CA2258634A1 - Inhibiteurs de la serine protease - Google Patents

Inhibiteurs de la serine protease Download PDF

Info

Publication number
CA2258634A1
CA2258634A1 CA002258634A CA2258634A CA2258634A1 CA 2258634 A1 CA2258634 A1 CA 2258634A1 CA 002258634 A CA002258634 A CA 002258634A CA 2258634 A CA2258634 A CA 2258634A CA 2258634 A1 CA2258634 A1 CA 2258634A1
Authority
CA
Canada
Prior art keywords
amino acid
solid phase
group
peptide
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002258634A
Other languages
English (en)
Inventor
Michael Finbarr Scully
Said Elgendy
Vijay Vir Kakkar
Emmanuel Skordalakes
Donovan Green
Christopher Andrew Goodwin
John Joseph Deadman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trigen Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2258634A1 publication Critical patent/CA2258634A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des inhibiteurs bifonctionnels de la sérine protéase et des procédés de préparation de peptides contenant du bore. Ces inhibiteurs comprennent une fraction catalytique dirigée qui se lie au site actif d'une sérine protéase et l'inhibe, et une fraction se liant à un exosite, ces deux fractions étant réunies par une fraction de couplage. La fraction dirigée catalytique et la fraction se liant à un exosite sont capables de se lier simultanément à une molécule de la sérine protéase.
CA002258634A 1996-06-29 1997-06-11 Inhibiteurs de la serine protease Abandoned CA2258634A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9613719.5A GB9613719D0 (en) 1996-06-29 1996-06-29 Serine protease inhibitors
GB9613719.5 1996-06-29
CN97195991A CN1223664A (zh) 1996-06-29 1997-06-11 丝氨酸蛋白酶抑制剂

Publications (1)

Publication Number Publication Date
CA2258634A1 true CA2258634A1 (fr) 1998-01-08

Family

ID=40243006

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258634A Abandoned CA2258634A1 (fr) 1996-06-29 1997-06-11 Inhibiteurs de la serine protease

Country Status (9)

Country Link
EP (1) EP0935611A1 (fr)
JP (1) JP2000516202A (fr)
KR (1) KR20000022350A (fr)
CN (1) CN1223664A (fr)
AU (1) AU729393C (fr)
CA (1) CA2258634A1 (fr)
GB (1) GB9613719D0 (fr)
NZ (1) NZ333390A (fr)
WO (1) WO1998000442A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0405267D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
US8598314B2 (en) * 2007-09-27 2013-12-03 Amylin Pharmaceuticals, Llc Peptide-peptidase-inhibitor conjugates and methods of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin

Also Published As

Publication number Publication date
WO1998000442A1 (fr) 1998-01-08
AU729393B2 (en) 2001-02-01
KR20000022350A (ko) 2000-04-25
JP2000516202A (ja) 2000-12-05
AU729393C (en) 2002-05-16
AU3042597A (en) 1998-01-21
GB9613719D0 (en) 1996-08-28
EP0935611A1 (fr) 1999-08-18
NZ333390A (en) 1999-11-29
CN1223664A (zh) 1999-07-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead