CA2240043A1 - Substituted biphenyl isoxazole sulfonamides - Google Patents

Info

Publication number

CA2240043A1

CA2240043A1 CA002240043A CA2240043A CA2240043A1 CA 2240043 A1 CA2240043 A1 CA 2240043A1 CA 002240043 A CA002240043 A CA 002240043A CA 2240043 A CA2240043 A CA 2240043A CA 2240043 A1 CA2240043 A1 CA 2240043A1

Authority

CA

Canada

Prior art keywords

methyl

dimethyl

oxazolyl

isoxazolyl

biphenyl

Prior art date

1996-02-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• KFJGHVOVYDCDOS-UHFFFAOYSA-N 1,1'-biphenyl;1,2-oxazole-3-sulfonamide Chemical class NS(=O)(=O)C=1C=CON=1.C1=CC=CC=C1C1=CC=CC=C1 KFJGHVOVYDCDOS-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 359
• -1 cycloalkenylalkyl Chemical group 0.000 claims abstract description 159
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 86
• 125000003118 aryl group Chemical group 0.000 claims abstract description 66
• 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 38
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 34
• 239000001257 hydrogen Substances 0.000 claims abstract description 33
• 229920006395 saturated elastomer Polymers 0.000 claims abstract description 33
• 125000003545 alkoxy group Chemical group 0.000 claims abstract description 30
• 125000003342 alkenyl group Chemical group 0.000 claims abstract description 27
• 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 23
• 125000004104 aryloxy group Chemical group 0.000 claims abstract description 23
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract description 22
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 21
• 125000004450 alkenylene group Chemical group 0.000 claims abstract description 21
• 125000002947 alkylene group Chemical group 0.000 claims abstract description 19
• 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 18
• 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 16
• 125000000304 alkynyl group Chemical group 0.000 claims abstract description 14
• 229910052799 carbon Inorganic materials 0.000 claims abstract description 14
• 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 14
• 102000002045 Endothelin Human genes 0.000 claims abstract description 12
• 108050009340 Endothelin Proteins 0.000 claims abstract description 12
• ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims abstract description 12
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 11
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 11
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 151
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 134
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 105
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 100
• 238000000034 method Methods 0.000 claims description 77
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 74
• 235000010290 biphenyl Nutrition 0.000 claims description 67
• 125000000623 heterocyclic group Chemical group 0.000 claims description 51
• 150000003839 salts Chemical class 0.000 claims description 44
• 229940124530 sulfonamide Drugs 0.000 claims description 40
• 238000011282 treatment Methods 0.000 claims description 36
• 229910052736 halogen Inorganic materials 0.000 claims description 26
• 150000002367 halogens Chemical group 0.000 claims description 25
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 23
• 125000005843 halogen group Chemical group 0.000 claims description 22
• 208000035475 disorder Diseases 0.000 claims description 18
• 229910052757 nitrogen Inorganic materials 0.000 claims description 17
• 206010020772 Hypertension Diseases 0.000 claims description 16
• 125000004470 heterocyclooxy group Chemical group 0.000 claims description 13
• 102000005862 Angiotensin II Human genes 0.000 claims description 12
• 101800000733 Angiotensin-2 Proteins 0.000 claims description 12
• CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims description 12
• 102000003729 Neprilysin Human genes 0.000 claims description 12
• 108090000028 Neprilysin Proteins 0.000 claims description 12
• 229950006323 angiotensin ii Drugs 0.000 claims description 12
• 150000002431 hydrogen Chemical class 0.000 claims description 12
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 12
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 10
• 125000001424 substituent group Chemical group 0.000 claims description 10
• SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 claims description 8
• 206010019280 Heart failures Diseases 0.000 claims description 8
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 8
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
• 206010007559 Cardiac failure congestive Diseases 0.000 claims description 7
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 7
• 150000003857 carboxamides Chemical group 0.000 claims description 7
• 230000001434 glomerular Effects 0.000 claims description 7
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 7
• 229910052760 oxygen Inorganic materials 0.000 claims description 7
• 229940044551 receptor antagonist Drugs 0.000 claims description 7
• 239000002464 receptor antagonist Substances 0.000 claims description 7
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 6
• 208000037487 Endotoxemia Diseases 0.000 claims description 6
• 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 claims description 6
• 208000019695 Migraine disease Diseases 0.000 claims description 6
• 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 6
• 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 6
• 125000004171 alkoxy aryl group Chemical group 0.000 claims description 6
• 125000004429 atom Chemical group 0.000 claims description 6
• 239000002368 cardiac glycoside Substances 0.000 claims description 6
• 229940097217 cardiac glycoside Drugs 0.000 claims description 6
• 239000002934 diuretic Substances 0.000 claims description 6
• 230000009977 dual effect Effects 0.000 claims description 6
• 210000003904 glomerular cell Anatomy 0.000 claims description 6
• 210000003584 mesangial cell Anatomy 0.000 claims description 6
• 206010027599 migraine Diseases 0.000 claims description 6
• 201000008312 primary pulmonary hypertension Diseases 0.000 claims description 6
• 239000002461 renin inhibitor Substances 0.000 claims description 6
• 229940086526 renin-inhibitors Drugs 0.000 claims description 6
• 208000037803 restenosis Diseases 0.000 claims description 6
• 229930002534 steroid glycoside Natural products 0.000 claims description 6
• 125000004952 trihaloalkoxy group Chemical group 0.000 claims description 6
• 125000004385 trihaloalkyl group Chemical group 0.000 claims description 6
• 239000005541 ACE inhibitor Substances 0.000 claims description 5
• 201000001320 Atherosclerosis Diseases 0.000 claims description 5
• 229940097420 Diuretic Drugs 0.000 claims description 5
• 108090000783 Renin Proteins 0.000 claims description 5
• 102100028255 Renin Human genes 0.000 claims description 5
• 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 5
• 125000004419 alkynylene group Chemical group 0.000 claims description 5
• 230000001882 diuretic effect Effects 0.000 claims description 5
• 208000028867 ischemia Diseases 0.000 claims description 5
• LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims description 5
• 208000002815 pulmonary hypertension Diseases 0.000 claims description 5
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 4
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 4
• 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 4
• 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 4
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 3
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 3
• 229910052717 sulfur Inorganic materials 0.000 claims description 3
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 2
• PMKLMFUQSSVLTH-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(2-methylpropoxymethyl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC(C)COCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C PMKLMFUQSSVLTH-UHFFFAOYSA-N 0.000 claims description 2
• ZDWGTSYAESFIST-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(2-propan-2-yl-1,3-oxazol-5-yl)phenyl]benzenesulfonamide Chemical compound O1C(C(C)C)=NC=C1C1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 ZDWGTSYAESFIST-UHFFFAOYSA-N 0.000 claims description 2
• NEDUADVRBCAVMC-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(4-propan-2-ylphenyl)phenyl]benzenesulfonamide Chemical compound C1=CC(C(C)C)=CC=C1C1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 NEDUADVRBCAVMC-UHFFFAOYSA-N 0.000 claims description 2
• 241000124008 Mammalia Species 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• NVBVHEMHRDQUDU-UHFFFAOYSA-N [2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl-methylcarbamic acid Chemical compound OC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C NVBVHEMHRDQUDU-UHFFFAOYSA-N 0.000 claims 2
• YPTUDAMUVCXESI-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(2-hydroxy-4-phenylbutyl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CC(O)CCC=2C=CC=CC=2)=C1C YPTUDAMUVCXESI-UHFFFAOYSA-N 0.000 claims 2
• ZHRNJYRTUCXIIO-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2,2,2-trifluoroethylamino)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNCC(F)(F)F)=C1C ZHRNJYRTUCXIIO-UHFFFAOYSA-N 0.000 claims 2
• ZSCNMSFOUJFSCQ-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-5-(trifluoromethyl)pyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC(Cl)=CC=2)C(C(F)(F)F)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ZSCNMSFOUJFSCQ-UHFFFAOYSA-N 0.000 claims 1
• LPFIACRBTOAWMJ-UHFFFAOYSA-N 1-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-1,3,3-trimethylurea Chemical compound CN(C)C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LPFIACRBTOAWMJ-UHFFFAOYSA-N 0.000 claims 1
• BPAOCPGDDRZWJH-UHFFFAOYSA-N 1-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-n,2-n-diethyl-1-n-methylbenzene-1,2-dicarboxamide Chemical compound CCN(CC)C(=O)C1=CC=CC=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 BPAOCPGDDRZWJH-UHFFFAOYSA-N 0.000 claims 1
• INELUNPYSRUKLL-UHFFFAOYSA-N 1-tert-butyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-3-phenyl-2h-triazole-4-carboxamide Chemical compound C=1N(C(C)(C)C)NN(C=2C=CC=CC=2)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C INELUNPYSRUKLL-UHFFFAOYSA-N 0.000 claims 1
• XFQSGCULFJFBRC-UHFFFAOYSA-N 2,4-dichloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XFQSGCULFJFBRC-UHFFFAOYSA-N 0.000 claims 1
• LRCCWUQSSJIFPQ-UHFFFAOYSA-N 2,6-dichloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpyridine-3-carboxamide Chemical compound C=1C=C(Cl)N=C(Cl)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LRCCWUQSSJIFPQ-UHFFFAOYSA-N 0.000 claims 1
• QWGPNOYBJJIPKU-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C=C2OCOC2=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QWGPNOYBJJIPKU-UHFFFAOYSA-N 0.000 claims 1
• QWCKTOAFWBBEKS-UHFFFAOYSA-N 2-(2,3-dihydro-1h-inden-2-yl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C1C2=CC=CC=C2CC1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QWCKTOAFWBBEKS-UHFFFAOYSA-N 0.000 claims 1
• ZMIONMXXVCNVLO-UHFFFAOYSA-N 2-(2,4-dichlorophenoxy)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1OCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ZMIONMXXVCNVLO-UHFFFAOYSA-N 0.000 claims 1
• LWJKHGFPGKWCJL-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C=C(F)C=C(F)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LWJKHGFPGKWCJL-UHFFFAOYSA-N 0.000 claims 1
• OFCNXISFSFDOGW-UHFFFAOYSA-N 2-(2,5-difluorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C(F)=CC=C(F)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C OFCNXISFSFDOGW-UHFFFAOYSA-N 0.000 claims 1
• IUWGBOFBBGJLED-UHFFFAOYSA-N 2-(2,6-dichlorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound ClC=1C=CC=C(Cl)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C IUWGBOFBBGJLED-UHFFFAOYSA-N 0.000 claims 1
• AGDZYIVTVFHWBR-UHFFFAOYSA-N 2-(2,6-difluorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound FC=1C=CC=C(F)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AGDZYIVTVFHWBR-UHFFFAOYSA-N 0.000 claims 1
• HTTFRNSJPDBTIT-UHFFFAOYSA-N 2-(2-chlorophenoxy)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2-dimethylpropanamide Chemical compound C=1C=CC=C(Cl)C=1OC(C)(C)C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C HTTFRNSJPDBTIT-UHFFFAOYSA-N 0.000 claims 1
• WSCXPXIEEVKUFP-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C=CC=C(Cl)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WSCXPXIEEVKUFP-UHFFFAOYSA-N 0.000 claims 1
• XFRGPKKWRCBJRL-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C(F)=CC(F)=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XFRGPKKWRCBJRL-UHFFFAOYSA-N 0.000 claims 1
• UGAPUOHUPJYDLC-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C=1C=C(Cl)C=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C UGAPUOHUPJYDLC-UHFFFAOYSA-N 0.000 claims 1
• QFTCSLNARCNKPG-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]acetamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC(=O)CC=2C=CC(Cl)=CC=2)=C1C QFTCSLNARCNKPG-UHFFFAOYSA-N 0.000 claims 1
• BXODLGZHBMJIOK-UHFFFAOYSA-N 2-[2,4-bis(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)C=2OC=CN=2)=C1C BXODLGZHBMJIOK-UHFFFAOYSA-N 0.000 claims 1
• IWCBABDMCZRDIE-UHFFFAOYSA-N 2-[2-(2,3-dihydroindol-1-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=CC=CC=C3CC2)=C1C IWCBABDMCZRDIE-UHFFFAOYSA-N 0.000 claims 1
• OOKCVMIHRNXADS-UHFFFAOYSA-N 2-[2-(2,3-dihydropyrido[3,2-b][1,4]oxazin-4-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=NC=CC=C3OCC2)=C1C OOKCVMIHRNXADS-UHFFFAOYSA-N 0.000 claims 1
• HSIXZHKJTORFCG-UHFFFAOYSA-N 2-[2-(3,4-dihydro-2h-quinolin-1-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=CC=CC=C3CCC2)=C1C HSIXZHKJTORFCG-UHFFFAOYSA-N 0.000 claims 1
• QUHXVQQJAFPZFW-UHFFFAOYSA-N 2-[2-(anilinomethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC=2C=CC=CC=2)=C1C QUHXVQQJAFPZFW-UHFFFAOYSA-N 0.000 claims 1
• AZHWYGDQMWBZRB-UHFFFAOYSA-N 2-[2-(benzimidazol-1-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=CC=CC=C3N=C2)=C1C AZHWYGDQMWBZRB-UHFFFAOYSA-N 0.000 claims 1
• YIUMWWIGGIGZRQ-UHFFFAOYSA-N 2-[2-(benzotriazol-1-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=CC=CC=C3N=N2)=C1C YIUMWWIGGIGZRQ-UHFFFAOYSA-N 0.000 claims 1
• GGCZLSKWMONHCL-UHFFFAOYSA-N 2-[2-(cyanomethyl)-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CC#N)=C1C GGCZLSKWMONHCL-UHFFFAOYSA-N 0.000 claims 1
• XDCHOZFZBSUVIW-UHFFFAOYSA-N 2-[2-[(1,3-benzothiazol-2-ylamino)methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC=2SC3=CC=CC=C3N=2)=C1C XDCHOZFZBSUVIW-UHFFFAOYSA-N 0.000 claims 1
• HLSAMCHUYSDBQN-UHFFFAOYSA-N 2-[2-[(3,3-difluoro-2-oxoindol-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=CC=CC=C3C(F)(F)C2=O)=C1C HLSAMCHUYSDBQN-UHFFFAOYSA-N 0.000 claims 1
• IBEVLLGNRBQAPY-UHFFFAOYSA-N 2-[2-[(3,3-difluoropyrrolidin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2CC(F)(F)CC2)=C1C IBEVLLGNRBQAPY-UHFFFAOYSA-N 0.000 claims 1
• WPUVWAWEZQZDRT-UHFFFAOYSA-N 2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-n-methyl-5-(1,3-oxazol-2-yl)benzamide Chemical compound CNC(=O)C1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WPUVWAWEZQZDRT-UHFFFAOYSA-N 0.000 claims 1
• HBGGXQHRNBXKQJ-UHFFFAOYSA-N 2-[2-[(4-acetylpiperazin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound C1CN(C(=O)C)CCN1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 HBGGXQHRNBXKQJ-UHFFFAOYSA-N 0.000 claims 1
• LZJBWBJQATUAPH-UHFFFAOYSA-N 2-[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]-n,n-dimethylacetamide Chemical compound CN(C)C(=O)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LZJBWBJQATUAPH-UHFFFAOYSA-N 0.000 claims 1
• XANFMLWYMBXADZ-UHFFFAOYSA-N 2-[2-[[(2,2-difluoro-2-phenylethyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNCC(F)(F)C=2C=CC=CC=2)=C1C XANFMLWYMBXADZ-UHFFFAOYSA-N 0.000 claims 1
• OBEHGZDKTNBUNX-UHFFFAOYSA-N 2-[2-[[(2-tert-butyl-5-methylpyrazol-3-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC(C)(C)N1N=C(C)C=C1NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 OBEHGZDKTNBUNX-UHFFFAOYSA-N 0.000 claims 1
• KVNKTTZYLSRLLO-UHFFFAOYSA-N 2-[2-[[(4-bromo-1h-pyrazol-5-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC=2C(=CNN=2)Br)=C1C KVNKTTZYLSRLLO-UHFFFAOYSA-N 0.000 claims 1
• CTPWGVYGQAJKMR-UHFFFAOYSA-N 2-[2-[[(4-cyano-1h-pyrazol-5-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC2=C(C=NN2)C#N)=C1C CTPWGVYGQAJKMR-UHFFFAOYSA-N 0.000 claims 1
• JNDAFPXPWNKYAF-UHFFFAOYSA-N 2-[2-[[[4-(4-chlorophenyl)-6-ethoxypyrimidin-2-yl]amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound N=1C(OCC)=CC(C=2C=CC(Cl)=CC=2)=NC=1NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C JNDAFPXPWNKYAF-UHFFFAOYSA-N 0.000 claims 1
• RCMUFDHWEBHTRS-UHFFFAOYSA-N 2-[2-[[benzyl(2,2,2-trifluoroethyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN(CC=2C=CC=CC=2)CC(F)(F)F)=C1C RCMUFDHWEBHTRS-UHFFFAOYSA-N 0.000 claims 1
• PXWCMQQOYOQBHY-UHFFFAOYSA-N 2-[2-[[benzyl(methyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]-n-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Chemical compound C=1C(C=2OC=CN=2)=CC=C(C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)C=1CN(C)CC1=CC=CC=C1 PXWCMQQOYOQBHY-UHFFFAOYSA-N 0.000 claims 1
• TWOPDWGQKAOIEE-UHFFFAOYSA-N 2-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3,4-dimethoxy-n-methylbenzamide Chemical compound ClC1=C(OC)C(OC)=CC=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 TWOPDWGQKAOIEE-UHFFFAOYSA-N 0.000 claims 1
• AVLALDJQKQJZDU-UHFFFAOYSA-N 2-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,6-dimethylpyridine-4-carboxamide Chemical compound C=1C(C)=NC(Cl)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AVLALDJQKQJZDU-UHFFFAOYSA-N 0.000 claims 1
• MFJGRCOYWNRVAF-UHFFFAOYSA-N 2-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-5-(trifluoromethyl)benzamide Chemical compound C=1C(C(F)(F)F)=CC=C(Cl)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C MFJGRCOYWNRVAF-UHFFFAOYSA-N 0.000 claims 1
• XSNLSOTYZXOIHW-UHFFFAOYSA-N 2-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C=CC=C(Cl)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XSNLSOTYZXOIHW-UHFFFAOYSA-N 0.000 claims 1
• XFVRGRHYQOBYLX-UHFFFAOYSA-N 2-cyclohexyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C1CCCCC1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XFVRGRHYQOBYLX-UHFFFAOYSA-N 0.000 claims 1
• WNANHGLKEBIVHY-UHFFFAOYSA-N 2-cyclopropyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylacetamide Chemical compound C1CC1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WNANHGLKEBIVHY-UHFFFAOYSA-N 0.000 claims 1
• LKGOVXVKPIZZQW-UHFFFAOYSA-N 3,4-dichloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LKGOVXVKPIZZQW-UHFFFAOYSA-N 0.000 claims 1
• LNPRLVTXUXFAEN-UHFFFAOYSA-N 3,5-dichloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C(Cl)=CC(Cl)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LNPRLVTXUXFAEN-UHFFFAOYSA-N 0.000 claims 1
• FYSHDDMHXXJVPM-UHFFFAOYSA-N 3-(2-chloro-6-fluorophenyl)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound CC=1ON=C(C=2C(=CC=CC=2F)Cl)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C FYSHDDMHXXJVPM-UHFFFAOYSA-N 0.000 claims 1
• MZMOQQOMQKPBDT-UHFFFAOYSA-N 3-(dimethylamino)-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound CN(C)C1=CC=CC(C(=O)N(C)CC=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1 MZMOQQOMQKPBDT-UHFFFAOYSA-N 0.000 claims 1
• AWFZHEQEWJOQSD-UHFFFAOYSA-N 3-acetamido-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,4-dimethylbenzamide Chemical compound C=1C=C(C)C(NC(C)=O)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AWFZHEQEWJOQSD-UHFFFAOYSA-N 0.000 claims 1
• AKEFPTXEXMEDKD-UHFFFAOYSA-N 3-cyano-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C=CC(C#N)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AKEFPTXEXMEDKD-UHFFFAOYSA-N 0.000 claims 1
• CAAPTIZNYDFUJL-UHFFFAOYSA-N 3-cyclohexyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpropanamide Chemical compound C1CCCCC1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CAAPTIZNYDFUJL-UHFFFAOYSA-N 0.000 claims 1
• BVVSJAIWZJUWQO-UHFFFAOYSA-N 3-cyclopentyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpropanamide Chemical compound C1CCCC1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C BVVSJAIWZJUWQO-UHFFFAOYSA-N 0.000 claims 1
• DCFRSMXRSJTQAQ-UHFFFAOYSA-N 4-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-methoxy-n-methylbenzamide Chemical compound COC1=CC(Cl)=CC=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 DCFRSMXRSJTQAQ-UHFFFAOYSA-N 0.000 claims 1
• ZBFJBNRRVFVKBS-UHFFFAOYSA-N 4-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,1,3-trimethylpyrazolo[3,4-b]pyridine-5-carboxamide Chemical compound C=1N=C2N(C)N=C(C)C2=C(Cl)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ZBFJBNRRVFVKBS-UHFFFAOYSA-N 0.000 claims 1
• MLSSDOTXUKQDNQ-UHFFFAOYSA-N 4-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C=C(Cl)C=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C MLSSDOTXUKQDNQ-UHFFFAOYSA-N 0.000 claims 1
• URXOVBCAVSFPLS-UHFFFAOYSA-N 4-tert-butyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylcyclohexane-1-carboxamide Chemical compound C1CC(C(C)(C)C)CCC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C URXOVBCAVSFPLS-UHFFFAOYSA-N 0.000 claims 1
• XJGCGLSKVQORCB-UHFFFAOYSA-N 5-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-methoxy-n-methylbenzamide Chemical compound COC1=CC=C(Cl)C=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 XJGCGLSKVQORCB-UHFFFAOYSA-N 0.000 claims 1
• KCVPFHOTMYFNRJ-UHFFFAOYSA-N 5-tert-butyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-ethyl-n-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C(C)(C)C)C=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 KCVPFHOTMYFNRJ-UHFFFAOYSA-N 0.000 claims 1
• IHCMRQJQKGEOAH-UHFFFAOYSA-N 5-tert-butyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2-dimethylpyrazole-3-carboxamide Chemical compound C=1C(C(C)(C)C)=NN(C)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C IHCMRQJQKGEOAH-UHFFFAOYSA-N 0.000 claims 1
• FLUBVWDEJPOBQC-UHFFFAOYSA-N 6-chloro-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpyridine-3-carboxamide Chemical compound C=1C=C(Cl)N=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C FLUBVWDEJPOBQC-UHFFFAOYSA-N 0.000 claims 1
• BVHQJNCPPABDNU-UHFFFAOYSA-N CC1=NOC(=C1C)NS(=O)(=O)C1=C(C=CC=C1)C1=C(C=C(C=C1)C=1OC=CN1)CN(C(CC1(C(=NCS1)C)C1=CC(=CC=C1)C(F)(F)F)=O)C Chemical compound CC1=NOC(=C1C)NS(=O)(=O)C1=C(C=CC=C1)C1=C(C=C(C=C1)C=1OC=CN1)CN(C(CC1(C(=NCS1)C)C1=CC(=CC=C1)C(F)(F)F)=O)C BVHQJNCPPABDNU-UHFFFAOYSA-N 0.000 claims 1
• LDECUSDQMXVUMP-UHFFFAOYSA-N benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]-hexylamino]-6-oxohexyl]-4-methyl-2-oxo-6-(4-phenylphenyl)-1,6-dihydropyrimidine-5-carboxylate Chemical compound O=C1NC(C=2C=CC(=CC=2)C=2C=CC=CC=2)C(C(=O)OCC=2C=CC=CC=2)=C(C)N1CCCCCC(=O)N(CCCCCC)C(C(=O)NCCCC)C1=CC=C(OCC(=O)OC)C(C(=O)OC)=C1 LDECUSDQMXVUMP-UHFFFAOYSA-N 0.000 claims 1
• GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 claims 1
• JPBDQBYSURHYGE-UHFFFAOYSA-N methyl 2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)benzoate Chemical compound COC(=O)C1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C JPBDQBYSURHYGE-UHFFFAOYSA-N 0.000 claims 1
• DLNXHVRTZQMILV-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(2-hydroxypropan-2-yl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)C(C)(C)O)=C1C DLNXHVRTZQMILV-UHFFFAOYSA-N 0.000 claims 1
• WTHKOFLWSYERTE-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(2-methylpropylsulfonylmethyl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC(C)CS(=O)(=O)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WTHKOFLWSYERTE-UHFFFAOYSA-N 0.000 claims 1
• YDTZJAPCQPQTCL-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(4-methylpentyl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC(C)CCCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C YDTZJAPCQPQTCL-UHFFFAOYSA-N 0.000 claims 1
• KAIWKTKPOCNWMM-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(imidazol-1-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C=NC=C2)=C1C KAIWKTKPOCNWMM-UHFFFAOYSA-N 0.000 claims 1
• PJCGZMDEEGILHT-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-(morpholin-4-ylmethyl)-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2CCOCC2)=C1C PJCGZMDEEGILHT-UHFFFAOYSA-N 0.000 claims 1
• OMCMMRWXVFIVAU-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(1,3-dioxoisoindol-2-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(C3=CC=CC=C3C2=O)=O)=C1C OMCMMRWXVFIVAU-UHFFFAOYSA-N 0.000 claims 1
• FPJPMEXULUCUCB-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(3,3-dimethyl-2-oxopiperidin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(C(C)(C)CCC2)=O)=C1C FPJPMEXULUCUCB-UHFFFAOYSA-N 0.000 claims 1
• XPBBDUYWSIZCNR-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(3,3-dimethyl-2-oxopyrrolidin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(C(C)(C)CC2)=O)=C1C XPBBDUYWSIZCNR-UHFFFAOYSA-N 0.000 claims 1
• XVGVBINHYILTRX-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(4,4-dimethyl-2-oxopyrrolidin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(CC(C)(C)C2)=O)=C1C XVGVBINHYILTRX-UHFFFAOYSA-N 0.000 claims 1
• RTQMBPHSYFCJTE-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(4,4-dimethyl-3-oxo-1,2-oxazolidin-2-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(C(C)(C)CO2)=O)=C1C RTQMBPHSYFCJTE-UHFFFAOYSA-N 0.000 claims 1
• MQAJURNCQNIUNP-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(4-methylpiperazin-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound C1CN(C)CCN1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 MQAJURNCQNIUNP-UHFFFAOYSA-N 0.000 claims 1
• AQSULWAQSVKHCF-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(5-methyltetrazol-1-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(=NN=N2)C)=C1C AQSULWAQSVKHCF-UHFFFAOYSA-N 0.000 claims 1
• CHZVZSBEXNPAMR-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(5-methyltetrazol-2-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound N1=C(C)N=NN1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 CHZVZSBEXNPAMR-UHFFFAOYSA-N 0.000 claims 1
• SBAZRXBBZHSZCP-BQYQJAHWSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(e)-4-methylpent-2-enyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC(C)\C=C\CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C SBAZRXBBZHSZCP-BQYQJAHWSA-N 0.000 claims 1
• HKMVKDPUVNFFAO-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(n-methylanilino)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound C=1C=CC=CC=1N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C HKMVKDPUVNFFAO-UHFFFAOYSA-N 0.000 claims 1
• SBAZRXBBZHSZCP-FPLPWBNLSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[(z)-4-methylpent-2-enyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC(C)\C=C/CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C SBAZRXBBZHSZCP-FPLPWBNLSA-N 0.000 claims 1
• JDANAOYEXPZZBG-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[(1,5-dimethyl-2h-pyrimidin-2-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CN1C=C(C)C=NC1NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 JDANAOYEXPZZBG-UHFFFAOYSA-N 0.000 claims 1
• KLJQBBVSGKGANG-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[(3,5-dimethylpyrazin-2-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC=2C(=NC(C)=CN=2)C)=C1C KLJQBBVSGKGANG-UHFFFAOYSA-N 0.000 claims 1
• VCSDMSSGBDIJRQ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound S1C(CC)=NN=C1NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 VCSDMSSGBDIJRQ-UHFFFAOYSA-N 0.000 claims 1
• IDELXZQRJNHEHG-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[(5-methyl-2h-1,3-oxazol-3-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound C1OC(C)=CN1NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 IDELXZQRJNHEHG-UHFFFAOYSA-N 0.000 claims 1
• AQZOCHDXKFUWHK-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[(6-methoxy-1,3-benzothiazol-2-yl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound S1C2=CC(OC)=CC=C2N=C1NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AQZOCHDXKFUWHK-UHFFFAOYSA-N 0.000 claims 1
• GPDOGUJTMVCKDJ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[3-(3-methylpyrazin-2-yl)pyrazol-1-yl]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=C(C=C2)C=2C(=NC=CN=2)C)=C1C GPDOGUJTMVCKDJ-UHFFFAOYSA-N 0.000 claims 1
• NQFGCBATQFGZSU-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[3-(6-methylpyridin-3-yl)pyrazol-1-yl]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=C(C=C2)C=2C=NC(C)=CC=2)=C1C NQFGCBATQFGZSU-UHFFFAOYSA-N 0.000 claims 1
• XWIPJASIQGZOMB-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[ethyl(2,2,2-trifluoroethyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound FC(F)(F)CN(CC)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XWIPJASIQGZOMB-UHFFFAOYSA-N 0.000 claims 1
• CLLGOUWASYEJSI-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[methyl(2,2,2-trifluoroethyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound FC(F)(F)CN(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CLLGOUWASYEJSI-UHFFFAOYSA-N 0.000 claims 1
• KFYGWINTMGEMTO-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[methyl(2-methylpropyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC(C)CN(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C KFYGWINTMGEMTO-UHFFFAOYSA-N 0.000 claims 1
• AIVFIZCUWVFRLW-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[[methyl(2-phenylethyl)amino]methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound C=1C(C=2OC=CN=2)=CC=C(C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)C=1CN(C)CCC1=CC=CC=C1 AIVFIZCUWVFRLW-UHFFFAOYSA-N 0.000 claims 1
• NICALTPQTBIDFE-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[2-[hydroxy-(5-phenyl-1,3-oxazol-2-yl)methyl]-4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)C(O)C=2OC(=CN=2)C=2C=CC=CC=2)=C1C NICALTPQTBIDFE-UHFFFAOYSA-N 0.000 claims 1
• QSDFLNIZMIGXOO-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(1,3-oxazol-2-ylmethyl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CC=2OC=CN=2)=C1C QSDFLNIZMIGXOO-UHFFFAOYSA-N 0.000 claims 1
• RRJPVWJPULDFFR-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(1,3-oxazol-4-yl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)C=2N=COC=2)=C1C RRJPVWJPULDFFR-UHFFFAOYSA-N 0.000 claims 1
• RTVXRMUGIHICQD-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(2-propan-2-yl-1,3-oxazol-4-yl)phenyl]benzenesulfonamide Chemical compound O1C(C(C)C)=NC(C=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1 RTVXRMUGIHICQD-UHFFFAOYSA-N 0.000 claims 1
• ISTGZCJLKKOIDT-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(2-propan-2-yloxyethyl)phenyl]benzenesulfonamide Chemical compound CC(C)OCCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ISTGZCJLKKOIDT-UHFFFAOYSA-N 0.000 claims 1
• VKOCRWGZZXSCIK-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(2-propan-2-ylsulfonylethyl)phenyl]benzenesulfonamide Chemical compound CC(C)S(=O)(=O)CCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C VKOCRWGZZXSCIK-UHFFFAOYSA-N 0.000 claims 1
• NJVWJMFBTIIYAH-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(2h-triazolo[4,5-b]pyridin-5-ylmethyl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CC=2N=C3N=NNC3=CC=2)=C1C NJVWJMFBTIIYAH-UHFFFAOYSA-N 0.000 claims 1
• OGVOJXXOELVVAT-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(3-phenylpropoxy)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)OCCCC=2C=CC=CC=2)=C1C OGVOJXXOELVVAT-UHFFFAOYSA-N 0.000 claims 1
• ZRAKYPOHCZFRPE-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(3-propan-2-ylphenyl)phenyl]benzenesulfonamide Chemical compound CC(C)C1=CC=CC(C=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1 ZRAKYPOHCZFRPE-UHFFFAOYSA-N 0.000 claims 1
• XJUXAAFCMXUBET-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(propan-2-yloxymethyl)phenyl]benzenesulfonamide Chemical compound CC(C)OCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XJUXAAFCMXUBET-UHFFFAOYSA-N 0.000 claims 1
• ZJLHLNFPEQWJRL-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(pyrazol-1-ylmethyl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=CC=C2)=C1C ZJLHLNFPEQWJRL-UHFFFAOYSA-N 0.000 claims 1
• SHSVECXLJIGVSL-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(triazol-1-ylmethyl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=NC=C2)=C1C SHSVECXLJIGVSL-UHFFFAOYSA-N 0.000 claims 1
• UFKVVPDBMKLMJQ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-(triazol-2-ylmethyl)phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=CC=N2)=C1C UFKVVPDBMKLMJQ-UHFFFAOYSA-N 0.000 claims 1
• WVKGITXVDJAYIJ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(1,1,1-trifluoropropan-2-ylamino)methyl]phenyl]benzenesulfonamide Chemical compound FC(F)(F)C(C)NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WVKGITXVDJAYIJ-UHFFFAOYSA-N 0.000 claims 1
• BJYUPFLEOPALMG-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(1-oxo-3,4-dihydroisoquinolin-2-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(C3=CC=CC=C3CC2)=O)=C1C BJYUPFLEOPALMG-UHFFFAOYSA-N 0.000 claims 1
• FONPXOQAANNMAS-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(1h-1,2,4-triazol-5-ylamino)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC2=NNC=N2)=C1C FONPXOQAANNMAS-UHFFFAOYSA-N 0.000 claims 1
• PODOOZNZOCZESQ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(1h-pyrazol-5-ylamino)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC=2NN=CC=2)=C1C PODOOZNZOCZESQ-UHFFFAOYSA-N 0.000 claims 1
• FOYNFAYDMYTZAZ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2-oxo-1,3-benzoxazol-3-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(OC3=CC=CC=C32)=O)=C1C FOYNFAYDMYTZAZ-UHFFFAOYSA-N 0.000 claims 1
• DJCQYKWBDNCMPD-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2-oxo-3-phenylimidazolidin-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(N(CC2)C=2C=CC=CC=2)=O)=C1C DJCQYKWBDNCMPD-UHFFFAOYSA-N 0.000 claims 1
• WLPJFUAPZNEFKC-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2-oxo-3-propan-2-ylimidazolidin-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound O=C1N(C(C)C)CCN1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 WLPJFUAPZNEFKC-UHFFFAOYSA-N 0.000 claims 1
• CHPSKRTXEXAIEO-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2-oxo-3h-indol-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C3=CC=CC=C3CC2=O)=C1C CHPSKRTXEXAIEO-UHFFFAOYSA-N 0.000 claims 1
• ZBMAVBQIEZKFNG-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2-phenylimidazol-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(=NC=C2)C=2C=CC=CC=2)=C1C ZBMAVBQIEZKFNG-UHFFFAOYSA-N 0.000 claims 1
• FNTLUBLDYLPILI-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(2-propan-2-ylimidazol-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC(C)C1=NC=CN1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 FNTLUBLDYLPILI-UHFFFAOYSA-N 0.000 claims 1
• ZFXKWXQFODJDEW-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(3-oxo-1h-isoindol-2-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2C(C3=CC=CC=C3C2)=O)=C1C ZFXKWXQFODJDEW-UHFFFAOYSA-N 0.000 claims 1
• ZBESNMIAWWTMDM-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(3-phenyl-1,2,4-triazol-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=C(N=C2)C=2C=CC=CC=2)=C1C ZBESNMIAWWTMDM-UHFFFAOYSA-N 0.000 claims 1
• URUIWGSPNGBSOO-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(3-phenylpyrazol-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=C(C=C2)C=2C=CC=CC=2)=C1C URUIWGSPNGBSOO-UHFFFAOYSA-N 0.000 claims 1
• OIJILGJDJYLLLD-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(4-phenylphenoxy)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)COC=2C=CC(=CC=2)C=2C=CC=CC=2)=C1C OIJILGJDJYLLLD-UHFFFAOYSA-N 0.000 claims 1
• GELRLDNXNUXHPW-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(4-phenylpiperazin-1-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2CCN(CC2)C=2C=CC=CC=2)=C1C GELRLDNXNUXHPW-UHFFFAOYSA-N 0.000 claims 1
• ZUHOMTJWMIUYDQ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(4-propan-2-yl-1,3-oxazol-2-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC(C)C1=COC(CC=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=N1 ZUHOMTJWMIUYDQ-UHFFFAOYSA-N 0.000 claims 1
• LGURIXCPSYBIDQ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(5-phenyl-1,3-oxazol-2-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CC=2OC(=CN=2)C=2C=CC=CC=2)=C1C LGURIXCPSYBIDQ-UHFFFAOYSA-N 0.000 claims 1
• QMJZDMGFJYHAGD-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(5-phenyltetrazol-2-yl)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=C(N=N2)C=2C=CC=CC=2)=C1C QMJZDMGFJYHAGD-UHFFFAOYSA-N 0.000 claims 1
• ZBANLLVSIMGZRW-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(5-propan-2-yl-1,3-oxazol-2-yl)methyl]phenyl]benzenesulfonamide Chemical compound O1C(C(C)C)=CN=C1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 ZBANLLVSIMGZRW-UHFFFAOYSA-N 0.000 claims 1
• UNZAVPNCBSRDCV-OUKQBFOZSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(e)-2-phenylethenyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)\C=C\C=2C=CC=CC=2)=C1C UNZAVPNCBSRDCV-OUKQBFOZSA-N 0.000 claims 1
• XHJSPJIDHBFQBC-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(propan-2-ylamino)methyl]phenyl]benzenesulfonamide Chemical compound CC(C)NCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XHJSPJIDHBFQBC-UHFFFAOYSA-N 0.000 claims 1
• VHHUBYWYNJXLPT-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(pyrimidin-4-ylamino)methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC=2N=CN=CC=2)=C1C VHHUBYWYNJXLPT-UHFFFAOYSA-N 0.000 claims 1
• UNZAVPNCBSRDCV-SEYXRHQNSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[(z)-2-phenylethenyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)\C=C/C=2C=CC=CC=2)=C1C UNZAVPNCBSRDCV-SEYXRHQNSA-N 0.000 claims 1
• JJEZFDSLYAIVIQ-QPPBQGQZSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[[(1s,2s)-2-propan-2-ylcyclopropyl]methyl]phenyl]benzenesulfonamide Chemical compound CC(C)[C@@H]1C[C@H]1CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 JJEZFDSLYAIVIQ-QPPBQGQZSA-N 0.000 claims 1
• ONXMZUQAVIXJEJ-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[[(5-thiophen-2-yl-1h-pyrazol-3-yl)amino]methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CNC2=NNC(=C2)C=2SC=CC=2)=C1C ONXMZUQAVIXJEJ-UHFFFAOYSA-N 0.000 claims 1
• XUNPAGDDNXAXMC-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]phenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2N=C(C=C2)C(F)(F)F)=C1C XUNPAGDDNXAXMC-UHFFFAOYSA-N 0.000 claims 1
• KLWCZZWSEDCMIF-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl]phenyl]benzenesulfonamide;dihydrochloride Chemical compound Cl.Cl.CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN2CCN(CC(F)(F)F)CC2)=C1C KLWCZZWSEDCMIF-UHFFFAOYSA-N 0.000 claims 1
• AHGZOZQQUKVWGC-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-[[propan-2-yl(2,2,2-trifluoroethyl)amino]methyl]phenyl]benzenesulfonamide Chemical compound FC(F)(F)CN(C(C)C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AHGZOZQQUKVWGC-UHFFFAOYSA-N 0.000 claims 1
• FGDSWSREZQFUJT-UHFFFAOYSA-N n-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)-2-phenylphenyl]benzenesulfonamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)C=2C=CC=CC=2)=C1C FGDSWSREZQFUJT-UHFFFAOYSA-N 0.000 claims 1
• KPHSNWGHQFZKIV-UHFFFAOYSA-N n-(4,5-dimethyl-1,2-oxazol-3-yl)-2-[4-(1,3-oxazol-2-yl)-2-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]phenyl]benzenesulfonamide Chemical compound CC1=C(C)ON=C1NS(=O)(=O)C1=CC=CC=C1C1=CC=C(C=2OC=CN=2)C=C1CN1N=C(C(F)(F)F)C=C1 KPHSNWGHQFZKIV-UHFFFAOYSA-N 0.000 claims 1
• UNEBKWQJXUALTC-UHFFFAOYSA-N n-[2-[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]ethyl]-n-methyl-2-phenylacetamide Chemical compound C=1C=CC=CC=1CC(=O)N(C)CCC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C UNEBKWQJXUALTC-UHFFFAOYSA-N 0.000 claims 1
• NDZGAFGACGYJTL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,2-dimethyl-n-(2,2,2-trifluoroethyl)propanamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN(CC(F)(F)F)C(=O)C(C)(C)C)=C1C NDZGAFGACGYJTL-UHFFFAOYSA-N 0.000 claims 1
• DIUGGNHRGFFKOH-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,2-dimethyl-n-propan-2-ylpropanamide Chemical compound CC(C)(C)C(=O)N(C(C)C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C DIUGGNHRGFFKOH-UHFFFAOYSA-N 0.000 claims 1
• XCEBHAKCKONQGK-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,3,5,6-tetrafluoro-n-methylbenzamide Chemical compound FC=1C(F)=CC(F)=C(F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XCEBHAKCKONQGK-UHFFFAOYSA-N 0.000 claims 1
• UZOPYCSSKQZJDP-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,3,6-trifluoro-n-methylbenzamide Chemical compound FC=1C=CC(F)=C(F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C UZOPYCSSKQZJDP-UHFFFAOYSA-N 0.000 claims 1
• BMZRFTYSBPAOOS-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,3-dimethoxy-n-methylbenzamide Chemical compound COC1=CC=CC(C(=O)N(C)CC=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1OC BMZRFTYSBPAOOS-UHFFFAOYSA-N 0.000 claims 1
• HFYMOQIZNQSPBG-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,4,6-trifluoro-n-methylbenzamide Chemical compound FC=1C=C(F)C=C(F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C HFYMOQIZNQSPBG-UHFFFAOYSA-N 0.000 claims 1
• LQGPBOCVAVOKIO-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,5-difluoro-n-methylbenzamide Chemical compound C=1C(F)=CC=C(F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LQGPBOCVAVOKIO-UHFFFAOYSA-N 0.000 claims 1
• JOMYAECCDFTILQ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,6-difluoro-n-methylbenzamide Chemical compound FC=1C=CC=C(F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C JOMYAECCDFTILQ-UHFFFAOYSA-N 0.000 claims 1
• CTWALGFLPPRWNX-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-(1h-indol-3-yl)-n-methylacetamide Chemical compound C=1NC2=CC=CC=C2C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CTWALGFLPPRWNX-UHFFFAOYSA-N 0.000 claims 1
• GOPWIHROLGPQBN-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-(2-fluorophenyl)-n-methylacetamide Chemical compound C=1C=CC=C(F)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C GOPWIHROLGPQBN-UHFFFAOYSA-N 0.000 claims 1
• HLIZLSJMMUPLCL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-(2-methoxyphenyl)-n-methylacetamide Chemical compound COC1=CC=CC=C1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 HLIZLSJMMUPLCL-UHFFFAOYSA-N 0.000 claims 1
• WNWHYJHBXQMWSC-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-(3-methoxyphenyl)-n-methylacetamide Chemical compound COC1=CC=CC(CC(=O)N(C)CC=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1 WNWHYJHBXQMWSC-UHFFFAOYSA-N 0.000 claims 1
• LWLWOFCWRGMTJP-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-(4-methoxyphenyl)-n-methylacetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 LWLWOFCWRGMTJP-UHFFFAOYSA-N 0.000 claims 1
• OYTZMFMEGBAHGE-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-ethyl-n,5-dimethylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 OYTZMFMEGBAHGE-UHFFFAOYSA-N 0.000 claims 1
• WTAKHYUAGZDFEL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-fluoro-n-methylbenzamide Chemical compound C=1C=CC=C(F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WTAKHYUAGZDFEL-UHFFFAOYSA-N 0.000 claims 1
• SSLOOPJPGHJZNS-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-indol-1-yl-n-methylacetamide Chemical compound C1=CC2=CC=CC=C2N1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C SSLOOPJPGHJZNS-UHFFFAOYSA-N 0.000 claims 1
• ROWAVCDXYVGEBK-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2-methoxy-n-methylbenzamide Chemical compound COC1=CC=CC=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 ROWAVCDXYVGEBK-UHFFFAOYSA-N 0.000 claims 1
• TWNPZFARHUKPBV-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3,3,3-trifluoro-n-methylpropanamide Chemical compound FC(F)(F)CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C TWNPZFARHUKPBV-UHFFFAOYSA-N 0.000 claims 1
• TXFSWBFOKOEEGN-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3,4,5-trifluoro-n-methylbenzamide Chemical compound C=1C(F)=C(F)C(F)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C TXFSWBFOKOEEGN-UHFFFAOYSA-N 0.000 claims 1
• CYPRURLLANVTCV-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3,4-difluoro-n-methylbenzamide Chemical compound C=1C=C(F)C(F)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CYPRURLLANVTCV-UHFFFAOYSA-N 0.000 claims 1
• XNUPNTLJAFODQL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3,5-difluoro-n-methylbenzamide Chemical compound C=1C(F)=CC(F)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XNUPNTLJAFODQL-UHFFFAOYSA-N 0.000 claims 1
• OGZBUNZNCKSTLJ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3,5-dimethoxy-n-methylbenzamide Chemical compound COC1=CC(OC)=CC(C(=O)N(C)CC=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1 OGZBUNZNCKSTLJ-UHFFFAOYSA-N 0.000 claims 1
• UOLTUFDYNANGTJ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3-(4-methoxyphenyl)-n-methylpropanamide Chemical compound C1=CC(OC)=CC=C1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 UOLTUFDYNANGTJ-UHFFFAOYSA-N 0.000 claims 1
• MQRNGQKXOMWXIQ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3-(9h-fluoren-9-yl)-n-methylpropanamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C MQRNGQKXOMWXIQ-UHFFFAOYSA-N 0.000 claims 1
• QHBQEKGJNPQJAQ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3-fluoro-n-methyl-5-(trifluoromethyl)benzamide Chemical compound C=1C(F)=CC(C(F)(F)F)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QHBQEKGJNPQJAQ-UHFFFAOYSA-N 0.000 claims 1
• XLBPLLJTTYWDJE-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3-fluoro-n-methylbenzamide Chemical compound C=1C=CC(F)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XLBPLLJTTYWDJE-UHFFFAOYSA-N 0.000 claims 1
• RMNSVPPJBNQLKU-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-3-methoxy-n-methylbenzamide Chemical compound COC1=CC=CC(C(=O)N(C)CC=2C(=CC=C(C=2)C=2OC=CN=2)C=2C(=CC=CC=2)S(=O)(=O)NC2=C(C(C)=NO2)C)=C1 RMNSVPPJBNQLKU-UHFFFAOYSA-N 0.000 claims 1
• DSSUXSYQURICTO-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-4-fluoro-n-methyl-2-(trifluoromethyl)benzamide Chemical compound C=1C=C(F)C=C(C(F)(F)F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C DSSUXSYQURICTO-UHFFFAOYSA-N 0.000 claims 1
• HNKRJTWUDLHHKX-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-4-fluoro-n-methylbenzamide Chemical compound C=1C=C(F)C=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C HNKRJTWUDLHHKX-UHFFFAOYSA-N 0.000 claims 1
• IYSBWOSAQIATBU-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-4-fluoro-n-methylnaphthalene-1-carboxamide Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C IYSBWOSAQIATBU-UHFFFAOYSA-N 0.000 claims 1
• CPNMBBUBXIVUFW-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-4-methoxy-n-methylquinoline-2-carboxamide Chemical compound N=1C2=CC=CC=C2C(OC)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CPNMBBUBXIVUFW-UHFFFAOYSA-N 0.000 claims 1
• KJGWUVOWSVFBHN-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-5-fluoro-n-methyl-1h-indole-2-carboxamide Chemical compound C=1C2=CC(F)=CC=C2NC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C KJGWUVOWSVFBHN-UHFFFAOYSA-N 0.000 claims 1
• ITTGFEIKXKSDPE-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,1,3,5-tetramethylpyrazole-4-carboxamide Chemical compound CC1=NN(C)C(C)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ITTGFEIKXKSDPE-UHFFFAOYSA-N 0.000 claims 1
• WQXYQMMBJYKMIL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,1,5-trimethylpyrazole-3-carboxamide Chemical compound C1=C(C)N(C)N=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WQXYQMMBJYKMIL-UHFFFAOYSA-N 0.000 claims 1
• AOOKNPITEDSSNB-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,1-dimethylindole-2-carboxamide Chemical compound C=1C2=CC=CC=C2N(C)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AOOKNPITEDSSNB-UHFFFAOYSA-N 0.000 claims 1
• IXDSIKQHFRBQFP-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,1-dimethylpyrazole-4-carboxamide Chemical compound C1=NN(C)C=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C IXDSIKQHFRBQFP-UHFFFAOYSA-N 0.000 claims 1
• VWBYBVIFHCKDDT-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2,2-trimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxamide Chemical compound CC(C)=CC1C(C)(C)C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C VWBYBVIFHCKDDT-UHFFFAOYSA-N 0.000 claims 1
• QXJMSZDXBBMLGU-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2,2-trimethylpropanamide Chemical compound CC(C)(C)C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QXJMSZDXBBMLGU-UHFFFAOYSA-N 0.000 claims 1
• XPHCVCZGNNGODS-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2,5-trimethylpyrazole-3-carboxamide Chemical compound C=1C(C)=NN(C)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XPHCVCZGNNGODS-UHFFFAOYSA-N 0.000 claims 1
• HXXJAUGLLHNDLA-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2-dimethyl-4-(trifluoromethyl)pyridine-3-carboxamide Chemical compound CC=1N=CC=C(C(F)(F)F)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C HXXJAUGLLHNDLA-UHFFFAOYSA-N 0.000 claims 1
• QGMUOSXKQHPOGD-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,2-dimethylpropanamide Chemical compound CC(C)C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QGMUOSXKQHPOGD-UHFFFAOYSA-N 0.000 claims 1
• QDKJEEQYGZGXKJ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3,3-trimethylbutanamide Chemical compound CC(C)(C)CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QDKJEEQYGZGXKJ-UHFFFAOYSA-N 0.000 claims 1
• VUDMNQYCSXTPIX-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3,5-trimethyl-1,2-oxazole-4-carboxamide Chemical compound CC1=NOC(C)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C VUDMNQYCSXTPIX-UHFFFAOYSA-N 0.000 claims 1
• KMSQOMIQKFBSSG-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3-dimethyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxamide Chemical compound CC1=NOC(C(F)(F)F)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C KMSQOMIQKFBSSG-UHFFFAOYSA-N 0.000 claims 1
• WMWSRURAXCVHQA-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3-dimethylbutanamide Chemical compound CC(C)CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WMWSRURAXCVHQA-UHFFFAOYSA-N 0.000 claims 1
• ONRZOMKVKOAFHV-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,3-dimethylthiophene-2-carboxamide Chemical compound S1C=CC(C)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ONRZOMKVKOAFHV-UHFFFAOYSA-N 0.000 claims 1
• UYHNZRLOXKWPKC-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,5-dimethyl-1-phenylpyrazole-4-carboxamide Chemical compound C1=NN(C=2C=CC=CC=2)C(C)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C UYHNZRLOXKWPKC-UHFFFAOYSA-N 0.000 claims 1
• MDAXPIAJLYIIMF-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,5-dimethyl-1h-pyrazole-3-carboxamide Chemical compound C1=C(C)NN=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C MDAXPIAJLYIIMF-UHFFFAOYSA-N 0.000 claims 1
• RWZYAMFYMXLUGR-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,5-dimethyl-2-phenyltriazole-4-carboxamide Chemical compound N=1N(C=2C=CC=CC=2)N=C(C)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C RWZYAMFYMXLUGR-UHFFFAOYSA-N 0.000 claims 1
• POEBRNXHTVFQQR-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,6-dimethylpyridine-2-carboxamide Chemical compound C=1C=CC(C)=NC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C POEBRNXHTVFQQR-UHFFFAOYSA-N 0.000 claims 1
• KGQFBDBYVHIYED-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-1,2,3,4-tetrahydronaphthalene-2-carboxamide Chemical compound C1CC2=CC=CC=C2CC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C KGQFBDBYVHIYED-UHFFFAOYSA-N 0.000 claims 1
• BPRJCJVCGXSMEB-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-1,3-benzodioxole-5-carboxamide Chemical compound C=1C=C2OCOC2=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C BPRJCJVCGXSMEB-UHFFFAOYSA-N 0.000 claims 1
• AIARXXZRXOTVFX-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-1,3-benzothiazole-6-carboxamide Chemical compound C=1C=C2N=CSC2=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AIARXXZRXOTVFX-UHFFFAOYSA-N 0.000 claims 1
• ALCHKTGFAUVURT-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-1,4-dithiaspiro[4.5]decane-8-carboxamide Chemical compound C1CC2(SCCS2)CCC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ALCHKTGFAUVURT-UHFFFAOYSA-N 0.000 claims 1
• KKCQMOPFIXORCG-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-1-phenylcyclopropane-1-carboxamide Chemical compound C1CC1(C=1C=CC=CC=1)C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C KKCQMOPFIXORCG-UHFFFAOYSA-N 0.000 claims 1
• HVQFJGHMEYETOZ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-1h-indole-2-carboxamide Chemical compound C=1C2=CC=CC=C2NC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C HVQFJGHMEYETOZ-UHFFFAOYSA-N 0.000 claims 1
• DMURPBTXFDGBQV-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2,3-dihydro-1h-indene-2-carboxamide Chemical compound C1C2=CC=CC=C2CC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C DMURPBTXFDGBQV-UHFFFAOYSA-N 0.000 claims 1
• PGZCJTHERWNNJN-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(1-phenyl-5-propylpyrazol-4-yl)acetamide Chemical compound C1=NN(C=2C=CC=CC=2)C(CCC)=C1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C PGZCJTHERWNNJN-UHFFFAOYSA-N 0.000 claims 1
• WZSYJAUQVWBRAC-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(2,4,6-trimethylphenyl)acetamide Chemical compound CC=1C=C(C)C=C(C)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WZSYJAUQVWBRAC-UHFFFAOYSA-N 0.000 claims 1
• QBEDPHFBAMFXEU-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(2-methylphenyl)acetamide Chemical compound C=1C=CC=C(C)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QBEDPHFBAMFXEU-UHFFFAOYSA-N 0.000 claims 1
• RXLJEXVPEZHEHN-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(2-phenylmethoxyphenyl)acetamide Chemical compound C=1C=CC=C(OCC=2C=CC=CC=2)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C RXLJEXVPEZHEHN-UHFFFAOYSA-N 0.000 claims 1
• CJFLQKWNHVXRDF-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(4-methyl-2-sulfanylidene-1,3-thiazol-3-yl)acetamide Chemical compound CC1=CSC(=S)N1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CJFLQKWNHVXRDF-UHFFFAOYSA-N 0.000 claims 1
• PCVBWXIDOIXKTI-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetamide Chemical compound N1=C(C=2C=CC=CC=2)OC(C)=C1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C PCVBWXIDOIXKTI-UHFFFAOYSA-N 0.000 claims 1
• CQMUBBIOERFYQP-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-(5-pyrrolidin-1-yltetrazol-2-yl)acetamide Chemical compound N1=NC(N2CCCC2)=NN1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CQMUBBIOERFYQP-UHFFFAOYSA-N 0.000 claims 1
• APQPWZYPUUIXDW-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-[2-(trifluoromethyl)phenyl]acetamide Chemical compound C=1C=CC=C(C(F)(F)F)C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C APQPWZYPUUIXDW-UHFFFAOYSA-N 0.000 claims 1
• GESHEWKJMUBHDA-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-[3-(trifluoromethyl)phenyl]acetamide Chemical compound C=1C=CC(C(F)(F)F)=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C GESHEWKJMUBHDA-UHFFFAOYSA-N 0.000 claims 1
• UIXIDUJBKFHBRP-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-[4-(trifluoromethyl)phenyl]acetamide Chemical compound C=1C=C(C(F)(F)F)C=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C UIXIDUJBKFHBRP-UHFFFAOYSA-N 0.000 claims 1
• IAUXXXGTXASETI-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-[5-[3-(trifluoromethyl)phenyl]tetrazol-2-yl]acetamide Chemical compound N1=NC(C=2C=C(C=CC=2)C(F)(F)F)=NN1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C IAUXXXGTXASETI-UHFFFAOYSA-N 0.000 claims 1
• RVZSHBCIPYJQKA-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-naphthalen-1-ylacetamide Chemical compound C=1C=CC2=CC=CC=C2C=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C RVZSHBCIPYJQKA-UHFFFAOYSA-N 0.000 claims 1
• PGRXJCPYSBLWQZ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-phenoxyacetamide Chemical compound C=1C=CC=CC=1OCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C PGRXJCPYSBLWQZ-UHFFFAOYSA-N 0.000 claims 1
• XJQBYVAZBHBUGD-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-phenoxypyridine-3-carboxamide Chemical compound C=1C=CN=C(OC=2C=CC=CC=2)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C XJQBYVAZBHBUGD-UHFFFAOYSA-N 0.000 claims 1
• CJGRNBWHDOSFES-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-phenylacetamide Chemical compound C=1C=CC=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CJGRNBWHDOSFES-UHFFFAOYSA-N 0.000 claims 1
• LIQDEPCQQQFLNL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-phenylbenzamide Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LIQDEPCQQQFLNL-UHFFFAOYSA-N 0.000 claims 1
• YRQIVEIVRAWSIB-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-pyridin-2-ylacetamide Chemical compound C=1C=CC=NC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C YRQIVEIVRAWSIB-UHFFFAOYSA-N 0.000 claims 1
• IYNPQOHNMMIMEG-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-pyridin-3-ylacetamide Chemical compound C=1C=CN=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C IYNPQOHNMMIMEG-UHFFFAOYSA-N 0.000 claims 1
• FGYVHQNEKKPTNJ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-pyridin-4-ylacetamide Chemical compound C=1C=NC=CC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C FGYVHQNEKKPTNJ-UHFFFAOYSA-N 0.000 claims 1
• NKRAMZYHQPIHHA-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-2-thiophen-2-ylacetamide Chemical compound C=1C=CSC=1CC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C NKRAMZYHQPIHHA-UHFFFAOYSA-N 0.000 claims 1
• QEGKNNWKXSXZCT-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-3-(1-methylbenzimidazol-2-yl)propanamide Chemical compound N=1C2=CC=CC=C2N(C)C=1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QEGKNNWKXSXZCT-UHFFFAOYSA-N 0.000 claims 1
• UIJPIKIRRMONAO-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-3-(2-oxo-1,3-benzoxazol-3-yl)propanamide Chemical compound C12=CC=CC=C2OC(=O)N1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C UIJPIKIRRMONAO-UHFFFAOYSA-N 0.000 claims 1
• YCWSPQKIPMAWBM-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-3-(trifluoromethyl)benzamide Chemical compound C=1C=CC(C(F)(F)F)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C YCWSPQKIPMAWBM-UHFFFAOYSA-N 0.000 claims 1
• MPDKEVTVPHQSNI-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-3-[(4-methylphenoxy)methyl]benzamide Chemical compound C=1C=CC(COC=2C=CC(C)=CC=2)=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C MPDKEVTVPHQSNI-UHFFFAOYSA-N 0.000 claims 1
• CMRIQBLOCJBMQY-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-3-phenylpropanamide Chemical compound C=1C=CC=CC=1CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CMRIQBLOCJBMQY-UHFFFAOYSA-N 0.000 claims 1
• AACHUQWCSMMWHM-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-4-(thiadiazol-4-yl)benzamide Chemical compound C=1C=C(C=2N=NSC=2)C=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C AACHUQWCSMMWHM-UHFFFAOYSA-N 0.000 claims 1
• RFUACYZIUARIOU-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-4-(trifluoromethoxy)benzamide Chemical compound C=1C=C(OC(F)(F)F)C=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C RFUACYZIUARIOU-UHFFFAOYSA-N 0.000 claims 1
• ODXIVBVDWHXEAO-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-4-(trifluoromethyl)benzamide Chemical compound C=1C=C(C(F)(F)F)C=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C ODXIVBVDWHXEAO-UHFFFAOYSA-N 0.000 claims 1
• TYBWFGJPUKHUPB-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-4-phenylbenzamide Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C TYBWFGJPUKHUPB-UHFFFAOYSA-N 0.000 claims 1
• CMVNXRCEQKICFL-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-4-phenylthiadiazole-5-carboxamide Chemical compound S1N=NC(C=2C=CC=CC=2)=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CMVNXRCEQKICFL-UHFFFAOYSA-N 0.000 claims 1
• HYOOTEWLOVLOOX-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-4-propan-2-yloxybenzamide Chemical compound C1=CC(OC(C)C)=CC=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=C(C)C(C)=NO1 HYOOTEWLOVLOOX-UHFFFAOYSA-N 0.000 claims 1
• GNSACZGSXOJQJC-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide Chemical compound C=1C=C(C=2N(N=C(C=2)C(F)(F)F)C)SC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C GNSACZGSXOJQJC-UHFFFAOYSA-N 0.000 claims 1
• QBQXYOYWLBEQOS-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyl-5-pyridin-2-ylthiophene-2-carboxamide Chemical compound C=1C=C(C=2N=CC=CC=2)SC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C QBQXYOYWLBEQOS-UHFFFAOYSA-N 0.000 claims 1
• KMOYVJSVLLXFQU-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbenzamide Chemical compound C=1C=CC=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C KMOYVJSVLLXFQU-UHFFFAOYSA-N 0.000 claims 1
• RQEXVPGDVBHGIR-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide Chemical compound C1C2=CC=CC=C2C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C RQEXVPGDVBHGIR-UHFFFAOYSA-N 0.000 claims 1
• TVENHHSFVCONFZ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylcinnoline-4-carboxamide Chemical compound C=1N=NC2=CC=CC=C2C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C TVENHHSFVCONFZ-UHFFFAOYSA-N 0.000 claims 1
• SRBQQHRFNCDDQH-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylcyclobutanecarboxamide Chemical compound C1CCC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C SRBQQHRFNCDDQH-UHFFFAOYSA-N 0.000 claims 1
• MWNSJQIOMFDDBE-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylcyclopropanecarboxamide Chemical compound C1CC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C MWNSJQIOMFDDBE-UHFFFAOYSA-N 0.000 claims 1
• CAPYHDUFQNQXNZ-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylnaphthalene-1-carboxamide Chemical compound C=1C=CC2=CC=CC=C2C=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C CAPYHDUFQNQXNZ-UHFFFAOYSA-N 0.000 claims 1
• WXYCKWKKERRICY-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methyloxolane-2-carboxamide Chemical compound C1CCOC1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WXYCKWKKERRICY-UHFFFAOYSA-N 0.000 claims 1
• LDUHHKKKMDLMKC-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpyrazine-2-carboxamide Chemical compound C=1N=CC=NC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C LDUHHKKKMDLMKC-UHFFFAOYSA-N 0.000 claims 1
• NPVXQIZTHBJVMG-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpyridine-2-carboxamide Chemical compound C=1C=CC=NC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C NPVXQIZTHBJVMG-UHFFFAOYSA-N 0.000 claims 1
• VXTCEHYJEGIMBC-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C VXTCEHYJEGIMBC-UHFFFAOYSA-N 0.000 claims 1
• SWEWDMZULVGCQX-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylpyridine-4-carboxamide Chemical compound C=1C=NC=CC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C SWEWDMZULVGCQX-UHFFFAOYSA-N 0.000 claims 1
• YNJMUZRZFZRORD-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylthiadiazole-4-carboxamide Chemical compound C=1SN=NC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C YNJMUZRZFZRORD-UHFFFAOYSA-N 0.000 claims 1
• STOLNKFWOZZZDM-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylthiophene-2-carboxamide Chemical compound C=1C=CSC=1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C STOLNKFWOZZZDM-UHFFFAOYSA-N 0.000 claims 1
• OMYLMVSHOLIIFN-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-methylthiophene-3-carboxamide Chemical compound C1=CSC=C1C(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C OMYLMVSHOLIIFN-UHFFFAOYSA-N 0.000 claims 1
• WMWPXHNXVWHOLE-UHFFFAOYSA-N n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n-propan-2-ylpropanamide Chemical compound CCC(=O)N(C(C)C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC=1ON=C(C)C=1C WMWPXHNXVWHOLE-UHFFFAOYSA-N 0.000 claims 1
• RTZCFICBPGNGBQ-UHFFFAOYSA-N n-[[2-[2-[(4,5-dimethyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-n,4,4-trimethylpentanamide Chemical compound CC(C)(C)CCC(=O)N(C)CC1=CC(C=2OC=CN=2)=CC=C1C1=CC=CC=C1S(=O)(=O)NC1=NOC(C)=C1C RTZCFICBPGNGBQ-UHFFFAOYSA-N 0.000 claims 1
• KTPXYCOGWGATSP-UHFFFAOYSA-N n-cyclopropyl-n-[[2-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]-2,2-dimethylpropanamide Chemical compound CC1=NOC(NS(=O)(=O)C=2C(=CC=CC=2)C=2C(=CC(=CC=2)C=2OC=CN=2)CN(C2CC2)C(=O)C(C)(C)C)=C1C KTPXYCOGWGATSP-UHFFFAOYSA-N 0.000 claims 1
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