- 1997-07-14 CZ CZ9979A patent/CZ7999A3/cs unknown
- 1997-07-14 TR TR1999/00127T patent/TR199900127T2/xx unknown
- 1997-07-14 EA EA199900268A patent/EA001138B1/ru not_active IP Right Cessation
- 1997-07-14 HU HU9903917A patent/HUP9903917A3/hu not_active Application Discontinuation
- 1997-07-14 NZ NZ333738A patent/NZ333738A/xx unknown
- 1997-07-14 CN CN97196422A patent/CN1116104C/zh not_active Expired - Fee Related
- 1997-07-14 WO PCT/US1997/012156 patent/WO1998002240A1/en not_active Ceased
-
1999
- 1999-01-14 NO NO990158A patent/NO990158L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000515856A (ja) | 2000-11-28 |
| AU714328B2 (en) | 1999-12-23 |
| CZ7999A3 (cs) | 1999-11-17 |
| NZ333738A (en) | 2000-09-29 |
| NO990158D0 (no) | 1999-01-14 |
| EP0914202A4 (en) | 2004-09-01 |
| HUP9903917A3 (en) | 2000-06-28 |
| AU3660697A (en) | 1998-02-09 |
| US5766520A (en) | 1998-06-16 |
| WO1998002240A1 (en) | 1998-01-22 |
| EP0914202A1 (en) | 1999-05-12 |
| EA001138B1 (ru) | 2000-10-30 |
| PL331174A1 (en) | 1999-06-21 |
| IL127971A (en) | 2001-09-13 |
| IL127971A0 (en) | 1999-11-30 |
| KR20000023779A (ko) | 2000-04-25 |
| HUP9903917A2 (hu) | 2000-03-28 |
| KR100457748B1 (ko) | 2004-11-17 |
| CN1116104C (zh) | 2003-07-30 |
| CN1226842A (zh) | 1999-08-25 |
| DE914202T1 (de) | 2000-02-17 |
| BR9711808A (pt) | 2000-01-18 |
| TR199900127T2 (xx) | 1999-04-21 |
| EA199900268A1 (ru) | 1999-10-28 |
| NO990158L (no) | 1999-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5766520A (en) | Preservation by foam formation | |
| WO1998002240B1 (en) | Preservation by foam formation | |
| US6509146B1 (en) | Scalable long-term shelf preservation of sensitive biological solutions and suspensions | |
| EP1032647B1 (en) | Preservation of sensitive biological samples by vitrification | |
| EP1750760B1 (en) | Preservation by vaporization | |
| US20030022333A1 (en) | Long-term shelf preservation by vitrification | |
| Hahn-Hägerdal | Water activity: a possible external regulator in biotechnical processes | |
| US6653062B1 (en) | Preservation and storage medium for biological materials | |
| US6872357B1 (en) | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying | |
| CN1237873C (zh) | 通过干燥处理制备于环境温度贮存的含有需稳定化的敏感性生物制品的保存用混合物 | |
| AU2001268057A1 (en) | Preservation and storage medium for biological materials | |
| CN115024310B (zh) | 一种细胞冻干保存剂及其制备方法 | |
| CN1286725A (zh) | 敏感性生物样品的玻化保质法 | |
| MXPA00005123A (en) | Preservation of sensitive biological samples by vitrification | |
| Rapoporta et al. | Anhydrobiosis in Yeast: Stabilization by Exogenous Lactose1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |