NZ333390A - Boron-containing peptides and bifunctional serine protease inhibitors - Google Patents
Boron-containing peptides and bifunctional serine protease inhibitorsInfo
- Publication number
- NZ333390A NZ333390A NZ333390A NZ33339097A NZ333390A NZ 333390 A NZ333390 A NZ 333390A NZ 333390 A NZ333390 A NZ 333390A NZ 33339097 A NZ33339097 A NZ 33339097A NZ 333390 A NZ333390 A NZ 333390A
- Authority
- NZ
- New Zealand
- Prior art keywords
- solid phase
- compound
- amino acid
- group
- functional groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
This method of making a peptide or peptide-containing compound comprises: a) providing a solid phase having a coupled thereto functional groups; b) causing a compound reactive with the functional groups selectively to react therewith; the reacted compound having a functional group capable of reacting with an amino group or with a carboxyl group or a reactive derivative thereof; c) causing the amino or carboxyl group of a terminal amino acid of a target amino acid sequence selectively to react with the functional groups of the reacted compound; d) coupling the amino acid sequentially following, in the target sequence, the sequentially preceding amino acid coupled to the solid phase of the preceding amino acid; e) repeating step (d) as often as necessary and f) cleaving a solid phase linked compound prepared using steps (a)-(e) from the solid phase by the action of an acid or base. A compound comprising a boronic acid group [-BOH)2] or a derivative thereof is incorporated in the solid phase-linked compound prior to its cleavage from the solid phase.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613719.5A GB9613719D0 (en) | 1996-06-29 | 1996-06-29 | Serine protease inhibitors |
| PCT/GB1997/001574 WO1998000442A1 (en) | 1996-06-29 | 1997-06-11 | Serine protease inhibitors |
| CN97195991A CN1223664A (en) | 1996-06-29 | 1997-06-11 | Serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ333390A true NZ333390A (en) | 1999-11-29 |
Family
ID=40243006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ333390A NZ333390A (en) | 1996-06-29 | 1997-06-11 | Boron-containing peptides and bifunctional serine protease inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0935611A1 (en) |
| JP (1) | JP2000516202A (en) |
| KR (1) | KR20000022350A (en) |
| CN (1) | CN1223664A (en) |
| AU (1) | AU729393C (en) |
| CA (1) | CA2258634A1 (en) |
| GB (1) | GB9613719D0 (en) |
| NZ (1) | NZ333390A (en) |
| WO (1) | WO1998000442A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0405267D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
| US8598314B2 (en) * | 2007-09-27 | 2013-12-03 | Amylin Pharmaceuticals, Llc | Peptide-peptidase-inhibitor conjugates and methods of making and using same |
| BR112022006082A2 (en) * | 2019-10-18 | 2022-06-21 | Basf Se | Enzyme preparation, detergent formulation, and use of at least one diol |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| US5240913A (en) * | 1989-08-18 | 1993-08-31 | Biogen, Inc. | Inhibitors of thrombin |
-
1996
- 1996-06-29 GB GBGB9613719.5A patent/GB9613719D0/en active Pending
-
1997
- 1997-06-11 CN CN97195991A patent/CN1223664A/en active Pending
- 1997-06-11 CA CA002258634A patent/CA2258634A1/en not_active Abandoned
- 1997-06-11 AU AU30425/97A patent/AU729393C/en not_active Ceased
- 1997-06-11 KR KR1019980710776A patent/KR20000022350A/en not_active Application Discontinuation
- 1997-06-11 WO PCT/GB1997/001574 patent/WO1998000442A1/en not_active Application Discontinuation
- 1997-06-11 JP JP10503897A patent/JP2000516202A/en active Pending
- 1997-06-11 EP EP97925197A patent/EP0935611A1/en not_active Withdrawn
- 1997-06-11 NZ NZ333390A patent/NZ333390A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000516202A (en) | 2000-12-05 |
| GB9613719D0 (en) | 1996-08-28 |
| AU3042597A (en) | 1998-01-21 |
| AU729393C (en) | 2002-05-16 |
| EP0935611A1 (en) | 1999-08-18 |
| KR20000022350A (en) | 2000-04-25 |
| CN1223664A (en) | 1999-07-21 |
| AU729393B2 (en) | 2001-02-01 |
| WO1998000442A1 (en) | 1998-01-08 |
| CA2258634A1 (en) | 1998-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |