CA2253238C - Novel agouti-related gene - Google Patents

Novel agouti-related gene Download PDF

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Publication number
CA2253238C
CA2253238C CA002253238A CA2253238A CA2253238C CA 2253238 C CA2253238 C CA 2253238C CA 002253238 A CA002253238 A CA 002253238A CA 2253238 A CA2253238 A CA 2253238A CA 2253238 C CA2253238 C CA 2253238C
Authority
CA
Canada
Prior art keywords
art
polypeptide
seq
nucleic acid
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002253238A
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English (en)
French (fr)
Other versions
CA2253238A1 (en
Inventor
Kevin Lee Stark
Roland Luethy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA2253238A1 publication Critical patent/CA2253238A1/en
Application granted granted Critical
Publication of CA2253238C publication Critical patent/CA2253238C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
CA002253238A 1996-05-10 1997-04-22 Novel agouti-related gene Expired - Fee Related CA2253238C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1750596P 1996-05-10 1996-05-10
US60/017,505 1996-05-10
US08/757,541 1996-11-27
US08/757,541 US5766877A (en) 1996-05-10 1996-11-27 Genes encoding art, an agouti-related transcript
PCT/US1997/006853 WO1997043412A1 (en) 1996-05-10 1997-04-22 Novel agouti-related gene

Publications (2)

Publication Number Publication Date
CA2253238A1 CA2253238A1 (en) 1997-11-20
CA2253238C true CA2253238C (en) 2008-08-12

Family

ID=26689965

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253238A Expired - Fee Related CA2253238C (en) 1996-05-10 1997-04-22 Novel agouti-related gene

Country Status (12)

