CA2258683C - Composition orale comprenant un compose antifongique de triazole - Google Patents

Composition orale comprenant un compose antifongique de triazole Download PDF

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Publication number
CA2258683C
CA2258683C CA002258683A CA2258683A CA2258683C CA 2258683 C CA2258683 C CA 2258683C CA 002258683 A CA002258683 A CA 002258683A CA 2258683 A CA2258683 A CA 2258683A CA 2258683 C CA2258683 C CA 2258683C
Authority
CA
Canada
Prior art keywords
composition
beads
antifungal compound
surfactant
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002258683A
Other languages
English (en)
Other versions
CA2258683A1 (fr
Inventor
Surendra A. Sangekar
Winston A. Vadino
Ping I. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2258683A1 publication Critical patent/CA2258683A1/fr
Application granted granted Critical
Publication of CA2258683C publication Critical patent/CA2258683C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composition pharmaceutique comprenant: i) des perles sensiblement inertes qui sont enrobées ii) d'un agent antifongique qui est (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorophényl)-tétrahydro-5-(1H-1,2,4-triazol-1-ylméthyl)furan-3-yl]méthoxy]phényl]-1-pipérazinyl]phényl]-2,4-dihydro-2-[(S)-1-éthyl-2(S)-hydroxypropyl]-3H-1,2,4-triazol-3-one; iii) un liant permettant au composé antifongique d'adhérer auxdites perles. La composition permet au composé antifongique, qui possède une très faible solubilité dans l'eau, d'avoir une meilleure biodisponibilité chez les mammifères tels que les êtres humains.
CA002258683A 1996-06-28 1997-06-25 Composition orale comprenant un compose antifongique de triazole Expired - Fee Related CA2258683C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67243296A 1996-06-28 1996-06-28
US08/672,432 1996-06-28
PCT/US1997/010122 WO1998000116A1 (fr) 1996-06-28 1997-06-25 Composition orale comprenant un compose antifongique de triazole

Publications (2)

Publication Number Publication Date
CA2258683A1 CA2258683A1 (fr) 1998-01-08
CA2258683C true CA2258683C (fr) 2007-07-31

Family

ID=24698529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258683A Expired - Fee Related CA2258683C (fr) 1996-06-28 1997-06-25 Composition orale comprenant un compose antifongique de triazole

Country Status (16)

Country Link
EP (1) EP0914100A1 (fr)
JP (1) JP2000514059A (fr)
KR (1) KR20000022294A (fr)
CN (1) CN1228693A (fr)
AU (1) AU731704B2 (fr)
BR (1) BR9710069A (fr)
CA (1) CA2258683C (fr)
CZ (1) CZ421498A3 (fr)
HU (1) HUP9903869A3 (fr)
IL (1) IL127780A0 (fr)
NO (1) NO986087L (fr)
NZ (1) NZ333514A (fr)
PL (1) PL330864A1 (fr)
SK (1) SK177598A3 (fr)
TR (1) TR199802718T2 (fr)
WO (1) WO1998000116A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9806174A (pt) * 1997-03-26 1999-10-19 Janssen Pharmaceutica Nv Péletes tendo um núcleo revestido com um antifúngico e um polìmero
DE1003485T1 (de) * 1998-06-11 2000-11-02 Em Industries, Inc. Mikroosmotisches gesteuertes arzneistoffabgabesysteme
TR200002217T2 (tr) 1998-07-17 2001-02-21 Janssen Pharmaceutica N.V. Bir mantar ilacı ve bir polimer ile kaplanmış bir çekirdeğe sahip taneler.
ES2157731B1 (es) 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
FR2795961B1 (fr) * 1999-07-09 2004-05-28 Ethypharm Lab Prod Ethiques Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation
US7863331B2 (en) 1999-07-09 2011-01-04 Ethypharm Pharmaceutical composition containing fenofibrate and method for the preparation thereof
KR100694667B1 (ko) * 1999-12-08 2007-03-14 동아제약주식회사 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
EP1842532A3 (fr) * 2001-02-06 2009-04-22 Stiefel Laboratories, Inc. Formules antifongiques à dissoudre dans l'eau et prise orale, et ses procédés de fabrication
FR2842736B1 (fr) 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
ITMI20031096A1 (it) * 2003-05-30 2004-11-30 Eurand Spa Microcapsule per coacervazione contenenti farmaco incorporato nel polimero di rivestimento
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2016033549A2 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Compositions de (17-ss)-3-oxoandrost-4-èn-17-yl tridécanoate et leurs procédés de préparation et d'utilisation
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
EP3544614A4 (fr) 2016-11-28 2020-08-05 Lipocine Inc. Traitement oral à base d'undécanoate de testostérone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
PL181193B1 (pl) * 1993-12-21 2001-06-29 Schering Corp Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków

Also Published As

Publication number Publication date
HUP9903869A3 (en) 2000-07-28
TR199802718T2 (xx) 1999-03-22
CZ421498A3 (cs) 1999-06-16
SK177598A3 (en) 1999-07-12
BR9710069A (pt) 1999-08-10
HUP9903869A2 (hu) 2000-06-28
CN1228693A (zh) 1999-09-15
AU3387497A (en) 1998-01-21
PL330864A1 (en) 1999-06-07
IL127780A0 (en) 1999-10-28
NO986087D0 (no) 1998-12-23
EP0914100A1 (fr) 1999-05-12
NZ333514A (en) 2000-05-26
WO1998000116A1 (fr) 1998-01-08
KR20000022294A (ko) 2000-04-25
AU731704B2 (en) 2001-04-05
CA2258683A1 (fr) 1998-01-08
JP2000514059A (ja) 2000-10-24
NO986087L (no) 1999-02-26

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