CA2242913A1 - Hydroxamic acid based collagenase inhibitors - Google Patents

Hydroxamic acid based collagenase inhibitors Download PDF

Info

Publication number
CA2242913A1
CA2242913A1 CA002242913A CA2242913A CA2242913A1 CA 2242913 A1 CA2242913 A1 CA 2242913A1 CA 002242913 A CA002242913 A CA 002242913A CA 2242913 A CA2242913 A CA 2242913A CA 2242913 A1 CA2242913 A1 CA 2242913A1
Authority
CA
Canada
Prior art keywords
compound
formula
benzyl
compounds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002242913A
Other languages
English (en)
French (fr)
Inventor
Stuart Bailey
Derek Richard Buckle
David Glynn Smith
Andrew Faller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2242913A1 publication Critical patent/CA2242913A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002242913A 1996-01-17 1997-01-14 Hydroxamic acid based collagenase inhibitors Abandoned CA2242913A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9601041.8A GB9601041D0 (en) 1996-01-17 1996-01-17 Novel compounds
GB9601041.8 1996-01-17

Publications (1)

Publication Number Publication Date
CA2242913A1 true CA2242913A1 (en) 1997-07-24

Family

ID=10787226

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002242913A Abandoned CA2242913A1 (en) 1996-01-17 1997-01-14 Hydroxamic acid based collagenase inhibitors

Country Status (19)

Country Link
EP (1) EP0912545A1 (cs)
JP (1) JP2000503312A (cs)
KR (1) KR19990077325A (cs)
CN (1) CN1213368A (cs)
AR (1) AR005472A1 (cs)
AU (1) AU725056B2 (cs)
BR (1) BR9707024A (cs)
CA (1) CA2242913A1 (cs)
CZ (1) CZ222498A3 (cs)
GB (1) GB9601041D0 (cs)
HU (1) HUP9901022A3 (cs)
IL (1) IL125381A0 (cs)
NO (1) NO983283L (cs)
NZ (1) NZ326352A (cs)
PL (1) PL327820A1 (cs)
TR (1) TR199801380T2 (cs)
TW (1) TW462967B (cs)
WO (1) WO1997026257A1 (cs)
ZA (1) ZA97345B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
GB9609795D0 (en) * 1996-05-10 1996-07-17 Smithkline Beecham Plc Novel compounds
WO2000040713A1 (en) * 1999-01-06 2000-07-13 Mcmaster University Method of preventing immune and hypersensitivity reactions
GB9922825D0 (en) * 1999-09-25 1999-11-24 Smithkline Beecham Biolog Medical use
WO2002006227A1 (fr) * 2000-07-18 2002-01-24 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de la metalloprotease matricielle
CA2473754C (en) * 2002-01-28 2012-04-10 Aimsco Limited Treatment of ms with goat serum
JPWO2006016399A1 (ja) 2004-08-10 2008-05-01 株式会社静岡カフェイン工業所 ヒドロキサム酸誘導体及びそれを有効成分とする医薬
KR100844277B1 (ko) * 2005-04-29 2008-07-07 (주)아모레퍼시픽 히드록삼산 유도체 및 이의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB9504084D0 (en) * 1995-03-01 1995-04-19 British Biotech Pharm Synthesis of carboxylic and hydroxamic acid derivatives

Also Published As

Publication number Publication date
NO983283D0 (no) 1998-07-16
HUP9901022A3 (en) 2001-11-28
TW462967B (en) 2001-11-11
AU725056B2 (en) 2000-10-05
EP0912545A1 (en) 1999-05-06
AU1443697A (en) 1997-08-11
CZ222498A3 (cs) 1999-03-17
BR9707024A (pt) 1999-07-20
NO983283L (no) 1998-09-16
CN1213368A (zh) 1999-04-07
KR19990077325A (ko) 1999-10-25
IL125381A0 (en) 1999-03-12
JP2000503312A (ja) 2000-03-21
NZ326352A (en) 2000-03-27
HUP9901022A2 (hu) 1999-07-28
WO1997026257A1 (en) 1997-07-24
GB9601041D0 (en) 1996-03-20
PL327820A1 (en) 1999-01-04
ZA97345B (en) 1998-07-16
AR005472A1 (es) 1999-06-23
TR199801380T2 (xx) 1998-10-21

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Legal Events

Date Code Title Description
FZDE Discontinued