Country Link
US (5) US5766877A (enExample)
EP (1) EP0917571B1 (enExample)
JP (1) JP4219404B2 (enExample)
AT (1) ATE283917T1 (enExample)
AU (1) AU2681497A (enExample)
CA (1) CA2253238C (enExample)
DE (1) DE69731834T2 (enExample)
DK (1) DK0917571T3 (enExample)
ES (1) ES2234015T3 (enExample)
PT (1) PT917571E (enExample)
SI (1) SI0917571T1 (enExample)
WO (1) WO1997043412A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843652A (en) * 1993-05-21 1998-12-01 Lockheed Martin Energy Systems, Inc. Isolation and characterization of Agouti: a diabetes/obesity related gene
US6310034B1 (en) 1993-05-21 2001-10-30 Ut-Battelle, Llc Agouti polypeptide compositions
WO2002064091A2 (en) * 2001-02-13 2002-08-22 Palatin Technologies, Inc. Melanocortin metallopeptides for treatment of sexual dysfunction
US5766877A (en) * 1996-05-10 1998-06-16 Amgen Inc. Genes encoding art, an agouti-related transcript
EP0942967A1 (en) * 1996-11-06 1999-09-22 Children's Medical Center Corporation Transgenic animal expressing a syndecan in the regions of hypothalamus
US6878520B1 (en) * 1997-12-16 2005-04-12 Merck & Co., Inc. C-terminal region of agouti-related transcript (ART) protein
DE69838104T2 (de) * 1997-12-16 2008-04-10 Merck & Co., Inc. C-terminale region des "agouti-related-transcript"-proteins (art)
AU3964499A (en) * 1998-03-30 1999-10-18 Gryphon Sciences Agouti-related protein analogs and methods of use
US6689873B1 (en) 1998-04-29 2004-02-10 Merck & Co., Inc. Nucleic acid encoding rat agouti related protein
JP2002524724A (ja) * 1998-09-03 2002-08-06 ミレニアム ファーマシューティカルズ インク． 薬物中毒を治療するために用いられる化合物を同定する際の標的としてのｍｃ４−ｒ
US6716810B1 (en) * 1998-12-09 2004-04-06 Eleanor Roosevelt Institute Composition and method for regulation of body weight and associated conditions
US6603058B1 (en) 1998-12-09 2003-08-05 Oklahoma Medical Research Foundation Non-human animal model for obesity and uses thereof
US6303749B1 (en) * 1999-01-29 2001-10-16 Amgen Inc. Agouti and agouti-related peptide analogs
US20030064921A1 (en) * 1999-10-27 2003-04-03 The Regents Of The University Of California Methods and compounds for modulating melanocortin receptor ligand binding and activity
EP1125579A3 (en) 2000-01-18 2003-01-02 Pfizer Products Inc. Uses of agrp-melanocortin receptor binding modulating compounds
CN100369940C (zh) * 2000-05-31 2008-02-20 纳幕尔杜邦公司 烯烃聚合催化剂
PT1385823E (pt) 2001-04-09 2007-01-31 Novartis Vaccines & Diagnostic Compostos de guanidino como agonistas do receptor de melanocortina-4 (r-mc4)
US20050124652A1 (en) * 2002-02-04 2005-06-09 Rustum Boyce Guanidino compounds
US20030207814A1 (en) * 2002-02-04 2003-11-06 Chiron Corporation Novel guanidinyl derivatives
US20030195187A1 (en) * 2002-02-04 2003-10-16 Chiron Corporation Guanidino compounds
US20030229025A1 (en) * 2002-02-25 2003-12-11 Chiron Corporation Intranasal administration of MC4-R agonists
DE60333937D1 (de) 2002-05-23 2010-10-07 Novartis Vaccines & Diagnostic Substituierte quinazolinone verbindungen
WO2004004447A2 (en) * 2002-07-03 2004-01-15 Merck & Co., Inc. Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism
AU2004249120B2 (en) * 2003-05-23 2008-07-24 Glaxosmithkline Guanidino-substituted quinazolinone compounds as MC4-R agonists
EP1656455B1 (en) * 2003-08-13 2012-09-19 Sandoz Ag Process for the purification of recombinant polypeptides
AU2004293012A1 (en) * 2003-11-19 2005-06-09 Rustum S. Boyce Quinazolinone compounds with reduced bioaccumulation
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
NZ550114A (en) * 2004-04-20 2011-02-25 Transtech Pharma Inc Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators
US7910101B2 (en) 2004-10-25 2011-03-22 Centocor, Inc. Melanocortin receptor binding mimetibodies, compositions, methods and uses
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
US7833927B2 (en) * 2005-08-31 2010-11-16 Rohm And Haas Company Single site palladium catalyst complexes
JP2012501334A (ja) * 2008-08-29 2012-01-19 トランス テック ファーマ，インコーポレイテッド 置換アミノチアゾール誘導体、医薬組成物、および使用の方法
WO2012100342A1 (en) 2011-01-27 2012-08-02 Université de Montréal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
ATE12348T1 (de) * 1980-11-10 1985-04-15 Gersonde Klaus Prof Dr Verfahren zur herstellung von lipid-vesikeln durch ultraschallbehandlung, anwendung des verfahrens und vorrichtung zur durchfuehrung des verfahrens.
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
EP0088046B1 (de) * 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
EP0143949B1 (en) * 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
DE3572982D1 (en) * 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
JP2989002B2 (ja) * 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド 化学修飾顆粒球コロニー刺激因子
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5766877A (en) * 1996-05-10 1998-06-16 Amgen Inc. Genes encoding art, an agouti-related transcript

Also Published As

Publication number Publication date
JP4219404B2 (ja) 2009-02-04
AU2681497A (en) 1997-12-05
ES2234015T3 (es) 2005-06-16
US20030082737A1 (en) 2003-05-01
JP2001517931A (ja) 2001-10-09
DE69731834T2 (de) 2005-12-15
US6060589A (en) 2000-05-09
WO1997043412A1 (en) 1997-11-20
PT917571E (pt) 2005-04-29
EP0917571A1 (en) 1999-05-26
US20010007752A1 (en) 2001-07-12
US5766877A (en) 1998-06-16
US6203995B1 (en) 2001-03-20
SI0917571T1 (en) 2005-06-30
DK0917571T3 (da) 2005-03-14
CA2253238A1 (en) 1997-11-20
DE69731834D1 (de) 2005-01-05
ATE283917T1 (de) 2004-12-15
US7122520B2 (en) 2006-10-17
EP0917571B1 (en) 2004-12-01

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